• Molecules and Cells
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• v.45 no.8
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• pp.588-602
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• 2022

Various RNA-binding proteins (RBPs) are key components in RNA metabolism and contribute to several neurodevelopmental disorders. To date, only a few of such RBPs have been characterized for their roles in neocortex development. Here, we show that the RBP, Rbms1, is required for radial migration, polarization and differentiation of neuronal progenitors to neurons in the neocortex development. Rbms1 expression is highest in the early development in the developing cortex, with its expression gradually diminishing from embryonic day 13.5 (E13.5) to postnatal day 0 (P0). From in utero electroporation (IUE) experiments when Rbms1 levels are knocked down in neuronal progenitors, their transition from multipolar to bipolar state is delayed and this is accompanied by a delay in radial migration of these cells. Reduced Rbms1 levels in vivo also reduces differentiation as evidenced by a decrease in levels of several differentiation markers, meanwhile having no significant effects on proliferation and cell cycle rates of these cells. As an RNA binding protein, we profiled the RNA binders of Rbms1 by a cross-linked-RIP sequencing assay, followed by quantitative real-time polymerase chain reaction verification and showed that Rbms1 binds and stabilizes the mRNA for Efr3a, a signaling adapter protein. We also demonstrate that ectopic Efr3a can recover the cells from the migration defects due to loss of Rbms1, both in vivo and in vitro migration assays with cultured cells. These imply that one of the functions of Rbms1 involves the stabilization of Efr3a RNA message, required for migration and maturation of neuronal progenitors in radial migration in the developing neocortex.

• Journal of the Korea Convergence Society
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• v.13 no.5
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• pp.1-8
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• 2022

In Korea, drones, which are at the core of the 4th industrial revolution, are used to promote Korean New Deal policies to digitalize the SOC. Overseas, the use of convergence sensors, such as thermal imaging cameras, on drones is increasing in various industrial fields. In this research, to improve pavement quality in highway bridge pavement construction, a thermal imaging camera was mounted on a drone to measure and verify the temperature of the pavement work section. Using a laser thermometer allows the partial measurement of pavement temperature. It was confirmed that the proposed method allows not only real-time temperature monitoring of the whole pavement work section but also uniformity verification by checking temperature distribution. The proposed method has the potential to control highway pavement quality and enable quick decision-making on traffic opening times by reducing the possibility of misjudging road opening times(pavement surface temperature ≦ 40℃).

• Proceedings of the Korea Water Resources Association Conference
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• 2023.05a
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• pp.315-315
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• 2023

급격한 기후변화에 기인하여 전 세계적으로 거듭되는 돌발홍수로 인한 피해가 급격히 증가하고 있는 실정이다. 우리나라에서도 최근 중소 규모의 하천 뿐 아니라 도시 생활하천, 도심지 저지대에서 갑작스런 홍수와 침수로 인해 많은 인명과 재산 피해를 경험하고 있다. 이런 문제를 인식하여 최근 정부차원에서 다양한 센서와 인공지능에 기반하는 많은 인프라 및 연구 투자가 이루어지고 있지만, 높은 설치 및 운영 비용과 우리나라의 복잡한 하천 환경 특성으로 인해 소하천이나 도심지 저지대에서는 그 효율성을 제대로 발휘하지 못하고 있다. 따라서 본 논문에서는 주변환경의 변화에 강인한 복합 센서단말을 통해, 하천 정보(유량, 유속, 수위 등)을 실시간 측정하고, 해당지역의 특성을 고려한 하천 또는 저지대의 위험도를 스스로 판단할 수 있는 기술을 제안한다. 또한, 본 논문에서는 제안한 저비용 초소형의 단말 장치로 지점의 하천 정보를 실시간 측정하여 IoT망을 통해 3차원 하천 디지털트윈 모델로 전달하여, 유속과 수위를 그대로 재연함으로써, 하천 침수 위험 감시의 효율성을 검증하였다. 3차원 DEM(Digital Elevation Models) 데이터와 실제 하천을 관측한 데이터를 이용한 디지털트윈 검증 결과, 데이터 전송 지연시간을 감안하여 3초 이내에 하천의 수위와 유속이 3차원 모델에 반영되는 것을 확인하였다. 이 결과로부터 열악한 환경에서도 실시간 하천 상황을 원거리에서 모니터링 할 수 있으며, 강우와 유출에 따른 하천 홍수 메카니즘을 새롭게 시뮬레이션할 수 있는 방법론을 제시할 수 있을 것으로 기대한다.

• Journal of the Korea Institute of Military Science and Technology
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• v.26 no.1
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• pp.91-101
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• 2023

Modeling and Simulation(M&S) technology has been widely used to solve constraints such as time, space, safety, and cost when we implement the same development and test environments as real warfare environments to develop, test, and evaluate weapon systems for the last several decades. The integration and test environments employed for development and test & evaluation are required to provide Live Virtual Construction(LVC) simulation environments for carrying out requirement analysis, design, integration, test and verification. Additionally, they are needed to provide computing environments which are possible to reconfigure computing resources and software components easily according to test configuration changes, and to run legacy software components independently on specific hardware and software environments. In this paper, an Integration Test and Simulation for Engagement Control(ITSEC) bed using a bare-metal virtualization mechanism is proposed to meet the above test and simulation requirements, and it is applied and implemented for an air missile defense system. The engagement simulation experiment results conducted on air and missile defense environments demonstrate that the proposed bed is a sufficiently cost-effective and feasible solution to reconfigure and expand application software and computing resources in accordance with various integration and test environments.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.28 no.5D
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• pp.587-595
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• 2008

Many studies on bus scheduling optimization have been done from the 1960s to recent years for establishing rational bus schedule plan that can improve convenience of bus passengers and minimize unnecessary runs. After 2000, as part of the Intelligent Transport Systems (ITS), the importance of the schedule management and providing schedule information through bus schedule optimization has become a big issue, and much research is being done to develop optimization models that will increase bus passenger convenience and, on the side of bus management, minimize unnecessary bus operation. The purpose of this study is to calculate the optimal bus frequency and create a timetable for each bus stop by applying DTR or DTRC model that use data for each bus stop and route segment. Model verification process was implemented using data collected from bus management system (BMS) and integrated transit-fare card system for bus route of Seoul's No. 472 line. In order to evaluate the reliability and uncertainty of optimal solution, sensitivity analysis was implemented for the various parameters and assumptions used in the bus scheduling model.

• Journal of IKEEE
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• v.27 no.4
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• pp.601-609
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• 2023

In this paper, we propose an artificial intelligence-based high-speed fault diagnosis method using an FPGA in the event of a ground fault in a DC system. When applying artificial intelligence algorithms to fault diagnosis, a substantial amount of computation and real-time data processing are required. By employing an FPGA with AI-based high-speed fault diagnosis, the DC breaker can operate more rapidly, thereby reducing the breaking capacity of the DC breaker. therefore, in this paper, an intelligent high-speed diagnosis algorithm was implemented by collecting fault data through fault simulation of a DC system using Matlab/Simulink. Subsequently, the proposed intelligent high-speed fault diagnosis algorithm was applied to the FPGA, and performance verification was conducted.

• The Journal of the Korea institute of electronic communication sciences
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• v.18 no.5
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• pp.817-826
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• 2023

In this paper, a fault determination methodology based on an artificial neural network was proposed to protect the system from faults on the lines in the smart grid distribution system. In the proposed methodology, first, it was designed to determine whether there is a low impedance line fault (LIF) based on the magnitude of the current RMS value, and if it is determined to be a normal current, it was designed to determine whether a high impedance ground fault (HIF) is present using Normal/HIF classifier based on artificial neural network. Among repetitive DSP module-based algorithm verification tests, the normal/HIF classifier recognized the current waveform as normal and did not show reclosing operation for the cases of normal state current waveform simulation test where the RMS value was smaller than the minimum operating current value. On the other hand, for the cases of LIF where RMS value is greater than the minimum operating current value, the validity of the proposed methodology could be confirmed by immediately recognizing it as a fault state and showing reclosing operation according to the prescribed procedure.

• Journal of Internet of Things and Convergence
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• v.10 no.2
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• pp.25-41
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• 2024

For the scenario of open pit mining, at present, manual periodic verification is mainly carried out in China with the help of video surveillance, which requires continuous investment in labor cost and has poor timeliness. In order to solve this difficult problem of early warning and monitoring, this paper researches a spatialized algorithmic model and designs an early warning system for open-pit mine transboundary mining, which is realized by calculating the coordinate information of the mining and extracting equipments and comparing it with the layer coordinates of the approval range of the mines in real time, so as to realize the determination of the transboundary mining behavior of the mines. By taking the Pingxiang area of Jiangxi Province as the research object, after the field experiment, it shows that the system runs stably and reliably, and verifies that the target tracking accuracy of the system is high, which can effectively improve the early warning capability of the open-pit mines' overstepping the boundary, improve the timeliness and accuracy of mine supervision, and reduce the supervision cost.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.44 no.1
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• pp.117-124
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• 2024

The objective of Value Engineering (VE) is to derive the optimal value at the most efficient life cycle cost, comprising three stages: Pre-Study, Study, and Post-Study. In this study, we propose a method for information collection and analysis during planned site visit surveys in the preparation stage of VE. The 3D spatial model, created using a drone, facilitated observation and analysis of the study area from various angles, both from the center and the outside. Additionally, through the utilization of drones, we conducted on-site investigations of the research area's 3D spatial model, enabling a macroscopic perspective previously only feasible through a microscopic viewpoint during planned site visits in the pre-study phase. Furthermore, the utilization of actual spatial data obtained from observations allowed for real-time information verification during Design VE workshops, enhancing the efficiency and reliability of the VE project.

• Journal of the Korea Society of Computer and Information
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• v.29 no.1
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• pp.121-130
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• 2024

In this paper, we propose an installation approach for Naval Combat Management System(CMS) software that identifies potential data anomalies during installation. With the popularization of wireless communication methods, such as Low Earth Orbit(LEO) satellite communications, various utilization methods using wireless networks are being discussed in CMS. One of these methods includes the use of wireless network communications for installation, which is expected to enhance the real-time performance of the CMS. However, wireless networks are relatively more vulnerable to security threats compared to wired networks, necessitating additional security measures. This paper presents a method where files are transmitted to multiple nodes using encryption, and after the installation of the files, a validity check is performed to determine if there has been any tampering or alteration during transmission, ensuring proper installation. The feasibility of applying the proposed method to Naval Combat Systems is demonstrated by evaluating transmission performance, security, and stability, and based on these evaluations, results sufficient for application to CMS have been derived.