• Journal of Veterinary Clinics
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• v.21 no.4
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• pp.409-412
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• 2004

Authors introduce a case of successful orthopedic surgery for humeral fracture of Common buzzard (Buteo buteo). The bird, juvenile male, was rescued due to illegal gun shot in Yeoncheon-Gun, Kyonggi-Do. The external skeletal fixation (ESF) with intramedullary pinning (Tie-in method) using Imex clamps was chosen for this fracture case. The common buzzard was anesthetized with hand made face mask and Isoflurane. In particular, the rescued bird was needed rehabilitating procedures, such as flight training or physical exercise for their survivals in wild habitats. The injured buzzard is successfully recovered without any damage to ligaments and nerves after 6 weeks.

• Journal of Veterinary Clinics
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• v.41 no.3
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• pp.189-194
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• 2024

Cinereous vulture (Aegypius monachus) is a large raptor that belongs to the family Accipitridae in the order Falconiformes. It is a migratory bird that returns to Mongolia after wintering in the Korean Peninsula. In February 2015, a cinereous vulture was rescued from Asan-si, Chungcheongnam-do Province as it could not fly. It was transferred to the Chungnam Wild Animal Rescue Center in Korea. It was found to have a closed fracture on the right radius through radiographic examination, a basic procedure. Surgery was performed at the fracture site using a shuttle pin and wire. After successful physical therapy and rehabilitation, the cinereous vulture was released in October 2015. A metal ring (150-00713) and wing tags (G/BL 3) were attached to the bird before its release for subsequent identification. Two years and 4 months later, in March 2018, the cinereous vulture was rescued and brought back to the center. It was diagnosed with secondary pesticide poisoning. After receiving treatment, a radiography test revealed no specific findings related to the previous fracture surgery. Considering that migratory birds travel long distances, it was confirmed that the treatment for reducing the fracture in the radius using a shuttle pin and a cerclage wire was suitable.

• Journal of Trauma and Injury
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• v.25 no.4
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• pp.230-240
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• 2012

Purpose: We aimed to compare the transport time, the proportion of direct hospital visit and the emergency procedures between the current mountain rescue helicopter emergency medical service (HEMS) and physician-staffed mountain-rescue HEMS. Methods: During weekends from October 2, to November 21, 2010, 9 emergency physicians participated as HEMS staff in the mountain-rescue HEMS program of the Seoul fire department. Patient demographic data, transport time, proportion of direct hospital visits, and emergency procedures were recorded. We also collected data on HEMS mountain-rescued patients from June 1, to September 1, 2010, and we compared them to those for the study patients. After an eight-week trial of the HEMS, we performed a delphi survey to determine the attitude of the physician staff, as well as the feasibility of using a physician staff. Results: Twenty-four(24) patients were rescued from mountains by physician-staffed HEMS during the study period, and 35 patients were rescued during the pre-study period. Patient demographic findings were not statistically different between the two groups, but the transport time and the emergency procedures were. During the study period, the time from call to take-off was $6.1{\pm}4.1min$ (vs. $12.1{\pm}8.9min$ during the pre-study period, p-value=0.001), and the time from call to arrival at the scene was $15.0{\pm}4.8min$ (vs. $22.3{\pm}8.1min$ during the pre-study period, p-value=0.0001). The proportions of direct hospital visit were not different between the two groups, but more aggressive emergency procedures were implemented in the study group. The delphi survey showed positive agreement on indications for HEMS, rapidity of transport and overall satisfaction. Conclusion: A pilot trial of physician-staffed HEMS for mountain rescue showed rapid response and more aggressive performance of emergency procedures with high satisfaction among the attending physicians.

• Journal of Microbiology and Biotechnology
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• v.24 no.9
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• pp.1207-1215
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• 2014

Candida albicans, the major human fungal pathogen, undergoes morphological transition from the budding yeast form to filamentous growth in response to nitrogen starvation. In this study, we identified a new function of GST2, whose expression was required for filamentous growth of C. albicans under nitrogen-limiting conditions. The Gst2p showed Gst activity and required response to oxidative stress. The ${\Delta}gst2$ mutant displayed predominantly yeast phase growth in low ammonium media. Such morphological defect of ${\Delta}gst2$ mutants was not rescued by overexpression of Mep2p, Cph1p, or Efg1p, but was rescued by either overexpression of a hyperactive $RAS1^{G13V}$ allele or through exogenous addition of cyclic AMP. In addition, the ${\Delta}gst2$ mutants had lower levels of RAS1 transcripts than wild-type cells under conditions of nitrogen starvation. These results were consistent with the Ras1-cAMP pathway as a possible downstream target of Gst2p. These findings suggest that Gst2p is a significant component of nitrogen starvation-induced filamentation in C. albicans.

• Journal of Veterinary Clinics
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• v.35 no.5
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• pp.184-189
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• 2018

Wild birds rescued for various reasons are injured and admitted to a wild animal rescue center. With the case of collision with cars, buildings and wires on a power pole, most wild birds are severely traumatized or get fractured, which need intensive veterinary treatment. In general, inhalation anesthesia to wild birds is the best choice for the medical and surgical procedure, and intubation is recommended for the stable anesthesia. Although the certain size of an endotracheal tube can be chosen depending on the size and morphology of the bird, there are a few standardized guidelines. Therefore, the optimal endotracheal size of the rescued 162 individual birds of 41 species for four years from March 2014 to December 2017 was investigated and sorted empirically, suggesting possibly the appropriate endotracheal sizes for diverse avian species. It may provide practical information data for wildlife veterinarians to select the size of an endotracheal tube according to the size of the domestic wild bird species, especially during surgery in the emergency cases.

• The Korean Journal of Emergency Medical Services
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• v.6 no.1
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• pp.55-64
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• 2002

This analysis is accomplished by using 331 rescue and medical evacuation cases performed by KangWonDo Fire Service Department Aviation(KFSA-119 Heicopters) between Jan. 1998 and Oct. 2002. By analysing injury causes, annual differences, sexual, scenic(locaional) distribution and wounded part distribution, this study tried to figure out the general tendency of the helicopter-transported patients in Korea. The results are as follows; 1. The whole population of the patients rescued and transported by helicopters is increasing by the annual rate of 150%~200%. 2. For the locational (scenic) distribution of the patients, 57% (190 cases) of the target population were injured on their mountain-climbing or tracking. 3. 12% (41 cases) of the target population were the Inter-Hospital transport cases. 4. 6% (16 cases) were the expired cases. 5. for the wounded part distribution, 46% (106 cases) were muscular skeletal injuries. 6. The aircraft and personnel of the KFSA were rescue-oriented, so for the EMS operations especially inter-hospital transport missions, different medical equipments and personnels are needed.

• Development and Reproduction
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• v.18 no.4
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• pp.225-231
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• 2014

Autophagy is a homeostatic degradation process that is involved in tumor development and normal development. Autophagy is induced in cancer cells in response to chemotherapeutic agents, and inhibition of autophagy results in enhanced cancer cell death or survival. Chloroquine (CQ), an anti-malarial drug, is a lysosomotropic agent and is currently used as a potential anticancer agent as well as an autophagy inhibitor. Here, we evaluate the characteristics of these dual activities of CQ using human colorectal cancer cell line HCT15. The results show that CQ inhibited cell viability in dose- and time-dependent manner in the range between 20 to 80 uM, while CQ did not show any antiproliferative activity at 5 and 10 uM. Cotreatment of CQ with antitumor agent NVP-BEZ235, a dual inhibitor of PI3K/mTOR, rescued the cell viability at low concentrations meaning that CQ acted as an autophagy inhibitor, but CQ induced the lethal effect at high concentrations. Acridine orange staining revealed that CQ at high doses induced lysosomal membrane permeabilization (LMP). High doses of CQ produced cellular reactive oxygen species (ROS) and cotreatment of antioxidants, such as NAC and trolox, with high doses of CQ rescued the cell viability. These results suggest that CQ may exert its dual activities, as autophagy inhibitor or LMP inducer, in concentration-dependent manner.

• Reproductive and Developmental Biology
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• v.34 no.2
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• pp.63-71
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• 2010

The spontaneous mutant circling mouse (cir/cir) shows a circling behavior and hearing loss. We produced transgenic mice overexpressing transmembrane inner ear (tmie) gene, the causative gene, for the phenotypic rescue of the circling mouse. Through the continuous breeding with circling mice, the cir/cir homozygous mice carrying the transgene (cir/cir-tg) were produced. The rescued cir/cir-tg mice were able to swim in the water with proper orientation and did not show any circling behavior like wild type mice. Western blot and immunohistochemical analysis exhibited that the transgenic tmie was expressed in the inner ear. Inner and outer hair cells were recovered in the cochlea and spiral ganglion neurons were also recovered in the rescued mice. Auditory brainstem response (ABR) test demonstrated that the cir/cir-tg mice are able to respond to sound. This study demonstrates that tmie transgene can recover the hearing impairment and abnormal behavior in the circling mouse.

• Journal of Veterinary Clinics
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• v.33 no.5
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• pp.261-265
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• 2016

The purpose of this study was to perform retrospective data collection of the sites and types of fracture in raptors in order to enable wildlife veterinarians to manage cases of fracture more effectively. This study included raptors with fracture, rescued between January 2013 and August 2015 in the Daegu-Gyeongbuk region in Republic of Korea. The data were collected from the medical reports and radiographic findings acquired from designated animal hospitals for wild animals, the Dongin Animal Hospital and the Kyungpook wildlife rescue center. The distribution, sites, and types of fracture, and outcomes of rescue and fracture management of the raptors included in this study were analyzed. Among the 31 birds included in this study, Falco tinnunculus was the most common species. Of the 42 sites of fracture, the diaphysis of the humerus was the most common site of fracture, and comminuted fracture was the most common type. Of the 31 birds, 13 were treated surgically. Intramedullary pinning with bandaging was the most common method of surgical treatment. While 7 of the 13 birds died, 2 were reintroduced into the wild, and 4 were kept captive. This study presents the evaluation of the data on the species, sites, and types of fracture, and treatment procedures and outcomes in raptors with fractures, rescued in the Daegu-Gyeongbuk region. The findings of this study could serve as a basic database for the treatment of fracture in raptors.

• Proceedings of the Microbiological Society of Korea Conference
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• 2005.05a
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• pp.209.2-209
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• 2005