• 대한약학회:학술대회논문집
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• 대한약학회 2000년도 춘계총회 및 학술대회
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• pp.195.2-195.2
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• 2000

• 대한약학회:학술대회논문집
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• 대한약학회 2000년도 NEW STRATEGY FOR DRUG DEVELOPMENT IN POST-GENOMIC ERA(대한약학회)
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• pp.251.2-251.2
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• 2000

• 대한약학회:학술대회논문집
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• 대한약학회 2000년도 춘계총회 및 학술대회
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• pp.198.1-198.1
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• 2000

• 약학회지
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• 제56권4호
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• pp.211-216
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• 2012

Drug dissolution test has been used for the purpose of both quality control of solid oral dosage forms and predicting in vivo drug release profiles. In this study, the dissolution profiles of buflomedil hydrochloride tablets and ticlopidine hydrochloride tablets were investigated according to the "Guidelines on Specifications of Dissolution tests for Oral dosage forms" of Korean Pharmacopoeia (KP). The analytical method using HPLC was validated. The validation was performed in terms of specificity, linearity, accuracy, precision and limit of quantitation.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.234.1-234.1
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• 2002

Any food additive as a chemical synthetic compound. whose criteria and standards are not notified publicly and foods using an food additives containing such a chemical synthetic compound or foods containing it shall not be sold. or manufactured. imported. processed. used. prepared. stored. transported. or displayed for the purpose of sale. Some food manufacturers have illegally added drugs to foods not notifying this. Moreover. structure-modified new drugs could be added. But it is almost impossible to detect these by ordinary laboratory inspection. Thus the study about the identification of analogues of pending drugs is imminent. (omitted)

• 한국환경과학회지
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• 제13권12호
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• pp.1109-1115
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• 2004

This study was investigated the residual contents of sulfur dioxide on the 373 kinds of herbal medicine distributed from Korea, China, and Japan. A modified Monier-Williams method was described for the determination of $SO_{2}$ contents in herbal medicines. The residual contents of $SO_{2}$ were not detected at 221 products$(59.8{\%})$ in total 373 products. Regardless of region, $SO_{2}$ contents were not found at Farfarae Flos, Zizyphi Spinosi Semen, Castanea crenata, and Strychni Ignatii Semen. But it's found at Asparagi Radix, Codonopsitis Radix, Lilii Bulbus, and Kaempferiae Rhizoma of every region collected the samples. Also, $SO_{2}$ contents were not detected at the herbal medicines which collected cultural fields of dometic. $SO_{2}$ contents ranged 11$\~$3990 mg/kg(mean 152 mg/kg) at domestic samples, 11$\~$3440 mg/kg(mean 603 mg/kg) at imported samples. After treated with water wash and hot water extraction, the reduction rates of sulfur dioxide were appeared with $24.4{\%}\~68.7{\%}\;and\;83.8{\%}\~100.0{\%},$ respectively. These data will be used to establish a criteron of residual sulfur dioxide in herbal medicines.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2006년도 하계학술대회 논문집 Vol.7
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• pp.339-340
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• 2006

In this paper, disk-type ultrasonic motor using radial and bending vibration modes is newly designed and fabricated to measure its characteristics. As the diameter of elastic body increases, the resonant frequency decreases and its resonant frequency is about 92kHz when the physical dimensions of piezoelectric ceramic and elastic body are 28mm of diameter and 2mm of thickness, and 32mm of diameter and 2mm of thickness, respectively. When the applied voltage is 20Vpp. its speed and torque are 200rpm and 1N, respectively.

• 농약과학회지
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• 제12권4호
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• pp.323-334
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• 2008

본 연구는 국내의 지리적표시제 등록특산물을 대상으로 농약 잔류실태를 조사하여 식품안전 정책수립의 기초자료와 잔류농약에 대한 식품의 안전성을 평가하고자, 지리적 표시 등록 특산물 17품목(마늘 1, 마늘 2, 마늘 3, 마늘 4,고추, 양파 1, 양파 2, 쌀 1, 쌀 2, 쌀 3, 참외, 사과, 밤, 대추, 황기, 표고버섯, 구기자)을 선정하여 잔류 실태를 조사하였다. 조사대상 농약으로는 다성분 분석농약 204종과 단성분 분석농약 5종(acephate, methamidophos, monocrotophos, omethoate, vamidothion)을 포함한 209종의 농약에 대해 잔류량을 조사하였으며, 분석장비로는 GC/MSMS, HPLC/UVD(PDA)와 GC/FPD를 사용하였다. 분석법방법으로는 식품공전의 83번 다성분분석법과 단성분분석법을 사용하였다. 분석결과 특산물 17품목 중 8품목(고추, 양파 1, 쌀 2, 쌀 3, 참외, 사과, 대추, 구기자)에서 잔류농약이 검출되었고, 검출시료수는 302건중 40건으로 13.2%의 잔류농약 검출율을 보였다. 그러나 모두 식품의 농약잔류허용기준 미만이었다.

• 한국식품과학회지
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• 제42권2호
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• pp.130-135
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• 2010

건강기능식품공전에서 유해물질로 분류되어 관리되고 있는 매실추출제품 중 시안화합물의 효과적인 분석을 위하여 피크린산지법, 효소-피크린산지법, IC 및 HPLC를 이용한 기기분석법을 검증하고 비교하였다. 먼저, 피크린산지법은 가장 분석소요시간이 짧았으며, 0.01 mg/$200\;mL\;CN^-$에서 피크린산지의 변색이 관찰되었으나, 배당체 형태의 아미그달린으로부터 유래되는 시안화합물을 검출하는 것에 한계가 있었다. 반면, $\beta$-glucosidase를 이용한 효소-피크린산지법은 아미그달린으로부터 유래되는 시안화합물을 포함한 총 시안화합물의 정성분석 및 분광광도계를 이용한 정량 분석이 가능하였다. 마지막으로, IC 및 HPLC를 이용한 시안화합물 분석법은 유리되어 있는 시안화합물과 아미그달린을 분석하기 위해 각각 서로 다른 전처리 과정을 거쳐야 하며, 분석시간 또한 가장 많이 소요되었다. 이러한 결과들을 미루어 볼 때, 매실추출제품에 존재하는 시안화합물 분석법으로는 효소-피크린산 지법이 가장 효과적임을 알 수 있었다.

• 분석과학
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• 제28권2호
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• pp.117-124
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• 2015

Genetically modified (GM) papaya line 55-1, which is resistant to PRSV infection, has been marketed globally. Prompt and sensitive protocols for specific detections are essential for the traceability of this line. Here, an event- and construct-specific real-time polymerase chain reaction (RT-PCR) method was established to detect 55-1. Qualitative detection was possible for fresh papaya fruit up to dilutions of 0.005% and 0.01% for the homozygous SunUp and heterozygous Rainbow cultivars, respectively, in non-GM papaya. The method was applied in the qualitative detection of 55-1 in eight types of commercially processed papaya products. Additionally, papaya products were monitored to distinguish GM papaya using the P35S and T-nos RT-PCR detection methods. As expected, detection capacity was improved via modified sample preparation and the established RT-PCR detection method. Taking these results together, it can be suggested that a suitable method for the extraction and purification of DNA from processed papaya products was established for the detection of GM papaya.