• Journal of Pharmaceutical Investigation
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• v.34 no.6
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• pp.499-504
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• 2004

Paroxetine, a potent and selective serotonine reuptake inhibitor, has been used for the treatment of depression, obsessive-compulsive disorder, panic disorder and social phobia. The bioequivalence of two paroxetine preparations was evaluated according to the guidelines of Korea Food & Drug Administration (KFDA). The test product was Samchully Paroxetine $tablet^{\circledR}$ made by Samchully Pharm. Co. and the reference product was Seroxat $tablet^{\circledR}$ made by GlaxoSmithKline. Twenty healthy male subjects, $22.4{\pm}2.6$ years old and $63.8{\pm}4.2\;kg$, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After one tablet containing 20 mg paroxetine was orally administered, blood was taken at predetermined time intervals and the concentration of paroxetine in plasma was determined using a validated HPLC method with fluorescence detector. Two pharmacokinetic parameters, $AUC_t$ and $C_{max}$, were calculated and analyzed statistically for the evaluation of bioequivalence of two products. Analysis of variance was carried out using logarithmically transformed parameter values. The 90% confidence intervals of $AUC_t$ and $C_{max}$ were log 0.84-log 1.16 and log 0.85-log 1.14, respectively. These values were within the acceptable bioequivalence intervals of log 0.8 to log 1.25. Thus, the criteria of the KFDA guidelines for the bioequivalence was satisfied, indicating that Samchully Paroxetine tablet is bioequivalent to Seroxat tablet.

• Journal of Sensor Science and Technology
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• v.21 no.2
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• pp.135-143
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• 2012

Arterial stiffness is causing the serious problems for human who is suffered from hypertension and metabolic syndrome. So it is important that measure the arterial stiffness for early prevention. Many researches point out that pulse wave velocity(PWV) is the reliable and simple method to predict arterial stiffness. In this paper, we developed the sensing parts that detect the pulse wave and ECG by using piezoelectric film and conductive textile with elastic band. Our system could detect 3ch pulse wave and ECG. Simultaneously, our algorithm extracts the features for calculating the delays among pulse waves. The delays are the significant parameter to estimate PWV, thus we design the experiment for evaluating the performance of our sensing parts. The reference is PP-1000(HanByul Meditech, Korea) that is good for performance evaluation. As a result, the start point of the pulse wave was the most reliable feature for comparing with PP-1000(r=0.691, P=0.00). The results between two operators showed that there is only a slight difference in the reproducibility of the devices. In conclusion, we assume that the suggested sensor could be more comfortable and faithful method for arterial stiffness.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.37 no.6
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• pp.537-544
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• 2009

This paper concerns analysis technique on determining of attitude control gain in the low frequency region using stability area. The stability area is defined by the D-Decomposition method, which was designed by Neimark. In this paper, it is introduced D-Decomposition method from reference paper and design attitude control gain of generic launch vehicle during first stage flight phase. For selecting PD control gain, it is considered the system parameter uncertainty about whole first-stage flight phase, represented the stability area boundary on each case. After deciding the PD control gain using stability area method, it is applied to launch vehicle linear model, and checking the stability margin requirement, frequency response characteristics.

• Nuclear Engineering and Technology
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• v.36 no.2
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• pp.196-202
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• 2004

KAERI (Korea Atomic Energy Research Institute) is at present preparing a preliminary performance assessment to set up the HLW disposal concept of Korea. The solubility of the radionuclides contained in HLW is necessary as a source term in order to predict their potential migration in both the near and far fields. The solubility of actinides (Th, Am, U, Np and Pu) for a reference deep groundwater of Korea has been calculated using a geochemical code with thermodynamic data selected by a peer review of existing thermodynamic databases and literature. The solubilities from the experimental study and/or field observations from natural analogue studies are compared. The sensitivity of solubility to the variability of three main parameters of groundwater (pH, Eh, and carbonate concentration) is also investigated. The results of the sensitivity analysis show that the solubility of actinides strongly depends on the parameters considered. Within the range of parameter values studied (pH=7 to 10, Eh=-0.4 to -0.1V, and carbonate concentration=1.E-5 to 1.E-2 mol/L), the solubility of each actinide exists between 1.4E-10 and 1.6E-6 mol/L for Am, 4.9E-9 and 2.8E-6 mol/L for Th, 3.2E-9 and 5.7E-4 mol/L for U, 1.1E-9 and 1.0E-7 mol/L for Np, and 4.0E-11 and 2.8E-6 mol/L for Pu, respectively.

• Journal of Welding and Joining
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• v.24 no.3
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• pp.27-33
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• 2006

Structural stress approach is well known as a mesh-size insensitive fatigue assessment method by using finite element analyses. It is, however, difficult to estimate the structural stress (SS) at weld end points due to stress singularities when shell elements are used. In this study, fatigue evaluations with longitudinal load carrying box fillet weldment under out-of-plane bending load have been performed by using virtual node method (VNM) in order to avoid the problem, which is called the weld end effect. Various combinations of virtual node parameters, such as reference point and virtual node locations, are investigated for the estimation of proper structural stress values applying VNM in a systematic manner. The appropriate guidance of virtual node parameter has been offered for the fillet weldment considered in the study. The structural stress values obtained by VNM have also been validated by comparing the result with finite element model including weld bead. Moreover, the fatigue strength of the fillet weldment based on the equivalent structural stress is shown to be consistent with the master S-N curve.

• Journal of Power Electronics
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• v.18 no.6
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• pp.1729-1750
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• 2018

Voltage source inverters (VSIs) are widely used to drive induction motors in industry applications. The quality of output waveforms depends on the switching sequences used in pulse width modulation (PWM). In this work, all existing optimal space vector pulse width modulation (SVPWM) switching strategies are studied. The performance of existing SVPWM switching strategies is optimized to realize a tradeoff between quality of output waveforms and switching losses. This study generalizes the existing optimal switching sequences for total harmonic distortions (THDs) and switching losses for different modulation indexes and reference angles with a parameter called quality factor. This factor provides a common platform in which the THDs and switching losses of different SVPWM techniques can be compared. The optimal spatial distribution of each sequence is derived on the basis of the quality factor to minimize harmonic current distortions and switching losses in a sector; the result is the minimum ripple loss SVPWM (MRSLPWM). By employing the sequences from optimized switching maps, the proposed method can simultaneously reduce THDs and switching losses. Two hybrid SVPWM techniques are proposed to reduce line current distortions and switching losses in motor drives. The proposed hybrid SVPWM strategies are MRSLPWM 30 and MRSLPWM 90. With a low-cost PIC microcontroller (PIC18F452), the proposed hybrid SVPWM techniques and the quality of output waveforms are experimentally validated on a 2 kVA VSI based on a three-phase two-level insulated gate bipolar transistor.

• Journal of Drive and Control
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• v.13 no.1
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• pp.1-9
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• 2016

Nowadays automatic transmission equipped vehicles prevail in construction and agricultural equipment due to their convenience in driving and operation. Though domestic vehicle manufacturers install imported electronic controlled transmissions at present, overseas products will be replaced by domestic ones in the near future owing to development efforts over the past 10 years. For passenger cars, there are many kinds of shift control algorithms that enhance the shift quality such as feedback and learning control. However, since shift control technologies for heavy duty vehicles are not highly developed, it is possible to improve the shift quality with an organized control method. A feedback control algorithm for neutral-into-gear shift, which is enabled during the inertia phase for the master clutch slip speed to track the slip speed reference, is proposed based on the power transmission structure of TH100. The performance of the feedback shift control is verified by a vehicle test which is implemented with firmware embedded TCU. As the master clutch engages along the predetermined speed trajectory, it can be concluded that the shift quality can be managed by a shift time control parameter. By extending the proposed feedback algorithm for neutral-into-gear shift to gear change and shuttle shift, it is expected that the quality of the shift can be improved.

• Annals of Laboratory Medicine
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• v.38 no.6
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• pp.518-523
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• 2018

Background: Lipemia, a significant source of analytical errors in clinical laboratory settings, should be removed prior to measuring biochemical parameters. We investigated whether lipemia in serum/plasma samples can be removed using a method that is easier and more practicable than ultracentrifugation, the current reference method. Methods: Seven hospital laboratories in Spain participated in this study. We first compared the effectiveness of ultracentrifugation ($108,200{\times}g$) and high-speed centrifugation ($10,000{\times}g$ for 15 minutes) in removing lipemia. Second, we compared high-speed centrifugation with two liquid-liquid extraction methods-LipoClear (StatSpin, Norwood, USA), and 1,1,2-trichlorotrifluoroethane (Merck, Darmstadt, Germany). We assessed 14 biochemical parameters: serum/plasma concentrations of sodium ion, potassium ion, chloride ion, glucose, total protein, albumin, creatinine, urea, alkaline phosphatase, gamma-glutamyl transferase, alanine aminotransferase, aspartate-aminotransferase, calcium, and bilirubin. We analyzed whether the differences between lipemia removal methods exceeded the limit for clinically significant interference (LCSI). Results: When ultracentrifugation and high-speed centrifugation were compared, no parameter had a difference that exceeded the LCSI. When high-speed centrifugation was compared with the two liquid-liquid extraction methods, we found differences exceeding the LCSI in protein, calcium, and aspartate aminotransferase in the comparison with 1,1,2-trichlorotrifluoroethane, and in protein, albumin, and calcium in the comparison with LipoClear. Differences in other parameters did not exceed the LCSI. Conclusions: High-speed centrifugation ($10,000{\times}g$ for 15 minutes) can be used instead of ultracentrifugation to remove lipemia in serum/plasma samples. LipoClear and 1,1,2-trichlorotrifluoroethane are unsuitable as they interfere with the measurement of certain parameters.

• Korean Journal of Remote Sensing
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• v.8 no.2
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• pp.79-91
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• 1992

With recent development in spaceborne imaging radar system, there are growing interests using satellite synthetic aperture radar(SAR) data in various applications. This study attempted to identify the relationships between several forest stand characteristics and radar backscatter, measured from space altitude altitude at three incidence angles. Shuttle Imaging Radar-B(SIR-B) data were collected over a forested area in northern Florida in October, 1984. By using various sources of reference data (forest type maps, inventory records, aerial photographs, and Landsat Thematic Mapper data), about 400 forest stands of known characteristics were carefully located in the radar data. Relative radar backscatter for the three incidence angles of SIR-B data were compared with known forest stand parameters such as mean tree height, diameter at breast height(DBH), stand density, biomass, and relative amount of understory vegetation. The results show that these stand parameters have statistically significant correlations with the radar backscatter. In addition, the SIR-B radar backscatter from a certain stand parameter turned out differently at the three different incidence angles. Finally, the types and characteristics of currently available satellite SAR data are discussed.

• Journal of the Korea Convergence Society
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• v.12 no.9
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• pp.1-10
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• 2021

In the past, designers relied primarily on past experience and reference to industry standard thresholds to design spaces. Such design often results in spaces that do not meet the needs of users. The purpose of this paper is to investigate the process and way of generating design parameters by constructing a BP neural network algorithm for spatial design. From the perspective. This paper adopts an experimental research method to take a kindergarten with a large number of complex needs in space as the object of study, and through the BP neural network algorithm in machine learning, the correlation between environmental behavior parameters and spatial design parameters is imprinted. The way of generating spatial design parameters is studied. In the future, the corresponding spatial design parameters can be derived by replacing specific environmental behavior influence factors, which can be applied to a wider range of scenarios and improve the efficiency of designers.