• Journal of Life Science
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• v.25 no.3
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• pp.299-306
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• 2015

Chrysanthemum zawadskii, a herbaceous perennial plant belonging to the Compositae, grows wild in Asian countries, including Japan, China, and Korea. The biological, antioxidative, anti-inflammatory, and antibacterial activities of C. zawadskii have been reported, its antiobesity activity has not been elucidated. In the present study, the effect of C. zawadskii methanol extract (CZME) on pancreatic lipase enzyme activity, adipocyte differentiation, and adipogenesis was investigated using an in vitro assay and a cell model system. CZME effectively suppressed lipase enzyme activity in a dose-dependent manner. CZME also inhibited insulin, dexamethasone, 3-isobutyl-1-methylxanthine (MDI)-induced adipocyte differentiation, lipid accumulation, and the level of triglyceride in 3T3-L1 preadipocytes in a dose-dependent manner, without cytotoxicity. The antiobesity effect of CZME might be modulated by gene and protein expression of cytidine-cytidine-adenosine-adenosine-thymidine (CCAAT)/enhancer binding proteins (C/EBP) α, C/EBPβ, and the peroxisome proliferator-activated receptor γ (PPAR γ). CZME also triggered lipolysis in a dose-dependent manner in MDI-induced 3T3-L1 preadipocytes. Taken together, these results provide important new insights into the antiobesity activities of C. zawadskii, showing that they involve pancreatic lipase inhibition, as well as antiadipogenic and lipolysis effects. CZME might be a promising source in the field of nutraceuticals. However, the active compounds that confer the antiobesity activities of CZME need to be identified.

• Journal of the Korean Geographical Society
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• v.43 no.3
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• pp.337-357
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• 2008

This study examines the characteristics of population ageing and the employment of aged workers in Seoul. Population indexes such as aged/child ratio and longevity degree are analyzed to identify the time-spatial changes and differentiation of population ageing by Gu. Job offerers, job seekers and employees related to the aged workers are also analyzed using data from Center of Job Placement for the Aged in Seoul. The results indicate that population ageing of Seoul has progressed faster than other regions in recent years. In addition, regional differences in tendency of population ageing is obvious even within Seoul. The percentage of unskilled laborer is much higher in Seoul compared with other regions. There is geographical differentiation in employment of aged workers among regions within Seoul. The employment opportunity of the aged is high in core economic areas of Seoul, while low in the outer residential area. This shows geographical mismatch between job offerers and seekers, which means that it is difficult for aged workers to get the jobs near to their residence. Accordingly, governmental support and intervention is needed considering their lower mobility.

• Korean Institute of Interior Design Journal
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• v.22 no.4
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• pp.167-177
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• 2013

The environmental considerations should be taken into full consideration in order to make the use of ground space as comfort and efficient as that of ground space. The visual environmental factors which provide visual informations in underground spaces where the environmental information can be acquired only by the surroundings expand their role as affordance for wayfinding. This study focuses on the visual performance evaluation of wayfinding factors on the subway transfer station platform and aisle as major space for movement in four subway transfe stations and analyzes the material, pattern, color, and lighting provided by the visual environment in underground space as directional marked label, regional differentiation and sign system. The results of this study comes are as follows. First, As to the directional marked label at the subway platform and transfer aisle, following patterns are colors, finishing materials and lighting for the sake of safety and convenience, And regional differentiation, following colors are patterns for the space division. Finally sign system which practically provides the most information, however, it is most insufficient to be a space-preception element. Second, According to the type of platform structures, such as an island platform and a separate platform, the main areas of and necessity for the space-perception elements may bring about changes. Third, these four stations that has been analyzed for this study, lighting, compared with color, finishing material and pattern, has been highly insufficient to be a perception element.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.5
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• pp.3151-3154
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• 2013

Introduction: Colorectal cancers are in the top of the cancer-related causes of death in the world and lymph node metastasis is accepted as the primary prognostic factor. In this study, correlations of FGF19 staining pattern with local invasion and lymph node metastasis in a series of colorectal cancers were investigated. Methods: This studyincluded 81 colorectal cancer patients who underwent surgery in our hospital with no evidence of preoperative radiological distant metastasis. Routine pathological examination of the resection material was performed in order to identify vascular, perineural and serosal infiltration, regional lymph node metastasis and the degree of differentiation. Tumor tissue samples were stained with an immunohistochemistry method for FGF 19 evaluation and the staining pattern was statistically compared with the above mentioned characteristics of the tumors. Results: The patient population consisted of 47 females and 34 males with a median age of 70 years. In 40 patients regional lymph nodes were positive and 51%, 32% and 38% had serosal, perineural and vascular invasion. While 64 cases were moderately-differentiated, 11 cases were well-differentiated and 6 poorlydifferentiated, there was no association with FGF 19 staining, including intensity. Conclusion: No evidence of significant statistically correlation was found between FGF 19 staining pattern and serosal, perineural, vascular invasion, lymph node involvement and degree of differentiation.

• Journal of Life Science
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• v.18 no.6
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• pp.897-901
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• 2008

Deep seawater (DSW; deep ocean water) is pure, rich in inorganic materials which have attracted attention for various applications. In this study we investigated the effects of the DSW upwelled from the East Sea, offshore Yang Yang (Korea) on the morphological differentiation of cultured rat hippocampal neurons, which were grown in the minimal essential medium containing 10% (v/v) fetal bovine serum and 25% (v/v) DSW with various hardness. DSW had no effect on initial morphological differentiation (17 hr post-plating). When observed on DIV3, 7, 14, and 17, low hardness (0 and 200) DSW reduced dendritic branching. However, dendritic branches within $80\;{\mu}m$ diameter from the center of soma nearly doubled in neurons grown in hardness 1,000 DSW-containing media. DSW with hardness 600 was more or less same as control groups. These results indicate that DSW with appropriate hardness ameliorates neuronal health.

• Journal of the Korean Geographical Society
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• v.31 no.2
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• pp.268-294
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• 1996

Social and population geography in Korea has been developed somewhat later than other special subjects of geography. But in recent years, it has attracted much interests of geographers, and accumulated a considerably large amount of research products. Seen in this context, it is resonable to expect that social and population geography will not only lead the development of geography in the future, but also contribute to the resolution of socio-spatial problems in Korea. From this point of view, we shall retrospect in this paper the progress of social and population geography in Korea since the 1950s, and look out its future prospect and further research tasks. In the first place, we discuss general concepts and major themes of social and population geography, and overview its development process, and than review in more details some important research products which would be categorized into five main subjects, that is, research methodology, urbanization and urban population phenomena, population movement and changing rural life, residential differentiation and urban redevelopment, and urban social life and regional social well-being. Finally, we consider briefly the future prospect and further tasks of social and population geography in Korea.

• Journal of Life Science
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• v.21 no.5
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• pp.720-728
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• 2011

Garlic (Allium sativum) has been used as a source food as well as a traditional folk medicine ingredient since ancient times. Aged black garlic is a type of fermented garlic and is expected to have stronger anticancer and antioxidant activities than raw garlic. However, the mechanisms of their inhibitory effects on adipocyte differentiation and adipogenesis are poorly understood. In the present study, the effects and mechanisms of water extracts of raw garlic (WERG) and aged black garlic (WEABG) on adipocyte differentiation and adipogenesis in 3T3-L1 preadipocytes were investigated. Treatment with WEABG significantly suppressed terminal differentiation of 3T3-L1 preadipocytes in a dose-dependent manner as confirmed by a decrease in lipid droplet number and lipid content through Oil Red O staining, however WERG had no such effect. In addition, WEABG reduced accumulation of cellular triglyceride, which is associated with a significant inhibition of key pro-adipogenic transcription factors including peroxisome proliferator-activated receptor ${\gamma}$ (PPAR${\gamma}$), cytidine-cytidine-adenosine-adenosine-thymidine (CCAAT)/enhancer binding proteins ${\alpha}$ (C/EBP${\alpha}$) and C/EBP${\beta}$. Taken together, these results provide important new insight that aged black garlic might inhibit adipogenesis by suppressing the pro-adipogenic transcription factors in 3T3-L1 preadipocytes, and further studies will be needed to identify the active compounds that confer the anti-obesity activity of aged black garlic.

• Journal of the Korean Geographical Society
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• v.35 no.5
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• pp.701-716
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• 2000

This study examines patterms of wage inequality across ownership types and its regional structure in post-reform China in order to understand an emerging process of inequality. Using industrial wage data, I explored historical changes of cross-ownership wage inequality and its spatial differentiation during the reform period. This stuy found that pattems of wage inequality need to be understood in the context of changing redistributive economy which shapes state-enterprise relation in china's industrial sector. This relationship in turn determines labor market outcomes during the reform period including wage inequality. Regional structure of cross-ownership wage inequality also needs to be understood in terms of the differentiated process in which reqional wage levels are related to different wage factors. The findings have significant implications for understanding new patterns of soical and spatial inequalities in post-reform China.

• Proceedings of the Korean Society of Near Infrared Spectroscopy Conference
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• 2001.06a
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• pp.1269-1269
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• 2001

The Bovine Spongiform Encephalopathy (BSE) is one of the more important problems that have affected the economy of european cattles and the Public Safety. Their transmission is mainly through digestive system, and the compound feeds made with animal proteins are one source of infection for healthy cows. Nowadays the official method for meat and bone meal (MBM) detection in compound feeds is a microscopy technique. However, this methodology is subjective, and that alter the fact to make one exhaustive quantitative analysis and one differentiation between mammalian and poultry bones. In addition, the separation of the differents fractions in a sample by density before the analysis, requires the use of organochlorates products as $CCl_4$, which produce serious damages in the atmosphere ozone content. NIR methodology is another possible way to confirm and identifying animal ingredients in compound feeds, Its capabilities for quantitative and qualitative analysis of foods and feeds has been enought demonstrated. The objective of this work was to use NIR as a tool to make an qualitative and quantitative analysis and a prediction of the meat and bone meal presence in compound feeds from North Spain cattle farms. Using a global population of compound feeds, on make three different groups depending of MBM percentage presence (0, 0-100, 100), to build and validate one calibration equation to determine MBM content and make one discriminant analysis between these three groups. The preliminary dates obtained with another differents samples of known composition showed promising results.

• Korean Journal of Plant Taxonomy
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• v.37 no.4
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• pp.363-386
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• 2007

Endemic element of the Russian Far East (RFE) flora includes 497 species of 150 genera and 46 families. The level of endemism in structure of regional natural flora reaches 11.1% as a whole, and in structure of its native fraction - 13.1%. As a result of chorologic and ecocenotic analysis of RFE flora endemic element it is revealed that it consists of 8 main geographical groups and 7 main floristic complexes. The largest number of endemic species is concentrated in Arctic - Alpine & Montane (140, 28.2%), Forest (107, 21.5%) and Maritime (88, 17.7%) floristic complexes as well as in Russian Far East - West-Pacific (136, 27.4%), Japan Sea (88, 17.7%) and North-East-Asian - Beringian (69, 13.9%) geographical groups. It's possible to distinguish three main areas with similar eco-geographical differentiation of endemics on RFE as follows: (1) North-East Asia sector of RFE which North-East-Asian - Beringian and Maritime Okhotia - Beringian geographical groups approximately correspond to, (2) Continental part of East Asia sector of RFE (West - Okhotian, Amur - Okhotian, Amur - Ussirian, Okhotsk Sea and Japan Sea groups) and (3) Oceanic part of East Asia sector (Russian Far East - West Pacific group). Taxonomical variety of RFE endemics on these territories makes up accordingly (1) - 99 species (19.9%), (2) - 259 (52.8%) and (3) - 136 (27.4%).