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The Relationship between the Serum Cytokine and Clinical Improvement in Major Depressive Disorder (주요 우울증에서 혈중 Cytokine과 임상적 호전과의 관계)

  • Kim, Hyon Chul;Lee, Sang Kyu;Kim, Do Hoon;Son, Bong Ki
    • Korean Journal of Biological Psychiatry
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    • v.10 no.1
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    • pp.70-79
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    • 2003
  • Object : Currently, the alteration of cytokine system has been known to play an important role in regard to depressive symptom. We focused on the relationship between immunological parameters and clinical improvement in major depressive disorder. Method : Data were collected on 26 patients with major depressive disorder using a 8-week prospective follow-up design. After 8-week treatment period with fluoxetine, patients were classified into a response group and a non-response group according to their psychopathological outcome as evaluated by Hamilton Depression Rating Scale. The differences of the immunological parameters between pre-treatment phase and post-treatment phase were compared among patients. The difference of those was also compared within each phase among them. The relationship between socio-demographic variables, depression, cytokine, mononuclear cells was examined by correlation analysis. Multiple regression analyses were performed to explore the predictors of clinical improvement of major depressive disorder. Result : Pre-treatment levels of IL-$1{\beta}$ in the response group were significantly higher than those in the non-response group. Pre-treatment levels of IL-$1{\beta}$ of all patients and in the response group were positively correlated with pre-treatment monocyte counts. Patients with subsequent remission showed significantly lower IL-6 values at baseline than those with non-response. Post-treatment values of IL-6 did not differ significantly among the patients. The correlation test showed more frequent relations among cytokines and mononuclear cells in the response group than in the non-responder group. Especially, serum level of IL-6 in pre-treatment phase was only significantly correlated with HAMD score after 8-week treatement phase, while other cytokines and mononuclear cells were not. Pretreatment level of IL-6 was of paramount importance in predicting clinical improvement of depressive symptom. Conclusion : The immune system of major depressive disorder patients might dichotomize the patients into subsequent responders and non-responders. Immune system might be of great influence on the clinical improvement of major depressive disorder. The mode of interaction between depression and cellular immune function and the mediators responsible for the cytokine production need to be studied further.

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An Innovative Solution for the Power Quality Problems in Induction Motor by Using Silica and Alumina Nano Fillers Mixed Enamel for the Coatings of the Windings

  • Mohanadasse, K.;Sharmeela, C.;Selvaraj, D. Edison
    • Journal of Electrical Engineering and Technology
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    • v.10 no.4
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    • pp.1621-1625
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    • 2015
  • Power quality has always been a concern of power engineers. Certainly an argument can be successfully made that most parts of power engineering have the ultimate objective to improve power quality. AC motors were widely used in industrial and domestic applications. Generally, AC motors were of two types: Induction and Synchronous motors. In motor many parameters like different load cycling, switching, working in hot weather and unbalances creates harmonics which creates major reasons for temperature rise of the motors. Due to high peak value of voltage, harmonics can weaken insulation in cables, windings and capacitors and different electronic components. Higher value of harmonics increase the motor current and decrease the power factor which will reduce the life time of the motor and increase the overall rating of all electrical equipments. Harmonics reduction of all the motors in India will save more power. Coating of windings of the motor with nano fillers will reduce the amount of harmonics in the motor. Based on the previous project works, actions were taken to use the enamel filled with various nano fillers for the coating of the windings of the different AC motors. Ball mill method was used to convert the micro particles of Al2O3, SiO2, TiO2, ZrO2 and ZnO into nano particles. SEM, TEM and XRD were used to augment the particle size of the powder. The synthesized nano powders were mixed with the enamel by using ultrasonic vibrator. Then the enamel mixed with the nano fillers was coated to the windings of the several AC motors. Harmonics were measured in terms of various indices like THD, VHD, CHD and DIN by using Harmonic analyzer. There are many other measures and indices to describe power quality, but none is applicable in all cases and in many instances, these indices may hide more than they show. Sometimes power quality indices were used as a basis of comparison and standardization. The efficiency of the motors was increased by 5 – 10 %. The thermal withstanding capacity of the motor was increased by 5º to 15º C. The harmonics of the motors were reduced by 10 – 50%.

Comparison of work measures for some physician services in Obstetrics & Gynecology (산부인과 의사의 일부 서비스 진료업무량 측정방법 비교에 관한 연구)

  • Hur, Yeong-Joo;Sohn, Myong-Sei;Park, Eun-Cheol;Kang, Hyung-Gon;Kim, Han-Joong
    • Journal of Preventive Medicine and Public Health
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    • v.28 no.3 s.51
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    • pp.623-639
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    • 1995
  • We have never seen any method to cope basically with complicated situation and problems around medical reimbursement rates here in Korea since 1977 witnessed by the beginning of medical insurance. By the way researchers concerned are beginning to propose some kinds of innovative and detailed ideas to government these days. They are Diagnosis-related group(DRG) and Resource-based .elative value scale(RBRVS). In the light of this situation it is so encouraging that our government can come up with that and move. In case of RBRVS research we have already been reaching even to the level of reviewing and revising methodology for its further development after naive pilot study on internal medicine and general surgery last year. However there might be something different conditions between USA and Korea to apply the same Dr. Hsiao's method and it must be vital to check so called' total work approach' compared with 'intra-service work approach' before expanding to the whole medical fields. According to the' Intra-service approach', the physician's work is supposed to be divided into three sub-works by the name of intraservice work, pre, and post service work. These sub-works, again should be merged together to be the pre-postwork subset through some statistical methods of the estimation process applied by Dr. Hsiao's methodology in RBRVS development later on. But in this paper that estimation process was not taken because we could have real values for all of those surveyed items related to just one specialty, OB & GY. Instead, We used some statistical comparison procedures relevant to demographic characteristics, reliability & validity and correlation analysis with American RVU(Relative value unit) between the total work and merged total work from intraservice work approach. The unit of analysis was individual physicians of OB & GY and 300 physicians were selected for each approach through statistical sampling method based on national population of OB & GY physicians in Korea. And also with the thankful help of Advisory Committee under Korean Association of OB & GY, questionnaires were made and mailed to the subjects, two times. As a result there were not any statistically significant differences in demographic characteristics between the two approaches except for the variable 'Response time for the questionnaires', but in other sections of comparisons, response rate, representative values, reliability & validity test, correlation analysis with American RVU, all showed 'Total approach' was not only more rational and statistically meaningful than 'Intra-service approach' but also had considerable merits. But we are not absolutely sure about this paper's robustness. Because of some limitations, we'd rather like to suggest further researches should be followed. In that sense the first thing would be a research for the influence of doctor's characteristics, especially 'frequency' on the rating of work and the way to define total work more clearly.

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Effectiveness Analysis of NCAP(New Car Assessment Program) on Traffic Safety (자동차 안전도평가제도의 정량적 효과분석)

  • Cho, Han-Seon;Shim, Jae-Ick;Sung, Nak-Moon
    • Journal of Korean Society of Transportation
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    • v.26 no.2
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    • pp.7-15
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    • 2008
  • New Car Assessment Program(NCAP) provides consumers with vehicle safety information, primarily front and side crash rating results, and more recently rollover ratings, to aid consumers in their vehicle purchase decisions. NCAP is a system to improve driver and passenger safety by providing market incentives for vehicle manufacturers to voluntarily design their vehicles to better protect drivers and passengers in a crash and be less susceptible to rollover, rather than by regulatory directives. NCAP have been performed since 1999 in Korea by the government in order to reduce fatalities and injuries caused by traffic accidents. Although as the number of vehicles models increases, more vehicle models are required to be test and NCAP is evaluated as a valuable system for vehicle safety, the expansion of the system is slow. It looks like that the benefit of NCAP quantitatively was not verified. In this study, based on the idea that the benefit of the NCAP is defined as the decrease of traffic accident severity by improving vehicle safety, a methodology to analyze the effectiveness of NCAP quantitatively in terms of traffic safety was developed. According to the developed methodology, the reduced numbers of fatalities and injuries were 1.51 and 466 in 2005.

Optimization of Wool Dyeing with Yellow Dye from Carthamus Tinctorius L. (홍화 황색소를 이용한 모염색의 최적화)

  • Shin, Youn-Sook;Son, Kyung-Hee;Yoo, Dong-Il
    • Journal of the Korean Society of Clothing and Textiles
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    • v.33 no.12
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    • pp.1971-1978
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    • 2009
  • This study investigated the adsorption of safflower yellow dye on wool protein fiber and the optimum dyeing conditions to test color reproducibility. In addition, the effects of mordants on dye adsorption, color, fastness, and photofading rate were also studied. The prepared dye in powder form was characterized with UV-vis spectroscopy and FT-IR spectrometric analysis. The color of dyed fabrics was characterized by CIE $L^*a^*b^*$ coordinates, H V/C, and K/S values. The color reproducibility of the dyed wool fabrics was examined. The amount of dye adsorption increased and also, the shade of the dyed wool fabrics became deeper and more saturated with increasing temperature, time, and dye concentration. The maximum color strength was obtained at pH 3.0. The shade of dyed wool fabrics ranged from light yellow to dark mustard yellow as the pH of the dye bath shifted from alkaline to acidic. Color reproducibility was reliable with color differences in the range of 0.53~1.75. Fastness to dry cleaning was relatively good at 4/5 rating irrespective of mordanting. Fe and Cu mordants showed the least color change of the dyed wool fabrics after exposure to light. Mordants did not contribute to improve dye uptake and color fastness, although they made variations in color tone. Safflower yellow dye can be used satisfactorily without mordants and will not cause damage to the environment.

Damage Characteristics of Korean Traditional Textiles by Acetaldehyde (아세트알데하이드에 의한 전통직물의 손상 특성)

  • Kim, Myoung Nam;Lim, Bo A;Lee, Sun Myung
    • Journal of Conservation Science
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    • v.32 no.3
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    • pp.321-331
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    • 2016
  • Textiles damage caused by acetaldehyde($CH_3CHO$) is not clear as compared to other materials. Total 20 specimens were prepared using 4 different materials (silk, cotton, ramie, hemp) after dyed with 4 colors (undyed, red, yellow, blue, black). The specimens were exposed to $CH_3CHO$ gas in the test chamber. First, textile specimens' damage by differert concentration of acetaldehyde(0.1, 0.5, 1, 10, 100, 500, 1000 ppm) was tested. Second, accelerared damage to the textile specimens were tested according to the temperature and humidity conditions at the damage levels. Third, damage of deliberately degraded textile specimens were examined at the damage levels. After the exposure, optical, chemical, and physical evaluation was carried out. As a result, at 1000 ppm/day, the color difference of cotton_yellow has increased. At the condition of $25^{\circ}C-80%$, $30^{\circ}C-50%$, $30^{\circ}C-80%$, the color difference of yellow specimens has increased and grey scale rating has decreased. At $30^{\circ}C-80%$, acetate of cotton_undyed increased and the pH of silk_undyed decreased. In the case of deliberately degraded textile specimens, actetate concentration of black specimens increased. In conclusion, damage to the traditional fabric by acetaldehyde is not impact. However, it is expected that yellow specimens will be bleach and black specimens' actetate concentration will be increase.

A Study on the Influence of the Navigator's Personal Characteristics on the Perceived Collision Risk in Close-quarter Situations (선박 근접상황에서 항해사의 인적특성요인이 지각한 충돌위험도에 미치는 영향에 관한 연구)

  • Kim, Do-Hoon
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.26 no.6
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    • pp.644-655
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    • 2020
  • This study focuses on the margin of human error when a navigator is embarrassed by the psychological fear of collision in a close-quarter situation (CQS) and is unable to perform as per the prescribed collision avoidance measures. The purpose of the study is to identify the effects of the navigator's personal characteristics or factors in relation to on-board career (OC), license rating (LR), and age on the perceived collision risk (PCR) in CQSs. In order to obtain quantified data regarding the collision risk perceived by the navigator in four typical CQSs between their own ship and a target ship, this study measured and collated the heart rate variability of 30 navigators on their own ship when two ships approached each other at a speed of 10 knots from 2.5 nautical miles to a collision situation. According to a multiple regression analysis of the measured values, the navigators' OC and LR factors had negative effects on the PCR, while the age factor had no significant effect on PCR. The t-test results showed that the PCR value was significantly higher for navigators with an OC ≤ 4 years than for those with an OC ≥ 5 years, and the LR factor was significantly higher for a class 4~6 group than for a class 2~3. This finding may be applied to the development of collision risk warning systems, particularly for navigators.

A prediction of the rock mass rating of tunnelling area using artificial neural networks (인공신경망을 이용한 터널구간의 암반분류 예측)

  • Han, Myung-Sik;Yang, In-Jae;Kim, Kwang-Myung
    • Journal of Korean Tunnelling and Underground Space Association
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    • v.4 no.4
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    • pp.277-286
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    • 2002
  • Most of the problems in dealing with the tunnel construction are the uncertainties and complexities of the stress conditions and rock strengths in ahead of the tunnel excavation. The limitations on the investigation technology, inaccessibility of borehole test in mountain area and public hatred also restrict our knowledge on the geologic conditions on the mountainous tunneling area. Nevertheless an extensive and superior geophysical exploration data is possibly acquired deep within the mountain area, with up to the tunnel locations in the case of alternative design or turn-key base projects. An appealing claim in the use of artificial neural networks (ANN) is that they give a more trustworthy results on our data based on identifying relevant input variables such as a little geotechnical information and biological learning principles. In this study, error back-propagation algorithm that is one of the teaching techniques of ANN is applied to presupposition on Rock Mass Ratings (RMR) for unknown tunnel area. In order to verify the applicability of this model, a 4km railway tunnel's field data are verified and used as input parameters for the prediction of RMR, with the learned pattern by error back propagation logics. ANN is one of basic methods in solving the geotechnical uncertainties and helpful in solving the problems with data consistency, but needs some modification on the technical problems and we hope our study to be developed in the future design work.

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Dynamic Model Based Ratio Calculation of Equivalent Reactance and Resistance of the Bulk Power Systems (동적모델을 이용한 대규모 전력계통의 등가 리액턴스와 저항 비율(X/R) 계산)

  • Kook, Kyung-Soo;Rho, Dae-Seok
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.12 no.6
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    • pp.2739-2746
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    • 2011
  • This paper proposes the method for more effectively calculating X/R which is the ratio of equivalent reactance(X) and resistance(R) of the bulk power system and analyses the characteristic of X/R values by applying the proposed method to the real bulk power systems. X/R is used to determine the rating of the relay in the bulk power systems and its value has been accepted to be big enough to ignore the equivalent resistance of the bulk power systems. However, X/R is calculated as a big number when only the upper transformer and transmission line are considered. The correct approach to calculating X/R needs to consider all the parameters including generators, transformers, lines and loads. This paper calculates X/R of the bulk power systems using dynamic models which have been used to analyse the power system stability. The effectiveness of the proposed method is verified by applying it to the test system and X/R values of the real bulk power systems are analyzed. In addition, the dependence of X/R on the closeness of its calculating locations to the generator is verified by using the marginal loss factor which has been used in the electricity market.

A Study on Psychoticism in College Freshmen (정신증적척도에 의한 대학신입생의 정신건강 평가)

  • Kim, Jin-Sung;Lee, Jong-Bum;Cheung, Seung-Douk;Park, Byung-Tak
    • Journal of Yeungnam Medical Science
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    • v.3 no.1
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    • pp.141-148
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    • 1986
  • The authors studied psychotic ism, using Derogatis's SCL-90, in the subjects of 3,499 male and 1,335 female college freshmen of Yeungnam University. The authors collected the reports of Self-Rating Psychoticism Scale during the periods from January to February, 1986, and applied ANOVA and t-test on psychoticism scores in order to compare them between various psychosocial factors, and sexes. The results are as follows : There was significant difference in the mean averages of total psychoticism socres between male and female students: male students scored 4.62+4.01, female students scored 5.03+3.89(P<0.01). Thirteen male students(0.4%) showed high psychoticism scores of 20 or higher, while seven female students(0.5%) showed the same scores. The male students who have maturated in city and the female students whose educational fees were paid by self, showed higher level of psychoticisrn scores(P<0.05). The male and female students who believed protestantism showed higher level of psychoticism scores(respectively P<0.05, P<0.01). There was a strong tendency toward higher psychoticisrn scores in the students who were dissatisfies with their home atmosphere, college, department and familiarity of parents and those who had pessimistic views of self in the past, present or future in both groups(P<0.001).

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