• Title/Summary/Keyword: release property

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Rheological Characteristics of Lipiodol-Anticancer Suspensions Containing Aluminum Monostearate (모노스테아린산 알루미늄이 첨가된 리피오돌-항암제 현탁액의 유동학적 특성)

  • Oh, Sun-Young;Ku, Young-Soon
    • YAKHAK HOEJI
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    • v.38 no.6
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    • pp.654-663
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    • 1994
  • Lipiodol-anticancer suspensions containing fluorouracil, tegafur, mitomycin C, methotrexate, or adriamycin were prepared by Shinohara method using aluminum monostearate as a dispersing stabilizer. Lipiodol-suspension showed thixotropic property when the concentration of aluminum monostearate was above 2%. Observed thixotropic area which reflects the extent of thixotropic breakdown indicated that the thixotropic property of Lipiodol-suspensions maintained for six weeks in a refrigerator$(4^{\circ}C)$. Lipiodol-anticancer suspensions containing 2% aluminum monostearate maintained a more stable suspension system compared with simple mixtures and Lipiodol-anticancer suspensions without aluminum monostearate. As the concentration of aluminum monostearate increased, the drug release from Lipiodol-anticancer suspensions was more retarded.

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The Comparative Study of Software Optimal Release Time of Finite NHPP Model Considering Property of Nonlinear Intensity Function (비선형 강도함수 특성을 이용한 유한고장 NHPP모형에 근거한 소프트웨어 최적방출시기 비교 연구)

  • Kim, Kyung-Soo;Kim, Hee-Cheul
    • Journal of Digital Convergence
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    • v.11 no.9
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    • pp.159-166
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    • 2013
  • In this paper, make a study decision problem called an optimal release policies after testing a software system in development phase and transfer it to the user. When correcting or modifying the software, finite failure non-homogeneous Poisson process model, presented and propose release policies of the life distribution, half-logistic property model which used to an area of reliability because of various shape and scale parameter. In this paper, discuss optimal software release policies which minimize a total average software cost of development and maintenance under the constraint of satisfying a software reliability requirement. In a numerical example, the parameters estimation using maximum likelihood estimation of failure time data, make out estimating software optimal release time. Software release time is used as prior information, potential security damages should be reduced.

The Comparative Study of Software Optimal Release Time of Finite NHPP Model Considering Half-Logistic and Log-logistic Distribution Property (반-로지스틱과 로그로지스틱 NHPP 분포 특성을 이용한 소프트웨어 최적방출시기 비교 연구)

  • Kim, Hee Cheul
    • Journal of Korea Society of Digital Industry and Information Management
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    • v.9 no.2
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    • pp.1-10
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    • 2013
  • In this paper, make a study decision problem called an optimal release policies after testing a software system in development phase and transfer it to the user. In the course of correcting or modifying the software, finite failure non-homogeneous Poisson process model, presented and was proposed release policies of the life distribution, half-logistic and log-logistic distributions model which used to an area of reliability because of various shape and scale parameter. In this paper, discuss optimal software release policies which minimize a total average software cost of development and maintenance under the constraint of satisfying a software reliability requirement. In a numerical example, the parameter estimation using maximum likelihood estimation of failure time data make out, and software optimal release time was estimated.

Low Formaldehyde Release D.P. Finish on Cotton Fabrics (면직물의 저$\cdot$Formaldehyde D.P. 가공)

  • Kim Sung Reon;Ryu Hyo Seon;Noh Hyung Eun
    • Journal of the Korean Society of Clothing and Textiles
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    • v.10 no.3
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    • pp.71-81
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    • 1986
  • In order to control the formaldehyde release from D.P. finished fabric, cotton fabric was padded in DMDHEU resin bath containing either $Zn(NO_3)_2$ or $MgCl_2$ catalyst and a form-aldehyde scavenger like Glycerol, Sorbitol, Formamide, Polyvinyl alcohol (PVA, n= 2000) or diols, then dried and cured. The results are as follows : 1. When Lewis acid catalyst like $Zn(NO_3)_2$ or $MgCl_2$ was added in pad bath, the fabric finished with $Zn(NO_3)_2$ catalyst released the lower formaldehyde than with $MgCl_2$. 2. When the effect of pad bath pH was examined with varying the kinds of catalyst and the scavenger, it was found that the pad bath pH influenced on the amount of formaldehyde release and the optimum pad bath pH is at 4.3. Especially, in case of finishing at pad bath pH 4.3 with adding Formamide, the amount of formaldehyde release was decreased by about $45\~$35\%$ with $Zn(NO_3)_2$, while by about $20\~$45\%$ with $MgCl_2$ catalyst. In case of varying the concentration of a scavenger (Formamide), $1\%$ concentration of a scavenger was found to be the optimum level ana the higher the curing temperature up to $180^{\circ}C$, the lesser the amount of formaldehyde release were observed. 3. When the diol was used as scavenger, the amount of formaldehyde release was decreased by about $40\~$50\%$, but the longer the intramolecular length between OH groups, the lessor the amount of decrease of formaldehyde release were observed. 4. When the mixture of scavengers (Formamide and Glycerol) was added in the pad bath, .synergistic effect on formaldehyde release between the two scavengers wasn't observed. 5. The tensile strength of the resin finished fabric was reduced with increasing the pad lath pH and was influenced by the kind of scavengers, and the tensile strength was severely reduced when scavengers, especially Formamide, was added. The wrinkle recovery property is generally improved by resin finish on cotton fabric. When Formamide was added, the wrinkle recovery property is slightly decreased compared with that of the fabrics resin finished without a scavenger, and when polyol was added, the wrinkle recovery property showed almost no change.

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Elastic Work Factor of CLS Specimen and Determination of $G_c$ for Graphite/Peek Composites by Using the Elastic Work Factor (CLS 시편의 탄성일인자 유도 및 이를 적용한 열가소성 Graphite/Peek 복합재의 파괴인성 $G_c$ 측정)

  • Lee, Gyeong-Yeop
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.20 no.9
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    • pp.2792-2799
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    • 1996
  • It was shown in the previous study that the numerically derived elastic work factor for CLS specimen was independent of fiber direction for a unidirectional case. Also, it was proposed the elastic work factor could be used to determine energy release rate from a single test record. In the present study, elastic work factor was derived from a simple beam theory to investigate its dependence on material property and geometric condition. Also, the elastic work factor of CLS specimen was applied experimentally to determine critical energy release rate in order to prove its validity determining critical energy release rate from a single specimen. For this purpose, critical energy release rate determined using the elastic work factor was compared with that determined by the compliance method. The results showed that while elastic work factor is affected by $t_2/t_1$ and $L_2/L_1$ it is independent of fiber angle for a unidirectional case. It was also found that critical energy release rates determined by both methods are comparable each other, thus elastic work factor approach can be used to determine energy release rate from a single test specimen.

The Study of a Correlation between Heat Release and Smoke Production by Using Oxygen Consumption Calorimeter Up to 10 MW Facility (10MW급 까지의 산소소모율법 칼로리미터를 활용한 열방출률과 연기발생률의 상관성에 관한 연구)

  • Ryu, Sang-Hoon;Yoo, Yong-Ho;Rie, Dong-Ho
    • Fire Science and Engineering
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    • v.24 no.3
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    • pp.58-65
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    • 2010
  • The fire accidents having recently occurred are getting more and more larger and causing lots of damage in terms of property loss and casualties increase, so there is in need of technical fire safety development like comprehensive prevention solution in order to effectively prevent. Especially, the needing of new paradigm for advanced fire safe technology is gathering strength in high-rise modern building construction. Therefore, we want to find out on this paper what is a correlation between heat release rate measurement and smoke release volume by three parts of oxygen consumption calorimeter in bench scale calorimeter (cone calorimeter/ISO 5660/Avg.500Kw), Medium scale calorimeter (Room corner tester, Single burning Item/ISO 9750, EN 13823/Avg.3MW), and large scale calorimeter (Industry calorimeter/Avg. 10MW). Thus, Smoke detective of new paradigm devised by making use of a correlation between heat release and smoke production is to help reduce loss property and casualties. Ultimately, based on this theory, a new concept of fire alarm and evacuation system will be developed and expected to apply to a skyscraper.

APPLICATIONS OF A MODEL TO COMPARE AFLAME SPREAD AND BEAT RELEASE PROPERTIES OF INFERIOR FINISH MATERIALS IN A COMPARTMENT

  • Kim, Woon-Hyung;James G. Quintiere
    • Proceedings of the Korea Institute of Fire Science and Engineering Conference
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    • 1997.11a
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    • pp.193-200
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    • 1997
  • Flame spread and heat release properties and incident heat flux of interior materials subject to an igniter heat flux in a compartment are investigated and compared by using computer model. A comer fire ignition source is maintained for 10 minutes at 100 kw and subsequently increased to 300kw. In executing the model, base-line material properties are selected and one is changed for each run. Also 4 different igniter heat flux conditions and examined. Results are compared for the 12 different materials tested by the ISO Room Comer Test (9705). The time for total energy release rate to reach 1MW is examined. The parameters considered include flame heat flux and thermal inertia, lateral flame spread parameter, heat of combustion and effective heat of gasfication. The model can show the importance of each property in causing fire growth on interior Hnish materials in a compartment. The effect of ignitor heat flux and material property effects were demonstrated by using dimensionless parameters a, b and Tb. Results show that for b greater than about zero, flashover time in the ISO Room-Corner test is principally proportional to ignition time and nothing more.

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A Comparative Functionality Evaluation of Paulownia Wood Storage Boxes and Acid-free Archival Boxes to Store the Annals of Joseon Dynasty - Indoor and Outdoor Temperature and Relative Humidity Controls, and Heat Release Rate -

  • Park, Hae Jin;Kim, Seong Eun;Lee, Jin Kyung;Chung, Yong Jae
    • Journal of Conservation Science
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    • v.38 no.1
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    • pp.72-79
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    • 2022
  • A paulownia wood has been widely used with various advantages as its low weight, permeability, convenient workability and aesthetic patterns for a long time. However, the related empirical researches and simultaneous evaluations of functionality are insufficient compared with acid-free archival boxes for now. In this study, the indoor and outdoor temperature and relative humidity control and heat release rate were evaluated under the controlled and uncontrolled circumstance in 2018. The paulownia wood storage box showed superior control effect of relative humidity than the acid-free archival box in constantly uncontrolled environment. Also, the possibility of the flame diffusion from the surface of the materials was higher for the paulownia materials, and the acid-free archival box showed more dangerous patterns in the early stages of the fire.

Controlled Release Behavior of Temperature Responsive Composite Hydrogel Containing Activated Carbon

  • Yun, Ju-Mi;Im, Ji-Sun;Jin, Dong-Hwee;Lee, Young-Seak;Kim, Hyung-Il
    • Carbon letters
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    • v.9 no.4
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    • pp.283-288
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    • 2008
  • The composites of temperature-sensitive hydrogel and activated carbons were prepared in order to improve both the mechanical strength of hydrogel matrix and the loading capacity of drug in a hydrogel drug delivery system. The swelling of composite hydrogel was varied depending on the temperature. Both the swelling and the release behavior of the composite hydrogel were varied depending on the kind of activated carbon. The release behavior showed the high efficiency which is important for practical applications.

Formulation and Evaluation of Loxoprofen Plasters (록소프로펜 플라스터의 제제설계 및 평가)

  • 김태성;전인구
    • Biomolecules & Therapeutics
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    • v.9 no.4
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    • pp.298-306
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    • 2001
  • To develop a novel transdermal delivery system of loxoprofen (LP), a potent antiinflammatory and analgesic agent, the effects of vehicle composition and drug loading dose on the skin permeation property were investigated. And in vivo skin absorption property studied by analysing the $C_{max}$ and AUC was investigated after applying the developed plaster systems on rabbit back skin. Addition of isopropyl myristate (IPM) and IPM-diethylene glycol monoethyl ether (DGME) cosolvent in the plaster showed higher permeation rates than those from propylene glycol laurate-DGME cosolvent systems. As the concentration of LP in the plaster increased from 0.56 mg/$\textrm{cm}^2$ to 1.19 mg/$\textrm{cm}^2$, the drug release and skin permeation rates increased linearly. At loading dose of 1.19 mg/$\textrm{cm}^2$, the flux reached 35.6 $\mu$g/$\textrm{cm}^2$/hr. New LP plasters showed a good adhesive property onto skin, and showed no crystal formation. The AU $C_{0-24hr}$ and $C_{max}$ after dermal application of LP plaster (60 mg/70 $\textrm{cm}^2$) were found to be 6951$\pm$230 ng.hr/ml and 400$\pm$44 ng/ml, respectively. And the plasma concentration maintained above 300 ng/ml up to 24 hr period. In the carrageenan-induced rat paw edema test, LP plaster showed similar inhibition rate with marketed ketoprofen (Ketoto $p^{R}$) plaster.aster.r.

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