• Biomolecules & Therapeutics
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• v.23 no.2
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• pp.195-200
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• 2015

We tested the hypothesis that micro-computed tomography (micro-CT) analysis provides a better quantitative readout of the therapeutic potential of methotrexate (MTX) for treating collagen-induced arthritis (CIA) in rats and compared to conventional histopathological examination. Rats were divided into three groups: Group 1 (G1) was treated with 0.9% saline, whereas groups 2 (G2) and 3 (G3) were boosted with type II collagen at days 0 and 7. Following the first collagen immunization, rats in G1 and G2 were treated with 0.9% saline and those in G3 were treated with 1.5 mg/kg MTX from day 14 to 28. All rats were sacrificed on day 28, at which point and all hind knee joints were analyzed by micro-CT and histopathological examination. Micro-CT analyses showed that bone volume and trabecular number were significantly decreased in G2 and G3 compared to G1 (p<0.01), as was percent bone volume (p<0.05 and p<0.01, respectively). However, bone surface/bone volume was significantly increased in G2 and G3 compared to G1 (p<0.05 and p<0.01, respectively). Trabecular separation was significantly increased in G3 compared to G1 (p<0.05). Histopathological examination showed that knee joints of rats in G2 and G3 showed severe joint destruction with inflammatory cell infiltration. However, cartilage destruction was slightly reduced in G3 compared to G2. Taken together, these results suggest that MTX treatment reduced cartilage destruction in rats with CIA, and micro-CT analyses made it possible to quantify arthritic bony lesion.

• Bulletin of the Korean Space Science Society
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• 2011.04a
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• pp.23.4-23.4
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• 2011

MIRIS is the main payload of the Science and Technology Satellite-3 (STSAT-3). which is being developed by KASI for infrared survey observation of the Galactic plane at Paschen alpha wavelength. Wideband filters in I and H band will also be used to observe cosmic infrared background. The MIRIS will perform astronomical observations in the near-infrared wavelengths of 0.9~2 ${\mu}m$ using a 256 ${\times}$ 256 Teledyne PICNIC FPA sensor providing a 3.67 ${\times}$ 3.67 degree field of view with a pixel scale of 51.6 arcsec. The flight model of the MIRIS has been recently developed, The system performance tests have been made in the laboratory, including opto-mechanics test, vibration test, thermal vacuum test and passive cooling test down to 200K, using a thermally controlled vacuum chamber. Several focus tests showed good agreements compared to initial design parameters. Recent efforts are being concentrated to improve the system performances, particularly to reduce readout noise level in electronics. After assembly and integration into the satellite bus, the MIRIS will be launched in 2012.

• Journal of Astronomy and Space Sciences
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• v.27 no.4
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• pp.401-406
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• 2010

We have measured and analyzed the dark data of two PICNIC IR arrays (P574 and P560) obtained through the Cosmic Infrared Background ExpeRiment (CIBER). First, we identified three types of bad pixels: the cold, the hot, and the transient, which are figured in total as 0.06% for P574 and 0.19% for P560. Then, after the bad pixels were masked, we determined the dark noise to be 20.5 ${\pm}$ 0.05 $e^-$ and 16.1 ${\pm}$ 0.05 $e^-$, and the dark current to be 0.6 ${\pm}$ 0.05 $e^-$/sec and 0.7 ${\pm}$ 0.05 $e^-$/sec for P574 and P560, respectively. Finally, we discussed glitches and readout modes for a future mission.

• Journal of Advanced Navigation Technology
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• v.21 no.6
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• pp.651-658
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• 2017

There were many studies on the development of radiation measuring instruments to detect the presence of radiation. In particular, the signal processing method and treatment without loss of the detection signal are very important. The common feature for these studies is the peak-hold method that keeps the peak value of input signal uniform for a short time, readouts its value, discharges electrical value, and then waits for next signal. We propose the new methodology to capture the pulse peak value from the radiation detector and read the value directly other than peak-hold method. This method has merit of accurate reading the input signal pulse peak value without complicate process of holding for a period or initializing of input signal, and then be verified to be adequate through simulation of actual example.

• Journal of The Korean Astronomical Society
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• v.43 no.3
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• pp.75-93
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• 2010

We present the characteristics of the Seoul National University 4k Camera (SNUCAM) and report its performance on the 1.5m telescope at the Maidanak observatory in Uzbekistan. SNUCAM is a CCD camera with a pixel scale of 0.266" in $4096{\times}4096$ format, covering $18.1'{\times}18.1'$ field of view on the 1.5m. The camera is currently equipped with Bessell UBVRI, $H{\alpha}$, SDSS ugriz, and Y-band filters, allowing us to carry out a variety of scientific programs ranging from exoplanet studies to survey of quasars at high redshift. We examine properties of SNUCAM such as the bias level and its temporal variation, the dark current, the readout noise, the gain, the linearity, the fringe patterns, the amplifier bias, and the bad pixels. From our observations, we also constructed the master fringe frames in I-, z-, and Y-band. We outline some of the current scientific programs being carried out with SNUCAM, and demonstrate that SNUCAM on the 1.5m can deliver excellent images that reach to the $5-{\sigma}$ detection limits of R~25.5 mag and z~22.7 mag in 1 hour total integration.

• Journal of the Korean Society of Radiology
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• v.8 no.7
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• pp.429-433
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• 2014

In this study, the morphology and the x-ray quantum efficient of mercury oxide (HgO) and lead oxide (PbO) sensors derived by particle sedimentation method were discussed. In the pursuit of this purpose, we investigated the electrical characteristics and the x-ray quantum efficiency of various thicknesses of HgO and PbO films in mammographic x-ray energy. We have therefore developed a particle-in-binder sedimentation method of fabricating large area polycrystalline films onto transparent glass substrates coated with indium tin oxide. We are currently optimizing the growth method to improve the quantum efficiency with the ultimate goal of obtaining as quantum efficiency close to that of single crystal performance. Our future efforts will concentrate on optimization of large area film growth techniques specifically for deposition on a-Si:H flat panel readout arrays.

• Journal of the Korean Society of Radiology
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• v.8 no.7
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• pp.377-382
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• 2014

Because of using computer system in the field of medical radiology, many artifacts which can not be seen in film/screen system are being created, especially ghosting artifacts. This artifacts could be yielded by taking advantage of a flat panel Thin-Film Transistor array detector. Ghosting artifacts can be rarely seen in clinical practice when an image that has a high-contrast object within a region of high exposure is quickly followed by another image that puts the high-contrast ghosting image in an area of lower radiation exposure. In this experiment, the ghosting artifacts were minimized for approximately 3 minutes with the unaided eye and almost disappeared for 6 minutes quantitatively between exposures. Moreover, the artifacts were influenced by more tube voltage than current and those depended not upon the number of readout cycles, but upon time.

• Journal of the Institute of Electronics and Information Engineers
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• v.53 no.4
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• pp.97-105
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• 2016

Radiography image detector produces digital images by collecting the charges from the incident x-ray photons and converting it to the voltage signals and then the digital signals. The fixed-pattern noise from the nonuinform amplifier gains in the employed multiple readout circuits. In order to correct the nonuniform gains, a gain-correction technique which is based on the gain map is conventionally used. Since the photon noise remains in the designed gain map, the noise contaminates the gain-corrected images. In this paper, experimental observations are conducted for filtering the remained noise in the gain map, and a filter optimization algorithm is proposed to efficiently remove the noise. For acquired x-ray images from detectors, the filtered gain maps are evaluated and it is shown that optimization algorithm can improve the filtering performance even for relatively strong fixed-pattern noises, which cannot be removed by a simple filter.

• Journal of Radiation Protection and Research
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• v.36 no.1
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• pp.35-43
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• 2011

The PHENIX Experiment is the largest of the four experiments that have taken data at the Relativistic Heavy Ion Collider. PHENIX, the Pioneering High Energy Nuclear Interaction eXperiment, is designed specifically to measure direct probes of the collisions such as electrons, muons, and photons. The primary goal of PHENIX is to discover and study a new state of matter called the Quark-Gluon Plasma. Among many particles, muons coming from W-boson decay gives us key information to analyze the spin of proton. Resistive plate chambers are proposed as a suitable solution as a muon trigger because of their fast response and good time resolution, flexibility in signal readout, robustness and the relatively low cost of production. The RPC detectors for upgrade were assembled and their performances were evaluated. The procedure to make the detectors better was optimized and described in detail in this thesis. The code based on ROOT was written and by using this the performance of the detectors made was evaluated, and all of the modules for north muon arm met the criteria and installation at PHENIX completed in November 2009. As RPC detectors that we made showed fast response, capacity of covering wide area with a resonable price and good spatial resolution, this will give the opportunity for applications, such as diagnosis and customs inspection system.

• Progress in Superconductivity
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• v.13 no.1
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• pp.1-6
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• 2011

Measurement of magnetic signals generated from electric activity of myocardium provides useful information for the functional diagnosis of heart diseases. Key technical component of the magnetocardiography (MCG) technology is SQUID. To measure MCG signals with high signal-to-noise ratio, sensitive SQUID magnetic field sensors are needed. Present magnetic field sensors based on Nb SQUIDs have field sensitivity good enough to measure most of MCG signals. However, for accurate measurement of fine signal pattern or detection of local atrial fibrillation signals, we may need higher field sensitivity. In addition to field sensitivity, economic aspect of the SQUID system is also important. To simplify the SQUID readout electronics, the output voltage or flux-to-voltage transfer of SQUID should be large enough so that direct measurement of SQUID output can be done using room-temperature preamplifiers. Double relaxation oscillation SQUID (DROS), having about 10 times larger flux-to-voltage transfers than those of DC-SQUIDs, was shown to be a good choice to make the electronics compact. For effective cancellation of external noise inside a thin economic shielded room, first-order axial gradiometer with high balance, simple structure and long-baseline is needed. We developed a technology to make the axial gradiometer compact using direct bonding of superconductive wires between pickup coil and input coil. Conventional insert has mechanical support to hold the gradiometer array, and the dewar neck has equal diameter with the dewar bottom. Boiling of the liquid He can generate mechanical vibrations in the gradiometer array due to mechanical connection structure. Elimination of the mechanical support, and direct mounting of the gradiometer array into the dewar bottom can reduce the dewar neck diameter, resulting in the reduction of liquid He consumption.