• 제목/요약/키워드: remedy

검색결과 1,215건 처리시간 0.026초

MPP+로 유도된 신경 독성에 대한 녹각의 보호 효과 (Neuroprotective Effects of Cervi Cornu in MPP+ Treated SH-SY5Y Cells)

  • 여수정
    • Korean Journal of Acupuncture
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    • 제37권2호
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    • pp.97-103
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    • 2020
  • Objectives : Parkinson's disease, a progressive neurodegenerative disease, is caused by the loss of dopaminergic neurons in the substantia nigra. There is no clear treatment or remedy for Parkinson's disease; therefore, the development of novel therapies related to anti-inflammatory and antioxidant effects is required. This study was performed to evaluate the neuroprotective effect of water extracts from Cervi Cornu (CC) in dopaminergic cells. Methods : We studied effects of CC on apoptosis, cell death and inflammation in SH-SY5Y neuroblastoma cells treated by methylpyridinium ion (MPP+). SH-SY5Y cell line was treated with CC for 24 hours and then 500 μM MPP+ for 18 hours. Results : Cervi Cornu treatment inhibited the decrease in tyrosine hydroxylase (TH) expression and decreased the activation of inflammatory factors mitochondrial cytochrome C oxidase (COX2) and inducible NO synthase (iNOS) against MPP+ neurotoxicity. Apoptosis factors BCL2 associated X, apoptosis regulator (BAX) levels were decreased and B-Cell CLL/Lymphoma 2 (BCL2) levels were increased. Conclusions : These results suggest that CC treatment had neuroprotective effects in the SH-SY5Y neuroblastoma cells against toxicity induced by MPP+. The results suggest new possibilities of CC for the treatment of Parkinson's disease.

ICSID 협약 제52조의 계약상 포기에 관한 연구 (A Study on the Contractual Waiver of Article 52 ICSID Convention)

  • 김용일;홍성규
    • 한국중재학회지:중재연구
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    • 제28권1호
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    • pp.3-26
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    • 2018
  • This article examines whether parties may agree to contractually waive the right to bring annulment proceedings. Alternately it looks at whether certain grounds of annulment may be waived. The ability for parties to resolve this issue contractually by waiving this element of Article 52(1)(b) ICSID offers a potentially powerful solution. For parties to agree beforehand to the circumstances where tribunals have not 'manifestly exceeded their power' could allow them to remove the unpredictability of annulment on this foundation. Even in the event that an ad hoc committee is against the validity of waiver, it may be possible for a party to frame this restriction as an interpretative agreement by the parties rather than strictly as waiver of a ground of annulment. Ultimately, the wish to enter into such an agreement would likely only be driven by a few exceptional commercial need or prior negative experience with the remedy of annulment. In that cases, and depending on the nature of the specific concern with annulment, a limited waiver or interpretative agreement on certain Article 52(1) ICSID grounds may certainly be appropriate.

론스타의 투자조약중재 제기 쟁점과 한국 정부의 전략적 대응방안 (The Key Issues of Lone Star Investment Treaty Arbitration and the Korean Government Strategy)

  • 오현석;김성룡
    • 한국중재학회지:중재연구
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    • 제27권4호
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    • pp.133-156
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    • 2017
  • The purpose of this paper is to take a countermeasure of the investment treaty arbitration that Lone Star claimed to the Korean government. In particular, this study suggests procedural measures to be prepared by the Korean government after the arbitration award. The actual remedy in ICSID arbitration is the annulment procedure of arbitration award. Therefore, this study analyzed the measures that the Korean government can prepare based on the annulment grounds: the inadequacy of the constitution of the arbitral tribunal, the excessive power of the arbitrator, the corruption of the arbitrator, and the serious violation of the rules. First, the Korean government should decide whether to proceed with the annulment procedure after the arbitration award. Second, if they decide to do it, they should review the grounds of annulment. For example, it is possible to analyze whether the relationship between the arbitrator and Lone Star can be properly in the constitution of the arbitral tribunal, whether Lone Star is eligible to apply for ICSID arbitration, or whether arbitration tribunal ignores the crucial evidence that can affect the arbitration award. Independently, the Korean government needs to discuss the investment arbitration appeal system in a long-term perspective.

가상화 환경에서 저널링 기법에 의한 입출력 성능저하 분석 및 개선 (Analysis and Improvement of I/O Performance Degradation by Journaling in a Virtualized Environment)

  • 김성환;이은지
    • 한국인터넷방송통신학회논문지
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    • 제16권6호
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    • pp.177-181
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    • 2016
  • 본 논문에서는 저널링을 사용하는 전가상화 시스템에서 호스트 캐시의 효율을 높이기 위한 기법을 제안한다. 게스트의 저널링 데이터는 쓰기를 위해 호스트 캐시에 한번만 접근되는 패턴과 빈번한 sync 명령으로 인해 캐시의 효율을 감소시킨다. 이러한 성능 감소를 줄이기 위하여 본 논문에서는 게스트의 저널링 데이터가 호스트 캐시에 접근하는 것을 막는 PDC라는 기법을 제안한다. PDC는 Linux 4.14 버전에서 QEMU-KVM 2.1 버전을 기반으로 구현하였으며, 다양한 워크로드에서 3-32%의 성능 향상을 보였다.

상장례문화의 변화에 따른 수의연구 (A Study on the Shroud, according to Change of Mourning & Funeral Custom)

  • 이민주
    • 복식문화연구
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    • 제8권6호
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    • pp.887-898
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    • 2000
  • Mourning & funeral ritual means a various kinds of ritual procedures which begins at the time of death, buried and created a graveyard, a manner of wearing funeral garment being mourning the death, finally go back to everyday life. Our mourning & funeral custom was burial at first time. After going through the era of the Three kingdoms, The unified Shilla and Korea dynasty, cremation method has been prevailed. However, based on Chu-tzu celebration in Chosun dynasty, the burial custom has been widely spread again. Nowadays, due to effective land utilization issue, excessive cost for burial and the change of thinking for cremation, the cremation is recognized as remedy of righteous funeral system. At this point, a shroud following existing burial custom burdens considerably for quality, price, size and design of it. Accordingly, it needs anew style of shroud corresponding to cremation system. As an alternative, the shroud is required simplification and standardization ; Firstly, in size, a shroud should be larger than plain clothes and differentiated in small, medium and large. Secondly, the material of a shroud would be white cotton, which can keep from pollution during burning time. Thirdly, it unifies the item. In case of man, 바지(把特, those are trousers), 저고리(赤古里, Korean-style jacket) and Durumagi(周衣, Korean topcoat). In case of woman, 치마(赤 , those are skirt), 저고리(赤古里, Koran-style jacket) and Durumagi(周衣, Korean topcoat).

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인터넷 기반 가상실험실의 구현 (Implementation of Virtual Laboratory Based on the Internet)

  • 주영훈;김문환;이호재;박진배
    • 한국지능시스템학회논문지
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    • 제13권4호
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    • pp.448-454
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    • 2003
  • 많은 공학 연구에서 실제 시스템을 활용한 검증은 매우 중요하다. 특히, 제어공학의 경우 개발된 새로운 이론을 적용 및 검증할 수 있는 실험장비의 확보는 필수적이다. 그러나, 현실적으로 적절한 실험장비를 확보하는 것은 비경제적이다. 인터넷을 활용하여 실험장비의 원격실험을 가능케 한 가상실험실은 제어공학 연구에 유용하다. 인터넷의 보급과 함께 가상실험실에 대한 연구가 활발히 진행되고 있으나, 대부분의 경우가 특정 시스템에 한정된 가상 실험실의 구축에 한정되어 있다. 본 논문에서는 기존 연구와 달리 다양한 실험 장비에 적용 가능하며 다양한 제어 기법을 제공하는 가상실험실의 구현을 제안한다. 제안된 가상실험실은 서버-클라이언트 구조를 가지며 다중 제어 인터페이스로 구현된다.

한국산 자생 수목 유래 수피추출물의 종양괴사인자 억제효과 (Inhibitory Effect of Extracts from Woody Plants on Tumor Necrosis $Factor-{\alpha}$ Production in Lipopolysaccharide-Stimulated RAW264.7 cells)

  • 조재열
    • 한국약용작물학회지
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    • 제15권4호
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    • pp.271-275
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    • 2007
  • Naturally occurring substances are important biomedical resources with low toxicity and ethnopharmacology-based efficacy. Four out of 45 extracts (Celastrus orbiculatus, Cercis chinensis, Stephanadra incisa, and Weigela subsessilis) prepared from the bark of Korea Forest plants exhibited more than 50% of inhibition on $TNF-{\alpha}$ production in lipopolysaccharide (LPS)-activated RAW264.7 cells at $100\;{\mu}g/m{\ell}$. In particular, potential inhibitory components of 4 extracts showed more than 50% inhibition seemed to be concentrated in methylene chloride (MC) fraction from C. orbiculatus, in ethyl acetate (EtOAc) fraction from C. chinensis and in hexane (Hx) fraction from S. incisa, whereas inhibitory activities of W. subssilis were broadly seen in non-polar solvent fractions such as Hx, MC and EtOAc. Therefore, our results suggest that extracts from C. orbiculatus, C. chinensis, S. incisa and W. subsessilis may be developed as a therapeutic remedy against $TNF-{\alpha}-mediated$ diseases such as rheumatoid arthritis or further fractionated to isolate active components having $antiTNF-{\alpha}$ inhibitory activity.

가정내 아동에 대한 성적 학대사실의 발견방법에 관한 일 연구 (A Study on Ways of Finding sexual Abuse Facts of Children at Home)

  • 전형미
    • 대한가정학회지
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    • 제35권6호
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    • pp.191-203
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    • 1997
  • This paper is study the ways of finding sexual abuse facts of children at home and the standards of recognizing such facts. The investigation and recognition about sexual abuse of children are necessary for remedy or care of children and their family and also for punishment upon the harmer or sanction against him by family laws. But, on account of the characteristics of sexual abuse acts and the standpoint that sufferers are children, it's very difficult to find those kinds of facts. Medical examinations, observations by specialists behavioral indicators, use of dolls & other props, and interviewing are applied to finding sexual abuse facts of children. However, these investigating methods have many uppermost limits, and don't necessarily have conformable conclusions. especially 'interviewing' is essentially used to find a child who has suffered sexual abuses and to investigate and examine a harmer who has been charged with such sexual acts. but 'interviewing' has no less obstacles in reality than has some utilities. For that reason, a follow-up study of (what is) the most effective method is required, with the case=by-case application of other methods. And along with that, it must be taken into consideration that, in process of finding a sexually abused child and in ex post facto measure against accompanying ill effects, the child's protection and the family's privacy ought to be legally guaranteed. So to speak, in making and enforcing the family laws, a profound study of the family to produce good fruits must be made.

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친환경건축물인증 아파트의 친환경계획요소 관리 실태 (A Study on the Management of Environmentally Friendly Planning Features in Condominiums with Green Building Certification)

  • 석희진;홍형옥
    • 대한가정학회지
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    • 제49권1호
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    • pp.41-53
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    • 2011
  • The purpose of this paper was to examine the management of Environmentally Friendly Planning Features(EFPF) in condominium with Green Building Certification(GBC). A questionnaire survey was conducted among management office staff and residents on six housing estates in Seoul. The data from 200 respondents were analysed using descriptive statistics and t-tests. The main findings were as followings : 1) Most of the staffs considered that garbage collection and recycling, and green spaces were well-managed. 2) The residents indicated that garbage collection and recycling, and green spaces were properly handled, but they failed to recognize these as EFPF. 3) Residency duration was unrelated to the residents' perceptions of the EFPF and their management. In conclusion, neither the residents nor the staff were aware of the GBC system or that their housing estates were built using EFPF. To remedy this, it can be assumed the residents' lack of appreciation of the EFPF can be resolved if they participate in the management of these features. So the residents will need education, and the management staff will require professional training.

각도 오프셋의 퍼지보상을 통한 외바퀴 이동 로봇의 균형제어 (Balancing Control of a Single-wheel Mobile Robot by Compensation of a Fuzzified Balancing Angle)

  • 하민수;정슬
    • 한국지능시스템학회논문지
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    • 제25권1호
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    • pp.1-6
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    • 2015
  • 본 논문에서는 한 바퀴 이동로봇의 균형제어를 위해 퍼지방법을 사용하였다. PD제어를 사용하여 균형을 유지하는 한 바퀴 로봇은 시간이 지남에 따라 플라이휠이 한 방향으로 기울어지게 되고 결국에는 균형이 무너지는 현상이 발생한다. 선행연구에서는 이를 해결하기 위해 게인 스케줄링 방법을 사용하였다. 본 논문에서는 퍼지방법을 사용하여 균형 각도를 보상하므로 균형 제어 성능을 높이고자 하였다. 퍼지제어를 통해 desired offset의 각도를 보상하므로 김벌이 한쪽으로 흘러 넘어지는 현상을 보완하였다. 한 바퀴 구동 이동로봇의 균형제어 실험을 통하여 제안하는 제어방식의 성능을 검증하였다.