• Biomolecules & Therapeutics
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• v.23 no.4
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• pp.301-312
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• 2015

Metastasis is one of hallmarks of cancer and a major cause of cancer death. Combatting metastasis is highly challenging. To overcome these difficulties, researchers have focused on physical properties of metastatic cancer cells. Metastatic cancer cells from patients are softer than benign cancer or normal cells. Changes of viscoelasticity of cancer cells are related to the keratin network. Unexpectedly, keratin network is dynamic and regulation of keratin network is important to the metastasis of cancer. Keratin is composed of heteropolymer of type I and II. Keratin connects from the plasma membrane to nucleus. Several proteins including kinases, and protein phosphatases bind to keratin intermediate filaments. Several endogenous compounds or toxic compounds induce phosphorylation and reorganization of keratin network in cancer cells, leading to increased migration. Continuous phosphorylation of keratin results in loss of keratin, which is one of the features of epithelial mesenchymal transition (EMT). Therefore, several proteins involved in phosphorylation and reorganization of keratin also have a role in EMT. It is likely that compounds controlling phosphorylation and reorganization of keratin are potential candidates for combating EMT and metastasis.

• Proceedings of the Korean Information Science Society Conference
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• 2001.04a
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• pp.40-42
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• 2001

본 논문에서는 공유 저장장치 기반 클러스터 시스템의 평균 서비스 시간을 줄이기 위해서 클러스터 시스템의 연선 종류와 부하량에 따라 재구성 시점을 결정하는 적응적 자료 재구성 방식(Adaptive Data Reorganization)을 제안한다. 또한 클러스터 시스템에서 처리해야할 서비스가 없고 서비스 요청도 없을 때 자료 재구성을 수행하는 지연 재구성 방식(Deferred Reorganization)을 채택하였다. 자료 재구성 방식은 전체적인 자료 재구성과 부분적인 자료 재구성으로 나누어 실행된다. 또한 적응적 자료 재구성 방식을 통한 공유 저장장치 기반 클러스터 시스템의 성능 평가를 위해 마르코프 모델(Markov Model)을 사용한다.

• Journal of the Korean Institute of Rural Architecture
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• v.13 no.3
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• pp.37-44
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• 2011

This study is to clarify the actual conditions of school facilities in the rural area. The purpose of this paper is to present the direction for reorganization of school facilities. Surbey area was Uiseong, Gyeongbuk, the number of students decreased rapidly. And elementary, middle and high school facilities were surveyed. The results are as the follows; 1)After consider living zone, commuting distance, opinions of residents, it is advisable that the small size school(the number of students under 60) will be combined stronghold school. 2)Reorganization of school facilities should be considered that the characteristics of living zone, exchanging educational program between elementary and middle schools and an integrated use of the facility.

• Korean Journal of Social Welfare
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• v.61 no.3
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• pp.155-177
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• 2009

This is a study to review provision and production system of social services in European welfare states and find out implications to Korea. Firstly, trends of social service extension and reorganization in welfare state restructuring process, and approaches in interventions to social service system are theoretically discussed. In this discussion, we focus on the discussion of Jessop's workfare in social service extension and reorganization and the concept of innovation in intervention to social service system by state. Then, In order to look at details of reorganization of social service system through restructuring of European welfare states, German case is reviewed. In this review, the reorganization of social service provision and production system in Germany is analyzed through the comparison with the pre-existing system in terms of relationships with public sector as well as between public and private sector respectively. Finally, implications of the European and German experiences to Korea are explored. In order to do so, the state of social services in Korea is examined whilst comparing to the European development process of social services. Also, pros and cons of the electronic voucher scheme, which transforming the social service provision system in Korea, are discussed then challenges in Korean social service delivery system are discussed.

• Journal of Korea Spatial Information System Society
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• v.8 no.1 s.16
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• pp.93-106
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• 2006

A Grid Database is a database management system to process effectively and use the distributed data in a grid computing environment. Spatial data is more important than other general data according to the local characteristics and requires a large storage. The grid database can be used as the optimal system for the management of the spatial data. However, contrary to the conventional distributed database systems, the Grid Database which guarantees the local autonomy has a possibility not to provide an effective system, or it is impossible to use a centralized management environment. In order to allow flexible responses to a dynamically changing environment, it is required to use effectively reorganized method. In this paper, hierarchical reorganization method is presented for dynamic reorganization in a grid database. When the reorganization is conducted, an organizer is created to collect the information of databases. In addition, the organizer which is constructed by the hierarchical structure supports information communication and reorganization, and then it allows the support of regional reorganization operation and effective balance control. The performance assessment of the proposed method shows that the processing capacity is increased after the reorganization.

• Journal of Korean Ophthalmic Optics Society
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• v.19 no.2
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• pp.247-252
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• 2014

Purpose: This study was to investigate the properties and the location of neural reorganization following eccentric viewing training. Methods: 14 subjects with normal vision took part in eccentric viewing training. The measurements of the light sensitivity and multifocal electroretinogram were performed before and after the training. Results: The measurements of the light sensitivity and multifocal electroretinogram for pre-eccentric viewing training and post-eccentric viewing training showed the significant difference (p<0.047 and p<0.028, respectively). Conclusions: The retinal outer plexiform layer is unable to regenerate. However, the neural reorganization in the retinal outer plexiform layer is able to take place following eccentric viewing training.

• Biomedical Science Letters
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• v.15 no.2
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• pp.113-118
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• 2009

Actin cytoskeletal architecture is believed to be a crucially important modulator of chondrocyte phenotype. 2DG(2-Dexoy-D-glucose) induces reorganization of actin cytoskeletal architecture in chondrocytes. In this study, we have investigated the effects of 2DG on dedifferentiation and inflammation via reorganization of cytoskeletal architecture in rabbit articular chondrocytes, with a focus on p38 kinase pathway. Treatment of 2DG alone reduced type II collagen and COX-2 expression in chondrocytes. But, 2DG reduced type II collagen was recovered by CD, disruptor of actin cytoskeletal architecture, whereas did not affect on COX-2 expression and production of $PGE_2$ compared with 2DG alone treated cells. Treatment of 2DG with JAS, inducer of cytoskeletal architecture polymerization, accelerated reduction of type II collagen expression and synthesis of proteoglycan but did not affect on COX-2 expression and production of $PGE_2$. Also, 2DG stimulated activation of p38 kinase. This result showed that 2DG regulates type II collagen but not cyclooxygenase-2 expression through reorganization of cytoskeletal architecture via p38 kinase pathway in rabbit articular chondrocytes.

• Journal of Digital Convergence
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• v.17 no.11
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• pp.509-515
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• 2019

The purpose of this study is to analyze the learning needs for lifelong education of the baby boom generation, the role of higher education and to reorganization plan the lifelong learning system at higher education levels to realize the lifelong learning system. In order to do this, this study analyzes the present condition of lifelong learning for each age group in South Korea, especially the participation and learning needs of the baby boom generation. Based on this, present lifelong learning reorganization plans in universities examine for the realization of a lifelong learning system.

• Journal of Elementary Mathematics Education in Korea
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• v.16 no.3
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• pp.471-489
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• 2012

2007 Curriculum Revision adopted new Inquiry Activities in mathematical textbooks. So it is critical to analyze the problems of actual application of Inquiry activities in the classrooms. For this purpose, we analyzed the Inquiry activities of Measurement Area of the textbooks and find the appropriate solutions. Secondly, we develop the reorganization materials to fix and solve the existing problems found in the previous problem analysis, and apply the development materials and examine the effects afterwards. The results of the survey indicated that most of teachers are well aware of the importance of Inquiry Activities. However, many teachers answered that Inquiry activities does contain neither diverse strategic approaches nor solutions accommodating with various learning levels of students. The most difficult points to educate Inquiry Activities are that it is difficult to teach students based on individual learning level and that activities consist of mainly short answers that makes it difficult to do in-depth Inquiry Activities. Analyzing Inquiry Activities in the textbook shows that Inquiry Activities in some chapters were constructed as simple sentence questions or presented with the solving process in the questions themselves. The following application classes were implemented by partially taking advantage of the newly developed reorganization materials. Then, the effects were measured by before and after questionnaires, the survey to teachers, and the results of activities. The reorganization materials were effective at arousing the curiosity from students as well as enabling the natural ability-level driven classes.

• The Journal of Fisheries Business Administration
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• v.33 no.2
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• pp.127-152
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• 2002

This study intends to review the development of Large Purse Seine Fisheries in Korea and Japan, and subsequent changes in the fisheries regime as well as management conditions and to examine reorganization directions. In the Northeast Asian Fishing Area, each country has done mutual operation, which causes the fishery competition and controls fishery development. Besides, Exclusive Economic Zon(EEZ) established in 1996 resulted in the prominent changes of fishery development as well as fishery relationship among each country, demands reorganization of fisheries. In the Large Purse Seine fisheries, Korea and Japan are not decreasing, they are stable. In other words, the increase in one country does not necessarily make the decrease in the other country. This is a difference from the case of the bottom fishery. Japan is the highest in the cost, the management is getting worse due to decreasing fish price and shortage of labor. In the case of Korea, the stagnant productivity has been compensated by the rising fish price, but the fishery of low productivity to cut down the size. In addition, during the 1990s the environment of fishery is getting worse because of the free import fishery, shortage of labor, etc. Following the new fisheries paradigm, each country should reorganize its fisheries structure. The principle for reorganization of fisheries structure in each country should be focused on the establishment of sustainable fisheries. The reorganization of fisheries structure for each country by EEZ establishment does not mean only dividing fishing ground and fisheries resources by countries, but means that countries should cooperate together in fisheries management for long-run benefits from fisheries.