• Journal of Pharmaceutical Investigation
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• v.37 no.4
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• pp.211-216
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• 2007

The bark of Alnus japonica has been used for the treatment of fever, hemorrhage and diarrehea in oriental traditional medicine. Recently, it was revealed that the diarylheptanoids from the bark of Alnus japonica possess anti-inflammatory activity and are expected to be applicable for atopic dermatitis. In this study, oregonin, one of major active components in the bark of Alnus japonica, was developed in the form of semisolid formulations for topical delivery. Oregonin was incorporated into four ointment bases: O/W cream, W/O cream, hydrophilic ointment and lipophilic ointment. Oregonin release from all formulation prepared was evaluated. Franz cell method and immersion method were employed to characterize the release patterns of drug from each formulation based on solvent availability. O/W cream showed a better release profile than the other formulations when evaluated with Franz cell method with an order of O/W cream, hydrophilic ointment, W/O cream and lipophilic ointment. In the immersion method, hydrophilic ointment showed the greatest release rate at times 1 hour exceeding compared to other bases with an order of hydrophilic ointment, O/W cream, W/O cream and lipophilic ointment. Hydrophilicity and solvent availability of formulation seems to significantly influence the release rate of oregonin from ointment bases. In this study, we successfully characterized the oregon in ointment and found that o/w cream is a promising formulation for the topical delivery of oregonin.

• Journal of Pharmaceutical Investigation
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• v.38 no.2
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• pp.105-110
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• 2008

Indapamide (4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoyl-benz-amide) is an oral antihypertensive diuretic agent indicated for the treatment of hypertensive. The diuretic and natriuretic effects are mainly due to the structure of o-chlorobenzenesulfonamide. The objective of this study was to formulate sustained release indapamide granules and assess their formulation variables. Granules were prepared by fluid bed coating method and consist of drug layer and membrane layer. The granules were coated with HPC and ethyl cellulose along with plasticizer dibuthyl sebacate. The release of indapamide depended on the type of Eudragit such as RS and NE 30 D used in the formulation controlled release layer. These results obtained clearly suggest that the sustained release oral delivery system for indapamide could be designed with satisfying drug release profile approved.

• Journal of International Academy of Physical Therapy Research
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• v.10 no.4
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• pp.1879-1888
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• 2019

Background: The treatment of pain in the iliotibial band friction syndrome has been difficult to determine, according to studies to date. However, recent studies have suggested that flexibility in the subacute stage of pain in the iliotibial band friction syndrome may help reduce pain. Objective: To investigate the immediate effect on pressure pain threshold and flexibility of the tensor fascia latae and iliotibial band by applying static and dynamic myofascial release foam rolling and self-stretching to adults with shortening iliotibial band. Design: Randomized controlled trial Methods: In this study, 50 subjects who were selected in advance as a randomized controlled trial were randomly allocated using a R Studio program. The included subjects were randomly allocated to three intervention groups. The static self-myofascial release 18 people, dynamic self-myofascial release group 16 people separated the self-stretching group 16 people and conducted a homogeneity check in advance. Before the start of the experiment, after of the experiment, 5 minutes after the end of the experiment, the pressure pain threshold and flexibility change for each part were measured. Results: The results of this study showed that the static self-myofascial release showed a significant difference in the pressure pain threshold in the tensor fascia latae and middle, lower part of the iliotibial band, compared with the other intervention groups (p<.05). In change of flexibility, the static self-myofascial release was significantly different than the other intervention groups (p<.05). Conclusion: The result of this study suggest that static self-myofascial release using foam roller may help to improve the pain and flexibility of the iliotibial band and to apply it as a more discerning intervention.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.5 no.1
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• pp.53-64
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• 2007

The dynamic release behavior of Cs from high burn-up spent PWR fuel was experimentally performed under the conditions of a thermal treatment process such as voloxidation and sintering conditions. In voloxidation process, influence of the oxidation and reduction atmosphere on the Cs release characteristic using fragment type of spent fuel heated up to $1,500^{\circ}C$ was compared. In sintering process, temperature history effect on Cs release behavior was evaluated using green pellet under 4% $H_2/Ar$ environment. Temperature range for complete Cs release from spent fuel fragment under voloxidation condition was about $800^{\circ}C{\sim}1,200^{\circ}C$, but that of green pellet under the reduction atmosphere was $1,100^{\circ}C{\sim}1,400^{\circ}C$. Key parameters on Cs release behavior from spent fuel was powder formation as well as the diffusion rate of Cs compound to grain boundary and fuel surface.

• Natural Product Sciences
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• v.19 no.1
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• pp.36-48
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• 2013

The aim of the present study was to investigate the effects of several fractions obtained from methylene chloride ($CH_2Cl_2$) extract of self-fermented pine needle (SFPNE) on the acetylcholine (ACh)-evoked CA release from the isolated perfused model of the rat adrenal medulla and to establish the mechanism of the most active fraction (Fr.)-induced inhibitory action on the CA release. We obtained 6 fractions from $CH_2Cl_2$ extract of self-fermented pine needle. For the ACh (5.32 mM)-evoked CA release, the following rank order of inhibitory potency was obtained: Fr.4-5 > Fr.8-11 ${\gg}$ Fr.3 > Fr.6 = Fr.7 > Fr.1-2. Fr. 4 - 5 (60 ${\mu}g/mL$) perfused into an adrenal vein for 90 min produced relatively time-dependent inhibition of the CA secretory responses to ACh (5.32 mM), DMPP (100 ${\mu}M$), McN-A-343 (100 ${\mu}M$) and high $K^+$ (56 mM). Fr. 4 - 5 itself did not affect basal CA secretion. Also, in the presence of Fr. 4 - 5 (60 ${\mu}g/mL$), the CA secretory responses to angiotensin II (AngII, 0.1 ${\mu}M$), veratridine (50 ${\mu}M$), Bay-K-8644 (10 ${\mu}M$), and cyclopiazonic acid (10 ${\mu}M$) were significantly reduced, respectively. In the simultaneous presence of Fr. 4 - 5 (60 ${\mu}g/mL$) and L-NAME (30 ${\mu}M$), the inhibitory responses of Fr. 4 - 5 on the CA secretion evoked by ACh, DMPP, high $K^+$, AngII, Bay-K-8644 and veratridine were considerably recovered to the extent of the corresponding control secretion compared with that of Fr. 4 - 5-treatment alone. The level of NO released from adrenal medulla after the treatment of Fr. 4 - 5 (60 ${\mu}g/mL$) was greatly elevated compared with the basal level. Taken together, these results demonstrate that Fr. 4 - 5 inhibits the CA secretion from the isolated perfused rat adrenal medulla evoked by stimulation of cholinergic receptors as well as by direct membrane-depolarization. It seems that this inhibitory effect of Fr. 4 - 5 is mediated by blocking the influx of $Ca^{2+}$ and $Na^+$ into the adrenomedullary chromaffin cells as well as by inhibition of $Ca^{2+}$ release from the cytoplasmic calcium store, which is evoked at least partly through the increased NO production due to the activation of NO synthase. Based on these results, it is also thought that Fr. 4 - 5 isolated from $CH_2Cl_2$ extract of pine needle may contain beneficial antihypertensive components to prevent or treat hypertension.

• Journal of the Korean Society of Clothing and Textiles
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• v.21 no.6
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• pp.1041-1050
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• 1997

This study was carried out to improve the thermal insulation properties of wool and wool- like fabrics by treating the fabrics with polyethylene glycol, to evaluate the fabric hand of PEG treated wool and wool-like fabrics and to grade up the fabric hand of the treated fabrics by treating with softening agents. Wool and wool-like fabrics were treated with high molecular PEG-8,000 by PDC. The thermal release/storage properties were measured on a DSC. Hand of specimens were evaluated by KES-FB system. The results were as follows; 1. PEG-treated fabrics showed thermal storage and thermal release properties by DSC and the heat contents were generally proportional to the add-ons. 2. PEG-treated fabrics showed higher Koshi and lower Numeri and Sofutosa values due to lower tensile energy and recovery and higher bending rigidity and shear stiffness as the add- ons increased. 3. PEG-treated fabrics showed much lower bending rigidity after softening agents treatment.

• Journal of the Korean Wood Science and Technology
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• v.42 no.5
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• pp.597-604
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• 2014

Laboratory-scale landfills (simulated landfills) were designed to determine the formaldehyde released into air and leachate from medium density fiberboard (MDF). Simulated landfills were constructed using cylindrical plastic containers containing alternating layers of soil and MDF for a total of five layers. The highest concentration of formaldehyde was found in the air and leachate from the MDF only treatment compared to treatments containing MDF and soil. At the end of the study (28 days), formaldehyde concentrations in air and leachate from treatments containing MDF and soil decreased by 70 percent and 99 percent, respectively, while the treatment containing MDF only still released formaldehyde into the air and leachate. Therefore, waste MDF after storing 4 weeks in water may be recycled as compost or mulch based on formaldehyde leaching. Also, these data indicate soil restricts formaldehyde release into air and leachate and provides new information about the fate of wood-based composite waste containing UF resin disposed in landfills.

• Journal of Pharmaceutical Investigation
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• v.19 no.1
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• pp.29-37
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• 1989

For the prevention of the aggregation during microencapsulation, the effects and role of polyisobutylene(PIB), as a protective colloid, were studied. The effects of sealant treatment on the microencapsulation were studied. Methyldopa was microencapsulated with ethylcellulose (EC) by polymer deposition from cyclohexane by temperature change using PIB. The EC-microencapsulated methyldopa was sealed with spermaceti. The dissolution of methyldopa was influenced by the drug to wall ratio. When PIB was used, low aggregation of microcapsules occurred and the surface was smooth with a few pores. Treatment of microcapsules with spermaceti retarded the release of methyldopa, the release being affected by the percentage of sealant used and the particle size of the product.

• Journal of the Korean Applied Science and Technology
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• v.27 no.4
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• pp.399-406
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• 2010

This study was performed to test the flame retardancy of zelkova sarrata-based materials by the treatment of ammonium salts. Zelkova sarrata plate was soaked by the treatment with three 20 wt% ammonium salt solutions consisting ammonium chloride (AMSL), monoammonium phosphate (MAPP), and diammonium phosphate (DAPP), respectively, at the room temperature. After the drying specimen treated with chemicals, combustion properties were examined by the cone calorimeter (ISO 5660-1). When the ammonium salts were used as the retardant for zelkova sarrata, the flame retardancy improved due to the treated ammonium salts in the virgin zelkova sarrata. However the specimen shows increasing CO over virgin zelkova sarrata and It is supposed that toxicities depend on extents. Also, the specimen with ammonium salts showed the higher total smoke release (TSR) than that of virgin plate. Of specimens treated with ammonium salts the ammonium chloride handled the test side was considered a improved inhibitory effect of combustion.

• Journal of Pharmaceutical Investigation
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• v.21 no.4
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• pp.253-262
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• 1991

Microencapsulation of sodium ascorbate with cellulose acetate phthalate(CAP) by coacervation/ phase separation method were carried out. Various factors affecting microencapsulation, i.e., surfactant concentration. CAP concentration, stirring speed and treatment of spermaceti as a sealing agent were studied. Dissolution rate. particle size distribution, surface feature and stability test were investigated. CAP microcapsules prepared using 0.5% span 80 as a surfactant showed smooth and round surfaces. The release of sodium ascorbate was retarded by microencapsulation with CAP and by sealant treatment with spermaceti. When triturated with sodium bicarbonate, CAP microcapsules were more stable than unencapsulated sodium ascorbate under various RH conditions at $37^{\circ}C$.