• The Korean Journal of Physiology and Pharmacology
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• v.25 no.3
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• pp.251-258
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• 2021

Flos magnoliae (FM), the dry flower buds of Magnolia officinalis or its related species, is a traditional herbal medicine commonly used in Asia for symptomatic relief of and treating allergic rhinitis, headache, and sinusitis. Although several studies have reported the effects of FM on store-operated calcium entry (SOCE) via the ORAI1 channel, which is essential during intracellular calcium signaling cascade generation for T cell activation and mast cell degranulation, the effects of its isolated constituents on SOCE remain unidentified. Therefore, we investigated which of the five major constituents of 30% ethanoic FM (vanillic acid, tiliroside, eudesmin, magnolin, and fargesin) inhibit SOCE and their physiological effects on immune cells. The conventional whole-cell patch clamp results showed that fargesin, magnolin, and eudesmin significantly inhibited SOCE and thus human primary CD4+ T lymphocyte proliferation, as well as allergen-induced histamine release in mast cells. Among them, fargesin demonstrated the most potent inhibitory effects not only on ORAI1 (IC50 = 12.46 ± 1.300 μM) but also on T-cell proliferation (by 87.74% ± 1.835%) and mast cell degranulation (by 20.11% ± 5.366%) at 100 μM. Our findings suggest that fargesin can be a promising candidate for the development of therapeutic drugs to treat allergic diseases.

• Journal of Forest and Environmental Science
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• v.35 no.1
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• pp.61-68
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• 2019

The purpose of this study is to evaluate the natural habitat of Hotaria unmunsana Doi, which was first discovered at Mt. Unmun also represents a landscape indicator species for Daegu and Gyeongbuk provinces, and Luciola lateralis Motschulsky, which is the object of experiential activation at festivals in some cities in the region. The spatial range of this study is limited by Daegu City and Gyeongbuk province, and is used to predict the preference of firefly for altitude, slope, direction, shaded relief, riparian buffer zone, river environment, and farmland to analyze the area that best matches the habitat of fireflies. As a result, fireflies are highly influenced by altitude and there may be no large-scale habitats in some areas through the Nakdong and the Baekdu mountain ranges, which occur at high altitude. In most of the cities, we found major habitats around the streams and wetlands. By region, the sites were widely distributed around the cities focused on Nakdong River, and many habitats emerged around the Nakdong River tributary and gentle slopes. In order to preserve and spread the habitat of fireflies, the physical environment as well as their relationship with food chains and symbiotic organisms should be established, and excessive use of pesticides and herbicides in agricultural areas should be avoided.

• Earthquakes and Structures
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• v.16 no.1
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• pp.119-127
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• 2019

When a structural wall is subjected to multi-directional ground motion, torsion-induced cracks degrade the stiffness of the wall. The effect of torsion should not be neglected. As a main lateral load resisting member, reinforced concrete (RC) structural wall has been widely studied under the combined action of bending and shear. Unfortunately, its seismic behavior under a combined action of torsion, bending and shear is rarely studied. In this study, torsional performances of the RC structural walls under the combined action is assessed from a comprehensive parametrical study. Finite element (FE) models are built and calibrated by comparing with the available experimental data. The study is then carried out to find out the critical design parameter affecting the torsional stiffness of RC structural walls, including the axial load ratio, aspect ratio, leg-thickness ratio, eccentricity of lateral force, longitudinal reinforcement ratio and transverse reinforcement ratio. Besides, to facilitate the application in practice, an empirical equation is developed to estimate the torsional stiffness of RC rectangular structural walls conveniently, which is found to agree well with the numerical results of the developed FE models.

• Journal of Drive and Control
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• v.18 no.3
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• pp.8-15
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• 2021

A rear axle steering (RAS) system is attached to the rear of medium and large commercial vehicles that transport large cargo. The existing RAS systems are driven by electro-hydraulic actuator (EHA), and most commercialized EHAs consist of electric motors, hydraulic pumps, relief valves, prefill valves and cylinders. The prefill valve required for such EHAs is a type of check valve with extremely low cracking pressure that should not allow RAS to have noise or vibration, and the prefill valve prevents system negative pressure as well as unstable operation. Most papers on this topic rely on experiments to predict valve performance, and theoretically detailed modeling of valves or pipelines is performed, but it is very rare to evaluate hydraulic vibration characteristics by analysing everything from hydraulic pumps to valves comprehensively. In this study, we proposed an experimental circuit that can predict the performance of the prefill valve. The study also analysed the pressure-flow pulsation that is transmitted to the valve through the pipeline, and how the transmitted pressure-flow pulsation affects the valve vibration.

• Journal of Korean Public Health Nursing
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• v.34 no.3
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• pp.391-404
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• 2020

Purpose: This study investigates the disaster preparedness behaviors of people residing in disaster areas and the factors affecting such behaviors, by examining the application of a Health Belief Model. Methods: A mixed-method approach was used for this study. Local residents were surveyed in Gyeongju and Pohang, which had experienced earthquakes one to two years earlier. Quantitative data (N=233) were collected through a questionnaire and analyzed using t-test, one-way ANOVA, Scheffe test and multiple regression. Qualitative data (N=11) were collected through focus group and individual interviews, and evaluated through content analysis. Results: Disaster preparedness behaviors scored 7.04 out of 18 points, and factors that significantly affected disaster preparedness included cut to action, marriage status, experience of education and training related to disaster, benefit-barriers factors of disaster preparedness behaviors, and gender. The focus group and individual interviews confirmed the contents corresponding to each variable of the disaster preparedness behaviors and heal belief model. Conclusion: The findings of this study indicate that in order to induce disaster preparedness behaviors as well as education and training opportunities related to disaster relief, we need to examine cue to action of disaster preparedness behaviors, benefits, and barriers for motivating interventions.

• Biomedical Science Letters
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• v.26 no.4
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• pp.327-335
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• 2020

As the interest in oral health is increasing with quality of life. The most representative oral diseases include dental caries, periodontal disease, and malocclusion, as well as dry mouth and oral mucosa. Cinnamaldehyde have an antioxidant effect that has been studied not only to treat rheumatism and hypertension, but also to protect liver, and gastrointestinal tract, but there are few studies related to the control of oral diseases. The purpose of this study was the effect of enhanced orofacial pain when oral administration of cinnamaldehyde in the oral diseases. Cinnamaldehyde (5, 12.5, 25, and 50 mg/kg) orally administered at a dose of 1 mL, and the change in biological response was confirmed after a week. In addition, 5% formalin (30, 50 μL) was injected into TMJ and subcutaneous areas of the whiskers of rats to observe the change in the threshold of the improved orofacial pain model. As a result of the experiment, in the xerostomia model, drinking water was decreased in the cinnamaldehyde-administered group, feed intake and weight increased, and saliva was also increased compared to the naïve group. In particular, the most significant increase trend was observed at the concentrations of 25 and 50 mg/kg. In addition, it was confirmed that the pain behavioral response of the orofacial area improved by oral diseases decreased depending on the concentration of cinnamaldehyde. Based on these results, cinnamaldehyde effectively reduced symptoms related to xerostomia and showed improved pain relief in the orofacial areas.

• Journal of Korean Biological Nursing Science
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• v.24 no.2
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• pp.86-94
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• 2022

Purpose: Patients experiencing chemotherapy-induced peripheral neuropathy (CIPN) apply various palliative care as well as drugs in their daily life to alleviate symptoms. There is a need to identify the influence of these efforts and patients' psychosocial status on the relief of CIPN symptoms. This short-term prospective study investigated how prescription drugs, non-pharmacological behaviors (exercise, massage, and heat therapy), and psychological states (social support, depression, and anxiety) affected CIPN symptoms. Methods: Participants scheduled to receive postoperative platinum or taxane-based chemotherapy were enrolled consecutively. CIPN was measured with the Neurotoxicity-12 subscale of the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity-12 instrument. Data were collected three times during the 4 or 5 cycles of chemotherapy. Results: At the end of the 2nd chemotherapy cycle, 93.1% of participants reported CIPN symptoms. Multiple regression analyses showed that a heat therapy (β= -.34, p< .001), massage (β= -.21, p= .012), and walking 5 times or more per week (β= -.26, p= .021) provided relieve for CIPN symptoms. Depression (β= .19, p= .027) significantly exacerbated CIPN symptoms. Conclusion: These results suggested that a comprehensive management program that includes walking, heat therapy, massage, and mood therapy should be encouraged. Moreover, patients should be educated at chemotherapy initiation to understand appropriate interventions that can relieve CIPN symptoms.

• Fashion & Textile Research Journal
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• v.23 no.2
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• pp.151-158
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• 2021

The purpose of this study was to develop high-quality naturally dyed leisurewear with images of traditional Korean clothing that keeps a psychologically comfortable and physically pleasant environment at home and in vacation spots. The root bark of elm trees, the atopic skin, is also known to be effective for the relief of rhinitis and atopic diseases as well as stress and insomnia. However, there is insufficient color in the bark for the dyeing of fashion products, so to compensate for the lack of color, for dyeing purposes it was combined with a composite extract called Rubia akane Nakai resulting in a relatively bright red color. Except for the light fastness, all the fastnesses were rated 4 to 5, showing excellent results. Through complex dyeing using elm bark and pods extract the author produced four high-quality vests, one-piece, a gown, and jeogori-pantsuits of silk materials with Korean images that are suitable wear for relaxing comfortably at home and during breaks and which provide a comfortable and physically pleasant experience. The vest was made with the formal style of Bae-ja and Dang-eu, the dress is made of Cheok-lik, and the gown is made of Wonsam. It will be meaningful at a time when the importance of rest is increasing due to the healing clothes worn by busy modern people.

• The Korean Journal of Food & Health Convergence
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• v.9 no.1
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• pp.19-28
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• 2023

The purpose of this study is to explore which areas have been more interested in depression research in Korea through analysis of academic papers related to depression, and then to provide insights that can solve future depression problems. 1,032 papers searched with the keyword "depression" in scienceON were analyzed using Python 3.7 for word frequency analysis, word co-occurrence analysis, BERTopic, LDA, and OLS regression analysis. The results of word frequency and co-occurrence frequency analysis showed that related words were composed around words such as patient, disorder and symptom. As a result of topic modeling, a total of 13 topics including 'childhood depression' and 'eating anxiety' were derived. And it has been identified as a topic of interest that 'suicidal thoughts', 'treatment', 'occupational health', and 'health treatment program' were statistically significant topics, while 'child depression' and 'female treatment' were relatively less. As a result of the analysis of research trends, future research will not only study physiological and psychological factors but also social and environmental causes, as well as it was suggested that various collaborative studies of experts in academia were needed such as convergence and complex perspectives for depression relief and treatment.

• The Journal of Korea Robotics Society
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• v.17 no.1
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• pp.48-57
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• 2022

In this paper, we propose a legged landing platform for the quadcopter taking off and landing in the ship environment. In the ship environment with waves and winds, the aircraft has risks being overturned by contact impact and excessive inclination during landing on the ship. This landing platform has four landing legs under the quadcopter for balancing and shock relief. In order to make the quadcopter balanced on ships, the position of each end effector was controlled by PID control. And shocks have mainly happened when quadcopter contacts the ship's surface as well as legs move fast. Hence, impedance control was used to cope with the shocks. The performance of the landing platform was demonstrated by a simulation and a prototype in three sea states based on a specific size of a ship. During landing and tracking the slope of the ship's surface, oscillations of rotation and translation from the shock were mitigated by the controller. As a result, it was verified that transient response and stability got better by adding impedance control in simulation models and prototype experiments.