Background: This study was to evaluate the survival of patients with pleural and intraperitoneal malignant mesothelioma and to investigate the efficacy of chemotherapy (CT) as well as radiotherapy (RTH) and surgery compared to best supportive care (BSC). Materials and Methods: Forty patients with malignant mesothelioma (38 with pleural and 2 with intraperitoneal) were enrolled. Twenty seven patients underwent (CT) chemotherapy of which 2 also received (RTH) and surgery was only for biopsy in 15/40. Combination chemotherapy included cisplatin-gemcitabine, cisplatin-navelbine and cisplatin (or carboplatin) with premetrexed. Thirteen patients received only best supportive care. Results: A total of 12 (30%) patients were male, and 28 (70%) female. Median age was 54.0 years and the male/female ratio was 1/2.33 (P=0.210). Residential exposure played a major role in two regions, Helwan and Shoubra, in 20% and 15%, respectively. Overall mean survival time was $13.9{\pm}2.29$ months. That for patients who had received best supportive care was $7.57{\pm}1.85$ months, for chemotherapy was $16.5{\pm}3.20$ months, and multimodality treatment regimen $27{\pm}21.0$ months (P=0.028). Kaplan-Meier survival did not significantly vary for sex, residence and the pathological types epithelial, mixed and sarcomatous. The median survival for performance status and treatment modalities was significant (P=0.001 and 0.028). Best supportive care using opioids with a mean dose of 147.1 mg (range 0-1680) of morphine sulphate produced good subjective response and reasonable quality of life but did not affect survival. Conclusions: We conclude that CT prolongs survival compared to BSC in patients with malignant mesothelioma. Moreover, using escalating doses of opioids provides good pain relief and subjective responses.
Stone-cultural-properties, distributed In the area, have been investigated and studied on the characteristics and the rock phases in the geological and conservational point of view. Stone-Buddhas in the area can be subdivided into Maebul-, General -, and Massive rock-types according to their styles. The rocks used in these stone-cultural-properties are mainly massive, coarse grained biotite granite of the Jurassic age, which is widely distributed around the Reckon-gun area. However, quartz-feldspathic banded gneiss, marble, phyllite and hornblendite are also used. These rocks are mainly distributed in the Yongin-gun area. This suggests that the rocks used. These rocks are strongly influenced by chemical weathering so that the rock surface is very irregular with $2\~3mm$ relief. Biotite granite used shows generally weathered surface of brown color due to chemical weathering of feldspars. Moss are pervasive partly on the surface to show black and/or green colors. The strong weathering may induce secondarily to appear the igneous lineation, onion-structure, and/or minor cracks latent in the rocks. The cultural properties In the area are relatively well conserved except Maebuls and one(Duchangri 3-story) pagoda. However, one stone-buddha may be grinded recently by machine to take off the weathered surface resulting in the loss of its age and the original detailed shape. For conservation, they must be scientifically considered on the shape, kind of the rock phase and characteristics of the weathered phenomena.
Journal of the Korean Association of Geographic Information Studies
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v.3
no.1
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pp.44-56
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2000
Through the ISODATA method of unsupervised classification, the micro-landform of Gomso-Bay tidal flat was classified into mud, mixed, and sand flats by using Landsat TM image. Each tidal flat shows on apparent differences in its topographical characteristics and grain size compositions. Mud flat is occupied the innermost part of the tidal flat. Sand flat is distributed adjacent to the entrance of the bay, while the mixed one is located in the central part of the bay. Mud flat deposits have fine grain size, more than 4 in average mean phi, bad sorting, more than 1 phi in standard devation, and positive skewness. Mixed and sand flat deposits have coarse grain size, less than 4 average mean phi, good sorting, less than 1 phi in standard daviation, and negative skewness. Topographically, the mud flat consists of flat surfaces and dissected channels. The average depth of dissected channels is about 2 meters. Meanwhile, sand flat has a very flat landform with well-developed ripple marks of less than 10 centimeters in average relief. And the mixed one shows the intermediate topographical characteristics of those of mud and sand flats.
This article aims at a discourse analysis on the selected 1970s Myungrang Manwhas, in the cases of Ggubungi, Doggaebi Gamtu, Yochul Balmyungwang. For the analysis, the history, pre-censorship, and distribution structure of Myungrang Manwha are referenced, as well as the considerable changes and developments on the definition of 'myungrang' since the 1920s. In employing Foucauldian discourse analysis to the texts, the selected Myungrang Manwhas are analyzed as discursive formation, which emerged within the social relations of the era; the characters' dialogues are analyzed as statement. The analysis examines the discourses that the texts disseminated, and the social context of the utterance. It is demonstrated that the Myungrang Manwhas are forms of representation, which implies 'the contested acquisition on capital and power', 'the emphasis on nationalist aspects', and 'the interpellation and discipline of subject active' of the time. Moreover, it is revealed that the forms of control, such as pre-censorship, were the articulation of the will to power, which drove the discoursive formation to function as an apparatus that meticulously constituted the ruling ideology. In conclusion, the Myungrang Manwhas are rather texts that encompasses political and social context of the era than a mere comic relief.
Stiffness of the elbow joint is relatively common after trauma, ectopic ossification, bum, postoperative scar, and etc. Mild flexion deformity can be reduced by use of active or passive motion exercise, dynamic sling, hinged distractor device, or turnbuckle orthosis. But these methods have disadvantages of difficulty in gaining acceptable range of motion only with stretching exercise, re-contracture after conservative managements and poor results that flexion contracture remained. The common described operative exposures for treatment of the stiff elbow are anterior, lateral, posterior, and medial approach. Through Anterior, lateral and medial approach each has not access to all compartments of the elbow. But, posterior approach has benefits that access to posterior, medial and lateral aspects of the elbow and as needed, fenestration to the olecranon fossa that produces a communication between the anterior and posterior compartments of the elbow are possible. From June 1991 through April 1997, 11 patients who had posttraumatic stiff elbow, were treated with debridement arthroplasty through the posterior approach. The purpose of this study are to introduce technique of the debridement arthroplasty and to evaluate final outcomes. With regarding to preoperative pain degree, mild degree matches to 3 cases, moderate to 3 cases, and severe to 2 cases. In preoperative motion, flexion was average 85° and extension was 30°. Postoperatively nine patients had got the complete relief of pain and two patients continued to have mild pain intermittentely. Postoperative flexion improved to 127° and extension to 2°, so that elbow flexion had improved by an average of 42° and elbow extension by 28°. On the objective scale all patients had good or excellent results and they all felt that they were improved by operation. Debridement arthroplasty is one of excellent procedures for the intractable stiff elbow if it is not unstable or it has not incongrous. But it need a meticulous operative technique and a well-programmed rehabilitation.
Transactions of the Korean Society of Mechanical Engineers A
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v.41
no.11
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pp.1131-1137
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2017
Recently, regulations on fuel efficiency and $CO_2$ emissions have been reinforced in automobile industries. As a result, many companies make an effort to satisfy these regulations by adapting composite materials to the automobile body as well as its components. In particular, the lower control arm in the suspension system is subjected to heavy loads and is designed to be thick to meet operating loads. Therefore, it is essential for the lower control arm to reduce weight and to secure the durability assessment. In this paper, we conducted structural analysis by performing stress and stiffness analysis under given load conditions through finite element analysis, and verified whether it satisfies the load and stiffness conditions. The inertia relief method is adapted to the process of analysis, and the principal stress is used as a criterion for evaluation. Based on these results, the durability assessment is carried out using the stress-life method.
The word 'lace' comes from the Latin, lacium, meaning a knot. There are two broad categories of lace: needlepoint lace and bobbin lace. Lace has enjoyed a multitude of uses, embellishing both liturgical and domestic objects. It has also played a major role in the history of western fashion, adorning the apparel of men as well as women. Lace lappets and cap crowns, cravat ends and veils were made for those who could afford them. Before the end of the sixteen century, more complex techniques were employed. The baroque period, needlepoint lace evolved from the early simple geometric patterns of punto in aria Which enhanced ruffs, to deeply scalloped designs, often referred to as collar lace, and thence to the bold and magnificent relief effects of Venetian gros point. Through the seventeenth century is noted for the infinite variety of its cravat, collar and kerchief, most of them lace trimmed and all artfully contrived for the wearer. The type of sleeve in women's dress reaching just below the elbow, ending in ruffles of lace which was called engageantes. Sometimes the ends of a fichu or headdress decorated of lace. In the nineteenth century, empress Eugenie's love of lace resulted in a marked increase in the use of that lovely, delicate fabrication. It was lavished upon sleeves, hats, capes, and handkerchieves. Entire flounces, parasols, jackets, and shawls of lace were created by skilled lace makers of Europe. By the time this magnificent piece was created, most lace was being produced by machine. Today, the tradition of handmade lace continues, but glorious examples are no longer made. However, the techniques have been taken up and revitalized within the fiber art movement.
Purpose: This review was performed to establish a reference intake of water for Korean (KDRI-water) adults in 2015 by examining current knowledge of the relationship between water intake and health and the general status of water intake and loss. We expect that this study will be utilized for further refinement of KDRI-water. Methods: Documents were searched using RISS, NDSL, DBPIA, CINAHL, and Pubmed with the keywords 'water intake, water supply, water ingestion, hydration, dehydration, water balance, and fluid balance'. Results: Water balance is essential for the maintenance of health. Based on this assumption, numerous studies have been performed to investigate the association of water intake with several diseases such as urolithasis, obesity, diabetes, and cancer as well as other health problems, including constipation, cognition, and fetal weight. Effects of water intake for prevention or relief of these health problems vary. Water is supplied to the body by eating foods and drinking liquids such as plain water and beverages. Metabolic water is another source of water input. Water is lost through urine, skin, respiration, and feces. KDRI-water 2015 was set by adequate intake (AI) based on water intake volume, which was the sum of water intakes from foods and fluids reported by the Korea National Health and Nutrition Examination Survey, with extra milk intake of 200 mL. AIs in some age groups were modified considering their estimated energy requirements. Conclusion: Accurate data of water intake is critically important for the establishment of KDRI-water. Therefore, improvement of systems investigating water intake is required, and more studies on the status of water intake and loss in Korean people are needed for definite KDRI-water establishment.
Hyun, Sun Hee;Kim, Sung Won;Seo, Hwi Won;Youn, Soo Hyun;Kyung, Jong Soo;Lee, Yong Yook;In, Gyo;Park, Chae-Kyu;Han, Chang-Kyun
Journal of Ginseng Research
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v.44
no.4
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pp.527-537
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2020
Panax ginseng, a medicinal plant, has been used as a blood-nourishing tonic for thousands of years in Asia, including Korea and China. P. ginseng exhibits adaptogen activity that maintains homeostasis by restoring general biological functions and non-specifically enhancing the body's resistance to external stress. Several P. ginseng effects have been reported. Korean Red Ginseng, in particular, has been reported in both basic and clinical studies to possess diverse effects such as enhanced immunity, fatigue relief, memory, blood circulation, and anti-oxidation. Moreover, it also protects against menopausal symptoms, cancer, cardiac diseases, and neurological disorders. The active components found in most Korean Red Ginseng varieties are known to include ginsenosides, polysaccharides, peptides, alkaloids, polyacetylene, and phenolic compounds. In this review, the identity and bioactivity of the non-saponin components of Korean Red Ginseng discovered to date are evaluated and the components are classified into polysaccharide and nitrogen compounds (protein, peptide, amino acid, nucleic acid, and alkaloid), as well as fat-soluble components such as polyacetylene, phenols, essential oils, and phytosterols. The distinct bioactivity of Korean Red Ginseng was found to originate from both saponin and non-saponin components rather than from only one or two specific components. Therefore, it is important to consider saponin and non-saponin elements together.
The purpose of this paper is to investigate an analytical approach for opening performance evaluation of the nuclear pressure safety valve based on standard codes such as ASME or KEPIC. It is well-known that safety valve is considered as one of pressure relief valves for protecting a boiler or pressure vessel from exceeding the maximum allowable working pressure. When pressure in a container reaches its set pressure, the safety valve commences discharging the internal fluid by a sudden opening called as popping. Safety valve is usually evaluated by set pressure, full open, blow-down, leakage and flow capacity. The test procedure and technical requirement for performance evaluation is described in international code of ASME code such as BPVC. The opening characteristics of steam safety valve can be analyzed by computational fluid dynamics (CFD) and steam shaft dynamics. First, the flow analysis along opening process is simulated by running the CFD models of the ten types of opening steps from 0 to 100%. As a analysis result, the various CFD outputs of flow pattern, pressure, forces on the disc and mass flow at each simulation step is demonstrated. The lift force is calculated by using the forces applied on disc from static pressure and secondary flow. And, the effect of huddle chamber or control chamber is studied by dynamic analysis based on CFD simulation results such as lift force. As a result, dynamics analysis shows opening features according to the sizes of control chamber.
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