• Title/Summary/Keyword: rate-limiting

Search Result 751, Processing Time 0.028 seconds

Study on Entering Improvement of Acceleration Lane onto an Expressway Using a Traffic Simulation (교통시뮬레이션을 활용한 고속도로 유입연결로 가속차로 진입 개선방안에 관한 연구)

  • Roh, Hee-Chan;Kim, Nak-seok
    • KSCE Journal of Civil and Environmental Engineering Research
    • /
    • v.42 no.3
    • /
    • pp.409-415
    • /
    • 2022
  • The length of the acceleration lane in the area of entrance terminals is calculated based on 13 PS/ton horsepower of a cargo truck in Korea, so it is generally overestimated compared with the capacity of most vehicles traveling on an entrance ramp. Most drivers have, therefore, an indiscreet tendency to enter the main lane in all sections of an acceleration lane, which affects the traffic flow of the main lane. Because of this tendency, measures are required to minimize the impact on traffic flow of the main lane. The operating speed, rate of entrance, and traffic volume for each vehicle were investigated at the entrance terminals of the interchanges (ICs) of Yangji IC, Suseok IC, Yongin IC, and Osan IC, and the level of improvement in traffic flow was analyzed via VISSIM simulation. From the VISSIM simulation analysis, 74.0 % of the total vehicles traveled over the specified speed from the nose point where drivers would be able to recognize the traffic condition of the main carriageway, or the point at which there is a simplification of the curve section. In addition, 88.6 % of the vehicles entered the main carriageway up to 0.8 points compared with the entire length of the acceleration lane. It was subsequently found that an improvement of average speed in the main carriageway and at the entrance ramp can be achieved from 60.1 km/h to 68.5 km/h by intentionally limiting the entrance point onto the main carriageway up to 0.265 points of the entrance ramp.

Relationships of Cocaine and Amphetamine Regulated Transcript with Serotonin in the Brain

  • Park, S. H.;B. S. Kwon;J. R. Chun;J. W. Jahng;Lee, H. T.;K. S. Chung
    • Proceedings of the KSAR Conference
    • /
    • 2001.03a
    • /
    • pp.51-51
    • /
    • 2001
  • Cocaine and amphetamine-regulated transcript (CART) is a satiety factor that is regulated by leptin. It was reported that the mice intracerebroventricularly injected with CART showed behavioral changes resembled with the typical behavioral alterations found in the mice carrying disorders in the brain serotonergic (5-HT) system. Hence, this study was conducted to find out the relationships between CART and 5-HT. We first examined the mRNA levels of CART after the injections of para-chlorophenylalanine (pCPA, 300 mg/kg i.p., single injection or daily for three consecutive days) in the rat brains by in situ hybridization using the mouse CART cDNA probe cloned in our laboratory. Systemic administrations of pCPA, a potent inhibitor of tryptophan hydroxylase, the rate limiting enzyme of 5-HT biosynthesis, acutely depletes the brain 5-HT transporter (5-HTT) in the dorsal raphe nucleus (DRN), which reuptakes terminal 5-HT. Results indicated that the mRNA level of CART significantly decreased in the arcuate nucleus, paraventricular nucleus, and lateral hypothalamic nucleus by three days of daily injection with pCPA with no noticeable change detected 24 hrs after the single injection. The message levels of 5-HTT in DRN decreased in both single and three days of injections. Secondly, to investigate whether CART affect to 5-HT, mouse genomic CART gene, which is consist of 3 exons and 2 introns and mouse neurofilament light (NF-L) chain promoter were cloned. Then, we constructed neuron specific expression vector, which was transfected into HeLa cell using lipid-mediated transfection system. Expression of GFP and CART linked to NF-L-chain promoter in the transfected HeLa cell were detected by using fluorescent microscope and RT-PCR. These results confirmed normal expression of DNA constructs in vitro. Then, to increase brain specific expression of CART in vivo transgenic mice carrying CART gene controlled the deleted NF-L-chain promoter were generated by the DNA microinjection into pronuclei of fertilized embryos. Transgenic mice were detected by Southern blot. Further study is necessary to examine CART expression and 5-HTT in these transgenic mice. Therefore, these results suggest that there maybe a positive molecular correlation between CART and 5-HT in responding to the stimuli.

  • PDF

Analysis and Evaluation of CPC / COLSS Related Test Result During YGN 3 Initial Startup (영광 3호기 초기 시운전 동안 CPC / COLSS 관련시험 결과 분석 및 평가)

  • Chi, S.G.;Yu, S.S.;In, W.K.;Auh, G.S.;Doo, J.Y.;Kim, D.K.
    • Nuclear Engineering and Technology
    • /
    • v.27 no.6
    • /
    • pp.877-887
    • /
    • 1995
  • YGN 3 is the first nuclear power plant to use the Core Protection Calculator (CPC) as the core protection system and the Core Operating Limit Supervisory System (COLSS) as the core monitor-ing system in Korea. The CPC is designed to provide on-line calculations of Departure from Nucleate Boiling Ratio (DNBR) and Local Power Density (LPD) and to initiate reactor trip if the core conditions exceed the DNBR or LPD design limit. The COLSS is designed to assist the operator in implementing the Limiting Conditions for Operation (LCOs) in Technical Specifications for DNBR/Linear Heat Rate (LHR) margin, azimuthal tilt, and axial shape index and to provide alarm when the LCOs are reached. During YGN 3 initial startup testing, extensive CPC/COLSS related tests ore peformed to ver-ify the CPC/COLSS performance and to obtain optimum CPC/COLSS calibration constants at var, -ious core conditions. Most of test results met their specific acceptance criteria. In the case of missing the acceptance criteria, the test results ore analyzed, evaluated, and justified. Through the analysis and evaluation of each of the CPC/COLSS related test results, it can be concluded that the CPC/COLSS are successfully Implemented as designed at YGN 3.

  • PDF

Altitude training as a powerful corrective intervention in correctin insulin resistance

  • Chen, Shu-Man;Kuo, Chia-Hua
    • Korean Journal of Exercise Nutrition
    • /
    • v.16 no.2
    • /
    • pp.65-71
    • /
    • 2012
  • Oxygen is the final acceptor of electron transport from fat and carbohydrate oxidation, which is the rate-limiting factor for cellular ATP production. Under altitude hypoxia condition, energy reliance on anaerobic glycolysis increases to compensate for the shortfall caused by reduced fatty acid oxidation [1]. Therefore, training at altitude is expected to strongly influence the human metabolic system, and has the potential to be designed as a non-pharmacological or recreational intervention regimen for correcting diabetes or related metabolic problems. However, most people cannot accommodate high altitude exposure above 4500 M due to acute mountain sickness (AMS) and insulin resistance corresponding to a increased levels of the stress hormones cortisol and catecholamine [2]. Thus, less stringent conditions were evaluated to determine whether glucose tolerance and insulin sensitivity could be improved by moderate altitude exposure (below 4000 M). In 2003, we and another group in Austria reported that short-term moderate altitude exposure plus endurance-related physical activity significantly improves glucose tolerance (not fasting glucose) in humans [3,4], which is associated with the improvement in the whole-body insulin sensitivity [5]. With daily hiking at an altitude of approximately 4000 M, glucose tolerance can still be improved but fasting glucose was slightly elevated. Individuals vary widely in their response to altitude challenge. In particular, the improvement in glucose tolerance and insulin sensitivity by prolonged altitude hiking activity is not apparent in those individuals with low baseline DHEA-S concentration [6]. In addition, hematopoietic adaptation against altitude hypoxia can also be impaired in individuals with low DHEA-S. In short-lived mammals like rodents, the DHEA-S level is barely detectable since their adrenal cortex does not appear to produce this steroid [7]. In this model, exercise training recovery under prolonged hypoxia exposure (14-15% oxygen, 8 h per day for 6 weeks) can still improve insulin sensitivity, secondary to an effective suppression of adiposity [8]. Genetically obese rats exhibit hyperinsulinemia (sign of insulin resistance) with up-regulated baseline levels of AMP-activated protein kinase and AS160 phosphorylation in skeletal muscle compared to lean rats. After prolonged hypoxia training, this abnormality can be reversed concomitant with an approximately 50% increase in GLUT4 protein expression. Additionally, prolonged moderate hypoxia training results in decreased diffusion distance of muscle fiber (reduced cross-sectional area) without affecting muscle weight. In humans, moderate hypoxia increases postprandial blood distribution towards skeletal muscle during a training recovery. This physiological response plays a role in the redistribution of fuel storage among important energy storage sites and may explain its potent effect on changing body composition. Conclusion: Prolonged moderate altitude hypoxia (rangingfrom 1700 to 2400 M), but not acute high attitude hypoxia (above 4000 M), can effectively improve insulin sensitivity and glucose tolerance for humans and antagonizes the obese phenotype in animals with a genetic defect. In humans, the magnitude of the improvementvaries widely and correlates with baseline plasma DHEA-S levels. Compared to training at sea-level, training at altitude effectively decreases fat mass in parallel with increased muscle mass. This change may be associated with increased perfusion of insulin and fuel towards skeletal muscle that favors muscle competing postprandial fuel in circulation against adipose tissues.

Effects of the Daylight Disturbance on the Growth and Yield of Spray Chrysanthemum 'Yellow Cap' and 'Peach PangPang' (일조방해가 스프레이 국화 '옐로우캡'과 '피치팡팡'의 생육 및 수량에 미치는 영향)

  • Yuri Lee;Sang Kun Park
    • Journal of Practical Agriculture & Fisheries Research
    • /
    • v.25 no.4
    • /
    • pp.78-83
    • /
    • 2024
  • This study was carried out to analyze the effect of changes in the light environment caused by the daylight disturbance on the growth, flowering, and cut flower quality of spray chrysanthemums. The spray chrysanthemum 'Yellow Cap' and 'Pitch PangPang' cultivars for cut flowers were artificially shaded to interfere with 66% of sunlight compared to the non-shading, and then the growing and flowering characteristics, and cut flower yield were investigated accordingly. There was no significant difference in the cut flower yield per unit area between the shading and the non-shading treatments. However, the number of days to flowering was 72.1 days for the 'Yellow Cap' and 65.2 days for the 'Pitch PangPang', which were delayed by 14.1 and 8.9 days, respectively, compared to the non-shading light. In the shading treatment, the flower diameter and the number of flowers also decreased by 10% and 15%, and 30% and 28% for both 'Yellow Cap' and 'Pitch PangPang', respectively. The stem length also decreased by 10% and 20%, the stem diameter by 23% and 37%, and fresh weight by 32% and 33%, respectively. The shading treatment delayed the flowering of chrysanthemums and reduced the growth such as flower diameter, number of flowers, and the length and weight of cut flowers. Based on these results, the daylight disturbance by artificial buildings is expected to reduce the productivity and quality of cut flowers by limiting the light intensity needed for chrysanthemum growth, flower bud differentiation, and flower development. Therefore, further research is needed on the rate of decrease in yield and market value according to the degree of shading to relieve damage to chrysanthemum growers caused by the daylight disturbance.

Responses of Root Growth Characters to Waterlogging in Soybean [Glycine max (L.) Merrill] (과습에 따른 콩 지하부 생육반응)

  • Lee, Jae-Eun;Kim, Hong-Sig;Kwon, Young-Up;Jung, Gun-Ho;Lee, Chun-Ki;Yun, Hong-Tai;Kim, Chung-Kon
    • KOREAN JOURNAL OF CROP SCIENCE
    • /
    • v.55 no.1
    • /
    • pp.1-7
    • /
    • 2010
  • Stress from excess water is one of the most harmful limiting factor in soybean yield during the wet season under the climate conditions. Soybean is very sensitive to excess water compare to other crops. This experiment was carried out to identify the growth responses for establishing a screening system related to waterlogging tolerance in soybean from 2003 to 2004. The root dry weight accumulation rate of per day for 21 days after waterlogging at V5 stage was the highest in Pungsannamulkong (47~56% of control) and was the lowest in Jangyeobkong (26~27% of control). The nodules dry weight recovery rate was the highest in Pungsannamulkong (83~91% of control), while the lowest in Myungjunamulkong (48~66% of control). After waterlogging, recovery rate of roots was high, which increased the root/shoot ratio of Pungsannamulkong, which also produced significantly more adventitious roots than in Jangyeobkong. The percentage of adventitious roots fresh weight to the total roots fresh weight was the lowest in Myungjunamulkong (14%), while the highest in Pungsannamulkong (38%). This results implies that the water and nutrients absorbing ability of Pungsannamulkong is more higher than that of Myungjunamulkong during late growth period.

Effect of Sowing Date and Plastic Film Mulching on Mositure and Temperature of Rhizosphere Soil and Early Growth of Sesame (참깨의 파종기별(播種期別) 플라스틱필름 피복이 근권토양수분(根圈土壤水分) 및 지온(地溫)에 미치는 영향(影響)과 그에 따른 초기생육(初期生育)의 변화(變化))

  • Oh, Dong-Shig;Kwon, Yong-Woong;Im, Jung-Nam;Um, Ki-Tae
    • Korean Journal of Soil Science and Fertilizer
    • /
    • v.27 no.2
    • /
    • pp.125-135
    • /
    • 1994
  • Field experiment was carried out in order to clarify effects of plastic film mulching on temperature and moisture of rhizosphere soil and their subsequent effects on seedling emergence, earlier growth, vegetative growth and grain yield of sesame. The textural class of the experimental field soil was the sandy loam(Bonyang series) and the variety of sesame planted was "Ansan-ggae". The experiment was conducted by combining four sowing dates of April 25, May 10, May 25, June 10 and two mulching treatments(mulching, non-mulching) over two year of 1991 and 1992. The results were summarized as follows : 1. The daily mean soil temperature of 5cm deep soil was increased by 1.4 to $2.8^{\circ}C$ by plastic film mulching. The average soil water content was increased by 0.5 to 3.0%(V/V) in the drier season, while decreased by 1.0 to 2.0%(V/V) in the rainy season by mulching. 2. The establishment rate of sesame seedling was very sensitive to soil temperature. For normal seedling emergence, from the seeding date to the 7th date after sowing, the daily mean soil temperature higher than $21.0^{\circ}C$ was required at the experimental field conditions. 3. The average soil water content in the range of 14.0 to 21.0%(V/V) at 5cm deep soil seemed not to be limiting for the germination and emergence of sesame. The effect of soil water content on seedling establishment was very small in this range, but the optimum level of soil water content ranged from 14.0 to 15.0%(V/V) in the experimented sandy loam. 4. The wetter the soil profile was, the larger the gap of soil temperature between the mulched and non-mulched condition was. The effect of mulching on the establishment rate of sesame seedlings was much greater in the lower air temperature conditions. However, when the sowing of sesame came earlier than at the date with the daily mean air temperature below $19.0^{\circ}C$, the effects of earlier sowing and mulching were offsetted by the retarded seedling growth due to the low air temperature, and thus earlier sowing with mulching did not enhance the grain yield of sesame.

  • PDF

Development and Evaluation of the Supplementary Foods for Korean Infants and Children (지역 식품을 이용한 이유 보충식의 개발과 이의 영양학적 검토 및 저장성에 관한 연구)

  • Ahn, Kyung-Mi;Moon, Soo-Jae;Choi, Hong-Sik;Kwak, Tong-Kyung
    • Journal of Nutrition and Health
    • /
    • v.18 no.4
    • /
    • pp.259-271
    • /
    • 1985
  • The purpose of this study was to develop supplementary foods for infants and young children in order to improve their nutritional status. Three formulas composed of rice, soybeans, fish, dry skim milk and sesame in varying proportions were studied. The three formulas, $RS_{1}S_{2}$, $RFS_{1}S_{2}$, and $RMS_{1}S_{2}$, were consisted of Rice(R), Soybean$(S_{1})$, Sesame$(S_{2})$ (60 : 35 : 5) , Rice, Fish(F), Soybean, Sesame (60 : 10 : 25 : 5) , and Rice, Dry Skin Milk (M), Soybean, Sesame (60 : 10 : 25 : 5), respectively. A proximate analysis and amino acid determination were made on the developed formulas. In the animal assay, growth rate, PER and FER were evaluated and biochemical analyses were also carried out. A storage test and the cost evaluation were also conducted. The summarized results are as follows : 1) The proximate composition of the three formulas were 7.3-7.4% of moisture, 15.9-21.5% of crude protein, 7.8-9.6% of crude fat and 2.5-2.8% ash. 2) The result of amino acid analysis showed that the 1st limiting amino acids of $RS_{1}S_{2}$ and $RFS_{1}S_{2}$ were lysine (amino acid score, 76.6) and threonine (amino acid score, 93.3), and that of $RMS_{1}S_{2}$ and the commercially prepared formula were sulfur containing amino acids (amino acid score, 82.0 and 54.4). When the contents of the amino acids of the three formulas were compared with mother's milk and cow's milk, the balance of the amino acid of each formula was superior to mother's milk but inferior to cow's milk. 3) In the animal assay, the growth rate of all groups increased gradually during the experimental period. 4) The C- PER, which was corrected on the basis of the casein PER of 2.5 was 2.99, 3.38 and 3.10 in the $RS_{1}S_{2}$, $RFS_{1}S_{2}$ and $RMS_{1}S_{2}$ respectively. The C- PER of $RFS_{1}S_{2}$ and $RMS_{1}S_{2}$ were Significantly (P<.05) higher than that of the casein. 5) The FER of the casein, $RS_{1}S_{2}$, $RFS_{1}S_{2}$, and $RMS_{1}S_{2}$ were 0.37, 0.39, 0.43 and 0.39, respectively. The FER of $RFS_{1}S_{2}$ and $RMS_{1}S_{2}$ were also significantly (P<.05) higher than that of the casein. 6) The concentrations of hematocrit, hemoglobin, total protein and albumin in the serum of the rats of all groups were not significantly different among groups. 7) The storage stability test showed that the total plate count (TPC), the coliforms count and the bacterial spore count in the ingredients were quiet low. However, after 30 and 60 days storage, the count in $RFS_{1}S_{2}$ increased and were higher at room temperature than refrigerated temperature. 8) In the cost evaluation, the cost of the developed formulas was \1,826-2,626 / kg. This was less than that of the commercially prepared formula (\3,300-4,073 / kg) and that of the imported formula (\4,250-8,720 / kg).

  • PDF

The study on increasing of biodegradability by pre-treatment of municipal wasted sludge in anaerobic digestion process (도시하수슬러지의 전처리에 따른 혐기성 소화공정의 생분해율 향상에 관한 연구)

  • Kang, Chang-Min
    • Journal of the Korea Organic Resources Recycling Association
    • /
    • v.10 no.1
    • /
    • pp.87-95
    • /
    • 2002
  • The slow degradation rate of sludge in anaerobic digestion is due to rate-limiting step of sludge hydrolysis. To upgrading of sludge hydrolysis and biodegradabiliry, the pre-treatment had been carried out using acidlc (pH 1.5, 3, 4, 5) and alkaline (pH 9, 10, 13), thermal (50, 100, 150, $200^{\circ}C$), and ultrasonic treatment (400W, 20kHz, 15, 20, 25, 30, 40, 50, 60, 90min). In the best conditions of each treatment, the Soluble SCOD Ratio(%)of treated/untreated sample were increased 102% in acid (pH5), 986% in alkali (pH 13), 595% in thermal ($200^{\circ}C$) and 1123% in ultrasonic (35min) treatment. As the result, the ultrasonic treatment was most effective, followed by alkali, thermal, acid treatment. In the effects of total gas productivity in vial test, the thermal ($200^{\circ}C$) pre-treatment was the highest, followed by thermal ($150^{\circ}C$), ultrasonic (90min), alkaline (pH 9), and ultrasonic (50min). We compared untreated samples and the most efficient pre-treatment samples(at $200^{\circ}C$, for 30min) on gas productivity with changes of HRT in continuous experiments IN thermal treated samples were 2.5 times in SCOD, 2 times in soluble protein and 3.3 times high in soluble carbohydrate than untreated ones. In gas productivity, the thermal treated samples were average 2 times high than untreated ones. And HRT 7 days was most effective. followed by HRT 10, HRT 15 days. But The gas productiviry of HRT 2.5 days was less than untreated, the reason of low gas productivity was come from high organic acids accumulation within reactor.

  • PDF

Effects of Gamma-Irradiation on the Sterilization of Primordial Germ Cells in Quail (메추리 원시생식세포 감소를 위한 감마선 조사의 효과)

  • Park, Kyung-Je;Kim, Tae-Min;Lee, Hyung-Chul;Jang, Hyun-Jun;Song, Gwon-Hwa;Han, Jae-Yong
    • Korean Journal of Poultry Science
    • /
    • v.37 no.2
    • /
    • pp.139-143
    • /
    • 2010
  • Quail is a very useful animal model for studying vertebrate development because of its small body size and unique reproductive traits. This species is also ideal model for producing germline chimeras via transferring exogenous primordial germ cells (PGCs) into the recipient embryo. To increase the contribution efficiency of donor PGCs into recipients' tissues, decreasing the population of endogenous PGCs has been rate-limiting factor. We therefore conducted this study to investigate if gamma ($\gamma$)-irradiation depletes endogenous PGCs in developing quail embryo. Firstly, freshly laid stage X quail embryos were irradiated with various output of $\gamma$-irradiation and its teratogenic effect on the embryo was evaluated. Although a dose-dependent increase in the number of embryo showing malformation was found as the output increased (0, 250, 500, 750, and 1,000 rads), only a maximum of 10.1% of embryos were abnormal in 1,000 rads. Immunocytochemical analysis using the QCR1 antibody, which is specific marker for quail PGCs, was conducted to analyze the effect of sterilization. As results, $\gamma$-rays at a dose-rate of 500 rads/73 sec onto undeveloped stage X embryo significantly reduced the number of germ cells to an average of 75.55 % and 82.03 % in male and female embryos, respectively. We conclude that $\gamma$-ray selectively targets PGCs while affects minimally to the somatic development in quail embryo. Our results will not only provide important data for germline chimera production but can be used for analyzing the effect of ionized rays on the differentiating germ cells in various stages during animal development.