• Korean Journal of Childcare and Education
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• v.13 no.3
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• pp.83-102
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• 2017

Objective: This study investigates the main effects and interaction effects of mother's reactions to young children's negative emotions on the children's problem behaviors. Methods: A total of 346 mothers with toddlers completed questionnaires, the data were analyzed using Pearson's correlation coefficient and multiple regression. Results: First, mothers' supportive response to young children's negative emotions, including expressive encouragement, emotion-focused reactions, and problem-focused reactions, showed negative relations with the children's internal and external problem behaviors. Mothers' unsupportive response to children's negative emotions, including distress reactions, minimization reactions, and punitive reactions, showed positive relations with the children's internal and external problem behaviors. Second, an interactive effect was observed. For external problem behavior, mothers' lower distress reactions accompanied by higher emotion-focused reactions, lower punitive reactions accompanied by higher emotion-focused reactions, lower distress reactions accompanied by higher problem-focused reactions, and lower punitive reactions accompanied by higher problem-focused reactions all decreased children′s problem behavior. However, for internal problem behavior, only mothers' lower distress reactions accompanied by higher emotion-focused reaction decreased children′s problem behavior. Conclusion/Implication: The main interaction effect on mothers' reaction to young children's negative emotional expression shows that preventive intervention is needed to address problem behavior.

• Korean Journal of Clinical Pharmacy
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• v.21 no.2
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• pp.138-144
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• 2011

In order to minimize such adverse drug reactions, governments and international organs have been on the watch for them. Also in South Korea, a system has been established in order that adverse drug reactions may be reported to Korea Food and Drug Administration(KFDA). This study is to analyze drugs to cause adverse reactions, the adverse reactions and patients concerned on the authority of the data of Korea FDA, which is expected to be the preliminary data on preventable adverse reactions. This study was conducted on the 74,037 cases of adverse drug reactions reported to Korea FDA between January 2007 and June 2010. Fentanyl, iopromide and tramadol caused adverse reactions with high frequencies. Oseltamivir showed a high frequency between 2009 and 2010 due to the influence of the new influenza A. Also, OTC drugs accounted for approximately 5% of the adverse reactions. In 2009, adverse drug reactions remarkably increased (2,106 cases; 10.1%) in infants and children due to the new influenza-A(H1N1). The patients aged between 31 and 64 accounted for approximately 55% during the given period. There was no significant intergender difference. In relation to regions, the adverse reactions most frequently occurred in the gastrointestinal system and the integumentary system for three and half years. In addition to anticancer drugs and immunosuppressive drugs that are known to cause adverse reactions frequently, not a few of OTC drugs and external preparations caused such reactions. In particular, the drugs containing specific ingredients caused adverse reactions more frequently than others from 2007 until the first half of 2010. It is advisable for prescribers to acquaint themselves with such adverse reactions and to prescribe drugs other than them. They also have need to sensibly cope with adverse drug reactions just in case they have no substitute drugs. In addition, patients also need to be trained to understand possible adverse reactions in order that they can sensibly accommodate them or choose healthcare services. The results of this study are expected to be helpful to minimize adverse drug reactions.

• Korean Journal of Human Ecology
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• v.16 no.3
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• pp.455-463
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• 2007

The purpose of this study was to compare Korean mothers' and fathers' reactions to their children's negative emotions. The survey with questionnaire was performed with 179 mothers and 179 fathers of children aged three to five-years-old from three child care centers in Seoul and Kyoungki Province. Parental emotion-related practices regarding children's negative emotions were assessed with an adaptation of the CCNES-R(Cortes, 2002), and parental reactions were categorized as problem-focused, emotion-focused, expressive encouragement, emotion-teaching, punitive, parental distress and minimizing. The main results were as follows. First, Korean mothers and fathers, in general, used more positive reactions than negative reactions when their children showed negative emotions, in particular problem-focused reactions were mostly used. In addition, Korean mothers were significantly higher than fathers on problem-focused and emotion-teaching reactions. Second, Korean mothers' and fathers' reactions to their children's negative emotions were significantly different depending on the educational level of mothers, mothers' job and fathers' job. But there was no significant differences in parent's reactions according to children's sex and age. The findings in this study provide implication for an association between parent's reactions to children's negative emotions and parent's socioeconomic background.

• Journal of the Korean Home Economics Association
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• v.44 no.11
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• pp.23-34
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• 2006

The purpose of this study was to examine: (1) how mothers generally react to children's negative emotions; (2) whether there were relationships between children's temperament and mothers' reactions to children's negative emotions; (3) whether there were relationships between mothers' depression and parenting stress, and their reactions to children's negative emotions; (4) whether there were relationships between mothers' reactions to children's negative emotions and children's behavior problems; and (5) whether there were relationships between mothers' reactions to children's negative emotions and children's social competence. The subjects were 246 preschoolers and their mothers. It was found that emotion-focused socialization and problem-focused socialization were the most frequently used reactions by mothers to cope with children's negative emotions. Relationships between children's temperament and mothers' reactions to children's negative emotions, those between mothers' depression and parenting stress and their reactions to children's negative emotions, those between mothers' reactions to children's negative emotions and children's behavior problems, and those between mothers' reactions to children's negative emotions and children's social competency were all partially significant. Sex differences were found in some of the relationships found significant.

• Korean Journal of Clinical Pharmacy
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• v.20 no.2
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• pp.151-158
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• 2010

Therapeutic drug monitoring of Mycophenolate mofetil(MMF) has been suggested in some clinical trials, but has not been widely adopted in Korea. The purpose of this study was to analyze the withdrawal rates of MMF and determine the characteristics of the patients who experienced adverse reactions with MMF therapy and to suggest the criteria for selecting patients who need monitoring of MMF levels. We retrospectively collected data of patients who started MMF between July 2007 and June 2008. A total of 154 adult patients were included in our study. Among them, ninety seven patients discontinued MMF with 59 cases being due to adverse drug reactions. Thirty one patients required dosage reduction of MMF with twenty three cases being due to adverse reactions. Twenty six patients continued the MMF without or with mild adverse reactions. Of the 82 adverse reaction cases, hematologic adverse reactions accounted for 38 cases (46%) and gastrointestinal (GI) adverse reactions accounted for 28 cases (34%). Older age and lower serum albumin levels were significantly different characteristics between the patients who withdraw MMF due to hematological adverse reactions and those who were able to continue therapy. The group who experienced GI adverse reactions had higher MMF dosages based on body weight and lower serum albumin levels. In conclusion, the factors affecting the adverse reactions of MMF were age, serum albumin level and higher dosage, therefore therapeutic drug monitoring of MMF should be considered in these patients.

• Bulletin of the Korean Chemical Society
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• v.12 no.1
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• pp.57-60
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• 1991

Benzosilacyclobutenes were prepared from the reactions of 1,1-dichlorobenzosilacyclobutene with Grignard reagents or t-butyllithium. In the thermal reactions with alcohols, benzosilacyclobutenes underwent both benzyl-silicon and aryl-silicon bond rupture to yield (dialkyl)alkoxy-o-tolylsilanes and (dialkyl)alkoxybenzylsilanes, respectively. The photochemical reactions, however, produced only the former products via o-silaquinone methides.

• Bulletin of the Korean Chemical Society
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• v.6 no.4
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• pp.206-209
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• 1985

The gas phase reactions of the photochemically generated t-butoxy radicals with phosphine ($PH_3$) were studied in the temperature range of $35-80^{\circ}C.$ We found the significant differences between high temperature thermal reactions and low temperature photo reactions. In comparison with the reactions of t-butoxy radicals with other hydrogen donors, some possible mechanistic suggestions were made for the explanation of the results.

• Archives of Pharmacal Research
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• v.16 no.3
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• pp.251-253
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• 1993

Several new coumarinoyl and coumarionyl-1, 2, 4-triazole derivatives were synthesised via dipolar cycloaddition reactions with 3-coumainohydraziodoyl halide. Structure were based on elemental analysis and spectral data.

• Child Studies in Asia-Pacific Contexts
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• v.3 no.2
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• pp.139-158
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• 2013

The present study investigated the direct and interactive effects of children's temperament and mothers' reactions to hypothetical vignettes of children's aggression on 3- to 6-year-old children's overt aggression (OA) and relational aggression (RA). A total of 317 mothers of 3- to 6-year-old children and 26 teachers from eight day-care centers and kindergartens were contacted. Each mother reported her child's background, assessed her child's temperament and responded to the Mothers' Reaction to Hypothetical Vignettes of Children's Aggression (MRCA) scale. Children's OA and RA were assessed by teachers. Results showed that high levels of children's surgency predicted children's OA and RA. Although mothers' reactions did not predict children's OA and RA directly, significant interactions indicated that mothers' restrictive reactions were more strongly related to children's OA for children with high levels of surgency and low levels of effortful control. In addition, mothers' responsive reactions were more strongly related to children's OA for children with low levels of surgency. This study demonstrates that relative contributions of children's temperament and mothers' reactions differ according to the form of children's aggression. It also shows that certain types and levels of mothers' reactions to children's aggressive behavior can be critical for children with certain types and levels of temperament in developing children's overt aggression. The findings of this study can be applied to building early prevention and future intervention programs for young children's aggression.

• Bulletin of the Korean Chemical Society
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• v.27 no.4
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• pp.539-544
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• 2006

Proton transfer reactions and ion-molecule reactions of bifunctional ethanes of $H_2NCH_2CH_2NH_2$, $H_2NCH_2CH_2OH$, and $HOCH_2CH_2OH$ were studied using Fourier transform mass spectrometry (FTMS). The rate constants for proton transfer reactions between the fragment ions and neutral molecules were obtained from the temporal variation of the ion abundances. The rate constants were consistent with the heats of reaction. The fastest proton transfer reactions were the reactions of $CH_2N^+$, $CHO^+$, and $CH_3O^+$ for $H_2NCH_2CH_2NH_2$, $H_2NCH_2CH_2OH$, and $HOCH_2CH_2OH$, respectively. The $[M+13]^+$ ion was formed by the ion-molecule reaction between $H_2C=NH_2 ^+$ or $H_2C=OH^+$ and the neutral molecule. The major product ions generated from the ion-molecule reactions between the protonated molecule and neutral molecule were $[2M+H]^+$, $[M+27]^+$, and $[M+15]^+$.