• Tuberculosis and Respiratory Diseases
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• 제82권1호
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• pp.1-5
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• 2019

Quitting smoking helps smokers maintain their health and extend their lifespan by 10 or more years. Treatment strategies for smoking cessation should be tailored to individual smokers with special needs based on their specific circumstances. It is recommended that pregnant women adopt smoking cessation through counseling and behavioral interventions because the safety of medications has yet to be established. Counseling is the main strategy for smoking cessation in adolescents and nicotine replacement therapy can be used with caution in individuals with serious nicotine dependence. It is important for smokers with psychiatric diseases to quit smoking following accurate assessment of their depression status. Nicotine replacement therapy, varenicline, and bupropion can be used for smoking cessation in smokers with psychiatric disorders. The incidence of cardiovascular disease decreased according to the smoking status and the duration of smoking cessation. In smokers with chronic obstructive pulmonary disease (COPD) who used a combination of counseling and pharmacotherapy the quitting rate was more than twice as high as subjects who used behavioral interventions alone. Varenicline can be used as the most effective anti-smoking drug by most smokers including those with psychiatric disorders, cardiovascular disease, and COPD.

• 한국식품조리과학회지
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• 제32권2호
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• pp.204-210
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• 2016

Purpose: This study analyzed and compared the physico-chemical and affective properties between mackerels cooked by an electric pan and under superheated steam. Methods: Mackerel were cooked by an electric pan ($95^{\circ}C$) for 10 min and mackerel cooked under superheated steam ($250^{\circ}C$) for 5 min to be internal temperatures of $75{\pm}5^{\circ}C$ and tests to measure proximate composition, color values, texture profiles, microorganism counts and sensory acceptance were performed. Results: The moisture contents were 60.30% and 73.81% in mackerels cooked by electric pan and under superheated steam, respectively. The rate of weight loss in mackerel cooked by electric pan was 39%, whereas it was 29% in mackerel cooked under superheated steam. Mackerel cooked under superheated steam exhibited more yellowness, higher springiness, cohesiveness, gumminess, chewiness, and resilience with more acceptable preferences (appearance, odor, taste, and texture) compared to the mackerel cooked by electric pan. Conclusion: The application of superheated steam technology to fish products could reduce the cooking time and nutritional loss. Also, it could produce highly preferred fish products compared to that prepared by conventional electric pan.

• IEIE Transactions on Smart Processing and Computing
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• 제6권2호
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• pp.133-139
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• 2017

Vehicles have increasingly evolved and become intelligent with convergence of information and communications technologies (ICT). Vehicle communications (VC) has become one of the major necessities for intelligent vehicles. However, VC suffers from serious security problems that hinder its commercialization. Hence, the IEEE 1609 Wireless Access Vehicular Environment (WAVE) protocol defines a security service for VC. This service includes Advanced Encryption Standard-Counter with CBC-MAC (AES-CCM) for data encryption in VC. A high-speed AES-CCM crypto module is necessary, because VC requires a fast communication rate between vehicles. In this study, we propose and implement an efficient AES-CCM hardware architecture for high-speed VC. First, we propose a 32-bit substitution table (S_Box) to reduce the AES module latency. Second, we employ key box register files to save key expansion results. Third, we save the input and processed data to internal register files for secure encryption and to secure data from external attacks. Finally, we design a parallel architecture for both cipher block chaining message authentication code (CBC-MAC) and the counter module in AES-CCM to improve performance. For implementation of the field programmable gate array (FPGA) hardware, we use a Xilinx Virtex-5 FPGA chip. The entire operation of the AES-CCM module is validated by timing simulations in Xilinx ISE at a speed of 166.2 MHz.

• 한국건축시공학회지
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• 제16권6호
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• pp.571-578
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• 2016

본 연구에서는 갯벌의 콘크리트용 혼화재 및 채움재로써의 활용 가능성에 대한 기초적 연구를 실시하였다. 먼저, 혼화재로서의 활용 가능성에 대해 화학 성분 분석을 실시한 결과 잠재수경성 및 포졸란 반응에 필요한 성분들이 함유되어있었지만 플라이애시 및 고로슬래그의 성분 분석 결과와 비교한 결과 성분 함유량이 소량으로 반응을 하기에는 부족한 양이었다. 또한, 물리적 실험 분석 결과 갯벌 치환율이 증가할수록 압축강도 및 인장강도가 감소하는 것으로 나타났다. 따라서 갯벌의 혼화재로서의 활용 가능성은 화학 성분분석에서 예상한 결과와 마찬가지로 낮은 것으로 나타났다. 채움재로서의 활용 가능성에 대한 시험을 실시한 결과 재령 28일 압축강도를 측정한 결과 갯벌의 채움재로서 활용가능성에 대한 분석을 통해 갯벌 치환율 10~30% 까지 벽돌의 압축강도 기준인 8MPa 이상의 강도를 발현하여 벽돌 등 2차 제품에 활용 가능할 것으로 판단되며, 향후 벽돌제작 등의 추가적인 실험이 필요할 것으로 판단된다. 플로우 시험결과에서는 갯벌 치환율이 증가할수록 플로우 값이 감소하는 것으로 나타났으며, 염화물 함유량 분석 결과를 통해 갯벌 자체의 염분 함유량이 많아 갯벌을 치환할 경우 철근 사용구조물에는 적용하기에는 부적합한 것으로 판단되며, 내장벽돌 등 철근을 사용하지 않는 제품에 활용이 가능할 것으로 판단된다.

• 대한핵의학회지
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• 제24권2호
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• pp.274-278
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• 1990

Metastases to the liver presents a common clinical problem in the management of patients with cole-rectal cancer, and are responsible for a high degree of morbidity and mortality associated with this malignancy. Unfortunately, attempts at preventing the development of liver metastases in "high risk" patients has so far been unsuccessful. Ongoing studies of adjuvant chemotherapy have not yet illustrated a significant increase in survival in patients receiving such therapy. The purpose of the study is to investigate the value of adjuvant radiotherapy given in the form of colloidal chromic phosphate P-32 suspension administered via portal vein after radical resection of the primary cancer, in preventing the growth of occult metastases in the liver. Twenty one patients (10 patients of treated group with 11 controls) were followed 18 months after operation. There was no significant change in the CBC and liver functions after administration of P-32 labeled colloidal chromic phosphate. The number of patients who showed local metastases at 18 months were 2 in the treated group and 3 in the control group. While liver metastases occurred in one patient at 6 months and in three at 12 months in the control group, there was no development of liver metastases by 12 months in the treated group. At 18 month follow-up CT scan one patient in the treated group showed a single nodule in the liver. In conclusion liver metastasis rate was lower in the patients who received colloidal P-32 chromic phosphate via portal vein after radical resection of the primary cole-rectal cancer.

• Journal of Ginseng Research
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• 제43권2호
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• pp.312-318
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• 2019

Background: To date, no study has described disease progression in Asian patients infected with HIV-1 subtype D. Methods: To determine whether the disease progression differs in patients infected with subtypes D and B prior to starting combination antiretroviral therapy, the annual decline (AD) in $CD^{4+}$ T cell counts over $96{\pm}59months$ was retrospectively analyzed in 163 patients and compared in subtypes D and B based on the nef gene. Results: $CD^{4+}$ T cell AD was significantly higher in the six subtype D-infected patients than in the 157 subtype B-infected patients irrespective of Korean Red Ginseng (KRG) treatment (p < 0.001). Of these, two subtype D-infected patients and 116 subtype B-infected patients had taken KRG. AD was significantly lower in patient in the KRG-treated group than in those in the $KRG-na{\ddot{i}}ve$ group irrespective of subtype (p < 0.05). To control for the effect of KRG, patients not treated with KRG were analyzed, with AD found to be significantly greater in subtype D-infected patients than in subtype B-infected patients (p < 0.01). KRG treatment had a greater effect on AD in subtype D-infected patients than in subtype B-infected patients (4.5-fold vs. 1.6-fold). Mortality rates were significantly higher in both the 45 $KRG-na{\ddot{i}}ve$ (p < 0.001) and all 163 (p < 0.01) patients infected with subtype D than subtype B. Conclusion: Subtype D infection is associated with a >2-fold higher risk of death and a 2.9-fold greater rate of progression than subtype B, regardless of KRG treatment.

• 대한예방한의학회지
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• 제13권3호
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• pp.29-41
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• 2009

Objectives : This study was performed to compare consciousness of doctors on cooperative practices of western medicine and traditional Korean medicine, and to provide policy implication for development of cooperative practices. Methods : The structured questionnaires were mailed to 132 doctors working in non-cooperative practicing university hospital and 77 doctors working in cooperative practicing hospitals in Busan metropolitan city. The response rate was 40.2% and 40.3% respectively. This survey was performed from 10 Oct. 2008 to 31 Oct. 2008. Results : The doctors working in general hospital had comparatively negative consciousness on basic concept, value and necessity for cooperative practices and traditional Korean medicine. In regards with disease treatment's effectiveness of cooperative practices, both groups evaluated musculoskeletal and immune disease were more effective than others. There were positive relationships between perception for cost-effectiveness and consciousness on intention to participate cooperative practices(p<0.05). Also doctors who experienced traditional medicine treatment had positive consciousness on cooperative practices(p=0.05). Conclusions : To activate cooperative practices of western medicine and traditional Korean medicine, some efforts should be carried out. These include promoting cooperative education programs in medical schools and traditional Korean medical schools, doing research on cost-effectiveness of cooperative practices, and trying to minimize legal and systemic restrictions for cooperative practices.

• 수산경영론집
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• 제52권2호
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• pp.1-31
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• 2021

This study is to evaluate the prior economic feasibility of the off-shore fisheries stock enhancement project. The main findings of this study can be summarized as follows: first, offshore fisheries stock enhancement project shall be implemented by dividing them into 1st·2nd·3rd projects for efficient promotion. The 1st·2nd·3rd projects will be conducted in a total of 50 locations (the eastern sea, the western sea, the southern sea, and the jeju sea areas), and the project period per unit will be five years, which will cost 1 trillion won. Second, according to the results of the survey on public awareness, the most consumed marine species in Korea over the past year were analyzed in the order of mackerel, hairtail, squid, yellow corvina, blue crab, and cod. The dominant response to the reason for consuming marine products in Korea was healthy well-being food and safe food. In addition, 67.9% of them have hesitated to purchase offshore fish species over the past year due to high prices, indicating that they are burdened by high prices. On the other hand, 79% of the respondents said that the government's policy was insufficient, according to a survey on whether the government's coastal marine resource creation policy was sufficient. Third, as a result of preliminary economic analysis of offshore fisheries stock enhancement project, the benefit-cost ratio is 4.01, net present price is 1,283.7 billion won, and internal rate of return is 91.7% per year, which means that the economic analysis ensures the feasibility of the projects. The results of this study provide useful information on securing or organizing budgets for offshore fisheries stock enhancement project by securing economic feasibility as a national infrastructure project that increases fishery income and public benefits such as consumption of marine products.

• 약학회지
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• 제42권5호
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• pp.473-479
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• 1998

Lovastatin (LOVA), a fungal metabolite isolated from cultures of Aspergillus terreus, is a competitive HMG-CoA reductase inhibitor used for the treatment of primary hyper cholesterolemia, and has also been shown to suppress growth in a variety of non-glioma tumor cell lines. A sensitive reversed-phase high-perfonnance liquid chromatographic method with ultraviolet (UV) absorbance detection has been developed to quantitate LOVA in human plasma and urine samples using liquid-liquid extraction procedure. Baseline separation of LOVA and internal standard, simvastatin was achieved on a Novapak $C_{18}$ analytical column with a mobile phase containing 0.025M $NaH_2PO_4$: CAN (35:65, v/v%), adjusted pH to 4.5. The flow rate was set at 1.5ml/min, and the column effluent was monitored by a UV detection at 238nm. The limit of quantification was determined to be 0.5${\mu}$g/ml while extraction efficiency of LOVA ranged from 73.4-82.9% at LOVA concentrations of 0.5 to 10${\mu}$g/ml. Good linearity with correlation coefficients greater than 0.999 was obtained in the range of LOVA concentrations from 0.5 to 10${\mu}$g/ml. The accuracy and the precision were proven excellent with relative standard deviation (RSD, %) and relative error (RE, %) of less than 4.2 and 4.0, respectively. Intraday precision, evaluated at five LOVA concentrations (0.5, 1, 2, 5, 10${\mu}$g/ml) and expressed as RSD ranged from 0-1.82% while the interday precision at the same concentrations ranged from 0.7-10.5%. The analytical method described was then successfully employed for the determination of LOVA concentrations in plasma samples obtained during a phase II clinical trial using high doses of LOVA (30-40mg/kg/day). This method could be further utilized for the ongoing pharmacolkinetic studies and therapeutic drug monitoring of the high-dose LOVA therapy in adenocarcinoma patients.

• 환경생물
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• 제22권4호
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• pp.507-512
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• 2004

This study was focused on the risk assessment of whether radiofrequency electromagnetic fields generated by mobile phone is cytogenetically toxic or not. We conducted the effects of 835-MHz electromagnetic field (EMF) on DNA strand breaks in mouse thymic lymphoma L5178Y $Tk^{+/1-}$ cells using alkaline comet assay. EMF frequency 835-MHz we chosen is one of the most popular communication frequency bands in Korean code-division multiple-access (CDMA) mobile phone system. The cells were exposed to 835-MHz EMF alone or 835-MHz EMF combined with cyclophosamide(CPA) or 4-nitroquinoline-1-oxide (4NQO) at specific absorption rate (SAR) of 4.0 W $kg^{-l}$ for 24 and 48hrs. DNA damage expressed as tail moment was increased more than two-fold after exposure to 835-MHz EMF for 24 and 48hr. In particular, CPA for 48hr and 4NQO for 24 hr enhanced notably the tail moment to 9-fold and 16-fold in the presence of 835-MHz EMF, respectively, compared to each single treatment. From these results, it appears that exposure to CDMA-mobile phone radiation at 835-MHz frequency may potentiate DNA strand breaks of mouse thymic lymphoma L5178Y $Tk^{+/1-}$;cells under the defined conditions of this study.