• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2004년도 가을 학술발표논문집 Vol.31 No.2 (2)
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• pp.295-297
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• 2004

생체 내의 모든 기능은 유전자 발현에 의해 결정된다. 유전자 발현은 않은 인자들에 의해 조절되며, 이러한 조절 과정에 따라 유전자 발현량이 결정되는 것이다. 세포 주기 역시 유전자 발현과 밀접한 연관성을 가지고 있다. 본 논문에서는 효모에서 세포 주기의 각 단계와 관련된 유전자들의 분석을 통해서 세포주기를 조절하는데 있어서 중요한 역할을 수행하는 전사 조절 모티프들이 무엇인지를 찾아보았다. 주요 모티프의 추출은 인공신경망 모델을 학습하고. 입출력 에러 분석을 통하여 이루어진다. 그 결과 MCB 등 기존의 실험 결과를 통하여 세포주기에 관련이 있다고 알려진 모티프들이 높은 점수를 보인다는 것을 알 수 있었고. 그 외에 세포주기의 각 단계에서 유전자 발현에 중요한 역할을 수행할 것으로 예상되는 다른 모티프들도 예측해볼 수 있었다.

• IMMUNE NETWORK
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• 제2권3호
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• pp.125-132
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• 2002

In the past, bioinformatics was often regarded as a difficult and rather remote field, practiced only by computer scientists and not a practical tool available to biologists. However, the various on-going genome projects have had a serious impact on biological sciences in various ways and now there is little doubt that bioinformatics is an essential part of the research environment, with a wealth of biological information to analyze and predict. Fully sequenced genomes made us to have additional insights into the functional properties of the encoded proteins and made it possible to develop new tools and schemes for functional biology on a proteomic scale. Among those are the yeast two-hybrid system, mass spectrometry and microarray: the technology of choice to detect protein-protein interactions. These functional insights emerge as networks of interacting proteins, also known as "pathway informatics" or "interactomics". Without exception it is no longer possible to make advances in the signaling/regulatory pathway studies without integrating information technologies with experimental technologies. In this paper, we will introduce the databases of protein interaction worldwide and discuss several challenging issues regarding the actual implementation of databases.

• Asian Journal of Innovation and Policy
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• 제4권2호
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• pp.178-199
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• 2015

This study provides a background on the growth of Indian automobile industry under different regulatory regimes. It is observed that the international joint ventures have played a key role in the growth of the sector. The study further examines the motives for forming IJVs in the auto component sector and also identifies the criteria for choosing the joint venture partner to mitigate conflicts. These two specific attributes form the core towards transfer of technology, promoting innovation and also act as a catalyst for adopting and choosing appropriate technology. The study brings out the relationship between motives, partner selection criteria and performance of the IJVs. Results indicate that firms gave maximum importance to technological skills, quality control measures and proprietary knowledge in selecting IJV partners. It is also observed that the motives affect the partner selection criteria in terms of skill and resources needed from the partner.

• Journal of Communications and Networks
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• 제8권2호
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• pp.144-150
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• 2006

A serious problem with traditional 'command & control' spectrum management techniques is that they do not easily accommodate new technologies and new services. This paper describes the necessary principles of flexible-use spectrum rights which may allow a wide variety of spectrum uses in a single general-purpose band. Based on the electrospace description of the radio spectrum, these principles allow general aggregation or division of licensed electrospace regions via secondary markets, providing rules for how regulatory limits change under aggregation or division. These flexible-use principles limit transmitter behaviors that tend to create a more difficult operating environment for receivers, while making receivers responsible for handling any remaining interference. The author shows how flexible-use principles could provide a basis for real-world flexible-use frequency bands.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2015년도 춘계학술대회
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• pp.781-782
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• 2015

클라우드, 소셜 네트워크, 빅데이터 등 보안 시장에 영향을 미칠 수 있는 성장 동력원이 급속히 성장하면서 정보보호산업 역시 급격히 진화하고 있다. 본고에서는 주요국의 정보보호정책을 간략히 살펴본 후, 최근 주요 선진국을 중심으로 이슈화되고 있는 IoT 정보보호 관련 법 규제 동향을 살펴보았다. 본 분석을 통하여 기존의 정보보호법을 사물인터넷에 적용하기 위한 대책을 서둘러야 한다는 시사점을 얻었다.

• BMB Reports
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• 제51권10호
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• pp.493-499
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• 2018

Cellular senescence is a state of permanent cell-cycle arrest triggered by different internal and external stimuli. This phenomenon is considered to be both beneficial and detrimental depending on the cell types and biological contexts. During normal embryonic development and after tissue injury, cellular senescence is critical for tissue remodeling. In addition, this process is useful for arresting growth of tumor cells, particularly during early onset of tumorigenesis. However, accumulation of senescent cells decreases tissue regenerative capabilities and induces inflammation, which is responsible for cancer and organismal aging. Therefore cellular senescence has to be tightly regulated, and dysregulation might lead to the aging and human diseases. Among many regulators of cellular senescence, in this review, I will focus on microRNAs, small non-coding RNAs playing critical roles in diverse biological events including cellular senescence.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2005년도 가을 학술발표논문집 Vol.32 No.2 (2)
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• pp.277-279
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• 2005

DNA 마이크로어레이 기술의 발전으로 유전자 발현에 대한 많은 양의 정보가 쏟아지게 되었고, 이러한 정보들을 이용하여 유전자 조절 네트워크를 수학적으로 모델링하는 것이 시스템 생물학의 중요 관심사로 떠오르고 있다. 본 논문에서는 실험에서 얻어낸 데이터를 유전 프로그래밍을 이용한 기호 회귀를 통해 데이터 지점을 조정하고 유전 프로그래밍의 결과 함수를 이용해 각 지점에서의 미분값을 얻어내었다. 그 뒤, 불리안 네트워크를 표현하는 이진 배열과 S-시스템을 표현하는 실수 배열을 결합한 해를 사용하는 유전 알고리즘으로 앞에서 얻은 데이터를 이용해 원하는 S-시스템의 구조와 매개변수를 구해내었다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2003년도 하계학술대회 논문집 D
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• pp.2254-2258
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• 2003

In recent years, the case to install small water treatment facility to every local area has increased. A key issue in the successful implementation of the control systems for the water treatment plants is the choice of control architecture. Within the framework of distributed control system(DCS), this paper presents a new development of intelligent control module and its novel application to open control architecture for water treatment plants. This control system so called NCS(Network Based Control System) with standard networks system with LonTalks protocol of ANSI/EIA 709.1, regulatory control function and information dispatch function has suitable functionality to operate these distributed water treatment facility effectively. This paper describes the case where NCS is applied for the filters system in water treatment facility of Heong Sung area.

• Communications for Statistical Applications and Methods
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• 제12권2호
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• pp.335-348
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• 2005

The rapid development of microarray technologies enabled the monitoring of expression levels of thousands of genes simultaneously. Recently, the time course gene expression data are often measured to study dynamic biological systems and gene regulatory networks. For the data, biologists are attempting to group genes based on the temporal pattern of their expression levels. We apply the consensus clustering algorithm to a time course gene expression data in order to infer statistically meaningful information from the measurements. We evaluate each of consensus clustering and existing clustering methods with various validation measures. In this paper, we consider hierarchical clustering and Diana of existing methods, and consensus clustering with hierarchical clustering, Diana and mixed hierachical and Diana methods and evaluate their performances on a real micro array data set and two simulated data sets.

• East Asian Economic Review
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• 제23권3호
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• pp.285-309
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• 2019

Unlike the popular belief, digital transformation mainly gets stymied by legal and regulatory issues related with legacy institutions in Asia rather than technical difficulties. The real challenges triggered by the PSD2 (Payment Services Directive 2) are how the region would overcome the overly fragmented, centralized, and hierarchical legacy framework to allow necessary changes to respond to the digital single market initiatives as promulgated by the European counterpart. The PSD2 is expected to bring about substantial changes in the payment ecosystem by allowing payment service providers to access customers' accounts and transactions information via API that have been traditionally controlled by banks. This paper suggests an incentive-compatible mechanism design for open collaboration among legacy institutions in the region to help them adapt to the PSD2. As evidenced by case studies in Korea, the Asian equivalent of PSD2 can be implemented and further expanded to create region-wide PCS (payment-clearing-settlement) network by reconnecting the dots of legacy infrastructures. These decentralized, diverse, small payment networks can be further combined with the expanded RTGS-CDS platform to evolve into the next phase of Asian Financial Network.