• The Korean Journal of Physiology
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• v.11 no.2
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• pp.9-16
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• 1977

The present experiment was conducted to see whether or not several cardioactive agents influence the 'regenerative $Ca^{++}$ release' in the mechanically disrupted cardiac cells. The mechanically disrupted cardiac cells were prepared by the method of Kerrick and Best from the ventricle of rat. The tension development of the disrupted cardiac cells was measured with a mechanoelectric transducer (RCA 5734). The results were summarized as follows 1) 2 mM caffeine enhanced the regenerative $Ca^{++}$ release, whereas 2 mM Procaine inhibited the $Ca^{++}$ release as reported by other investigators. 2) Epinephrine at concentrations of $10^{-7},\;10^{-6}\;and\;10^{-5}M$ increased the regenerative $Ca^{++}$ release significantly but showed a poor dose response on the $Ca^{++}$ release. 3) Propranolol showed no effect on the regenerative $Ca^{++}$ release when studied alone. Furthermore, it showed no antagonistic effect on an increased regenerative $Ca^{++}$ release induced by epinephrine. 4) Other cardioactive agents such as acetylcholine, ouabain, isoproterenol and c-AMP at concentrations of $10^{-6}M$ showed no effect on the regenerative $Ca^{++}$ release. From the above results, it may be concluded that the cardioactive actions of these agents are not related directly to the process of regenerative $Ca^{++}$ release.

• Journal of the Korean Society of Safety
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• v.25 no.5
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• pp.15-21
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• 2010

Regenerative Energy Storage System(ESS) is a system that saves regenerative energy which generated instantly in the regenerative braking of Electric Multiple Unit(EMU) and disappear, and reuse the stored energy when EMU is in powering. Such system related to a research field of renewable energy which emerged concerning climate change and high oil prices. In the case of existing domestic rolling stock, about 25% to 30% of generated regenerative energy is restored to power source and is regarded as direct factor of raising catenary voltage. Such rapid change of catenary voltage is a cause of the failure of EMU's electronic equipment and lowering its reliability and is also a cause of train's fault occurred by tripping circuit breaker. In this paper, we intend to investigate the effect on blending characteristics of electric-braking and pneumatic-braking whether the regenerative energy storage system is used or not in urban transit DC 1,500V feeding system, while trains run. And we also intend to investigate its effect on stabilization of the blending, fluctuation of catenary voltage and various electric equipments.

• Journal of the Korea Institute of Military Science and Technology
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• v.19 no.4
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• pp.517-525
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• 2016

In this research, the effect of the pressure control of cooperative control system with regenerative brake for a military series hybrid-electric vehicle was studied. A cooperative control system with regenerative brake was developed to maximize regenerative energy from electric traction motors of the vehicle. However, the pressure control method of the system was modified to solve a time delay problem and it deteriorates the performance of the system. A Simulink model including the hybrid-electric components, the cooperative control system with regenerative brake, and the vehicle dynamics was developed and used to find a solution. The regenerative energy ratio with respect to the whole brake energy was increased in this research from less than 60 % to over 80 %.

• International Journal of Fluid Machinery and Systems
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• v.1 no.1
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• pp.101-108
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• 2008

The effect of Reynolds number on the performance of a regenerative pump was examined in a low Reynolds number range in experiment. The head of the regenerative pump increased at low flow rates and decreased at high flow rates as the Reynolds number decreased. The computation of the internal flow was made to clarify the cause of the Reynolds number effect. At low flow rates, the head is decreased with increasing the Reynolds number due to the decrease of the shear force exerted by the impeller caused by the increase of leakage and hence local flow rate. At higher flow rates, the head is increased with increasing the Reynolds number with decreased loss at the inlet and outlet as well as the decreased shear stress on the casing wall.

• International Journal of Stem Cells
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• v.15 no.3
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• pp.311-323
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• 2022

Background and Objectives: Human mesenchymal stem cells (MSCs) are emerging as a treatment for atopic dermatitis (AD), a chronic inflammatory skin disorder that affects a large number of people across the world. Treatment of AD using human umbilical cord blood-derived MSCs (hUCB-MSCs) has recently been studied. However, the mechanism underlying their effect needs to be studied continuously. Thus, the objective of this study was to investigate the immunomodulatory effect of epidermal growth factor (EGF) secreted by hUCB-MSCs on AD. Methods and Results: To explore the mechanism involved in the therapeutic effect of MSCs for AD, a secretome array was performed using culture medium of hUCB-MSCs. Among the list of genes common for epithelium development and skin diseases, we focused on the function of EGF. To elucidate the effect of EGF secreted by hUCB-MSCs, EGF was downregulated in hUCB-MSCs using EGF-targeting small interfering RNA. These cells were then co-cultured with keratinocytes, Th2 cells, and mast cells. Depletion of EGF disrupted immunomodulatory effects of hUCB-MSCs on these AD-related inflammatory cells. In a Dermatophagoides farinae-induced AD mouse model, subcutaneous injection of hUCB-MSCs ameliorated gross scoring, histopathologic damage, and mast cell infiltration. It also significantly reduced levels of inflammatory cytokines including interleukin (IL)-4, tumor necrosis factor (TNF)-α, thymus and activation-regulated chemokine (TARC), and IL-22, as well as IgE levels. These therapeutic effects were significantly attenuated at all evaluation points in mice injected with EGF-depleted hUCB-MSCs. Conclusions: EGF secreted by hUCB-MSCs can improve AD by regulating inflammatory responses of keratinocytes, Th2 cells, and mast cells.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.56 no.4
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• pp.669-676
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• 2007

This paper presents a new power flow method to analyze the AC electric railway system effectively in both cases of traction and regenerative braking of the trains. The algorithm to easily solve the power flow of the AC electric railway system with the trains of regenerative braking from the system without a train of regenerative braking is derived. Using this new power flow method, the voltage characteristics of a typical AC electric railway system is easily analyzed in both cases of traction and regenerative braking of the trains. We show that the presented method can be applied effectively in order to analyze the AT-fed AC electric railway system in both cases of traction and regenerative braking of the trains. A STATCOM(Static Synchronous Compensator) is applied to the system in order to improve the voltage drop problem and this case is also analyzed to show the effect of STATCOM.

• International Journal of Stem Cells
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• v.15 no.3
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• pp.334-345
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• 2022

Background and Objectives: Flavonoids form the largest group of plant phenols and have various biological and pharmacological activities. In this study, we investigated the effect of a flavonoid, 3, 4'-dihydroxyflavone (3, 4'-DHF) on osteogenic differentiation of equine adipose-derived stromal cells (eADSCs). Methods and Results: Treatment of 3, 4'-DHF led to increased osteogenic differentiation of eADSCs by increasing phosphorylation of ERK and modulating Reactive Oxygen Species (ROS) generation. Although PD98059, an ERK inhibitor, suppressed osteogenic differentiation, another ERK inhibitor, U0126, apparently increased osteogenic differentiation of the 3, 4'-DHF-treated eADSCs, which may indicate that the effect of U0126 on bone morphogenetic protein signaling is involved in the regulation of 3, 4'-DHF in osteogenic differentiation of eADSCs. We revealed that 3, 4'-DHF could induce osteogenic differentiation of eADSCs by suppressing ROS generation and co-treatment of 3, 4'-DHF, U0126, and/or N-acetyl cysteine (NAC) resulted in the additive enhancement of osteogenic differentiation of eADSCs. Conclusions: Our results showed that co-treatment of 3, 4'-DHF, U0126, and/or NAC cumulatively regulated osteogenesis in eADSCs, suggesting that 3, 4'-DHF, a flavonoid, can provide a novel approach to the treatment of osteoporosis and can provide potential therapeutic applications in therapeutics and regenerative medicine for human and companion animals.

• Proceedings of the SAREK Conference
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• 2006.06a
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• pp.621-626
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• 2006

Regenerative evaporative cooling is known as an environment-friendly and energy efficient cooling method. A regenerative evaporative cooler (REC) consisting of dry and wet channels is able to cool down the air stream below the inlet wet-bulb temperature. In the regenerative evaporative cooler, the cooling effect is achieved by redirecting a portion of the air flown out of the dry channel into the wet channel and spraying water onto the redirected air. In this study, a horizontal regenerative cooler is considered. In the horizontal regenerative cooler, the flow direction of evaporating water has a right angle to the flow direction of supply air. This difference was investigated with visualization technique and simplified 2-module performance test was done in a thermo-environment chamber. Optimum design configuration is changed due to the wet channel which are easily fully covered with evaporating water and block the air flow inside the channel. Applying the optimized fin configuration design with the highly wetting surface treatment, a regenerative evaporative cooler was fabricated and tested to Identify the cooling performance improvement and operation characteristics. From the experimental results at the intake condition of $32^{\circ}C$ and 50% RH, the supply temperature was measured to be around $23.4^{\circ}C$. The cooling effectiveness based on the inlet dewpoint temperature was evaluated 73% which is almost close to the design expectation.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.65 no.11
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• pp.1900-1906
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• 2016

Recent energy efficiency policy of green growth for stable power supply is required. Urban transit vehicles is limited to reduce the use of power without reducing the number of runs. Accordingly, when urban rail vehicles is braking, the occurrence of regenerative power is systemically maximized for the purpose of saving energy. As a result when it is braking, the generated power efficiently is used and looking for a way to reduce the electrical energy. In this paper, the brake control system of the Subway Line 3 is analyzed the effect to meet the required regenerative braking produced electricity through minimizing air braking force of service braking.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.19 no.10
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• pp.687-694
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• 2007

Cycle simulation is peformed for two types of the desiccant cooling system incorporating a regenerative evaporative cooler. The cooling capacity and COP are evaluated at various effectiveness values of the regenerative evaporative cooler, the desiccant rotor and the sensible heat exchanger. As either of the effectiveness of the regenerative evaporative cooler or the humidity effectiveness of the desiccant rotor increases, both the cooling capacity and COP increase, but the enthalpy leak ratio gives the opposite effect on the system performance. It is found that COP of cycle A mainly depends on the humidity effectiveness of the desiccant rotor, while for cycle B enthalpy leak ratio of desiccant rotor has the major impact on COP. The effect of the sensible heat exchanger on the cooling capacity is small about 1/10 compared with those of other components.