• Polymer(Korea)
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• v.36 no.2
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• pp.202-207
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• 2012

Biodegradable poly(${\varepsilon}$-caprolactone)(PCL) microcapsules containing pseudomonas were prepared by W/O/W emulsion system. The characteristics and release behaviors of the microcapsules were investigated as a function of manufacturing conditions. The morphology and particle distribution of the microcapsules were observed by a scanning electron microscope and a particle size analyzer. The release behaviors of the pseudomonas were determined using a cell culture method. It was found that smooth and spherical microcapsules were formed by W/O/W emulsion system and particle size was in the range of 10 to 60 ${\mu}m$. The release behaviors of the pseudomonas were influenced by the manufacturing conditions. It was indicated that the increase of the surfactant content and stirring rate led to an increased release rate, resulting from the high specific surface area of the smaller particle size, and the increase of the PCL content provided the sustained release behaviors by the delay effect of diffusion in the release medium.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.32 no.6
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• pp.413-420
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• 2008

The unsteady heat release characteristics play a significant role in combustion instabilities observed in low emissions gas turbine combustors. Such combustion instabilities are often caused by coupling mechanisms between unsteady heat release rates and acoustic perturbations. A generalized model of the turbulent flame response to acoustic perturbations is analytically formulated by considering a distributed heat release along a curved mean flame front and using the flame's kinematic model that incorporates the turbulent flame development. The effects of the development of flame speed on the flame transfer functions are examined by calculating the transfer functions with a constant or developing flame speed. The flame transfer function due to velocity fluctuation shows that, when a developing flame speed is used, the transfer function magnitude decreases faster with Strouhal number than the results with a constant flame speed at low Strouhal numbers. The flame transfer function due to mixture ratio fluctuation, however, exhibits the opposite results: the transfer function magnitude with a developing flame speed increases faster than that with a constant flame speed at low Strouhal numbers. Oscillatory behaviors of both transfer function magnitudes are shown to be damped when a developing flame speed is used. Both transfer functions also show similar behaviors in the phase characteristics: The phases of both transfer functions with a developing flame speed increase more rapidly than those with a constant flame speed.

• Polymer(Korea)
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• v.28 no.2
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• pp.103-110
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• 2004

The biodegradable poly($\varepsilon$-caprolactone) (PCL) microcapsules containing tocopherol were prepared by oil-in-water emulsion solvent evaporation method. The features of the microcapsules were investigated in the manufacturing conditions and degradation behaviors. The form and structural feature of the microcapsules were measured by scanning electron microscope and X-ray diffraction, respectively. The surface free energy of the microcapsules was executed using contact angle measurement. As a result, the microcapsules were more stable and spherical with poly(vinyl alcohol) given in a surfactant. The surface free energy and crystallinity of microcapsules were decreased with increasing the core concentration, and degradation of PCL was occurred after 21 days. The release behaviors were examined by Uv/vis. spectrophotometer. It was found that the release rate of the microcapsules was increased with increasing the stirring rate, due to the increased interface between microcapsules and release media.

• Proceedings of the KSR Conference
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• 2009.05a
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• pp.206-212
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• 2009

Chemical behaviors of each surface material for interior facilities affect to fire initiation and growth in general fire situation. These chemical behaviors were characterized by thermal properties (Heat release rate, Pyrolysis rate, specific heat, etc) which could be derived from experimental test. Especially, Heat release rate which indicates aspect of fire size is one of the most important property to asses fire hazard and protection needs. The cone calorimeter test (ISO 5660) has recently assumed to a dominant role in bench scale fire testing to obtain the Heat release rate of materials. This value could be calculated by the 'Oxygen Consumption Method' under various producing irradiances to each surface of materials. In this study, Process of the cone calorimeter test was simulated by Pyrolysis model of FDS (Fire Dynamics Simulator by NIST) base on the ISO 5660 international standard. Then, we could estimate the simulation method of FDS in case of single materials through the comparative study with test results.

• Journal of Pharmaceutical Investigation
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• v.19 no.4
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• pp.179-183
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• 1989

Drug release experiments were performed based on pH-sensitive swelling behaviors of polymethacrylic acid. 5-Fluorouracil as a nonionic model drug revealed release patterns depending solely on pH-dependent swelling kinetics of polymethacrylic acid. In contrast, release of propranolol hydrochloride as a cationic model drug was significantly affected by ionic drug-polymer interaction as well as the swelling kinetics. Accordingly, a zero-order release pattern was obtained at pH 7, which was distinguished from the general matrix type drug release pattern.

• Macromolecular Research
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• v.16 no.5
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• pp.429-433
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• 2008

Alginate/carboxymethyl scleroglucan (CMSG) hydrogels were suggested as a novel carrier for the controlled release of protein drugs. The drug release characteristics of alginate hydrogels were improved by CMSG addition. Scleroglucan (Sclg) was carboxymethylated using monochloroacetic acid in aqueous alkaline medium. Alginate/CMSG hydrogels were prepared by dropping the mixture solution of alginate/CMSG into calcium chloride solution. The swelling behaviors and drug release characteristics of the hydrogels were investigated in the buffers of pH 1.2 or 7.4. As the CMSG content increased in the hydrogels, the swelling ratio of the alginate/CMSG hydrogel increased rapidly in the buffer of pH 7.4. At pH 1.2, however, the swelling ratio significantly decreased compared to that at pH 7.4. According to in vitro release tests, only 15% of ovalbumin, investigated as a model protein drug, was released from the alginate/CMSG hydrogels at pH 1.2 within 6 h. At pH 7.4, however, the drug release significantly increased due to the rapid swelling of the hydrogels. The release and swelling behaviors of the hydrogels could be controlled by changing the CMSG content in the hydrogels. These results supported the use of alginate/CMSG hydrogels as a suitable carrier for the controlled release of protein drugs in a pH responsive manner.

• Proceedings of the PSK Conference
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• 2000.10a
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• pp.260.1-260.1
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• 2000

• Polymer(Korea)
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• v.29 no.6
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• pp.593-598
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• 2005

This work studied the loading capabilities and release behaviors of poly(ethylene-alt-maleic anhydride) (PEMAh)/poly(4-vinyl pyridine) (P4VP) multilayer films formed by the layer-by-layer(LbL) sequential self-assembly method, using Rodamine 6G(R6G) as an indicator. Thickness of the multilayer, and loading and subsequent release behavior of R6G from the multilayer were studied using UV-visible spectroscopy. The amount of R6G loaded in multilayer film increased linearly with increasing film thickness. pH-Sensitive permeability was observed, where lower pH environments increased both release rate and release amount. By additional assembling of PEMAh/poly(ethyleneimine) (PEI) capping layers on top of (PEMAh/P4VP)n multilayers, the release of R6G was better controlled.

• Nuclear Engineering and Technology
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• v.43 no.6
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• pp.499-508
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• 2011

The paper briefs a fuel performance code, COSMOS, which can be utilized for an analysis of the thermal behavior and fission gas release of fuel, up to a high burnup. Of particular concern are the models for the fuel thermal conductivity, the fission gas release, and the cladding corrosion and creep in $UO_2$ fuel. In addition, the code was developed so as to consider the inhomogeneity of MOX fuel, which requires restructuring the thermal conductivity and fission gas release models. These improvements enhanced COSMOS's precision for predicting the in-pile behavior of MOX fuel. The COSMOS code also extends its applicability to the instrumented fuel test in a research reactor. The various in-pile test results were analyzed and compared with the code's prediction. The database consists of the $UO_2$ irradiation test up to an ultra-high burnup, power ramp test of MOX fuel, and instrumented MOX fuel test in a research reactor after base irradiation in a commercial reactor. The comparisons demonstrated that the COSMOS code predicted the in-pile behaviors well, such as the fuel temperature, rod internal pressure, fission gas release, and cladding properties of MOX and $UO_2$ fuel. This sufficient accuracy reveals that the COSMOS can be utilized by both fuel vendors for fuel design, and license organizations for an understanding of fuel in-pile behaviors.

• Proceedings of the KOSOMBE Conference
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• v.1996 no.11
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• pp.281-285
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• 1996

Pulsatile swelling behaviors and their application to drug delivery system were studied by using interpenetrating polymer networks(IPN) hydrogels constructed with poly(vinyl alcohol) and poly(acrylic acid). The PVA/PAAc IPNs hydrogels were symthesized by UV irradiation tallowed by repetitive freezing and thawing method. These hydrogels showed pH and temperature sensitive swelling behaviors. From the release experiment, the release amount of model drug incorporated into these hydrogels showed pulsatile patterns. Permeability coefficients obtained by various solutes differed in response to changes of permeation conditions.