• 대한핵의학회지
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• 제37권6호
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• pp.355-363
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• 2003

목적: 게이트 심근 SPECT 영상에서 국소부피변화를 얻으면, 요골동맥 긴장도를 측정하여 얻은 중심 동맥의 압력 곡선으로부터 최대탄성률을 얻을 수 있다. 이 연구에서는 좌심실의 국소탄성률을 평가하기 위한 방법을 개발하고 국소탄성률 측정의 재현성을 평가하였다. 대상 및 방법: 게이트 Tc-99m MIBI 심근 관류 SPECT를 두 번 연속으로 시행한 환자 7명(남:여=5:2, $58{\pm}11.9$세)을 대상으로 하였다. 국소적 부피변화를 측정하기 위하여 개발한 CSA(Cardiac SPECT Analyzer) 소프트웨어를 이용하여 좌심실의 부피변화를 측정하였으며, 시간-압력곡선과 국소 시간-부피 곡선을 이용하여 반복연산을 통하여 구한 국소 시간-탄성률 곡선에서 국소탄성률을 얻었다. 같은 SPECT 영상에 대해서 두 번 측정한 국소탄성률의 재현성과, 같은 환자에서 연속하여 두 번 얻은 SPECT 영상에 대해서 측정한 국소탄성률의 재현성을 평가하였다. 결과: 평균 국소탄성률은 15분할모델에서 $3.36{\pm}3.38mmHg/mL$이었으며, 7분할모델과 5분할모델에서 각각 $3.16{\pm}2.25mmHg/mL,\;3.11{\pm}2.52mmHg/mL$이었다. 국소탄성률의 조화평균은 전체탄성률과 일치하였다. 동일한 데이터에서 두 번 측정한 국소탄성률 값의 상관계수는 모든 모델에서 0.97이상이었고, Bland Altman 도표에서 차이의 2-표준편차는 각각 1.5%, 1.0%, 0.9%였다. 동일 환자에서 두 번 연속 촬영한 SPECT 데이터로부터 측정한 국소탄성률의 상관계수는 모든 모델에서 0.95이상이었으며, Bland Altman 도표에서 차이의 2-표준편차는 각각 2.2%, 1.0%, 1.2%였다. 결론: 게이트 심근 SPECT를 이용한 좌심실의 국소탄성률을 측정하였으며 재현성 있는 결과를 얻었다. 심근 SPECT를 이용하여 얻은 국소탄성률의 평가방법은 향후 임상적인 데이터를 바탕으로 새로운 심기능 분석지표로 활용될 수 있을 것이다.

• Journal of Gastric Cancer
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• 제16권3호
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• pp.182-190
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• 2016

Purpose: This study aimed to establish a large-scale database of patients with gastric cancer to facilitate the development of a nationalcancer management system and a comprehensive cancer control policy. Materials and Methods: An observational prospective cohort study on gastric cancer was initiated in 2010. A total of 14 cancer centers throughout the country and 152 researchers were involved in this study. Patient enrollment began in January 2011, and data regarding clinicopathological characteristics, life style-related factors, quality of life, as well as diet diaries were collected. Results: In total, 4,963 patients were enrolled until December 2014, and approximately 5% of all Korean patients with gastric cancer annually were included. The mean age was $58.2{\pm}11.5$ years, and 68.2% were men. The number of patients in each stage was as follows: 3,394 patients (68.4%) were in stage IA/B; 514 patients (10.4%), in stage IIA/B; 469 patients (9.5%), in stage IIIA/B/C; and 127 patients (2.6%), in stage IV. Surgical treatment was performed in 3,958 patients (79.8%), endoscopic resection was performed in 700 patients (14.1%), and 167 patients (3.4%) received palliative chemotherapy. The response rate for the questionnaire on the quality of life was 95%; however, diet diaries were only collected for 27% of patients. Conclusions: To provide comprehensive information on gastric cancer for patients, physicians, and government officials, a large-scale database of Korean patients with gastric cancer was established. Based on the findings of this cohort study, an effective cancer management system and national cancer control policy could be developed.

• Asian Pacific Journal of Cancer Prevention
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• 제16권10호
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• pp.4285-4289
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• 2015

Purpose: Blood hemoglobin levels are known to influence response to radiotherapy. This retrospective analysis compared the effect of hemoglobin levels upon response to radiation among patients treated with radiation alone (by accelerated hyperfractionated radiotherapy) versus those treated with concurrent cisplatin chemoradiotherapy. Materials and Methods: Among patients treated for locally advanced carcinoma of the cervix (LACC) during 2009-10, a total of 60 fulfilled the eligibility criteria. In this time frame, external beam radiotherapy was delivered with either concurrent chemoradiotherapy (CRT, n=31) (45Gy over 25 fractions, with weekly cisplatin at 40mg/m2), or with accelerated hyperfractionated radiotherapy (AHRT, n=29) (20Gy over 10 daily fractions over the first two weeks, followed by 30Gy over 20 fractions over the next two weeks, with two fractions of 1.5Gy per day, without the use of chemotherapy). Mean weekly hemoglobin (MWH) levels of all patients were calculated as the arithmetic means of weekly recorded blood hemoglobin levels. As per MWH, patients in both of the AHRT or the CRT groups were classified into two subgroups-those with MWH between 10-10.9g/dL, or with MWH>11g/dL. Complete response (CR) to external beam RT phase (prior to brachytherapy) was declared after clinical examinations and computed tomography. The CR rate was noted for both MWH sub-groups within each of the AHRT and CRT groups. Results: Within the AHRT group, patients with MWH>11g/dL had a much better CR rate in comparison to those with MWH:10-10.9g/dL (80% vs. 21.1%) which was statistically significant (p 0.0045). Within the CRT group, there was no significant difference in the outcomes within the MWH>11g/dL and MWH:10-10.9g/dL sub-groups (CR rates of 80% vs. 61.9%, p=0.4285). Conclusions: The importance of maintaining a minimum hemoglobin level of 11g/dL during RT is much greater for patients treated with RT alone, than for patients treated with concurrent chemoradiotherapy. Enhanced haemoglobin levels during RT may to an extent negate the ill-effects that may otherwise arise due to non-use of concurrent chemotherapy.

• 한국산학기술학회논문지
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• 제21권10호
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• pp.72-76
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• 2020

중앙정부에서는 대한민국의 균형발전을 위하여 국가균형발전특별회계를 운영하고 있으며, 이를 통하여 지역의 발전을 꾀하고 있다. 많은 지방정부에서는 자생적 자립을 위한 발판을 마련하고자 여러 가지 형태의 노력을 하고 있는데, 그 중 지역의 경제성장을 이끌 수 있는 지역거점 기관 조성 등이 있다. 따라서 충남은 2019년부터 2023년까지 190억원을 투자하여 도내에 소재하고 있는 금속소재관련 기업의 성장을 지원하기 위한 '충남 첨단금속소재 플랫폼 구축사업'을 추진하고 있다. 이에 본 연구에서는 충남에 구축되는 지역거점센터에 투입되는 비용을 바탕으로 지역경제에 미치는 효과를 분석하였다. 분석시 산업연관분석모형을 사용하였으며, 연차별 투입금액에 따른 효과를 세부적으로 분석하여 제시하였다. 구체적으로 생산유발효과, 부가가치유발효과, 취업유발효과를 제시함으로써 동 사업의 효과성을 제시하였다. 분석결과 생산유발효과는 322억 3천만원으로 나타났으며, 총 부가가치 유발효과는 138억 2천만원, 취업유발인원은 101명으로 나타났다. 이러한 분석결과들은 동 사업의 추진에 대한 타당한 근거로 사용될 수 있다. 특히 편익의 항목으로 사용될 수 있는 생산유발 및 부가가치유발효과가 투입대비 높게 나타났기 때문이다. 또한 취업유발효과를 이용하여 동 사업을 통한 신규일자리 창출 및 고용인원을 파악할 수 있다.

• 한국작물학회지
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• 제44권3호
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• pp.256-262
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• 1999

To evaluate the genetic diversity and structure of the South Korean soybean population, 233 landraces collected in various regions of the country were surveyed for 15 allozyme loci and one protein locus. The South Korean population was fixed or nearly fixed at seven of the 16 loci tested. The number of alleles per locus was 2.06 and Nei’s gene diversity was 0.194. These values were lower than the values for the same 16 loci previously reported for the Japanese and Chinese populations. The differences among eight regional groups were not so marked, with only 7.2% of the total variation arising from regional differentiation. Three southern regional groups (Chollabuk-do, Chollanam-do and Kyong-sangnam-do) exhibited a relatively high variability because of frequent occurrence of alleles characteristic of the Japanese population. A marked difference was found in allelic frequencies at the Dial locus between large-seeded landraces and small-seeded ones, suggesting that the latter, which are used mainly for bean sprouts, had been established independently of the former, which are used mostly for soy sauce and cooking with rice. Not only the region but also the usage as food materials should therefore be taken into consideration in designing an efficient collection and preservation method for the Korean soybean landraces.

• 디지털융복합연구
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• 제12권6호
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• pp.597-605
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• 2014

대전시가 추진하고 있는 전지훈련 팀 유치를 통한 지역경제 활성화 방안을 살펴보고자 관련 자료를 분석한 결과 대전시는 타 시도에 비해 훈련시설이 부족하였고, 기온, 바람, 강수량의 기후 조건도 타 시도에 비해 특별히 유리하지는 않았다. 그러므로 전지훈련 팀을 유치하기 위해서는 지역 내 전지훈련 팀의 유치를 전담할 수 있는 전담팀을 설치하고 학교, 실업 및 연맹 간 협력체계를 구축해야 하며, 전지훈련 팀의 경기력을 향상시켜 줄 수 있는 최첨단 의료 및 경기력 향상 서비스를 제공해 주어야 한다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권1호
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• pp.353-356
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• 2016

Background: This study used receiver operating characteristic curve to analyze Surveillance, Epidemiology and End Results (SEER) for glassy cell carcinoma data to identify predictive models and potential disparities in outcome. Materials and Methods: This study analyzed socio-economic, staging and treatment factors. For risk modeling, each factor was fitted by a generalized linear model to predict the cause specific survival. Area under the receiver operating characteristic curves (ROCs) were computed. Similar strata were combined to construct the most parsimonious models. A random sampling algorithm was used to estimate modeling errors. Risk of glassy cell carcinoma death was computed for the predictors for comparison. Results: There were 79 patients included in this study. The mean follow up time (S.D.) was 37 (32.8) months. Female patients outnumbered males 4:1. The mean (S.D.) age was 54.4 (19.8) years. SEER stage was the most predictive factor of outcome (ROC area of 0.69). The risks of cause specific death were, respectively, 9.4% for localized, 16.7% for regional, 35% for the un-staged/others category, and 60% for distant disease. After optimization, separation between the regional and unstaged/others category was removed with a higher ROC area of 0.72. Several socio-economic factors had small but measurable effects on outcome. Radiotherapy had not been used in 90% of patients with regional disease. Conclusions: Optimized SEER stage was predictive and useful in treatment selection. Underuse of radiotherapy may have contributed to poor outcome.

• 농촌계획
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• 제3권2호
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• pp.90-101
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• 1997

The objectives of the study are to identify the issues and problems encountered in Korea's current integrated rural regional development(IRRD) program and to suggest policy remedies to cope with them. Secondary data and materials ate mainly used for the study. Since the mid-1980s, rural settlement planning has been carried out in the Republic of Korea, In the planning process,'scale of economy'perspectives and settlement policy have been emphasized for increasing the efficiency of investment. During the 1990s, rural settlement and major village development projects have been implemented under the rural structure transformation programs. Agricultural structure adjustment projects for land consolidation and sizable farming have been separated from the rural settlement and mojor village development projects. Based on the evaluative analysis for the rural structure transformation policy and program, some problematic issues were raised as follows: (a) lack of integrative control function in the program'(b) weak linkage between living environment improvement and agricultural development projects: and (c) lack of comprehensive village development planning and implementation system. The policy issues to solve the problems were suggested as follows: (a) adoption of bottom-up approach in new IRRD planning and project system : (b) projection of comprehensive development planning and project at the village level; and (c) introduction of new regional agriculture development projects such as direct payment system for farming in less favorable areas and organic farming.

• 한국농공학회논문집
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• 제56권6호
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• pp.113-119
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• 2014

This study aims to evaluate the behavior of poorly-compacted raised reservoir levee with water level raising by using centrifugal model test. From the test results, it seems that the hydraulic fracturing at the core of the raised reservoir levee with low degree of compaction possibly occurs due to the drastical increase of pore water pressure by water level raising. Additionally, the continuous infiltration may induce crack and/or sinkhole on the surface of the poorly-compacted raised reservoir levee owing to the increase of the subsidences at the crown and the front side of that. Therefore, reasonable construction management for the compaction of the raised reservoir levee is needed.

• International Journal of Computer Science & Network Security
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• 제22권10호
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• pp.91-96
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• 2022

Article materials reflect the results of scientific research and generalization of experience concerning quality measurement of student's educational activities in the context of innovative development of the educational process, which is ensured by introducing educational innovations. The main point of monitoring of higher education students' activities and also phenomenon of education quality, particularly its results, are determined in the research. Guided by the scientific theory and personal experience of scientific and pedagogical activities, the attempt to single out the key components, important indicators and to introduce component indicator model of quality of higher education students' activities on the qualimetry base has been performed. Methodical solutions concerning the application of the developed model to determine the dynamics of pedagogical students' educational achievements by particular educational components in the process of innovative development of educational process are proposed. The advanced studies that relate to the development of methods for monitoring the quality of pedagogical higher education students' activities on the basis of systemic, competence and qualimetry approaches taking into account the levels of education and chosen specialties have been decided.