• Nuclear Engineering and Technology
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• 제55권2호
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• pp.669-673
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• 2023

Introduction: The crucial step in preclinical process of radiopharmaceutical production is internal dosimetry evaluation by different ways to realize radiobiological dose-response relationships and to extract the results for clinical use. Till now several bone-seeking radiopharmaceuticals have been developed for bone metastasis. Interesting features of bisphosphonates attracted attentions to them in the field of radiopharmaceutical therapy and studies on new generation of them have been doing too. Materials and methods: In this study, we used ZNA as representative of the third generation. The radiopharmaceutical ¹⁸⁸Re-ZNA was produced and its radiochemical purity was investigated. Then, the biological distribution of the produced radiopharmaceutical at 1, 2, 4 and 24 h after injection on different organs of mice were investigated. Finally, the absorbed dose of organs in the human body was assessed using the RADAR method. Results: The results show 96% radiochemical purity of the ¹⁸⁸Re-ZNA radiopharmaceutical. The amount of %ID/g in bone is 1.131% after 1 h and in 24 h it has a significant amount compared to other organs, that is 0.516%. Also dosimetric results show that the highest absorption dose is related to bone and the amount of this dose is 0.050 mGy/MBq. Conclusion: Considering the possibility of producing the ¹⁸⁸Re-ZNA radiopharmaceutical, as well as the proper distribution of this radiopharmaceutical in target and non-target organs and increasing the absorbed dose in bone, it can be concluded that this radiopharmaceutical can be useful in the "radiopharmaceutical therapy" in metastases.

• 한국통신학회논문지
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• 제34권6B호
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• pp.559-567
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• 2009

본 논문에서는 콘텐츠 재분배 기능을 갖는 CDN (RDCDN)의 구조를 제안하고, 제안된 구조에 대한 특성과 콘텐츠 재분배 알고리즘에 대해 설명한다. 본 논문에서 제안한 방식은 대리시스템의 메모리 공간을 효율적으로 관리하며, 부하조절을 위한 특별한 알고리즘 없이 능동적인 부하조절 기능을 수행할 수 있다. 또한, 주 대리시스템(Main surrogate) 기능을 통해, 각 대리시스템에서 임의적인 콘텐츠 삭제가 일어나는 경우, 발생할 수 있는 신뢰성 저하를 방지할 수 있다. 제안한 방식의 특성을 평가하기 위해, 기존 DCDN과 비교하여 대리시스템의 메모리 사용량, 대리시스템 신뢰성의 우수함을 확인하였으며, 콘텐츠 재분배 비율에 관한 시뮬레이션을 통해 RDCDN의 콘텐츠 재분배 기능의 특성을 파악하였다. 또한, 기존 상업용 CDN 모델과 DCDN의 성능을 비교하여 RDCDN의 성능의 우수성을 분명히 확인하였다.

• The Journal of Advanced Prosthodontics
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• 제8권4호
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• pp.321-328
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• 2016

PURPOSE. This study was designed to investigate the maintenance of teeth and implants in patients with viral liver disease. MATERIALS AND METHODS. 316 patients without any significant systemic disease were selected as a control group. Liver disease group was consisted of 230 patients. Necessary data were collected using clinical records and panoramic radiographs. Then, the patients were subdivided into 2 groups based on the type of active dental therapy received before maintenance period (Pre-Tx). Analysis for finding statistically significant difference was performed based on the need for re-treatment of active dental therapy (Re-Tx) and change in the number of teeth (N-teeth) and implants (N-implants). RESULTS. Comparing to control group, the patients with liver disease showed higher value on N-teeth, N-implants, and Re-Tx. Statistically significant differences were found on N-teeth (P=.000) and Re-Tx (P=.000) in patients with non-surgical Pre-Tx. Analysis based on severity of liver disease showed that N-teeth and Re-Tx were directly related to severity of liver disease regardless of received type of Pre-Tx. Significant differences were found on N-teeth (P=.003) and Re-Tx (P=.044) in patients with non-surgical Pre-Tx. CONCLUSION. In this study, it was concluded that liver disease might influence the loss of teeth and cause the relapse of dental disease during maintenance period in patients. A significant positive relationship between tooth and implant loss and severity of liver disease seems to exist.

• 대한인간공학회지
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• 제24권2호
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• pp.25-33
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• 2005

In order to minimize a biased view of evaluators in usability test, a multiple evaluation method so called Multi-Centered Usability Evaluation Method(MCUEM) was suggested and structured in this study. To use MCUEM, the existing evaluation methods were re-categorized into 'developer and evaluator-centered', 'evaluator-centered', 'user-centered', 'evaluator and user-centered', and the 'developer, evaluator, and user-centered methods. Furthermore, in order to verify the relevance of MCUEM, the usability of mobile phone was tested in this study. In results, it was found that different evaluation methods generated greatly different results, that showed the risk of using a particular usability method due to different perspectives of evaluators. At the same time, it was found that MCUEM could greatly minimize such biases. Therefore, it was concluded that using MCUEM could help the usability engineer design a test protocol with a minimal risk of bias due to different perspective of evaluators.

• 융합보안논문지
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• 제4권2호
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• pp.71-75
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• 2004

The Common Criteria (CC) philosophy is to provide assurance based upon an evaluation of the IT product or system that is to be trusted. Evaluation has been the traditional means of providing assurance. It is essential that not only the customer' srequirements for software functionality should be satisfied but also the security requirements imposed on the software development should be effectively analyzed and implemented in contributing to the security objectives of customer's requirements. Unless suitable requirements are established at the start of the software development process, the re suiting end product, however well engineered, may not meet the objectives of its anticipated consumers. By the security evaluation, customer can sure about the quality of the products or sys tems they will buy and operate. In this paper, we propose a selection guide for If products by show ing relationship between security engineering and security evaluation and make help user and customer select appropriate products or system.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2016년도 춘계 학술논문 발표대회
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• pp.261-262
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• 2016

In Korea, Green building certification system had been operated for more than 10 years and Expired certification buildings are ever-increasing. However, post management of building and qualification standard for re-certification(G-SEED) aren't exist, certificated green building don't have smoothly maintenance and management. Therefore, analysing the status and situation of similar system such as building maintenance and management, to suggest the direction of evaluation for green standard for energy and environmental design.

• Structural Engineering and Mechanics
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• 제27권6호
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• pp.671-682
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• 2007

The probability and the reliability-based seismic performance evaluation procedure proposed in the FEMA-355F was applied to a reinforced concrete moment frame building in this study. For the FEMA procedure, which was originally developed for steel moment frame structures, to be applied to other structural systems, the capacity should be re-defined and the factors reflecting the uncertainties related to capacity and demand need to be determined. To perform the evaluation procedure a prototype building was designed per IBC 2003, and inelastic dynamic analyses were conducted applying site-specific ground motions to determine the parameters for performance evaluation. According to the analysis results, distribution of the determined capacities turned out to be relatively smaller than that of the demands, which showed that the defined capacity was reasonable. It was also shown that the prototype building satisfied the target performance since the determined confidence levels exceeded the objectives for both local and global collapses.

• 산업경영시스템학회지
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• 제20권43호
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• pp.277-285
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• 1997

In this paper, the definition to flexibility is examined through the literature and re-classified to set up an evaluation model. Flexibility is classified into three categories to find the flexibility types for evaluation. The flexibility type called as manufacturing flexibility is defined and a model is developed to make the performance evaluation possible, The manufacturing flexibility has a heavy relationship to the machine flexibility; and 5 flexibility types out of 8 have relationship to the machine flexibility. This indicates that it is possible to have a pretty good evaluation measure if the machine flexibility related types could be evaluated using a model. There are four different inter-arrival times in the model. A big time saving is observed if the processing time is set equal to 72 second. This indicates that a flexibility affects the system a lot if the inter-arrival time is close to the processing time. The model used in this paper includes multi-processes in a production line with machine failure. However, development of realistic models with buffer between processes and some of the flexibility types not included in this model are remained for further research.

• Journal of Nutrition and Health
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• 제46권3호
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• pp.226-238
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• 2013

Omega-3 polyunsaturated fatty acids are essential fatty acids because humans cannot synthesize them de novo and must obtain them in their diet. Fish and fish oil are rich sources of omega-3 fatty acids, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Significant evidence of the beneficial role of dietary intake of omega-3 fatty acids in blood flow has been reported and putative mechanisms for improvement of blood flow include anti-thrombotic effects, lowered blood pressure, improved endothelial function, and anti-atherogenic effects. Edible oils containing omega-3 fatty acids were registered as functional ingredients in the Korea Health Functional Food Code. Although omega-3 fatty acids have been evaluated by the Korea Food and Drug Administration (KFDA) based on scientific evidence, periodic re-evaluation may be needed because emerging data related to omega-3 fatty acids have accumulated. Therefore, in this study, we re-evaluated scientific evidence for the effect of omega-3 fatty acids as a functional ingredient in health functional food on improvement of blood flow. A comprehensive literature search was conducted for collection of relevant human studies using the Medline and Cochrane, KISS, and IBIDS databases for the years 1955-2012. Search keywords were used by combination of terms related to omega-3 fatty acids and blood flow. The search was limited to human studies published in Korean, English, and Japanese. Using the KFDA's evidence based evaluation system for scientific evaluation of health claims, 112 human studies were identified and reviewed in order to evaluate the strength of the evidence supporting a relation between omega-3 fatty acids and blood flow. Among 112 studies, significant effects on improvement of blood flow were reported in 84 studies and the daily intake amount was ranged from 0.1 to 15 g. According to this methodology of systematic review, we concluded that there was possible evidence to support a relation between omega-3 fatty acid intake and blood flow. However, because inconsistent results have recently been reported, future studies should be monitored.

• 한국식품영양과학회지
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• 제43권2호
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• pp.293-299
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• 2014

글루코사민의 관절건강 기능성을 건강기능식품 재평가 기준에 맞추어 체계적 고찰을 실시하였다. 2012년 5월 기준 DB 검색을 통해 703건의 자료를 수집하여, 선정/제외 기준에 따라 선별한 결과 총 34건의 연구가 평가되었다. 34건 중 28건(4,225명)의 연구에서 통계적으로 유의한 개선 효과가 나타났으며(P<0.05), 일일 섭취량은 1.5~2 g으로 공전에서 제시되어 있는 섭취량 범위에 해당하였다. 글루코사민의 기능성 재평가 이후의 연구 결과는 16건이었고, 이 중 1,158명 대상 14건의 연구에서 유의한 관절건강 개선효과를 보였다(P<0.05). 연구대상자에 따른 분석 결과, 방사선 검사 기준에 따라 관절 연골의 손상 정도가 심한 대상자를 제외한 연구는 11건이었으며, 이 중 2,934명 대상 10건의 연구에서 글루코사민이 관절건강에 유의한 개선 효과를 보였다(P<0.05). 따라서 현시점에서 건강기능식품인 글루코사민의 관절건강 기능성은 인정될 것으로 판단되나 향후 연구 결과 추이를 지속적으로 지켜볼 필요가 있다.