• Korean Chemical Engineering Research
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• v.48 no.6
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• pp.757-762
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• 2010

Since the quality and performance of medicinal products are heavily dependent upon the size, shape and polymorphism of active pharmaceutical ingredients(APIs), their crystallization has been regarded as one of the most important pharmaceutical processes. In this study, NIR-based inline measurements were employed to monitor key attributes of API particles real-time during the crystallization process. Principal component analysis(PCA) method was selected to correlate inline NIR spectra while the well-known aspirin was studied as a model drug. According to our characterization results, the ratio of ethanol to acetone did not cause any change in polymorphism, but resulted in a significant difference in the nucleation time, crystal growth and crystal shape. These phenomenological changes were well correlated with the PCA's implications. It turned out that the NIR-based inline monitoring technology can be employed well in observing and predicting key quality attributes such as crystal size during pharmaceutical crystallization processes.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2002.11a
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• pp.440-443
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• 2002

Present1y the X-Ray diagnosis system is a real condition that is changing by digital ways in it's existent analog ways. This digital radiation detector is divided by the direct method and the indirect method. The indirect method of applied voltage has special qualities that the resolution is low than direct method by diffusion effect that happens. The conversion process ( radiation${\rightarrow}$visible ray${\rightarrow}$electrical signal of two times, has shortcomings that the energy conversion efficiency of electrical signal is low. The direct method has shortcomings that need strong electric fie1d to detect electrical signal efficiently. This research achieved to develop digital detector of the Hybrid method that have form that mixes two ways to supplement shortcoming of direct. indirect method. A studied electrical characteristic by Iodine's Mixture ratio change is added to selenium in the detector which has a multi-layer structure (Oxybromide + a-Se). There are 8 kinds of Manufactured compositions to amorphous selenium Iodine each 30ppm, 100ppm, 200 ppm, 300ppm, 400ppm, 500ppm, 600ppm, 700ppm by a doped photoconductor through a vacuum thermal evaporation method. The phosphor layer is consisted of Oxybromide ($BrO_2$) which uses optical adhesives multi-layer structure. The manufactured compositions calculates and compares Net Charge and signal to noise ratio measuring Photocurrent about Darkcurrent and X-ray. When doped Iodine Mixture ratio is 500ppm to the multi-layer structure (Oxybromide + a-Se), applied voltage of $3V/{\mu}m$, leakage current of compositions $2.61nA/cm^2$ and net charge value by 764pC/$cm^2$/mR then the best result appeared.

• Journal of the Korea Society of Computer and Information
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• v.18 no.3
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• pp.107-118
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• 2013

In this paper, we developed the semiconductor monitoring system for the etching process. Around the world, expert companies are competing fiercely since the semiconductor industry is a leading value-added industry that produces the essential components of electronic products. As a result, many researches have been conducted in order to improve the quality, productivity, and characteristics of semiconductor products. Process monitoring techniques has an important role to give an equivalent quality and productivity to produce semiconductor. In fact, since the etching process to form a semiconductor circuit causes great damage to the semiconductors, it is very necessary to develop a system for monitoring the process. The proposed monitoring system is mainly focused on the dry etching process using plasma and it provides the detailed observation, analysis and feedback to managers. It has the functionality of setting scenarios to match the process control automatically. In addition, it maximizes the efficiency of process automation. The result can be immediately reflected to the system since it performs real-time monitoring. UI (User Interface) provides managers with diagnosis of the current state in the process. The monitoring system has diverse functionalities to control the process according to the scenario written in advance, to stop the process efficiently and finally to increase production efficiency.

• Journal of Magnetics
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• v.19 no.2
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• pp.161-169
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• 2014

The aim of this study is to investigate the efficacy of pulsed electromagnetic field (PEMF) on the alleviation of lumbar myalgia. This is a randomized, real-sham, double blind pilot study. 38 patients were divided into the PEMF group and the Sham group, each of which was composed of 19 patients (1 patient dropped out in the Sham group) of randomized allocation. The PEMF group was treated by using the PEMF device and the Sham group by using a sham device on the lumbar muscle and acupuncture points, three times a week for a total of two weeks. Evaluations of Visual Analogue Scale for bothersomeness (VASB), Visual Analogue Scale for pain intensity (VASP), Oswestry Disability Index (ODI), 36-Item Short Form Health Survey Instrument (SF-36), EuroQol-5Dimension (EQ-5D), Beck's Depression Inventory (BDI) and Roland-Morris Disability Questionnaire (RMDQ), etc. before and 1 week after treatment were carried out. The primary outcome measure was the VASB, measured 1 week after the end of the pulsed electromagnetic therapy. VASB scores for the PEMF group changed by $-2.06{\pm}2.12$ from the baseline, and that for the Sham group changed by $-0.52{\pm}0.82$ (p < 0.05). VASP scores for the PEMF group were reduced by $-2.10{\pm}2.12$ from the base line, and that for the Sham group was reduced by $-0.53{\pm}1.50$ (p < 0.05). PEMF group showed significant improvements in all VASB, VASP, ODI, SF-36, EQ-5D, BDI and RMDQ scores, while the Sham group showed significant improvements in all scores, except the VASP score. However, the VASB, VASP and RMDQ scores of the PEMF group were much lower than those of the Sham group. The two groups showed no significant difference in ODI, SF-36, EQ-5D and BDI. This study demonstrates the effectiveness of PEMF treatment for alleviating lumbar myalgia.

• Food Science and Preservation
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• v.20 no.5
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• pp.699-704
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• 2013

Buckwheat Soksungjang (BS) is a bealmijang manufactured with buckwheat and soybeans. We manufactured BS using Bacillus subtilis HJ18-4 (HJ18-4), which has high enzyme activities and antibacterial effects. HJ18-4 was inoculated in a different process during the BS manufacturing, which was the meju-making time (Treat 1), and the salt water time was added (Treat 2). The physiochemical and microbial characteristics of the BS were analyzed. As a result, the total aerobic counts (7~8 log CFU/mL) in the BS increased after 15 days of fermentation. Especially, Treat 1 showed higher total aerobic counts and amino-type nitrogen (65.38~202.52 mg%) than Treat 2. During the BS fermentation, the reduction of the sugar contents and the enzyme (protease and amylase) activities decreased. In the relative quantitative expression level of PlcR, Treat 1 did not show toxin gene expressions at the end of the fermentation on Day 23. Treat 1 showed suitable B. cereus physiochemical quality characteristics and inhibition effects. When the modified-form type of fermented soybean paste was manufactured with a single starter, it could not reproduce the natural fermentation quality. These results suggest that the addition of a starter (HJ18-4) in the Meju manufacturing process could enhance the quality characteristics of the manufactured BS via natural fermentation and by suppressing B. cereus.

• Journal of the Korea institute for structural maintenance and inspection
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• v.20 no.1
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• pp.64-71
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• 2016

In this paper, when the composite beam is made with UHPC deck and steel girder, the steel girder takes the form of the inverted-T shape without top flange because of high strength and stiffness of UHPC deck. There is no evaluation by experiment and analysis about the shear connector behavior on the web of steel girder and flexural behavior of inverted-T shape composite beam. By this reason, this study compares between experiment and analysis by using tension softening model of UHPC on the basis of flexural test results of 16 members considering compressive strength of UHPC, spacing of stud and thickness of deck as variables. The results of tensile strength of UHPC by inverse analysis were 6.57 MPa(in case of 120 MPa) and 9.57 MPa(in case of 150 MPa). In case of the test members with small stud spacing, the results of analysis and test were close clearly, and the test members with thick deck and low UHPC compressive strength also similar, but effects were small. As it compared between analysis and experiment totally, the results of analysis and experiment agree well. So the tension softening model of UHPC is reasonably reflected on the real behavior of composite beam of UHPC.

• Journal of the Korean Association of Geographic Information Studies
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• v.15 no.1
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• pp.159-171
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• 2012

This study has developed a technology for river basin including the management of the data related with riverbed and the analysis of the riverbed maintenance based on the high-resolution imagery data and LiDAR (Light Detection and Raging) in order to enhance the utilization of river management by using RIMGIS(River Information Management GIS) and to acquire the advanced operation for river management. Using the detailed river topographical map specially designed in the form of LiDAR or high-resolution images, riverbed data and river bank channel information that are dynamically changed were informationized and established in the RIMGIS DB. At this stage, a monitoring techniques that is established in the river management system associated with RIMGIS and minimized the impact of riverbed maintenance (fluctuations) has been studied. In addition, functions and data structure of RIMGIS containing the information of geography and management of the river have been supplemented to make an improvement of the real-time management of the river. Furthermore, a technology that is capable of supplementing RIMGIS has been developed, making it feasible to maintain the river in use of structural method including an structural scheme of cross-section of the river by providing the information of riverbed and cross-section of the river. This is considered to solve an issue of insufficient data on accuracy and based on a lack of information of the river based on the two-dimensional lines, making it feasible to (steadily) improve the function of RIMGIS and to operate management tasks. Therefore, it is highly expected to enhance aforementioned technology of the river information management as a great foundation that maximizes the utilization of the river management to support RIMGIS for the development of national river management data.

• Journal of Korea Game Society
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• v.14 no.5
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• pp.161-182
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• 2014

As environmental problems such as global warming, and ecocide have a great influence on society, the attention to environmental pollution is being expanded. To solve the environmental problems, the awareness and practice of members of society in question is required. However, it has been found that few people are participating in practising environmental protection in real life. Our main goals are to show that Gamification has great potential in delivering messages for public interest and to suggest guidelines for researchers and public contents developers who engage in designing in relation to Gamification. Based on the domestic and foreign theoretical investigations, we found that Gamification mechanism made based on psychological mechanism of users aims at public interests' value by maximizing motivations of users and spreading social relationships among people. As shown in the case study, if contents are developed by reflecting the elements which stimulate challenging of users, the elements which can express their opinions, and the elements of altruism which form the sympathy in the development of public interest contents in the future, practical participation of people to solve social problems can be expected.

• Tuberculosis and Respiratory Diseases
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• v.77 no.2
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• pp.73-80
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• 2014

Background: Low levels of serum vitamin D is associated with several lung diseases. The production and activation of matrix metalloproteinases (MMPs) may play an important role in the pathogenesis of emphysema. The aim of the current study therefore is to investigate if vitamin D modulates the expression and activation of MMP-2 and MMP-9 in human lung fibroblasts (HFL-1) cells. Methods: HFL-1 cells were cast into three-dimensional collagen gels and stimulated with or without interleukin-$1{\beta}$ (IL-$1{\beta}$) in the presence or absence of 100 nM 25-hydroxyvitamin D (25(OH)D) or 1,25-dihydroxyvitamin D ($1,25(OH)_2D$) for 48 hours. Trypsin was then added into the culture medium in order to activate MMPs. To investigate the activity of MMP-2 and MMP-9, gelatin zymography was performed. The expression of the tissue inhibitor of metalloproteinase (TIMP-1, TIMP-2) was measured by enzyme-linked immunosorbent assay. Expression of MMP-9 mRNA and TIMP-1, TIMP-2 mRNA was quantified by real time reverse transcription polymerase chain reaction. Results: IL-$1{\beta}$ significantly stimulated MMP-9 production and mRNA expression. Trypsin converted latent MMP-2 and MMP-9 into their active forms of MMP-2 (66 kDa) and MMP-9 (82 kDa) within 24 hours. This conversion was significantly inhibited by 25(OH)D (100 nM) and $1,25(OH)_2D$ (100 nM). The expression of MMP-9 mRNA was also significantly inhibited by 25(OH)D and $1,25(OH)_2D$. Conclusion: Vitamin D, 25(OH)D, and $1,25(OH)_2D$ play a role in regulating human lung fibroblast functions in wound repair and tissue remodeling through not only inhibiting IL-$1{\beta}$ stimulated MMP-9 production and conversion to its active form but also inhibiting IL-$1{\beta}$ inhibition on TIMP-1 and TIMP-2 production.

• Journal of Information Technology and Architecture
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• v.10 no.1
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• pp.79-91
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• 2013

This paper proposes a systematic methodology that could be used to decide which one shows the best performance among space filling curves (SFCs) in applying lower-dimensional transformations to histogram sequences. A histogram sequence represents a time-series converted from an image by the given SFC. Due to the high-dimensionality nature, histogram sequences are very difficult to be stored and searched in their original form. To solve this problem, we generally use lower-dimensional transformations, which produce lower bounds among high dimensional sequences, but the tightness of those lower-bounds is highly affected by the types of SFC. In this paper, we attack a challenging problem of evaluating which SFC shows the better performance when we apply the lower-dimensional transformation to histogram sequences. For this, we first present a concept of spatial locality, which comes from an intuition of "if the entries are adjacent in a histogram sequence, their corresponding cells should also be adjacent in its original image." We also propose spatial locality preservation metric (slpm in short) that quantitatively evaluates spatial locality and present its formal computation method. We then evaluate five SFCs from the perspective of slpm and verify that this evaluation result concurs with the performance evaluation of lower-dimensional transformations in real image matching. Finally, we perform k-NN (k-nearest neighbors) search based on lower-dimensional transformations and validate accuracy of the proposed slpm by providing that the Hilbert-order with the highest slpm also shows the best performance in k-NN search.