• Journal of information and communication convergence engineering
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• 제15권4호
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• pp.227-231
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• 2017

Recently, as the number of safety accidents caused by reagents increases, researches on a system that can reduce safety accidents are underway. Existing systems managed reagent cabinet through various sensors. On the other hand, there are disadvantages in that countermeasures against simultaneous danger situations are insufficient at multi-reagents cabinet. In order to solve this problem, this paper proposes a system to manage the reagents cabinet through danger priority. Danger priorities are selected through domestic chemical accident cases and the Chemical Safety Management Act. If a danger situation occurs in the reagent cabinet, make sure it is from a single or multiple reagent cabinets. For multiple reagent cabinets, compare the reagent cabinet priorities and run the device sequentially from the reagent cabinet with the highest priority. Thus, by operating the device according to the danger priority, the chain reaction can be prevented in advance and the reagent cabinet can be safely managed.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2016년도 추계학술대회
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• pp.790-791
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• 2016

의료, 화학 분야의 연구실에서 사용되는 시스템은 일반적으로 내부 온도만 측정하여 보관하고 내부의 시약 관리를 수기로 기록한다. 이로 인해 시약 보관 시 내부에서 발생하는 문제를 실시간으로 인식하지 못해 사고가 발생하고 시약 보관 시 사용 기록이 누락되어 효율적인 시약 관리에 대한 문제점이 대두되고 있다. 본 논문에서는 이를 해결하기 위해 실험실에서 임베디드 보드와 센서를 활용해 시약을 효과적으로 관리하는 시약 관리 시스템을 제안한다. 이를 위해 NFC(Near Field Communication)를 이용해 시약의 정보를 데이터화 하여 관리자가 위험 시약을 등록 및 관리하고, 시약 사용자를 식별 할 수 있으며, 온도, 습도, VOC 센서들을 활용하여 제어하게 한다. 또한 특정 위험 상황 발생 시 관리자에게 메시지를 전달하여 알려준다. 이는 실험실에서 효율적인 시약 관리를 가능하게 할 것으로 사료된다.

• Archives of Pharmacal Research
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• 제11권2호
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• pp.134-138
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• 1988

Urine measurements by MNR were made for 25 persons including cancer and non-cancer patients. The aromatic proton signals of NMR wer observed much more often in cancer patients' urine than non-cancer patients' one. To compare the amount of the phenolic compounds excreted in urine between cancer and non-cancer patient, urine analysis by HPLC with UV detector was performed. Total peak area and major peak areas of cancer patients' urine wer emuch greater than those of non-cancer patients' one. To check the phenolic compound excreted in urine, a new jellied reagent named Gift reagent which was based on Millon's reagent, was developed for urine color reaction. When the reagent was tested, the sensitivity and specificity for urine samples of 69 persons including cancer and non-cancer patients were measured by 85.3% and 91.4%, respectively, indicating that the Gift reagent afford a possibility of cancer diagnosis.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2017년도 춘계학술대회
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• pp.579-580
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• 2017

최근 실험실에서 시약에 의한 안전사고가 늘어남에 따라 시약을 안전하게 관리하기 위한 시스템들이 개발되고 있다. 기존 시스템은 웹 페이지를 통해 시약장을 모니터링하고 관리하지만 시약장의 내부 환경 변화를 고려하거나 원격 모니터링 및 제어 기능은 미비한 실정이다. 이를 해결하기 위해 본 논문에서는 시약장 내부에 적재되어 있는 시약의 변질을 예측하고 원격모니터링 및 제어가 가능한 시스템을 제안한다. 시약장 내부에 부착된 온도, 습도 센서에서 측정한 값과 시약의 유효기간을 통해 시약의 변질을 예측하고 관리자에게 경고 메시지를 전송한다. 관리자는 어플리케이션을 통해 시약장을 모니터링 및 제어한다. 시약의 변질을 사전에 예측하고 원격으로 시약장을 관리함으로써 시약에 의한 안전사고를 줄일 수 있을 것으로 사료된다.

• 한국정보통신학회논문지
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• 제23권6호
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• pp.652-658
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• 2019

사물인터넷을 이화학, 약학, 생물학 및 의학 등 다양한 연구실험분야에 적용한 경우 다양한 센서와 기기를 부착하여 지능적으로 연구장비 및 환경을 모니터링하고 제어함으로써 연구실험자의 안전성과 편의성을 증대시킬 수 있다. 시약의 정확하고 편리한 기록관리 및 실험과정의 연구이력과 근거, 역추적성 등을 위해서는 실시간 시약 계량 및 등록의 연구지원 자동화 서비스를 제공해야 한다. 현재 기존 시약관리방법은 전산 관리방법을 이용하지만 시약등록과 관리가 일체화된 자동화가 많이 이루어져 있지 않다. 또한 수기에 의한 기록 관리가 대부분으로 실험에 대한 기록오류 및 많은 시약에 대한 계량 및 등록에 대한 소요시간이 큰 점 등 번거로움과 문제점들이 많다. 이에 본 논문에서는 영상인식 및 NFC(Near Field Communication) 방식에 의한 시약 등록과 동시에 전자저울로 계량 측정된 시약정보를 자동으로 관리할 수 있는 IoT 기반 실시간 시약 계량 및 등록 방법을 연구하였다.

• 약학회지
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• 제35권4호
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• pp.288-294
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• 1991

A new fluorescent derivatizing reagent was developed to be used in HPLC for the trace determination of primary and secondary amines. This new reagent, 1-(N,N-dimethylamino)pyrene-6-sulfonyl chloride, was synthesized by the chlorination of sodium 1-(N,N-dimethylamino)pyrene-6-sulfonate which was obtained from 1-(N,N-dimethylamino)pyrene after sulfonation. Ephedrine and norephedrine were derivatized quantitatively by this reagent. The optimum conditions for the derivatization such as pH, reagent concentration, reaction time and reaction temperature ware examined. The structures of derivatives were identified by IR, $^{1}$H-NMR and MS methods. The fluorescence properties and the stability of the derivatives were examined. The derivatives were separated on silica column with an isocratic elution using the mixture of n-hexane and ethylacetate and monitored by fluorescene detector. Linear calibration curves were obtained and detection limits in a 10 $\mu$l injection volume were 5 picomole for ephedrine and norephedrine.

• Bulletin of the Korean Chemical Society
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• 제8권4호
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• pp.313-318
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• 1987

The approximate rate and stoichiometry of the reaction of excess Thexylbromoborane-methyl sulfide, $ThxBHBr{\cdot}SMe_2,$ with selected organic compounds containing representative functional groups under standardized conditions (methylene chloride, $0^{\circ}C)$ were studied in order to characterize the reducing characteristics of the reagent for selective reductions. The selectivity of the reagent was also compared to the selectivity of thexylchloroborane-methyl sulfide. Thexylbromoborane appears to be a much milder and hence more selective reducing agent than thexylchloroborane. The reagent tolerates many organic functionalities. Thus, the reagent shows very little reactivity or no reactivity toward acid chlorides, esters, epoxides, amides, nitro compounds including simple olefins. However, this reagent can reduce aldehydes, ketones, carboxylic acids, nitriles, and sulfoxides. Especially the reagent reduces carboxylic acids including ${\alpha},{\beta}$ -unsaturated ones and nitriles to the corresponding aldehydes. In addition to that, thexylbromoborane shows good stereoselectivity toward cyclic ketones, much better than the chloro-derivative.

• 분석과학
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• 제36권1호
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• pp.1-11
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• 2023

A new, sensitive, and reliable flow injection methodology was investigated for the determination of lead ion (II) in vegetables' samples using a laboratory-prepared reagent 2-[(6-methoxy-2-benzothiazoly)azo]-4-methoxy phenol (6-MBTAMP). Infrared spectroscopy, UV-visible spectrophotometry, Energy dispersive X-ray spectroscopy (EDX), Elemental Analysis (CHN), nuclear magnetic resonance spectroscopy ¹HNMR, and ¹³CNMR techniques were used to characterize the reagent and lead (II) complex. The method is based on lead ion (II) reacting with the reagent (6-MBTAMP) in a neutral solution to produce a green-red complex with a maximum absorbance at 670 nm. The optimum conditions, such as flow rate, lead ion (II) volume, reagent volume, medium pH, reagent concentration, and reaction coil length were thoroughly examined. The limits of detection (LOD) and quantification (LOQ) were determined to be 0.621 mg·L^-1 and 2.069 mg·L^-1 , respectively, while Sandell's sensitivity was determined to be 0.345 ㎍·cm^-2.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2016년도 추계학술대회
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• pp.798-799
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• 2016

기존의 시약장의 경우 시약들을 성상 별로 분류하지 않고 관리하게 되면 위험 상황이 발생할 수 있는 문제점이 있다. 또한 위험 상황 발생 시 외부에서 시약장을 제어할 수 있는 기능이 미비한 실정이다. 본 논문에서는 시약들을 관리하기 위해 성상 별로 분류하고 모바일 디바이스에서 시약장을 관리할 수 있는 시스템을 설계한다. 성상 분류를 통해 제 1류에서 제 6류까지 각 시약들을 분류에 맞게 관리하고 모바일 디바이스에서는 센서 제어, 시약 및 센서 데이터 모니터링, 위험 상황 발생 시 알람 메시지를 전송한다. 이로 인해 성상 분류를 통하여 연구실 내 사고를 줄이고 위험 상황 발생 시 외부에서도 신속한 대처가 가능할 것으로 사료된다.

• 핵의학기술
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• 제28권1호
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• pp.81-87
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• 2024

Purpose: CA 19-9 is the most widely used tumor marker for the diagnosis of digestive system tumor, especially pancreatic and biliary tract cancer. This study was conducted to improve the result value near reference range by comparing the reagents of CA 19-9 one step method and two step method. In addition, it was intended to establish a standard for selecting reagents. Material and Methods: 120 patients who visited the National Cancer Center in 2023 were selected as subjects for this study. The reagents used in the study were CA 19-9 IRMA kits (Shinjin, Korea) and three types of reagents were compared. Two step method reagent that is currently being used (A), one step method reagent (B) and two step method reagent improved by request (C) were compared and regression analysis was performed on their data. And we also performed recovery test, linearity test and hook effect test for each reagent. Result: There were 46 cases of reagent B in which the concentration value was lower than the result measured in reagent A that was previously used, and 77 cases of reagent C. As a result of regression analysis of reagents A, B, and C, the coefficients of determination of reagents A and B, reagents A and C, and reagents B and C were 0.653, 0.577, and 0.875. In the recovery rate test and the linearity test, the results of all reagents were good, and in the hook effect test, reagent B showed a hook effect at a low value. Conclusion: The improved reagent C appears to have been improved based on the concentration value of reagent B, which the manufacturer judged to be more stable at low concentrations. The hook effect in reagent B can be a fatal reason for disqualification when selecting reagents in general patient samples which high-concentration samples appear frequently. The first improved reagent C will be able to be used once it is confirmed that it has more stability for various concentration values.