• Journal of the Optical Society of Korea
• /
• 제7권3호
• /
• pp.160-164
• /
• 2003

Materials processing by ultrashort pulsed laser is actively being applied to micromachining technology due to its advantages with regard to non-thermal machining. In this study, materials processing with ultrashort pulses was studied by using the high repetition rate of a 800 nm Ti:sapphire regenerative amplifier. This revealed that the highly precise micromachining of metallic thin film and bulk glass with a minimal heat affected zone (HAZ) could be obtained by using near damage threshold energy. Grooves with diffraction limited sub-micrometer width were obtained with widths of 620 nm on Cr thin film and 800 nm on a soda-lime glass substrate. The machined patterns were investigated through SEM images. We also phenomenologically examined the influence of variations of parameters and proposed the optimal process conditions for microfabrication.

• 한국항공우주학회지
• /
• 제33권12호
• /
• pp.109-116
• /
• 2005

재생냉각형 액체로켓 연소기의 냉각채널 설계에 대한 탄-소성 구조설계를 수행하였다. 구조해석에 필요한 데이터를 얻기 위하여 여러 가지 온도에서 재생냉각 챔버 제작에 사용하는 구리합금의 단축인장시험을 수행하였다. 재료시험 결과 구리합금은 브레이징 공정 후에 연화되어 강도 값이 매우 저하되며 온도가 증가함에 따라 유동 응력 값이 더 작게 나타났다. 재료시험 데이터를 이용하여 냉각채널의 구조해석을 수행한 결과 채널 내부 냉각유체에 의한 내부압력보다 고온의 연소가스에 의한 열 하중에 의하여 채널의 변형이 심하게 발생함을 확인하였다. 따라서 기계적인 하중을 견딜 수 있는 한도 내에서 냉각채널의 두께를 감소시켜 열 하중을 최소화함으로서 연소기의 무게 감소, 냉각성능 향상, 그리고 구조적인 안정성을 향상시킬 수 있다는 것을 알 수 있었다.

• International Neurourology Journal
• /
• 제22권4호
• /
• pp.260-267
• /
• 2018

Purpose: A major question remaining in approaches to tissue engineering and organ replacement is the role of native mobilized native cells in the regeneration process of damaged tissues and organs. The goal of this study was to compare the cell mobilizing effects of the chemokine CXCL12 and cell therapy on the urinary sphincter of nonhuman primates (NHP) with chronic intrinsic urinary sphincter dysfunction. Methods: Either autologous lenti-M-cherry labeled skeletal muscle precursor cells (skMPCs) or CXCL12 were injected directly into the sphincter complex of female NHPs with or without surgery-induced chronic urinary sphincter dysfunction (n=4/treatment condition). All monkeys had partial bone marrow transplantation with autologous lenti-green fluorescent protein (GFP) bone marrow cells prior to treatment. Labeled cells were identified, characterized and quantified using computer-assisted immunohistochemistry 6 months posttreatment. Results: GFP-labeled bone marrow cells (BMCs) were identified in the bone marrow and both BMCs and skMPCs were found in the urinary sphincter at 6-month postinjection. BMCs and skMPCs were present in the striated muscle, smooth muscle, and lamina propria/urothelium of the sphincter tissue. Sphincter injury increased the sphincter content of BMCs when analyzed 6-month postinjection. CXCL12 treatment, but not skMPCs, increased the number of BMCs in all layers of the sphincter complex (P<0.05). CXCL12 only modestly (P=0.15) increased the number of skMPCs in the sphincter complex. Conclusions: This dual labeling methodology now provides us with the tools to measure the relative number of locally injected cells versus bone marrow transplanted cells. The results of this study suggest that CXCL12 promotes mobilization of cells to the sphincter, which may contribute more to sphincter regeneration than injected cells.

• Journal of Electrical Engineering and Technology
• /
• 제9권6호
• /
• pp.1795-1804
• /
• 2014

Owing to the reduction in the peak power of a DC railway subsystem, many studies on energy storage system (ESS) applications have received attention. Each application focuses on improving the efficiency and addressing regulation issues by utilizing the huge regenerative energy generated by braking-phase vehicles. The ESS applications are widely divided into installation on a vehicle or in a substation, depending on the target system characteristics. As the main purpose of the ESS application is to reduce the peak power of starting-phase vehicles, an optimized ESS utilization can be achieved by the operating at the highest peak power section. However, the weight of an entire vehicle, including those of the passengers, continuously changes during operation; thus, considering the total power consumption and the discharging point is difficult. As a contribution to the various storage device algorithms, this study deals with ESS on board vehicles and introduces an ESS operating plan for peak-power reduction by investigating the weight of a train on a real-time basis. This process is performed using a train-performance simulator, and the simulation accuracy can be increased because the weight in each phase can be adopted in the simulation.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• 제44권3호
• /
• pp.93-102
• /
• 2018

Angiogenesis is one of the essential processes that occur during wound healing. It is responsible for providing immunity as well as the regenerative cells, nutrition, and oxygen needed for the healing of the alveolar socket following tooth extraction. The inappropriate removal of formed blood clots causes the undesirable phenomenon of alveolar osteitis (AO) or dry socket. In this review, we aimed to investigate whether enhanced angiogenesis contributes to a more effective prevention of AO. The potential pro- or anti-angiogenic activity of different materials used for the treatment of AO were evaluated. An electronic search was performed in the PubMed, MEDLINE, and EMBASE databases via OVID from January 2000 to September 2016 using the keywords mentioned in the PubMed and MeSH (Medical Subject Headings) terms regarding the role of angiogenesis in the prevention of AO. Our initial search identified 408 articles using the keywords indicated above, with 38 of them meeting the inclusion criteria set for this review. Due to the undeniable role of angiogenesis in the socket healing process, it is beneficial if strategies for preventing AO are directed toward more proangiogenic materials and modalities.

• 한국유체기계학회 논문집
• /
• 제15권5호
• /
• pp.32-36
• /
• 2012

The positive displacement pump and the regenerative pump are widely used in the range of low specific speed, $n_s{\leq}100$[rpm, m3/min, m]. The positive displacement pump is not suitable for miniaturization and operation in high rotational speed. The regenerative pump has a problem with large leakage flow and low efficiency. While the centrifugal pump has advantages of high efficiency, miniaturization and high rotational speed, efficiency drops sharply with decrease in specific speed. Therefore the purpose of this study is to design a new type of centrifugal pump that has advantages of centrifugal pumps in operation in low specific speed. The name of this new type of pump was called 'Pipe type centrifugal pump', since the flow path through the impeller is simple circular pipe. Due to the simple shape of impeller, the manufacturing process is simple and cost is low. There is strong jet flow at the outlet of the impeller. This jet induces flow path loss, meridional dynamic pressure loss and mixing loss. Large disk friction makes the efficiency be limitted in the range of low specific speed. Even though the loss and the low efficiency, 'Pipe type centrifugal pump' represents stable performance, affordable pressure ratio and efficiency better than that of other low specific speed pumps.

• 한국추진공학회:학술대회논문집
• /
• 한국추진공학회 2017년도 제48회 춘계학술대회논문집
• /
• pp.643-646
• /
• 2017

탄화수소계열의 연료를 사용하는 액체로켓엔진에서 높은 열유속으로 인해 연소실 벽면이 구조적으로 손상 및 변형되는 것을 방지하기 위하여 연소실 벽면의 냉각은 필수적이다. 여러 가지 방법 중 연료를 냉각제로 사용 후 연소과정에 투입시키는 재생냉각 방식은 엔진 성능을 높여준다. 본 연구는 구리 단면적, 채널 내 유속, 채널에 가해지는 전류를 변화시켜 냉각제로 사용하는 케로신의 열전달 특성에 대해 알아보았다. 채널의 구리 단면적이 작을수록, 케로신의 유속이 빠를수록 대류 열전달이 빠르게 일어남을 알 수 있었다.

• International Journal of Stem Cells
• /
• 제16권2호
• /
• pp.156-167
• /
• 2023

Background and Objectives: Cellular reprogramming in regenerative medicine holds great promise for treating patients with neurological disorders. In this regard, small molecule-mediated cellular conversion has attracted special attention because of its ease of reproducibility, applicability, and fewer safety concerns. However, currently available protocols for the direct conversion of somatic cells to neurons are limited in clinical application due of their complex nature, lengthy process, and low conversion efficiency. Methods and Results: Here, we report a new protocol involving chemical-based direct conversion of human fibroblasts (HF) to matured neuron-like cells with a short duration and high conversion efficiency using temporal and strategic dual epigenetic regulation. In this protocol, epigenetic modulation by inhibition of histone deacetylase and bromodomain enabled to overcome "recalcitrant" nature of adult fibroblasts and shorten the duration of neuronal reprogramming. We further observed that an extended epigenetic regulation is necessary to maintain the induced neuronal program to generate a homogenous population of neuron-like cells. Conclusions: Therefore, our study provides a new protocol to produce neurons-like cells and highlights the need of proper epigenetic resetting to establish and maintain neuronal program in HF.

• 전자공학회논문지A
• /
• 제33A권5호
• /
• pp.212-221
• /
• 1996

A CMOS comparator is designed for low voltage and low power operations. The proposed comparator consists of a preadmplifier followed by a regenerative latch. The preasmplifier reduces the power consumption to a half with the power-down mode and the dynamic offsets of the latch, which is affected by each device mismatch, is statistically analyzed. The circuit is designed and simulated using a 0.8.mu.m n-well CMOS process and the dissipated power is 0.16mW at a 20MHz clock speed based on a 3V supply.

• Journal of the Korean Statistical Society
• /
• 제33권3호
• /
• pp.283-298
• /
• 2004

We present a trial solution approach to GI/M/l queues with generalized vacations. Specific types of generalized vacations we consider are N -policy and a combination of N-policy and exponential multiple vacations. Discussions about how to find trial solutions are given.