• Journal of Oral Medicine and Pain
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• 제33권2호
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• pp.187-194
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• 2008

재발성 아프타성 궤양은 흔히 발생하는 비특이적 구강점막질환이다. 궤양은 비각화 점막에 발생하고 일정시간이 흐른 후 치유가 되지만, 심한 통증으로 저작과 대화 등의 일상활동에 큰 지장을 초래한다. 그러나 아직까지 정확한 원인과 기전이 밝혀지지 않아 특별한 치료방법이 없어서 대증적인 방법으로 치료가 이루어진다. 이에 저자는 아프타성 궤양의 원인과 기전에 대한 문헌을 고찰하여 최신개념을 파악하고, 향후 나아가야 할 연구방향을 생각해 보고자 한다.

• Journal of Oral Medicine and Pain
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• 제20권2호
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• pp.449-459
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• 1995

To investigate the relationship between recurrent aphthous ulcer and oral mucosal keratinization, exfoliative cytology in buccal mucosa, lip mucosa, tongue mucosa were performed on 25 recurrent aphthous ulcer patients and 25 controls whose age ranged from 10 to 65. Keratinization cell ratio was then measured. The results were as follows : 1. Yellow cell ratio in the control group was more than that in the patient group in buccal mucosa, lip mucosa, tongue mucosa. Red cell ratio in the control group was more than that in the patient group in lip mucosa. Blue cell ratio in the patient group was more than that in control group in all regions( p(0.01) 2. In the comparison by sex, the patient group showed no significant difference in all site but, the control group showed different results according to the site; males were more than females in yellow cell, but less than females in red cell Females were more than males in yellow cell, but less than males in red cell. 3. In the comparison by age, patient group showed no significant difference in all site, but the control group showed significantly high yellow cell ratio in buccal and tongue mucosa over the age of 50. In conclusion, there was close relationship between recurrent aphthous ulcer and decreased oral mucosal keratinization. In other words, reduced oral mucosal keratinization must be recommended for prevention of recurrent aphthous ulcer.

• 대한한방내과학회지
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• 제44권2호
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• pp.107-116
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• 2023

Objective: This case study reports on the results of the Korean medical treatment of a major aphthous oral ulcer patient. Methods: A 19-year-old male Korean patient with a major aphthous oral ulcer received acupuncture, herbal medicine, and moxibustion for three weeks in a hospital. Results: After treatment, changes were observed in the numeric rating scale (NRS) from 8 to 5, World Health Organization oral toxicity scale (WHO OTS) from grades 3 to 2, oral perception guide from 11 to 15, and Oral Health Impact Profile-14 (OHIP-14) from 19 to 34. Conclusion: It is worth examining the progress of Korean medical treatment for a major aphthous oral ulcer patient.

• Journal of Oral Medicine and Pain
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• 제37권1호
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• pp.19-25
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• 2012

2010년부터 2011년까지 양산부산대학교 치과병원 구강내과에 초진 내원한 외래환자 중 재발성 아프타성 구내궤양(RAU)으로 임상 진단된 환자 20명과 구강편평태선으로 임상진단 된 환자 33명, 부산대학교 치의학전문대학원생 59명을 대조군으로 정하고 간이정신진단검사를 시행하여 다음과 같은 결론을 얻었다. 1. RAU 환자군과 편평태선 환자군, 대조군은 9개 증상차원 기본척도의 T 점수 평균값은 모두 65 이하로 정상범위 내에 있었다. 2. RAU 환자군은 정상 대조군에 비하여 SOM 지수가 유의하게 높았으며 (P<0.05), DEP 지수에서 높은 경향을 보였다. 3. RAU의 여성 환자군은 여성 대조군에 비하여 SOM, DEP, HOS 지수가 유의하게 높았고 (P<0.05), ANX 지수에서 높은 경향을 보였다. 4. RAU 환자군은 편평태선 환자군에 비하여 HOS 지수가 유의하게 높았으며 (P<0.05), O-C, I-S, DEP 지수에서 높은 경향을 보였다.

• 한방안이비인후피부과학회지
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• 제33권2호
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• pp.140-155
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• 2020

Objectives : The purpose of this study is to report the effectiveness of korean medical treatments on recurrent aphthous stomatitis(RAS) diagnosed as excess pattern(實證) based on symptoms of damum(痰飮), blood stasis(瘀血) and fire-heat(火熱). Methods : We treated a 61-year-old male patient who has RAS by korean medicine, pharmacopuncture and acupuncture treatment. These treatments were performed from 2020.01.22. to 2020.02.29. We have confirmed the improvement of ulcer lesions and pain. We recorded images that include change of symptoms. Results : After the treatments were done, the scores of numeric rating scale(NRS), oral health impact profile-14 (OHIP-14), oral assessment guide (OAG) and world health organization oral toxicity scale (WHO OTS) were decreased. The NRS score was decreased from 7 to 1. The OHIP-14 score was decreased from 30 to 14. The OAG score was decreased from 17 to 9. The WHO OTS score was decreased from 2 to 1. And ulcer lesions were clearly decreased. Conclusions : According to the result, korean medical treatments such as korean medicine, pharmacopuncture and acupuncture treatment, that are targeted at excess pattern(實證) caused by damum(痰飮), blood stasis(瘀血) and fire-heat(火熱) can be effective for the treatment of RAS.

• 대한치과의사협회지
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• 제55권9호
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• pp.634-639
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• 2017

Oral ulcerative and/or vesicular diseases have similar characteristics of clinical phenotypes. Detailed and careful history taking is the cornerstone of the diagnosis of oral mucosal disease. Moreover, complete screening of review of system for patient is important. Through this article, the simple ulcerative, recurrent ulcerative, acute multiple ulcer, chronic multiple ulcerative diseases will be discussed. Clinicians have to keep in mind its differential diagnosis and management.

• Journal of Oral Medicine and Pain
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• 제37권4호
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• pp.195-203
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• 2012

재발성 아프타성 구내궤양은 5~60%의 유병률을 가진 가장 흔한 형태의 구강 궤양이다. 가장 흔히 발병하는 나이는 10세~19세이며 환자의 성인기 및 평생 동안 지속될 수 있고, 성별의 차이는 없으며 소아프타, 대아프타 및 포진성 궤양의 세가지 형태로 나누어진다. 원인은 정확히 알려져 있지 않으나 다양한 유발인자 혹은 기여요인들이 있다. 이러한 기여요인에는 가족력 혹은 유전적 소인, Allergy 반응, 약물, 호르몬, 스트레스 또는 불안 및 면역계 이상 등을 들 수 있다. 구강 질환의 발병과정에 있어서 정신적 요인에 대한 고려의 필요성이 지난 몇 십 년 동안 점점 더 인정되고 있으며 많은 연구들이 구강질환에 있어서 정신사회적 요소들에 초점을 두고 있다. 이번 연구에서도 정서적 스트레스가 재발성 아프타성 구내궤양에 어떠한 영향을 미치는지 평가하고자 한다. 임상검사 결과 재발성 아프타성 구내궤양으로 진단된 환자 30명과 부산대학교 치의학전문대학원 학생들 중 재발성 아프타성 구내염의 증상 및 병력이 없는 60명을 대상으로 하였다. 스트레스 상황의 평가를 위해서는 한국적 문화에 맞게 적절하게 변형한 Holmes와 Rahe의 사회적 재적응 평정척도 설문지(SRRS)를 이용하였다. 분석결과 재발성 아프타성 구내염 환자들이 대조군에 비해 내원 전 7개월에서 12개월 사이 기간 및 내원 전 1년 동안의 스트레스를 경험하는 빈도 및 스트레스의 정도에 있어서 유의하게 높은 것으로 나타났다.

• Journal of Periodontal and Implant Science
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• 제23권1호
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• pp.193-200
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• 1993

The purpose of this study is to investigate the relationship between occurrence and inducing factors of herpes labialis developed after periodontal therapy and to suggest prediction model of this lesion. A total of 100 patients were studied. A standard schedule was used for interviews of patients. It included demographic information, patient and familial history of recurrent aphthous ulcer and recurrent herpes labialis, history of systemic disease, religion, and emotional state. In case of female patients, the association of dysmenorrhea and onset of recurrent herpes labialis was also observed. After periodontal therapy, some details about therapy, such as the kind of therapy, location, spending time were recorded. At next appointment, the appearance and location of herpes labialis were examined. The frequency of herpes labialis after periodontal therapy was 8% and the location was predominantly mouth angle. The significant relationship was found between the onset of herpes labialis and the history of recurrent herpes labialis, surgical therapy rather than non-surgical therapy, and spending time. The prediction model of herpes labialis was not apparently established with the results of this study. In conclusion it is suggested that we should minimize traumatic manipulation and treatment time to prevent the onset of herpes labialis after periodontal therapy.

• 대한기관식도과학회지
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• 제10권2호
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• pp.72-75
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• 2004

Pemphigus vulgaris is a rin, chronic intraepidermal bullous disease with potentially fatal outcome. Oral lesions precede skin lesions in at least $70\%$ of cases, and in cutaneous disease, concomitant oral lesions are encountered in $90\%$ of patients. This disorder involve the skin and mucous membranes, especially the oral and pharyngeal mucosa, but may also involve the nasal, oropharyngeal, laryngeal and esophageal mucosa. Oral lesions are initially vesicobullous but rapidly rupture, leaving a painful erosion that shows little tendency to heal. Pemphigus vulgaris affecting the oral mucosa is still diagnosed only after considerable delay, because oral ulceration in common, and clinicians believed the lesions to be caused by more common conditions such as recurrent aphthous stomatitis rather than a rare disorder such as pemphigus vulgaris. The definitive diagnosis of pemphigus vulgaris should be undertaken as early as possible, so that treatment can be started at an earl·y stage. Because of the presence of nonspecific oral ulcer, high degree of suspicion is often required to ultimately make the diagnosis of pemphigus vulgaris and then we report a case of pemphigus vulgaris with a literature review.

• Journal of Oral Medicine and Pain
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• 제24권2호
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• pp.125-135
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• 1999

This study was performed to discover the underlining influences of Herpes Simplex virus (HSV) and Varicella Zoster virus (VZV), to detect the changes of whole protein and mucin level and to observe protein profiles in the saliva when recurrent aphthous ulcer (RAU) was present. Unstimulated whole saliva was collected from 23 patients who for over three years had a clinical history of RAU, in a group of 10 women and 13 men, ranging from 11 to 72 years of age, and 20 healthy subjects, in a group of 8 women and 12 men, who did not have the symptoms nor a past history of RAU. Through the means of Polymerization Chain Reaction, genomic DNA from the HSV and VZV was purified from the saliva samples for identifying precisely the two types of viruses, and the level of whole protein and sialic acids in the saliva and the ratio of sialic acid to whole protein were measured, and SDS-polyacrylamide gel electrophoresis was performed. The results obtained were as follows ; 1. 39.13% of patients showed 224 bp bands of VZV DNA, those were appeared more in patients than in control group (p<0.01), but there was no significant difference between patients and control group in HSV DNA (p>0.05). 2. The concentration of whole protein in men patients was lower than in men control group (p<0.05), but there were no significant differences between patients and control in other groups (p>0.05). 3. The concentration of sialic acids from patients was lower than control group in all groups (p<0.05). 4. The concentration of sialic acids in proportion to that of whole protein was lower in patients than in control group (p<0.05), and in the two women groups (p<0.01), but no noticeable difference was found between the two men groups (p>0.05). 5. There were no consistent differences observed in the protein profiles of patients with control group except that certain protein bands near 50 kDa was lower in patients than in control group. These results suggest that viruses such as HSV and VZV and reduction of salivary whole protein and mucin levels are related to development of RAU.