• Nuclear Medicine and Molecular Imaging
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• v.42 no.sup1
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• pp.46-51
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• 2008

Gastrointestinal stromal tumors (GIST) are the most common mesenchymal neoplasm of the gastrointestinal tract, and can be distinguished from the smooth muscle or neural tumors in approximately 95% of patients by expression of the KIT receptor tyrosine kinase (CD117). GISTs are known to have high malignant potential and none can be labeled definitely as benign. However, GISTs are unresponsive to standard sarcoma chemotherapy, and only complete surgical resection provides chance for cure. Although the imaging modality of choice is enhanced CT scan in patients with GIST, FDG PET can reflect the malignant potential of GIST. Clinical management of patients with GISTs has dramatically changed with the introduction of novel therapeutics, such as imatinib mesylate (Glivec). This has created a need to re-evaluate the existing criteria used to assess treatment response. FDG PET as functional imaging modality proved to be significantly more accurate than CT alone when assessing GIST response to imatinib. And, FDG PET and PET ICT have been found to be highly sensitive in detecting early response, and to be useful in predicting long-term response to imatinib in patients with recurrent or metastatic GISTs.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.37 no.1
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• pp.62-66
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• 2011

Introduction: Endoscope-assisted open reduction and internal fixation (EAORIF) reduces the amount of facial scaring, but limitations, such as the possibility to convert to the open technique and the large learning curve, remain. Materials and Methods: The medical records of 19 patients diagnosed as lateral overridden subcondyle fractures and treated with endoscope-assisted open reduction and internal fixation at Yonsei University Health System from December 2006 to August 2010 were reviewed. Results: 11 patients underwent temporary discomfort or pain such as limitation of mouth opening, temporomandibular joint discomfort, lip paresthesia or facial weakness, but the symptoms disappeared within 3 months. There was no severe long-term complication except 2 patients with re-fractures of operated subcondyles. Conclusion: Subcondyle fracture with lateral overridden proximal segment is a better indication of endoscope-assisted open reduction and internal fixation than a condylar head/neck fracture, or medial overridden subcondyle fracture: allowing an anatomic reduction.

• Proceedings of the KSRS Conference
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• 2007.10a
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• pp.504-507
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• 2007

The KOMPSAT-2 satellite is a push-broom system with MSC (Multi Spectral Camera) which contains a panchromatic band and four multi-spectral bands covering the spectral range from 450nm to 900nm. The PAN band is composed of six CCD array with 2528 pixels. And the MS band has one CCD array with 3792 pixels. Raw imagery generated from a push-broom sensor contains vertical streaks caused by variability in detector response, variability in lens falloff, pixel area, output amplifiers and especially electrical gain and offset. Relative radiometric calibration is necessary to account for the detector-to-detector non-uniformity in this raw imagery. Non-uniformity correction (NUC) is that the process of performing on-board relative correction of gain and offset for each pixel to improve data compressibility and to reduce banding and streaking from aggregation or re-sampling in the imagery. A relative gain and offset are calculated for each detector using scenes from uniform target area such as a large desert, forest, sea. In the NUC of KOMPSAT-2, The NUC table for each pixel are divided as HF NUC (high frequency NUC) and LF NUC (low frequency NUC) to apply to few restricted facts in the operating system ofKOMPSAT-2. This work presents the algorithm and process of NUC table generation and shows the imagery to compare with and without calibration.

• Nuclear Engineering and Technology
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• v.40 no.6
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• pp.517-526
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• 2008

The widespread concern regarding the management of spent fuel that mainly contributes to nuclear waste has led to the development of the sodium-cooled fast reactor (SFR) as one of the most promising future types of reactors at both national and international levels. Various reactor deployment scenarios with SFR introductions with different conversion ratios in the existing PWR-dominant nuclear fleet have been assessed to optimize the SFR deployment strategy to replace PWRs with the view toward a reduction in the level of spent fuel as well as efficient uranium utilization through its reuse in a closed fuel cycle. An efficient reactor deployment strategy with the SFR introduction starting in 2040 has been drawn based on an SFR deployment strategy in which burners are deployed prior to breakeven reactors to reduce the amount of PWR spent fuel substantially at the early deployment stage. The PWR spent fuel disposal is reduced in this way by 98% and the cumulative uranium demand for PWRs to 2100 is projected to be 445 ktU, implying a uranium savings of 115 ktU. The SFR mix ratio in the nuclear fleet near the year 2100 is estimated to be approximately 35-40%. PWRs will remain as a main power reactor type until 2100 and SFRs will support waste minimization and fuel utilization.

• Land and Housing Review
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• v.4 no.1
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• pp.23-31
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• 2013

The regional economic crises in the late 1990s and the global economic crisis in the late 2000s had reduced the differences in housing policies among the major Asian economies. This paper attempts to explain and compare housing welfare policy shifts between subsidizing home owning and subsidized renting from the perspectives of the economic and social roles of housing, the lock-in effect of policy processes, and the welfare provision strategy of the East Asian economies. It argues that the impact of economic crises on housing welfare policy in East Asia depended on the duration and the intensity of the crisis and the length and severity of the subsequent economic depression. Another important factor was the role of housing in the economic and social development, especially whether housing market development was considered as an engine of economic growth or revival, and whether the tools of housing policy caused the economic crisis. The loss of impetus for home ownership drive and the new emphasis on rental subsidy provision are new policy trends. Nonetheless, the economic revival since mid-2009 has caused the re-introduction of home ownership subsidies for quenching the housing affordability problems and enhancing home ownership making use of the strong economic conditions.

• The Journal of the Korea Contents Association
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• v.16 no.12
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• pp.258-266
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• 2016

This study analyzes what contents the general programming channels have been programming since they opened in December, 2011. The findings reveal that their programming tends to center on specific genres such as news, current affairs, variety shows etc., although the general programming channels have programmed diverse contents. This study also shows that the concentrated programming of these genres has been intensified in all the general programming channels as time goes by. The ratio of re-run is shown to be comparatively high, reaching the level of 50%. Thus, it is necessary that they program more diverse genres in order to satisfy the original purpose of the introduction of the general programming channels and to provide the audience with more chances to select programs.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.16 no.4
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• pp.122-131
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• 2017

This study was a drone-utilized case study motivated by that drones can obtain sophisticated video image data previously not feasible. The dilemma zones on selected intersection approaches were identified and locations of drivers' decision making to stop or go at the onset of yellow were determined by analyzing drone video images. The gap between the drivers' decision making location and invisible stop/go border line provided by the yellow time interval was defined as "risky passing zone". To improve the dilemma zone safety problems, re-optimization of yellow time intervals and introduction of new pavement marking that can help drivers decision making on yellow indication are suggested.

• Archives of Pharmacal Research
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• v.19 no.3
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• pp.246-247
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• 1996

In the previous reports (Park et al., 1991, and 1993), we described the synthesis and analgesic effects of various homovanillic amides as analogs of capsaicin. In the study, we tried to enhance the analgesic actvity of capsaicin by structural modification. Our study has been performed in three directions. First, the amide bond of capsaicin was transposed. Second, a phenyl ring was introduced to replace a double bond of capsaicin. Finally, aminoethylation was performed on 4-hydroxy group of capsaicin to improve oral bioavailability. These studies have led to N-(3-phenylpropyl)homovanillic amide 2 which has high analgesic activity. Our continuing efforts in this area have focused on the introduction of various substituents on the phenyl ring of 2 as well as their pharmacological studies. We report herein the synthesis of homovanillic amide derivatives and their analgesic activity.

• YAKHAK HOEJI
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• v.57 no.1
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• pp.43-54
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• 2013

Viral hepatitis is the inflammation of liver cells caused by viruses, and still one of the major health-care problems worldwide. A number of viruses to cause hepatitis are type A, B, C, D, E or G. Among these viruses leading to hepatitis, B and C are more troublesome being more prone to chronic illness which can cause the potentially fatal conditions of hepatocellular carcinoma (HCC) and/or liver failure. If immediate treatment is not initiated, liver transplant is the only option left. Over the past few decades there has been remarkable progress in diagnose and monitor all hepatitis virus infections for treatment and prevention. Nonetheless, important challenges remain to develop more effective and safe vaccines for prevention as well as antiviral agents to reduce viremia/viral load by inhibiting viral replication. The development and evaluation of antiviral agents through carefully designed clinical trials over the last 25 years has heralded a new dawn in the treatment of patients chronically infected with the hepatitis B and C viruses, but not so for the D virus. The introduction of Direct Acting Antivirals (DDAs) for the treatment of HBV carriers has permitted the long term use of these compounds for the continuous suppression of viral replication. This review aims to summarize the current status and development approaches of antiviral drugs for the treatment of viral hepatitis and future perspectives.

• Nuclear Engineering and Technology
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• v.49 no.3
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• pp.621-631
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• 2017

Many developing countries considering the introduction of nuclear power find that large-scale reactor plants in the range of 1,000 MWe to 1,600 MWe are not grid appropriate for their current circumstance. By contrast, small modular reactors are generally too small to make significant contributions toward rapidly growing electricity demand and to date have not been demonstrated. This paper proposes a radically simplified re-design for the nuclear steam cycle for a medium-sized reactor plant in the range of 600 MWe. Historically, balance of plant designs for units of this size have emphasized reliability and efficiency. It will be demonstrated here that advances over the past 50 years in component design, materials, and fabrication techniques allow both of these goals to be met with a less complex design. A disciplined approach to reduce component count will result in substantial benefits in the life cycle cost of the units. Specifically, fabrication, transportation, construction, operations, and maintenance costs and expenses can all see significant reductions. In addition, the design described here can also be expected to significantly reduce both construction duration and operational requirements for maintenance and inspections.