• Journal of Korea Water Resources Association
• /
• v.42 no.2
• /
• pp.161-168
• /
• 2009

The purpose of this study is to evaluate the variation of probability flood according to the flow regulation by multi-purpose dams (Soyang and Chungju) in the Han-river basin, Korea. SWAT-K (Soil and Water Assessment Tool-Korea) was used in order to generate regulated and unregulated daily streamflows upstream of Paldang dam. Simulated flow regulated by the Soyang and Chungju dams was calibrated by comparison with the observed inflow data at Paldang reservoir. Generally the ratio of flood flows to daily streamflows is known to decrease with drainage area in a watershed. Regulated and unregulated flood flows were obtained from the relationship between flood flows and daily streamflows. Extreme Type-I distribution was applied for flood frequency analysis and L-moment method was used for parameter estimation. This is a novel approach capable of understanding the variation in flood frequency with dam operation for the relatively large watershed scale, and this will helps improve the applicability of daily stream flow data for use in flood control as well as in water utilization.

• Journal of Korean Society on Water Environment
• /
• v.32 no.2
• /
• pp.135-141
• /
• 2016

This study investigated changes of hydrology, soil characteristics, riparian vegetation communities, and geomorphology in sandbars before and after sand-mining to determine the effect of sand-mining at upstream of Guemgang and Bochungcheon streams in Korea. Sand-mining events affected the mining area. They supplied organic matters and nutrients during flood. Sediment deposition caused soil texture change and expansion of vegetation area. However, riverbeds were stabilized after the disturbance. According to the analyses of aerial photographs, the vegetation area was significantly expanded in both dam-regulated streams and dam-unregulated streams after sand-mining. Willow shrubs advanced in disturbed area at an average of 10 years after sand-mining. It took willows trees 10.6 years to become dominant communities. Therefore, it took a total of 20.6 years for new riparian forest to form in sandbar after sand-mining. Our results confirmed that stream flow condition were dependent on vegetation recruitment in dam-regulated streams and dam-unregulated streams. For willow recruitment in unregulated streams, calculation of water level below dimensionless bed shear stress is important because low water level variation is a limiting factor of vegetation recruitment.

• 한국지구물리탐사학회:학술대회논문집
• /
• 2003.11a
• /
• pp.544-547
• /
• 2003

The objective of this study is to investigate the contamination levels and dispersion patterns of arsenic and heavy metals and to estimate the bioaccessible fraction of the metals in soil and plant samples in the vicinity of the abandoned Songcheon Au-Ag mine. Tailings, soils, plants (Chinese cabbage, red pepper, soybean, radish, sesame leaves, green onion, lettuce, potato leaves, angelica and groundsel) and waters were collected around the mine site. After appropriate preparation, all samples were analyzed for As, Cd, Cu, Pb and Zn by ICP-AES and ICP-MS. Elevated levels of As and heavy metals were found in tailings. Mean concentrations of As in agricultural soils were higher than the permissible level. Especially, maximum level of As in farmland soil was 513 mg/kg. The highest concentrations of As and Zn were found in Chinese cabbage (6.7 mg/kg and 359 mg/kg, respectively). Concentrations of As, Cd, and Zn in most stream waters which are used for drinking water around this mine area were higher than the permissible levels regulated in Korea. Maximum levels of As, Cd and Zn in stream waters were 0.78 mg/L, 0.19 mg/L and 5.4 mg/L, respectively. These results indicate that mine tailings can be the main contamination sources of As and heavy metals in the soil-water system in the mine area. The average of estimated bioaccessible fraction of As in farmland soils were $3.7\%$ (in simulated stomach) and $10.8\%$ (in simulated small intestine). The highest value of bioaccessible fraction of metal in farmland soils was $46.5\%$ for Cd.

• Korean Journal of Biological Psychiatry
• /
• v.20 no.4
• /
• pp.159-165
• /
• 2013

Objectives Mechanisms of clinical synergistic effects, induced by co-treatments of lithium and valproate, are unclear. Extracellular signal-regulated kinase (ERK) has been suggested to play important roles in mechanisms of the action of mood stabilizers. In this study, effects of co-treatments of lithium and valproate on the ERK1/2 signal pathway and its down-stream transcription factors, ELK1 and C-FOS, were investigated in vitro. Methods PC12 cells, human pheochromocytoma cells, were treated with lithium chloride (30 mM), valproate (1 mM) or lithium chloride + valproate. The phosphorylation of ERK1/2 was analyzed with immunoblot analysis. Transcriptional activities of ELK1 and C-FOS were analyzed with reporter gene assay. Results Single treatment of lithium and valproate increased the phosphorylation of ERK and transcriptional activities of ELK1 and C-FOS, respectively. Combined treatments of lithium and valproate induced more robust increase in the phosphorylation of ERK1/2 and transcriptional activities of ELK1 and C-FOS, compared to those in response to single treatment of lithium or valproate. Conclusions Co-treatments of lithium and valproate induced synergistic increase in the phosphorylation of ERK1/2 and transcriptional activities of its down-stream transcription factors, ELK1 and C-FOS, compared to effects of single treatment. The findings might suggest potentiating effects of lithium and valproate augmentation treatment strategy.

• Journal of the Korean Society of Safety
• /
• v.28 no.6
• /
• pp.11-16
• /
• 2013

This paper presents a study on the analyzing reliability of smoke fire detector using accelerated life test. In general, the smoke fire detector is broken by dust which flow in smoke detection chamber. In order to conduct accelerated life test of smoke fire detector dust is set accelerated factor in this paper. The dust is fly-ash which is test particle 5th regulated by KS A 0090. The dust accelerated level is 60 g, 180 g and 360 g and failure time is measured by smoke sensitivity testing. It is considered to failure of detector if detector don't operate within 30 secconds when subjected to an air stream having a velocity of 20 cm/s~40 cm/s containing smoke with a concentration of 15% of rate of light-response of 1 m. The goodness of fit test and mean life prediction conduct using the failure time. The result show that life distribution fits the weibull distribution for failure time data and the mean lifes calculate 22.5 year in domestic product and 14.7 years in overseas product applied dust stress only.

• Proceedings of the Korean Society of Food Science and Nutrition Conference
• /
• 2004.11a
• /
• pp.185-197
• /
• 2004

Type 2 diabetes is characterized by hyperglycemia and hyperinsulinemia, features of insulin resistance. In vivo treatment of ob/ob mice with hydrolyzed fibroin reverses these pathological attributes (6). To explore the mechanism underlying this effect, we have used the 3T3-Ll adipocytes as a cell type which would represent the periphery, in vivo. Exposure of 3T3-Ll adipocytes to chronic insulin leads to the a 50% loss of insulin-stimulated glucose uptake. Chronic exposure to fibroin blocked, in part, the response to chronic insulin but also increased the sensitivity of control cells to the acute action of insulin. The later effect was most robust at physiological concentrations of insulin. Fibroin did not prevent the insulin-induced down-regulation of the insulin receptor or the tyrosine kinase activity associated with the receptor. Further, fibroin had no affect on the loss in activity of the insulin-sensitive down-stream kinase, Akt. Interestingly, fibroin accelerated glucose metabolism and glycogen turnover independent of insulin action. In addition, fibroin up-regulated GLUT1 which increased its expression at the cell surface and caused the redistribution of GLUT4 to the plasma membrane. Together, these later effects would lead to an improvement in hyperglycemia in vivo which would in turn reduce the need for insulin.

• Journal of Biomedical Engineering Research
• /
• v.28 no.4
• /
• pp.455-460
• /
• 2007

Flow mismatch between blood and dialysate is invariably encountered during conventional hemodialysis, and this deteriorates diffusive mass transfer. A modification of a conventional dialyzer was conceived to prevent this mismatch. The modified dialyzer includes two independent blood flow regions (central and peripheral regions), which were achieved by redesigning the dialyzer cap. Resultantly, the blood stream was divided into two concentric dialyzer regions. Solutes clearances obtained using the modified dialyzers were compared with those of conventional dialyzers. Solutes clearances by conventional dialyzers were uniform, but solutes clearances by modified dialyzers were found to be dependent on the simulated blood split into dialyzer central and peripheral regions. Maximal clearances using the modified dialyzer were improved by up to approximately 7.6% for urea and 7.3% for creatinine, as compared with those of conventional dialyzers. More optimizations are required for clinical applications, but the finding that blood flowrates through central and peripheral fiber bundles can be easily regulated is encouraging.

• YAKHAK HOEJI
• /
• v.21 no.4
• /
• pp.193-199
• /
• 1977

ABS, Alkyl benzene sulfonate, persists for long periods in stream because of its resistance to biologic degradation. Its bio-degradation is very varied in the environments. This investigation was therefore undertaken in order to know the biodegradation of synthetic detergents which are comprising soft and hard forms from February 1976 to September 1976. The biodegradations by spontaneuos settling and aeration were determined. The reduction rates of ABS, DBS, and LAS were 9.8%, 13.7% and 10.4% by the settlings for 5 days at $25^{\circ}$ and 63.3%, 27.2%, and 43.9% by aeration respectively. It was not contributed effectively to biodegradate the synthetic detergents by the simulaneous incubation with micro-organisms isolated from sewage such as Enterobacter sp., E. coli, Bacillus sp., Flavobacterium sp., Pseudomonas sp., Staphylococcus sp., and etc. Tricking filter could also eliminate some amount of detergent. By the application of this investigation, it could be designed that detergents would be regulated in abuse in context with water pollution and be treated at a proper process in the sewage treatment plant to be installed.

• Korean Journal of Ecology and Environment
• /
• v.38 no.spc
• /
• pp.39-43
• /
• 2005

The dynamics of water quality with the storm events were analyzed in a small reservoir for irrigation, Lake Wangkung. Water quality of the inflowing stream fluctuated seasonally with the variation of flow rate. Thermal stratification was consistent from April to October below 2 m depths and anoxic layer was developed below 2 m depth in summer. The unique feature of temperature showed that thermal stratification was disrupted by a heavy rain event during monsoon, but hypolimnetic hypoxia were reestablished after a few days. Phosphorus and nitrogen increased immediately following storm events. The marked increase may be due to the input of P-rich storm runoff from the watershed. Internal phosphorus loading can be one of the explanations for TP increases in summer. When there was a storm, total populations of phytoplankton and zooplankton was reduced immediately following the storm, indicating possible flushing of algae and zooplankton. After a lag period of low-density the plankton population bloomed to a peak again within five days after the storm. Turbid water in lake became clear again which coincided with the time of the phytoplankton buildup. The results demonstrate that water quality is regulated greatly by rainfall intensity in Lake Wangkung.

• Molecules and Cells
• /
• v.20 no.2
• /
• pp.157-166
• /
• 2005

The c-myc proto-oncogene encodes a nuclear protein that is deregulated and/or mutated in most human cancers. Acting primarily as an activator and sometimes as a repressor, MYC protein controls the synthesis of up to 10-15% of genes. The key MYC targets contributing to oncogenesis are incompletely enumerated and it is not known whether pathology arises from the expression of physiologic targets at abnormal levels or from the pathologic response of new target genes that are not normally regulated by MYC. Regardless of which, available evidence indicates that the level of MYC expression is an important determinant of MYC biology. The c-myc promoter has architectural and functional features that contribute to uniform expression and help to prevent or mitigate conditions that might otherwise create noisy expression. Those features include the use of an expanded proximal promoter, the averaging of input from dozens of transcription factors, and real-time feedback using the supercoil-deformable Far UpStream Element (FUSE) as physical sensor of ongoing transcriptional activity, and the FUSE binding protein (FBP) as well as the FBP interacting repressor (FIR) as effectors to enforce normal transcription from the c-myc promoter.