• Biomolecules & Therapeutics
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• 제16권3호
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• pp.261-269
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• 2008

This experiment was performed to investigate the anxiolytic-like effects of cyclopeptide fraction alkaloids of Zizyphi Spinosi Semen (CFAZ), by using the experimental paradigms of anxiety, and compared with those of a known anxiolytic, diazepam. CFAZ (8.0 mg/kg, p.o.) increased the percentage of time spent on the open arms and the number of open arms entries in the elevated plus-maze test, increased the number of head dips in the hole-board test, and increased the percentage of center zone ambulatory time in the open-field box. However, CFAZ has no effect on the locomotor activity, while diazepam (2.0 mg/kg, p.o.) significantly reduced locomotor activity. CFAZ did not influence the grip force in the grip strength meter test, either. From the molecular experiments, CFAZ increased chloride influx in cultured cerebellar granule cells. In addition, $GABA_A$ receptors $\gamma$-subunit were over-expressed by CFAZ in cultured cerebellar granule cells. It is concluded that CFAZ may have anxiolytic-like effects, and these effects may be mediated by $GABA_A$ receptors.

• 한국수정란이식학회:학술대회논문집
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• 한국수정란이식학회 2001년도 춘계학술세미나 및 워크숍
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• pp.4-16
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• 2001

Sperm competent for fertilization can become capacitated, bind to the zona pellucida (ZP)of an egg in a specific manner, and complete acrosomal exocytosis. Failure to carry out these functions results in infertility. Although the interactions between the ZP and the plasma membrane overlying the sperm acrosome have been considered important for sperm-egg recognition and signalling recent results have prompted a reassessment of current paradigms concerning these interactions. In this review, we're going to discuss about the roles of the acrosomal matrix, the particulate component of the acrosomal contents, in fertilization. The general hypothesis is that acrosomal exocytosis leads to the exposure of acrosomal matrix proteins that become de facto extracellula matrix(ECM) on the surface of the sperm head, and that the dynamic interactions of this newly-exposed sperm ECM with the egg ECM (the ZP) govern sperm-egg recognition and sperm penetration of the ZP. Informations from these experiments may provide new ways to address the poor ZP binding of sperm from some human infertility patients and may offer new avenues for contraception through the disruption of purposeful sperm-ZP binding.

• 한국멀티미디어학회논문지
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• 제2권2호
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• pp.129-136
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• 1999

특정 이미지에서의 선형적 특정은 이미지를 분석하고 이해하는데 충분한 정보를 제공하기도 한다. 본고에 서는 이미지에서 선형적 특징을 추출하기 위한 신뢰성 있는 방법을 제시한다. 일반적으로 후프 변형 방법은 이러한 선형적 특정을 추출하는 최적의 방법 중의 하나로 인식되어 왔다. 대부분의 후프 기반 방법들은 특정 edge 모델올 선택하고, 인식된 edge 픽셀의 속성을 반영하는 변형식을 활용하여 파라미터 공간에 그 발생빈도 를 기록하는 과정을 거치게 된다. 주로 edge 픽셀의 gradient 크기와 방향이 선형적 특정을 결정하는데 사용되 지만, 본고에서는 그 값틀이 퍼지변수로 활용될 수 있음을 보이고 파라미터 공간에 누적값을 계산하는데 활용한다- 이 방법을 기존의 방법과 비교하기 위하여 에러 측정 방식을 제안하고, 실험을 한 결과, 기존의 방법과 비교하여 우수한 성능을 보인다.

• 산업공학
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• 제18권1호
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• pp.52-62
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• 2005

Recently, several attempts have been made to introduce the process concept to knowledge management (KM) or the knowledge concept to business process management (BPM) in order to combine the advantages of the two approaches. However, clear description about their interrelationship or a comprehensive framework to combine them has not been provided. This paper explores how KM and BPM can complement each other and proposes a framework to integrate the two paradigms. The concept of process knowledge proposed by this paper focuses on the importance of business processes as knowledge, which is overlooked by existing KM or BPM research efforts. The paper proposes a framework that combines and extends the functionalities of existing knowledge management systems (KMSs) and business process management systems (BPMSs) by identifying the functionalities required to manage process knowledge from the lifecycle perspective of both knowledge management and business process management. A prototype system is also presented to demonstrate the feasibility of the proposed framework.

• Asian Pacific Journal of Cancer Prevention
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• 제15권16호
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• pp.6485-6488
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• 2014

Research over the years has progressively and sequentially provided near complete resolution of regulators of the DNA repair pathways which are so important for cancer prevention. Ataxia-telangiectasia mutated kinase (ATM), a high-molecular-weight PI3K-family kinase has emerged as a master regulator of DNA damage signaling and extensive cross-talk between ATM and downstream proteins forms an interlaced signaling network. There is rapidly growing scientific evidence emphasizing newly emerging paradigms in ATM biology. In this review, we provide latest information regarding how oxidative stress induced activation of ATM can be utilized as a therapeutic target in different cancer cell lines and in xenografted mice. Moreover, crosstalk between autophagy and ATM is also discussed with focus on how autophagy inhibition induces apoptosis in cancer cells.

• 정보관리학회지
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• 제19권4호
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• pp.214-231
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• 2002

본 연구는 디지털참고정보서비스의 최근 개발 동향을 고찰한 것이다. 디지털참고정보서비스와 관련한 국내외 선행 연구를 개관하였고 기술 개발로 인한 새로운 서비스 패러다임을 설명하였다. 그리고 웹 상의 참고정보서비스로서 도서관이 제공하는 것, 출판사에 의한 것, 전문가에 의한 것, 그리고 이용자 직접 탐색 등을 간략하게 열거하였다. 최근의 추세는 협력 모델이 주목을 받고 있으므로 Collaborative Digital Reference Service(CDRS)와 같은 디지털참고정보서비스 협력을 중점적으로 소개하였다. 도서관 전문직들은 디지털 환경에 적합한 참고정보서비스 협력에 관심을 가지고 그 필요성을 분석해야 할 것이다.

• 한국경영과학회:학술대회논문집
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• 한국경영과학회 1998년도 추계학술대회 논문집
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• pp.407-410
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• 1998

Configuration is a set of building block processes, a series of selection and combining parts or components which composes a whole thing. A whole thing could be such a configurable object as manufacturing product, network system, financial portfolio, system development plan, project team, etc. Configuration problem could happen during any phase of product life cycle: design, production, sales, installation, and maintenance. Configuration has long been one of cost and time consuming work, because only high salaried technical experts on product and components can do configuration. Rework for error adjustments of configurations at later process causes far much cost and time, so accurate configuration is required. Under the on-line electronic commerce environment, configuration problem solving becomes more important, because component-based sales should be done automatically on the merchant web site. Automated product search, order placement, order fulfillment and payment make that manual configuration is no longer feasible. Automated configuration means that all the constraints among components should be checked and confirmed by configuration engine automatically. In addition, technical constraints and customer preferences like price range and a specific function required should be considered. This paper gives an brief overview of configuration problems: characteristics, representation paradigms, and solving algorithms and introduce CRSP(Constraint and Rule Satisfaction Problem) method. CRSP method adopts both constraint and rule for configuration domain knowledge representation. A survey and analysis on web sites adopting configuration functions are provided. Future directions of configuration for EC is discussed in the three aspects: methodology itself, companies adopting configuration function, and electronic commerce industry.

• 한국환경교육학회지:환경교육
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• 제14권1호
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• pp.1-18
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• 2001

The purpose of this study is to research new paradigms of environmental ethics and environmental ethics education to overcome ecological crisis and to develop an alternative model of systematic environmental ethics education for establishing eco-centred life values. According to deep ecologists, they assert the necessity of basic reorientation of crucial components of present political, economic and social orders to overcome ecological crisis today. This means the movement from the mechanistic worldview to the ecological worldview and the shift from Dominant Social Paradigm(DSP) to New Ecological Paradigm(NEP). Environmental ethics education should be 'eco-centred environmental ethics education'which makes some contribution to overcome ecological crisis and to create new alternatives. Also it should be not a simple behavior change but 'eco-centred environmental ethics education', what is called, as 'ecological literacy education'which changes the views of values, thoughts and attitudes etc. In this, as a new social curriculum, 'ecological literacy education'means to cultivate the ability which can recognize environmental problems correctly and to overcome ecological crisis wisely we face with today. To perform this ecological environmental ethics education, we suggested 'eco-centred life values', we place a criterion of moral value judgment according to 'ecological conscience'on 'life', and we presented 'an alternative model of environmental ethics education' giving consideration to human being, nature and environment at the same time.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제9권6호
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• pp.1979-1995
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• 2015

Network convergence is regarded as the development tendency of the future wireless networks, for which self-organization paradigms provide a promising solution to alleviate the upgrading capital expenditures (CAPEX) and operating expenditures (OPEX). Self-optimization, as a critical functionality of self-organization, employs a decentralized paradigm to dynamically adapt the varying environmental circumstances while without relying on centralized control or human intervention. In this paper, we present comprehensive surveys of heterogeneous networks (HetNets) and investigate the enhanced self-optimization models. Self-optimization approaches such as dynamic mobile access network selection, spectrum resource allocation and power control for HetNets, etc., are surveyed and compared, with possible methodologies to achieve self-optimization summarized. We hope this survey paper can provide the insight and the roadmap for future research efforts in the self-optimization of convergence networks.

• 한국실내디자인학회논문집
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• 제24권2호
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• pp.117-124
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• 2015

With the modern society approaching, a lot of new paradigms have been created which can be explained by the existing space notions while suspicions on the true essence and existence of space have been raised. Ontology regards as the beginning the cause for a 'Field' which will be faced for the research of the essence of a space where 'being-in-the-world' exists. This study has analyzed the existing method of space construction in the spatial thinking and works of Peter Zumthor who mentioning ontological viewpoint as the physiological background of his works so that the ontological spatial concept may be clarified. The following is the study results. First, in order to construct the structures of his own designing into a 'Field' for experiencing the existential meaning, Zumthor chose a reductive pattern with the entire additional elements removed. The materials leading the subjects to call attention to memory and experience and the methods dealing with it enables the realization of various spatial essences. Second, the ontological event-system is required for the formation of relationship among beings. He tried to create a spatial meaning by introducing external environment into the inside and using the materials reflecting regional features and phenomenological empiricism through the multisensory experience. Third, he applied assimilation/insert/adjustment/formative change as the way of constructing the relationship between site and structure.