• Title/Summary/Keyword: reproductive hormone

Search Result 532, Processing Time 0.025 seconds

The Consequences of Mutations in the Reproductive Endocrine System

  • Choi, Donchan
    • Development and Reproduction
    • /
    • v.16 no.4
    • /
    • pp.235-251
    • /
    • 2012

  • The reproductive activity in male mammals is well known to be regulated by the hypothalamus-pituitary-gonad axis. The hypothalamic neurons secreting gonadotropin releasing hormone (GnRH) govern the reproductive neuroendocrine system by integrating all the exogenous information impinging on themselves. The GnRH synthesized and released from the hypothalamus arrives at the anterior pituitary through the portal vessels, provoking the production of the gonadotropins(follicle-stimulating hormone (FSH) and luteinizing hormone (LH)) at the same time. The gonadotropins affect the gonads to promote spermatogenesis and to secret testosterone. Testosterone acts on the GnRH neurons by a feedback loop through the circulatory system, resulting in the balance of all the hormones by regulating reproductive activities. These hormones exert their effects by acting on their own receptors, which are included in the signal transduction pathways as well. Unexpected aberrants are arised during this course of action of each hormone. This review summarizes these abnormal phenomena, including various mutations of molecules and their actions related to the reproductive function.

  • PDF KSCI

A Case of Pregnancy Using Recombinant Follicle Stimulating Hormone and Gonadotropin Releasing Hormone Antagonist (유전자 재조합 난포자극호르몬과 성선자극호르몬 분비호르몬 길항제를 이용한 임신 1례)

  • Nam, Yoon-Sung;Kim, Nam-Keun;Kim, Eun-Kyung;Chung, Hyung-Min;Cha, Kwang-Yul
    • Clinical and Experimental Reproductive Medicine
    • /
    • v.28 no.1
    • /
    • pp.73-77
    • /
    • 2001

  • Objective: To report the pregnancy which was made by in vitro fertilization using recombinant follicle stimulating hormone and gonadotropin releasing hormone antagonist. Material and Method: Case report. Results: Six oocytes were retrieved and all were fertilized by intracytoplasmic sperm injection. Six embryos were transferred and the pregnancy was confirmed. Conclusion: It is envisaged that the availability of recombinant gonadotropins and gonadotropin releasing hormone antagonists will ultimately lead to shorter, cheaper and safer treatments, using reduced dosages.

  • PDF