• Asian Pacific Journal of Cancer Prevention
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• 제14권7호
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• pp.4061-4066
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• 2013

The extranodal natural killer/T-cell lymphoma (ENKTL) shows high local or systemic failure rates when radiotherapy (RT) is taken as the primary treatment, suggesting a role for chemotherapy (CT) added to RT for this disease. However, the appropriate mode of combined modality therapy (CMT) has not been fully defined. A total of one hundred and twenty-one patients with ENKTL receiving sandwich CT with RT were reviewed between January 2003 and August 2012. The primary endpoints were the response rate, progression-free survival (PFS), overall survival (OS), and the relapse rate. After the initial CT, there were 84 (69.4%) patients in CR, 22 (18.2%) patients in PR, 9 (7.4%) patients in SD, and 6 (5%) patients in PD, respectively. At the end of RT, the CR, PR, SD, and PD rates for all patients were 90.9% (n=110), 1.7% (n=2), 4.1% (n=5), and 3.3% (n=4), respectively. After a median follow-up of 42.3 months (3.5~112.3 months), the 5-year PFS was 74.7% (95% CI 70.4%~79.0%), and 5-year OS was 77.3% (95% CI 67.9%~86.7%). Disease progression was documented in 25 (20.7%) patients. The rates of systemic failure, local failure, and regional failure were 18.2%, 5.8%, 1.7%, respectively. Twenty death events (16.5%) were observed for the entire group of patients (18 deaths related to PD). Furthermore, CR to the initial CT and low Korean Prognostic Index (KPI) can independently predict long PFS and OS. The sandwich CMT achieved an excellent outcome for localized ENKTL with acceptable toxicity. We recommend it can be applied as the optimal choice for localized ENKTL.

• Asian Pacific Journal of Cancer Prevention
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• 제13권10호
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• pp.5263-5272
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• 2012

Background: Gastric cancer (GC) is one of the most common cancers in China. Adjuvant chemotherapy (AC) is a routine auxiliary treatment for GC recommended by the guidelines issued in 2011 by the Ministry of Health of the People's Republic of China, but the relevant credible consequences in China have been insufficient because of China's late start and ethical concerns. Methods: A series of databases, including Cochrane Library, MEDLINE, EMBASE, the Chinese database of the National Knowledge Infrastructure and the VIP database, were searched by 2 reviewers independently for studies investigating AC for GC through March 2012. The retrieved literature was screened according to the eligibility criteria. Results: A total of 35 randomized control trials (RCTs) were subjected to the final analysis, including 4,043 patients in treatment group and 3,884 in the control group, as well as 4 clinical-control trials (CCTs), which accessed the final analysis with 238 and 252 patients, respectively. AC reduced the risk of death as a protective treatment with statistical significance (HR=0.91, 95%CI: [0.85, 0.97], P=0.002), and it seemed more effective for Asian than non-Asian patients. The effects of AC were not influenced by the starting time (P>0.05). D2 lymphadenectomy-based chemotherapy was effective (HR=0.89, 95%CI: [0.80, 0.99], P=0.04). Oral S-1 40 mg/m2 after D2 lymphadenectomy might be a better choice for Asians with advanced GC and might result in a greater reduction of adverse events than in non-Asian patients. GRADE quality assessment determined that the strength of the evidence from foreign studies from Europe, the United States and Asian countries other than China was high, while it was moderate for Chinese studies. Conclusion: AC was effective or even curative in Chinese patients in general, although it is still necessary to optimize a targeted AC scheme for Chinese patients with GC.

• 복식
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• 제59권7호
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• pp.17-33
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• 2009

The purpose of this study was to get some pieces of prior information to eventually develop high value-added fashion cultural products design using local cultural resources, to promote the cultural tourism festival. For this purpose, this study is carried out the investigation of cultural product stores and visitors' questionnaire survey. The subjects of this study were festivals which were selected as cultural tourism festival by the Ministry of Culture, Sports and Tourism from 2000 to 2008. Of them, six festivals were finally selected but food festival was excluded. The results of this study were as follows; First, the store survey was conduced to analyze the situation of the products of cultural tourism festival. The most frequent product was accessories. And a T-shirt was found to be sold every festival probably because it was the most popular item and basic item which people could buy without burden. While the most diverse kinds of products were found in the Andong, the Jinju and Gangjin were found not to develop various products. In the design motif used for cultural products, most products did not use festival or local image. The highest use of the festival and local image was found in Gangjin and Muju. The Andong and Chungju were found to sell very common products buying anywhere rather than products using local cultural resources or image. In the material of cultural products, most products use metal. And In the price of cultural products, 10,000-30,000 won was found highest. Second, the purchase conditions of cultural tourism festival visitors were examined. The visiting goal and companion of visitors was found to vary with the type of cultural tourism festival. The types of visitors were also found to have an effect on the choice of items in the purchase of cultural products sold in the festival. Only one third of respondents responded buying one and more cultural products. The purchase rate was found high in the festival where cultural product items were various and there were many products symbolizing festival or region. The most purchased item was a mobile phone hanger and the amount of purchasing cultural products was 10,000-30,000 won. The reason not to purchase cultural products was dissatisfaction with utility, originality, possibility of a present, symbolism, and price. The most important attribute in the purchase of cultural products was design, followed by symbolism, price, originality, and innovation. The highly preferred product group included clothing, miscellaneous goods, and accessories. Specifically, T-shirt was found highest. Based on these research results, it was found that the design strategy for the cultural products development should consider both regional and festival images. The items and designs of the cultural products should reflect visitors' characteristics and the price zone should be varied.

• 한국지역사회생활과학회지
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• 제20권3호
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• pp.397-411
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• 2009

The use of local product foods and fresh-cut products, the dietitian's recognition, the required items and the quality for school foodservice was investigated to increase the consumption of high-quality agricultural products. Data from 578 elementary schools, 228 middle schools and 116 high schools were collected by school foodservice personnels in each regional Education Administration in Gyeong-gi province. The first criteria of buying food materials was reliability/safety for all school foodservice. The second criteria were the origin of the product and freshness/ripeness for elementary and middle schools and high school, respectively. The most important consideration for selecting a supplier was the quality of the material. The appearance/status of the food was the first factor for buying food materials. The origin and the seasonality were very important for buying farm products. Dietitians in Gyeong-gi province recognized the local products, and used them weekly. The advantages of using local products were the quick supply, freshness and safety. On the other hand, the disadvantages were the lack of information and the uncertainty of supply. Sixty eight percent of the subjects had experienced the high-quality agricultural products in school meals, but the frequency was low. The main reasons for not servicing high-quality agricultural products were the high cost and the lack of trust on the quality. Among fresh-cut products, seasonings and root vegetables were purchased most frequently, but leaf vegetables was 5.7% only. The purchase of fresh-cut products was not frequent, but usually satisfied. The advantages of fresh-cut products were the reduced workload and waste, but the reason for not using them were poor hygiene and the high price. The diverse supply system and the promotion of the local product foods would be necessary since the most food materials were purchased through suppliers. In addition, the problems related to the high cost and distrust should be resolved to expand the consumption of the high-quality agricultural products and the fresh-cut vegetables. The institutions for certifying the quality should be needed to increase the confidence of these products.

• 교육녹색환경연구
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• 제14권2호
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• pp.12-25
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• 2015

본 연구는 시대적으로 글로벌 지식기반 사회가 정착되면서 학교를 중심으로 하는 교육정책 영역은 다양성과 자율성을 보장하게 되고 모방형 인재가 아닌 미래성장 동력인 창조적 인적자본의 육성을 절실히 필요하게 되었다. 그러나 현재 한국의 교육환경은 여전히 입시교육 위주의 지필평가를 위한 교육정책과 학생들의 흥미나 즐거움을 유발하지 못하는 학교교육으로 인해 창의적 인재를 양성해야하는 글로벌 지식사회에 대응하지 못하는 상황에 직면하고 있다. 이를 극복하기 위한 2015 개정 교육과정은 물론 자유학기제 등을 강조하는 교육정책과 더불어 학교는 창의적 융합교육 환경을 조성해야할 시점이다. 본 연구의 목적은 미래지식사회에 상호 관계적 연계성을 중요시하는 특성과 포스트모더니즘이후 현대철학 사상에 나타난 인간에 대한 탈중심적 사유를 통한 창의성 촉발을 중요한 생성론적 특징으로 언급한 철학자 질 들뢰즈의 교육과 공간담론의 개념적 사유로 창의적 교육공간 특성을 이해하고 서로의 상호 연관관계를 드러내고 있다. 그러므로 현대 구조주의적 사상을 근본으로 하는 현대 철학적 사유를 통한 창의적 학교는 구성원들의 탈중심적인 협력 중점의 융합적 교육과정 및 학교 운영의 자율성이 중심이 되는 창의성 교육환경, 즉 환경공간의 속성으로서 다변화적 지원공간, 유동적 실외공간, 연계적 중심공간, 사건적 상황에 따른 다양한 종류 및 규모 공간, 개방적 공간 및 융합적 공간이 다양한 교육공간 요소와 함께 구성되어짐을 볼 수 있다.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2011년도 학술발표회
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• pp.14-14
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• 2011

Groundwater in the Waikatoregion is a valuable resource for agriculture, water supply, forestry and industries. The 434,000 ha study area comprises the upper Waikato River catchment from the outflow of Lake Taupo (New Zealand's largest lake) through to Lake Karapiro (a man-made hydro lake with high recreational value) (Figure 1). Water quality in the area is naturally high. However, there are indications that this quality is deteriorating as a result of land use intensification and deforestation. Compounding this concern for decision makers is the lag time between land use changes and the realisation of effects on groundwater and surface water quality. It is expected that the effects of land use changes have not yet fully manifested, and additional intensification may take decadesto fully develop, further compounding the deterioration. Consequently, Environment Waikato (EW) have proposed a programme of work to develop a groundwater model to assist managing water quality and appropriate policy development within the catchment. One of the most important and critical decisions of any modelling exercise is the choice of the modelling platform to be used. It must not inhibit future decision making and scenario exploration and needs to allow as accurate representation of reality as feasible. With this in mind, EW requested that two modelling platforms, MODFLOW/MT3DMS and FEFLOW, be assessed for their ability to deliver the long-term modelling objectives for this project. The two platforms were compared alongside various selection criteria including complexity of model set-up and development, computational burden, ease and accuracy of representing surface water-groundwater interactions, precision in predictive scenarios and ease with which the model input and output files could be interrogated. This latter criteria is essential for the thorough assessment of predictive uncertainty with third-party software, such as PEST. This paper will focus on the attributes of each modelling platform and the comparison of the two approaches against the key criteria in the selection process. Primarily due to the ease of handling and developing input files and interrogating output files, MODFLOW/MT3DMS was selected as the preferred platform. Other advantages and disadvantages of the two modelling platforms were somewhat balanced. A preliminary regional groundwater numerical model of the study area was subsequently constructed. The model simulates steady state groundwater and surface water flows using MODFLOW and transient contaminant transport with MT3DMS, focussing on nitrate nitrogen (as a conservative solute). Geological information for this project was provided by GNS Science. Professional peer review was completed by Dr. Vince Bidwell (of Lincoln Environmental).

• 한국사회정책
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• 제25권4호
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• pp.265-299
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• 2018

2015년부터 보건복지부는 지역자활센터 법인 형태를 사회적협동조합으로 전환하여 지역자활센터의 자활근로사업 위주 사업에 다양성 및 자율성을 부여하고, 자활사업 대상자 확대 및 근로빈곤층의 일자리 창출에 기여하고자 지역자활센터 유형다변화 시범사업을 시작하였다. 본 연구는 지역자활센터 유형다변화 사업이 점차 확대되는 상황에서 지역자활센터의 사회적협동조합의 전환과정과 변화 분석을 통해 긍정적인 요소를 강화하고 부정적인 요소는 제거하는데 도움이 되는 정책적 제언을 하고자 하였다. 분석 결과, 지역자활센터가 시범사업 참여, 즉 사회적협동조합으로의 전환은 지역자활센터의 주도적인 변화라기보다 조직의 지속 가능성을 모색하는 하나의 선택이었다. 그리고 이사회와 조합원 구성에서 생산자나 소비자의 참여는 저조하였고, 사회적협동조합으로의 전환은 종사자의 적극성과 책임성의 증가라는 긍정적 효과를 보였다. 또한 사회적협동조합 지역자활센터에 대한 운영비 활용의 자율성 확대로 매출 증가를 위한 적극적인 영업 활동과 전문성 제고의 결과를 낳았다. 사회적협동조합 설립 후 지역자활센터의 가장 큰 변화는 지역사회 내에서 자활사업의 인지도 향상과 지역사회 협력의 증가였다. 지역사회 네트워크를 통해서 지역자활센터가 새로운 사업에 참여하고 지자체의 우선 지원사업 대상이 되는 기회가 확대되었다. 그렇지만 사회적경제 조직이 활성화되지 않은 지역에서는 큰 변화가 없는 한계도 있었다. 지역자활센터의 사회적협동조합으로의 전환은 긍정적인 요소도 있지만 자활사업 참여자의 감소와 근로능력이 저하되는 상황을 고려한 유형다변화 사업의 방향과 내용 설계에 대한 고민이 필요하다.

• 한국의학물리학회지:의학물리
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• 제30권1호
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• pp.7-13
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• 2019

Purpose: To compare the dosimetrical and radiobiological parameters among various volumetric modulated arc therapy (VMAT) techniques using restricted and continuous arc beams for left-sided breast cancer. Materials and Methods: Ten patients with left-sided breast cancer without regional nodes were retrospectively selected and prescribed the dose of 42.6 Gy in 16 fractions on the planning target volume (PTV). For each patient, three plans were generated using the $Eclipse^{TM}$ system (Varian Medical System, Palo Alto, CA) with one partial arc 1pVMAT, two partial arcs 2pVMAT, and two tangential arcs 2tVMAT. All plans were calculated through anisotropic analytic algorithm and photon optimizer with 6 MV photon beam of $VitalBEAM^{TM}$. The same dose objectives for each plan were used to achieve a fair comparison during optimization. Results: For PTV, dosimetrical parameters such as Homogeneity index, conformity index, and conformal number were superior in 2pVMAT than those in both techniques. $V_{95%}$, which indicates PTV coverage, was 91.86%, 96.60%, and 96.65% for 1pVMAT, 2pVMAT, and 2tVMAT, respectively. In most organs at risk (OARs), 2pVMAT significantly reduced the delivered doses compared with the other techniques, excluding the doses to contralateral lung. For the analysis of radiobiological parameters, a significant difference in normal tissue complication probability was observed in ipsilateral lung while no difference was observed in the other OARs. Conclusions: Our study showed that 2pVMAT had better plan quality and normal tissue sparing than 1pVMAT and 2tVMAT but not for all parameters. Therefore, 2pVMAT could be considered the priority choice for the treatment planning for left breast cancer.

• 문화기술의 융합
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• 제7권2호
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• pp.239-246
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• 2021

통일은 북한이 유지했던 계획경제 체계를 포기하고 시장경제 체제로 바꾸는 것으로 수십 년 동안 계획경제 체제 하에서 살았던 북한 주민들에게는 큰 혼란과 어려움을 야기할 것이다. 이를 위해 최근 공감대를 얻고 있는 행태경제학(Behavioral Economics)의 관점을 반영할 필요가 있다. 구체적으로 선정한 교육내용은 ① 금융 전반(금융내역기록하기, 인플레이션의 영향, 현대 금융투자시장에서 상품 선택의 물리적 어려움, 금융투자자의 제한적 합리성 등) ② 대출(개인 신용 관리, 금융권별 대출금리 차이 등) ③ 금융투자(비용이 수익률에 미치는 영향, 복리와 단리의 차이, 기대수익과 위험의 상관관계, 투자위험 유형, 분산투자의 중요성, 적극적 투자와 소극적 투자 등)이다. 다만, 각 내용의 깊이와 넓이는 북한 주민들이 직관적으로 이해할 수 있는 최소한도로 한다. 이러한 직관적이고 기본적인 금융교육을 통해 필수적인 금융지식을 갖춘 다음 구체적인 금융의사결정은 독립투자자문업자(Independent Financial Adviser, IFA)와 상의(자문)받도록 하는 것이 바람직하다. 즉, 최소한의 경제·금융지식을 갖추는데 필요한 직관적인 내용으로 국한하고 의사결정은 IFA를 활용하는 것이 합리적임을 교육하는 것이다. 이러한 '직관적 기본 금융 교육 + 독립투자자문업자(IFA)' 결합 모형은 통일후 북한 주민을 대상으로 하는 경제금융교육에 소요되는 시간과 노력을 크게 줄이면서 효과를 극대화할 수 있을 것이다.

• 법제연구
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• 제41호
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• pp.229-260
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• 2011

유럽연합에서 회사법 통일의 노력은 리스본조약 이전부터 회사법과 관련한 규칙과 지침을 설정했다는 점에서 중요한 의미를 지닌다. 유럽연합 회사법의 법규범은 자체의 규칙을 통해 유럽주식회사라는 개념을 설정하였으며, 공개유한책임회사인 유럽주식회사와 더불어, 2008년 이후에는 중소기업을 위한 폐쇄유한책임회사에 대한 입법도 추진하고 있다. 최근 유럽주식회사법을 근거로 설립된 회사의 수가 증가되면서 발전된 형태의 회사법에 대한 논의가 활발히 진행되고 있으며, 이는 우리나라 회사법 분야에서도 흥미로운 주제가 된다. 기존의 유럽회사법에 관한 국내연구는 전반적인 유럽회사규칙 및 지침에 대한 내용을 소개하고 있으나, 근래에 이루어지고 있는 회원국 법률간 하향경쟁과 이를 통한 회원국의 입법에서의 변화, 그리고 유럽에서의 회사법연구에 대한 최근 논의에 대해서 다시 다루어 볼 필요가 있다. 따라서 이글에서는 유럽연합조약을 통한 설립의 자유와 이를 통한 각 회원국의 법률 간 경쟁과 유럽주식회사규칙의 제정 배경에 대해서 살펴보고 현재 유럽주식회사규칙의 내용을 평가한다.