• Journal of Chest Surgery
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• 제29권10호
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• pp.1076-1080
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• 1996

허혈후 재관류시 일산화질소의 전구체인 L-arginin에 심근기능에 미치는 영향은 각 연구의 조건에 따라 일정하지 않다. 저자들은 L-arginine의 농도에 의한 심근보호효과의 차이를 알아보고자 본 연구를 시행하였다. 란겐돌프 관류장치하의 흰쥐 적출심장에 37.5$^{\circ}C$에서 30분의 허혈과 30분의 재관류를 실시하면서 재관류시 관류액에 L-arginine을 첨가하여 농도를 1, 2, 3, 4 mm/L로 하였고 대 조군에는 L-arginine을 첨가하지 않았다. 허혈기 직전과 재관류 30분에 좌심실 수축기능(좌심실 발생압, 좌심실압 최대 순간 증가율), 이완기능(좌심실압 최대 순간 감소율)과 관상관류량을 측정하였다. L-arginine 농도가 1mm/L, 2 mm/L인 실험군은 좌심실 발생압, 좌심실압 최대 순간증가율, 좌심실압 최대 순간감소율 및 관상관류량의 회복률이 대조군에 비해 통계적 유의성은 없었으나 우수한 경향을 보였다. 그러나 L-arginine의 농도가 증가함에 따라 회복률은 감소하여 4 mM/L농도의 실험군은 대조군보다 유의하게 낮은 회복률을 보였다(p(0.05). 이러한 연구결과를 통해 심근허혈후 재관류시 심근기능 및 관상관류량 회복을 향상시키기 위해서는 L-arginine을 2mM/ 이하의 농도로 투여 해야 하며 향후 그 이상의 높은 농도에서 나타난 회복 저하에 관한 연구가 필요할 것으로 생각된다.

• 대한한방부인과학회지
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• 제19권4호
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• pp.216-224
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• 2006

Purpose : This study was conducted to investigate the effect of Mokhyangsaenghwa-tang beverage on postpartum recovery and lactation. One theory of oriental medical treatment for postpartum care is focused on increasing vitality and building up blood. Saengwha-tang are representative remedies for these respective principle of treatment. This experiment was carried out to evaluate the clinical effects of Mokhyangsaenghwa-tang on blood components, Body weight, BMI and prolactin level in postpartum. Methods : 65 postpartum women applied for this study, and 30 of them were included in this study. They were divided two groups. The experimental group were treated by Mokhyangsaenghwa-tang beverage, the control group were treated by citron beverage during 40 days. Then we observed the changes of the body weight, BMI, complete blood cell count, liver function test, renal function test, level of serum prolactin, Urine analysis and general conditon Questionnaire among baseline(before treatment), 1st phase(after 20 days treatment) and 2nd phase(after 40 days treatment). Results : After taking Mokhyangsaenghwa-tang beverage, body weight, body water, edema index, prolactin ana general condtion became better, but they were not statistically significant. Conclusion : This study shows that Mokhyangsaenghwa-tang can improve postpartum recovery, but more research is needed.

• 대한한방부인과학회지
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• 제18권1호
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• pp.111-127
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• 2005

Objective : This study was conducted to investigate the effect of Mokhyangsaenghwa-tang (MS) and Mokhyangsaenghwa-tang plus Cervi Pantotrichum Cornu (MS-C) on postpartum recovery and lactation. Materials and Methods : We used 18-week pregnant Spraque Dawley rats and administered the decoctions of MS and MS-C to rats once a day for 4 days or 8 days. Then we observed changes in the body weight of pup rats and complete blood cell count, liver function test, renal function test, mammary gland tissue, level of serum prolactin, ${\beta}-casein$ and WAP of postpartum rats. Result : A significant increase in body weight was observed in MS-C treated pup rats compared with in MS treated group. The levels of WBC and platelet from MS group and MS-C group were decreased compared with the control group. The levels of RBC, hemoglobin and hematocrit from MS group and MS-C group showed statistically significant increases compared with the control group. The levels of protein, albumin from MS group and MS-C group were increased compared with the control group. The levels of BUN, creatinine from MS group and MS-C group did not show statistically significant changes compared with the control group. The mammary gland tissues from MS group and MS-C group showed increased angiogenesis. The levels of serum prolactin from MS group and MS-C group were increased compared with the control group. The expression of ${\beta}-casein$ and WAP genes from postpartum rats treated with MS and MS-C was increased. Conclusion : This study shows that MS and MS-C improved postpartum recovery and lactation in rats.

• 한국항공우주학회지
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• 제34권9호
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• pp.11-19
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• 2006

초음속 축대칭 흡입구의 형상 설계를 위하여 원추 유동 해법과 충격파 근사 기법을 기반으로 하고 구배 기반의 최적화 기법을 이용한 설계 프로그램을 개발하였다. 압력 회복률과 항력을 고려한 두 가지 목적 함수에 대하여 충격파 위치와 카울의 형상, 흡입관 목 면적 등에 대한 제한 조건 등을 고려하여 여러 운용 조건에 대해 흡입구 설계를 수행하였다. 최적 설계를 위하여 압력 회복률과 항력을 동시에 고려한 목적 함수를 제안하고 압력 회복률만을 고려하여 설계된 흡입구 형상과 비교하였다. 설계된 결과는 전산 유체 역학을 이용한 비점성/점성 유동 해석으로부터 산출된 흡입구 성능 결과와 비교하여 검증하였으며 예측된 성능이 계산된 결과와 잘 일치하였다.

• 한국동물생명공학회지
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• 제34권3호
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• pp.166-172
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• 2019

Heart rate is a relatively simple and non-invasive method that is used as an important physiological indicator in many studies and has a close relationship with heart structure and function, cardiovascular disease and sudden cardiac death. In general, appropriately low heart rate during resting means effective heart function and cardiovascular fitness; heart rate at recovery is an important indicator of health and disease condition. We found a beagle dog (Dog_1) with a high heart rate in the previous preliminary experiment. Therefore, purpose of this study was to compare the heart rate response of the Dog_1 with the control group during 12 weeks of interval exercise, to evaluate the structural and functional abnormalities of the heart and to verify the applicability of exercise program. Heart rate was checked during 12 weeks of interval exercise, and after the exercise was over, imaging examination and hematological and serum biochemistry were performed. As a result, Dog_1 (165.6 ± 1.5) showed significantly higher heart rate in low intensity session of interval exercise than control group (133.3 ± 0.5, p < 0.01). In addition, Dog_1 (181.2 ± 1.4) showed significantly higher heart rate than control group (155.1 ± 0.9) in high intensity session (p < 0.01). The heart rate (30 sec, 60 sec) during recovery state was higher in Dog_1 (30 sec: 156.8 ± 4.0, 60 sec: 166.8 ± 5.8) than in the control group (30 sec: 111.2 ± 2.5, 60 sec: 104.0 ± 5.1, p < 0.01). The results of the imaging examination of Dog_1 with high heart rate confirmed that the heart had no functional and structural abnormalities. All beagles with the interval exercise program did not show maladjustment, and in the hematological and serum biochemistry results, all the parameter were within the reference range. If the interval exercise program of this study is used in the future, it is expected to be used as an important basic data to achieve the purpose of health, welfare, and physical fitness improvement of dogs.

• 대한한의학회지
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• 제43권3호
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• pp.164-180
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• 2022

Objectives: The purpose of this study was to evaluate the effects of shenfu injection on myocardial protective effects after mitral valve replacement surgery. Methods: We searched four international databases (PUBMED, Embase, Web of Science and CNKI) and three domestic electronic databases (OASIS, RISS and NDSL) for relevant studies. We used following keywords 'shenfu', 'valve replacement', 'mitral valve' at PUBMED, Embase and Web of Science; '二尖瓣', '参附注射液', '瓣膜' at CNKI and '이첨판', '판막', '삼부' at domestic databases. The search range included randomized controlled trials. When appropriate, meta-analyses were performed. Results: Seven randomized controlled trials were selected. All studies used Shenfu injection after mitral valve replacement surgery. We analyzed myocardial damage, cardiac function, patients' recovery rate, with various evaluation indicators. We also used meta-analysis for CK-MB, cTnI, MDA and voluntary recovery of heartbeat. CK-MB was analyzed in two subgroups: 8 hours and 24 hours after surgery. Std was -2.34(95% CI -4.10, -0.58) for 8 hours and -1.95(95% CI -4.79 to 0.88) for 24 hours. 8 hours showed statistically significant difference. cTnI appeared significant decrease with Std of -2.13(95% CI -2.60, -1.66). MDA showed significant decrease with Std of -0.95(95% CI -1.43 to -0.47). Voluntary recovery of heartbeat significantly increased with the odd ratio of 4.34(95% CI 1.76, 10.70). Conclusions: We suggest that Shenfu injection after Mitral valve replacement surgery may have significant myocardial protective effects in terms of reducing myocardial damages, reactive oxygen species, increasing cardiac function and patients' recovery after surgery. However, the evidence is limited, further research is required.

• 핵의학기술
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• 제22권1호
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• pp.43-45
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• 2018

NEMA IEC body phantom으로 PET/MR 스캐너를 이용해 MR 영상 기반의 감쇠보정 된 PET 영상을 얻고, 반복재구성 기반의 점 확산 함수(PSF)에 적용 유무에 따라 PET 영상을 Contrast recovery 와 SNR 의 평가 인자를 적용해 평가하였다. 또한, 동일한 재구성 방법에 따라 본원의 내원한 환자의 영상도 평가하였다. 데이터는 임상환자 와 팬텀 실험 모두 PSF를 적용해 재구성한 영상이 모두 영상의 질이 향상됨을 확인하였다. MR 기반으로 얻어진 PET 영상 평가가 추후에도 계속해서 필요하다고 사료된다.

• 한국운동역학회지
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• 제22권2호
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• pp.209-217
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• 2012

The purpose of this study was to develop a turn-type treatment program which applies the principle of spotting and a roll-type treatment program that induces off-vertical axis. 29 collegiate students volunteered for this study. 12-week treatment programs were applied to both 15 students for turn-type treatment group and 14 students for roll-type treatment group. As an analytic tool, eye camera was employed to verify the treatment programs for a stimulus upon a turn, recovery after a stimulus upon a turn, and nystagmus that affects a vestibular system. Two-way ANOVA with repeated measures was applied to see the significant differences between the treatment groups, and between the test periods. For Post-Hoc Test, paired t-test was used to within the group and independent t-test was used to between the groups. The results indicated that roll-type treatment training has maximized a stimulus on nystagmyus during the stimulus by a roll. Turn-type treatment training has maximized a stimulus on nystagmyus right after a stimulus by a roll and significantly decreased the intensity of nystagmyus during the recovery. Both turn and roll type treatments have reduced the recovery time which from nystagmyus to a normal status. Roll-type treatment has showed a much shorter recovery time for nystagmyus than the roll-type treatment has. Based on the results of treatment programs developed in this study, we expect the treatment programs can be applied to treat dizziness and to improve the function of vestibular system as a rehabilitation tool.

• Journal of Korean Neurosurgical Society
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• 제46권2호
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• pp.109-115
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• 2009

Objective: The decision to adopt a conservative or surgical modality for a relatively small volume of spontaneous intracerebral hemorrhage (SICH) is difficult and often controversial, especially when consciousness is tolerable. The authors examined the results of stereotactic-guided evacuation of SICH for relatively small volumes with respect to functional outcome. Methods: This prospective study was performed on 387 patients with SICH who underwent stereotactic-guided evacuation (n = 204, group A) or conservative treatment (n = 183, group B) during the past 8 years. The primary end-point was recovery of functional status, which was estimated using the Modified Barthel Index (MBI) and the modified Rankin Scale (mRS). Results: All patients had a Glasgow coma scale (GCS) score of $\geq$ 13 and unilateral hemiparesis of less than motor power grade 3. Group demographic characteristics and initial neurological statuses were similar. In all cases, the volume of SICH involved was < 30 cm$^3$ and location was limited to basal ganglia and thalamus. At 6-month follow-ups, MBI was 90.9 in group A and 62.4 in group B (p < 005), and MRS was 1.2 in group A and 3.0 in group B (p < 0.05). Better motor function and stereotactic-guided evacuation had a significant effect on a functional recovery in regression analyses. Conclusion: Even in patients with a small volume of SICH, stereotactic-guided evacuation improved functional recovery in activities in daily life than conservative treatment did.

• 융합보안논문지
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• 제3권3호
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• pp.51-57
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• 2003

실시간 DBMS는 제한된 시간내에 사용자가 처리를 요청한 데이터를 가장 빠르고 안전하게 보관, 조작, 제어하는 기능을 제공해야 한다[3]. 이러한 실시간 제어 및 조작 기능을 담당하기 위하여, 실시간 DBMS 내에서 수행되는 트랜잭션에 대한 처리 과정의 상세 기록(로그)이 매우 중요하다. 본 논문에서는 이러한 기록을 기반으로 트랜잭션 로그에 대한 새로운 회복 기능을 제안한다. 본 회복 방안은 기본적으로 LIFO(Last-In-First-Out) 의 개념을 사용하였다. 제안하는 방법은 같은 속성을 가진, 연속적인 트랜잭션 로그를 효율적으로 기록, 처리 할 수 있는 방안이 될 것이다.