• Journal of Sasang Constitutional Medicine
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• v.28 no.2
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• pp.147-162
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• 2016

Objectives The objective of this study is to develop a taeeumin animal-experimental model induced lung fibrosis with Bleomycin and evaluate the effect on obesity in this animal-experimental model.Methods The subjects were divided into 3 groups : normal group, high fat diet(HFD) control group, and HFD group administered with bleomycin(n=10 per group). To develop taeeumin animal-experimental model with reduced respiratory metabolism, 8-week-old C57BL/6 mice were administered with 0.03ml solution of bleomycin 1U/ml dissolved in distilled water, intratracheal(IT), once. Then, the HFD control group and the experimental group were fed with high fat diet for 6 weeks. Airway hyperresponsiveness(AHR) to methacholine was measured at the 1st and 3rd week after bleomycin was administered. Food intake and body weight were measured at regular time weekly. After the final experiment, blood was gathered by cardiac puncture for bloodchemical examination and organs(liver, fatty tissue) were remoed, weighted, and mRNA was analyzed.Results and Conclusions Through the experiment, it was found that Bleomycin induced Taeeumin animal-experimental models have leptin resistace. In the experimental group administered with Bleomycin, fatty acid synthesizing gene expression increased and energy metabolizing gene expression decreased. As mRNA expression of adiponectin decreased, it was found that Taeeuim animal-experimental model is susceptible to metabolic syndrome and cardiovascular diseases.

• The Journal of Korean Obstetrics and Gynecology
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• v.18 no.1
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• pp.1-14
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• 2005

This study was performed to evaluate antithrombotic activities of Saegeumsan (瑞金散, SGS) which has effects of activating blood, removing thrombus. This study is designed to measure the effect which was given to blood flow rate through the regular volume of glass tube after the blood was diluted five times with ACD solution. Antithrombotic effect was calculated as a percentage of the experimental animal figure protected from the paralysis of hind legs or death of the mouse that is caused from the administration of platelet aggregation regent. We standardized the time when the experimental animals were incapable of functioning the hind legs more than 20 minutes or maintained trembling. Being classified one group of eight mice, each of them was divided into Normal, Control, and SGS. The normal group supplied a saline solution and the control group brought the dextran extravasated blood after an hour of administering the saline solution. Also, SGS was dissolved in $2m{\ell}$ saline solution and then we dosed it to the experimental mice with Oral Zonde one day before the experiment. After that, the mice were abstained from food. And then we gave a measured amount of it before an hour. Finally, it gave rise to dextran extravasated blood in the same way as the Control group. The results were obtained as follows, SGS significantly inhibited platelet aggregation induced by ADP and epinephrine when analyzed by the Sigmoid $E_{max}$ model in WinNonlin. $EC_{50}$ values of SGS were 4.61 mg/ml and 12.41 mg/ml for ADP and epinephrine respectively. SGS showed fibrinolytic activity insignificantly as compared with the control group. SGS increased blood flow rate significantly as compared with the control group in vitro. SGS inhibited pulmonary embolism induced by collagen and epinephrine(inhibitive rate is 37.5 %). SGS increased number of platelet and fibrinogen amount significantly, and shortened PT and APTT as compared with the control group in thrombus model induced by dextran. According to, SGS is effective antithrombotic activity from experimental result.

• Biomaterials and Biomechanics in Bioengineering
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• v.2 no.4
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• pp.249-269
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• 2015

A problem faced by oil companies is the maintenance of the location register of pipelines that cross the surf zone, the regular survey of their location, and also their inspection. A survey of the state of art did not allow identifying operating systems capable of executing such tasks. Commercial technologies available on the market also do not address this problem and/or do not satisfy the presented requirements. A possible solution is to use robotic systems which have the ability to walk on the shore and in the surf zone, subject to existing currents and ripples, and being able to withstand these ambient conditions. In this sense, the authors propose the development of a spider crab biologically inspired robot to achieve those tasks. Based on these ideas, this work presents a biomechanical study of the spider crab, its modeling and simulation using the SimMechanics toolbox of Matlab/Simulink, which is the first phase of this more vast project. Results show a robot model that is moving in an "animal like" manner, the locomotion, the algorithm presented in this paper allows the crab to walk sideways, in the desired direction.

• Journal of Ocean Engineering and Technology
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• v.24 no.6
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• pp.16-22
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• 2010

In this paper, the diffraction problems for fixed offshore structures are solved using a hybrid scheme. In this hybrid scheme, potential-based solutions and the Navier-Stokes-based finite volume method (FVM) with a volume-of-fluid (VOF) method are combined. We introduce a buffer zone for efficient wave-making and damping. In this buffer zone, the near field solution from FVM-VOF is gradually changed to Stokes' 2nd order wave solutions. Three different models, including the truncated cylinder, sphere, and wigleyIII model, are numerically investigated in regular waves with a wave steepness of 1/30. The efficiency and accuracy of the hybrid scheme are numerically validated from results using different domain sizes and buffer zones. The wave exciting forces from the FVM-VOF simulations are compared with experiments and potential-based solutions from the higher-order boundary element method (HOBEM). This comparison shows good agreement between the hybrid scheme and potential-based solutions.

• Korean Journal of Metals and Materials
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• v.46 no.10
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• pp.662-671
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• 2008

The behavior of hydrogen in the steel making process was investigated. The relation between the composition of ladle slag and hydrogen concentration in molten steel was considered. The hydrogen distribution ratio between ladle slag and molten steel was increased with increasing basicity of the slag; it was about 20 when the basicity of slag was 15. Hydroxyl capacity measured from the hydrogen distribution ratio between slag and the molten steel was comparatively corresponding to the value of hydroxyl capacity measured by the equilibrium reaction of slag and $H_2O$ gas. However, it is considerably different from the value calculated by regular solution model. The influence of hydrogen on a sticking type breakout is considered. The effect of hydrogen and $H_2O$ gas on the crystallization behavior of mold powder was investigated by DHTT (Dual hot thermocouple technique). As a result, it was proved that mold powder could be crystallized by $H_2O$ gas in the atmosphere. Therefore, it is concluded that $H_2O$ gas in the atmosphere can be a possible cause of the sticking type breakout that occasionally occurs in the continuous casting process.

• The Journal of Korean Obstetrics and Gynecology
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• v.22 no.1
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• pp.110-124
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• 2009

Purpose: This study was performed to evaluate anti-thrombotic effect of Jogantanggagambang extract (JGTG). Methods: Blood flow rate through the regular volume of glass tube after the blood was diluted five times with ACD solution. Antithrombotic effect was calculated as a percentage of the experimental animal figure protected from the paralysis of hind legs or death of the mouse that was caused from the administration of platelet aggregation regent. Results: 1. JGTG inhibited the platelet aggregation induced by ADP, epinephrine, collagen and arachidonic acid as compared with the control group. 2. JGTG inhibited pulmonary embolism induced by collagen and epinephrine (inhibitory rate is 37.5%). 3. JGTG increased platelet number and fibrinogen amount significantly and also JGTG shortened PT and APTT significantly as compared with the control group in thrombus model induced by dextran. 4. JGTG increased blood flow rate significantly as compared with the control group in vivo. Conclusion: These results suggest that JGTG can be used for treating various female diseases caused by thrombosis.

• Journal of Ocean Engineering and Technology
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• v.27 no.4
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• pp.76-82
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• 2013

Motion reduction of an offshore structure at resonant frequency is essential for avoiding critical damage to the topside and mooring system. A damping plate has a distinct advantage in reducing the motion of a floating structure by increasing the added mass and the damping coefficient. In this study, the heave motion responses of a circular cylinder with an impermeable and a permeable damping plate attached at the bottom of the cylinder were investigated thru a model test. The viscous damping coefficients for various combinations of porosity were obtained from a free-decay test by determining the ratio between any pair of successive amplitudes. Maximum energy dissipation occurred at a porous plate with a porosity P = 0.1008. Experimental results for regular and irregular waves were compared with an analytical solution by Cho (2011). The measured heave RAO and spectrum reasonably followed the trends of the predicted values. A significant motion reduction at resonant frequency was pronounced and the heaving-motion energy calculated by the integration of the area under the heave motion spectrum was reduced by more than 75% by the damping plate. However, additional energy dissipation by eddies of strong vorticity and flow separation inside a porous damping plate was not found in the present experiments.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.35 no.9B
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• pp.1259-1265
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• 2010

Recently, on-line social network has been increasing according to development of internet. The most representative service is blog. A Blog is a type of personal web site, usually maintained by an individual with regular entries of commentary. These blogs are related to each other, and it is called Blog Network in this paper. In a blog network, posts in a blog can be diffused to other blogs. Analyzing information diffusion in a blog world is a very useful research issue, which can be used for predicting information diffusion, abnormally detection, marketing, and revitalizing the blog world. Existing studies on network analysis have no consideration for the passage of time and these approaches can only measure network activity for a node by the number of direct connections that a given node has. As one solution, this paper suggests the new method of measuring the blog network activity using logistic curve model and Cosine-similarity in key words by the Map/Reduce programming model.

• Journal of the Korean Chemical Society
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• v.59 no.4
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• pp.271-279
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• 2015

The critical micelle concentration (CMC), the counter ion binding constant (B) and the aggregation number (N^* ) for the mixed micellization of sodium dodecanoate and sodium n-octanoate as two anionic surfactants have been investigated by means of electric conductivity and light scattering. As its experimental results are found to be deviated from ideal mixed model, thus two different kinds of regular solution models such as Rubingh and Motomura are used for interpreting our experimental data. The stability of the mixed micelles has been confirmed from the negative values of the standard Gibbs energy of mixed micellization ΔG^micel,0 over all compositions and the measured values of ΔG^micel,0 agreed with the theoretical ones within the experimental error.

• Magazine of the Korean Society of Agricultural Engineers
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• v.37 no.3_4
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• pp.34-47
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• 1995

It is experienced fact as a regular annual event that the structure to he designed on unreasonable flood for the agricultural structures including reservoirs have been brought not only loss of lives, but also enormous property damage. For the solution of this problem at issue, this study was conducted to develop an optimal runoff hydrograph model by comparison of the peak flows and time to peak between observed and simulated flows derived by linear time-invariant and linear time-variant models under the condition of having a short duration of heavy rainfall with uniform rainfall intensity at nine small watersheds which are within the range of 55.9 to 140.7 square kilometers in area in Han, Geum, Nagdong and Yeongsan Rivers. The results obtained through this study can be summarized as follows. 1. Storage constants and Gamma function arguments were calculated within the range of 1.2 to 6.42 and of 1.28 to 8.05 respectively by the moment method as the parameters for the analysis of runoff hydrograph based on linear time-invariant model. 2. Parameters for both linear time-invariant and linear time-variant models were calibrated with nine gaged watershed data, using a trial and error method. The resulting parameters including Gamma function argument, N and storage constant, K for linear time-invariant model were related statistically to watershed characteristic variables such as area, slope, length of main stream and the centroid length of the basin. 3. Average relative errors of the simulated peak discharge of calibrated runoff hydrographs by using linear time-variant and linear time-invariant models were shown to be 0.75 and 5.42 percent respectively to the peak of observed runoff hydrographs. Correlation coefficients for the statistical analysis in the same condition were shown to be 0.999 and 0.978 with a high significance respectively. Therefore, it can be concluded that the accuracy of a linear time-variant model is approaching more closely to the observed runoff hydrograph than that of a linear time-invariant model in the applied watersheds. 4. Average relative errors of the time to peak of calibrated runoff hydrographs by using linear time-variant and linear time-invariant models were shown to be 16.44 and 19.89 percent respectively to the time to peak of observed runoff hydrographs. Correlation coefficients in the same condition were also shown to be 0.999 and 0.886 with a high significance respectively. 5. It can be seen that the shape of simulated hydrograph based on a linear time- variant model is getting closer to the observed runoff hydrograph than that of a linear time-invariant model in the applied watersheds. 6. Two different models were verified with different rainfall-runoff events from data for the calibration by relative error and correlation analysis. Consequently, it can be generally concluded that verification results for the peak discharge and time to peak of simulated runoff hydrographs were in good agreement with those of calibrated runoff hydrographs.