• Computers and Concrete
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• v.15 no.4
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• pp.673-686
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• 2015

R-curve based on the size effect law previously developed for geometrically similar specimens (geometry type III) is extended to geometries with variable depth (geometry type I) as well as with variable notch (geometry type II), where the R-curve is defined as the envelope of the family of critical strain energy release rates from specimens of different sizes. The results show that the extended R-curve for type I tends to be the same for different specimen configurations, while it is greatly dependent on specimen geometry in terms of the initial crack length. Furthermore, the predicted load-deflection responses from the suggested R-curve are found to agree well with the testing results on concrete and rock materials. Besides, maximum loads for type II specimen are predicted well from the extended R-curve.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.25 no.3B
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• pp.565-569
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• 2000

We compose the two-stage recurrent neural network that returns both signals of a hidden and an output layer to the hidden layer. It is tested on the basis of syllables for Korean spoken digit from /gong/to /gu. For these experiments, we adjust the neuron number of the hidden layer, the predictive order of input data and self-recurrent coefficient of the decision state layer. By the experimental results, the recognition rate of this neural network is between 91% and 97.5% in the speaker-dependent case and between 80.75% and 92% in the speaker-independent case. In the speaker-dependent case, this network shows an equivalent recognition performance to Jordan and Elman network but in the speaker-independent case, it does improved performance.

• Bulletin of the Korean Chemical Society
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• v.15 no.10
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• pp.896-900
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• 1994

The pH-dependent reduction behavior of N-monosubstituted-4,4'-bipyridinium ions ($RBPY^+: R=methyl(C_1)$; benzyl; n-octyl; n-dodecyl) has been investigated by electrochemical and spectroelectrochemical techniques. At acidic condition, $RBPY^+$ is protonated and the protonated species are reduced by two consecutive one-electron processes. The $2e^-$ reduced species undergoes a chemical reaction with $H^+$. The second-order rate constant $(k_H)$ of the homogeneous chemical process is $(3.7{\pm}0.3){\times}10^3M^{-1}s^{-1}$ for the two electron reduction product of $C_1BPY^+$. At high pH, the electrode reduction of $RBPY^+$ is one-step $2e^-$ transfer process with concomitant addition of $H^+$, which is confirmed by cyclic voltammetric study using a microdisk electrode.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.336.1-336.1
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• 2002

HSP100/Clp family functions as molecular chaperone and ATP dependent protease. The Streptococcus pneumoniae ClpL. a homologue of bacterial ClpB and yeast cytosolic HSP 104. is one of major heat shock proteins but its biochemical properties are unknown. In this study. ClpL in Streptococcus pneumoniaewas characterized using histidine tagged recombinant ClpL. When ATP hydrolysis activity was compared in the presence or absence of a variety of nucleotides or divalent ions. either ATP or Mn$2^＋$ ion was found to increase significantly the rate of ATP hydrolysis. Furthermore. glutaraldehyde cross-linking and subsequent native-PAGE analfysis showed that ClpL forms dimer. but in the presence of 4 mM concentration of $Mn^{2＋}$ion as a cofactor for ATP hydrolysis and oligormerization in vitro.

• Anatomy and Cell Biology
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• v.56 no.1
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• pp.16-24
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• 2023

Endothelial cells (EC) are the anatomical boundaries between the intravascular and extravascular space. Damage to ECs is catastrophic and induces endothelial cell dysfunction. The pathogenesis is multifactorial and involves dysregulation in the signaling pathways, membrane lipids ratio disturbance, cell-cell adhesion disturbance, unfolded protein response, lysosomal and mitochondrial stress, autophagy dysregulation, and oxidative stress. Autophagy is a lysosomal-dependent turnover of intracellular components. Autophagy was recognized early in the pathogenesis of endothelial dysfunction. Autophagy is a remarkable patho (physiological) process in the cell homeostasis regulation including EC. Regulation of autophagy rate is disease-dependent and impaired with aging. Up-regulation of autophagy induces endothelial cell regeneration/differentiation and improves the function of impaired ones. The paper scrutinizes the molecular mechanisms and triggers of EC dysregulation and current perspectives for future therapeutic strategies by autophagy targeting.

• The Journal of Society for e-Business Studies
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• v.23 no.1
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• pp.47-63
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• 2018

This study suggested quantitative models to calculate a royalty rate as an important input factor of the relief from royalty method which has the characteristics of income approach method and market approach method that are generally used in the valuation of intangible assets. This study built a royalty rate regression model by referring to the patent infringement damages cases based on royalties, i.e., by using the royalty rates as a dependent variable and the patent indexes of the corresponding patent right as independent variables. Then, a logistic regression model was constructed by referring to inter-partes review cases of patent rights, i.e. by using not-unpatentable results as a dependent variable and the patent indexes of the corresponding patent right as independent variables. A final royalty rate was calculated by matching the royalty rate from the royalty rate regression model with a not-unpatentable probability from the logistic regression model. The suggested royalty rate was compared with the royalty rate obtained by the traditional methods to check its reliability.

• 한국연소학회:학술대회논문집
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• 2003.05a
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• pp.93-101
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• 2003

The extinction of unsteady diffusion flame was experimentally studied in an opposing jet counterflow burner using diluted methane. The stabilized flame was perturbed by linearly varying velocity change that was generated by pistons installed on both sides of the air and fuel stream. As the results, the extinction of unsteady flame is dependent not only on the history of unsteadiness, but also on the initial condition. We found that there are several unsteady effects on the flame extinction. First, the extinction strain rates of unsteady cases are extended well beyond steady state extinction limits. Second, as the slope of the strain rate change increases, the unsteady extinction strain rate becomes larger. Third, the extension of unsteady extinction strain rate becomes smaller as the initial strain rate increases. We also found that the extension of the extinction limit mainly results from the unsteady response of the reaction zone because there is no retardation effect of a mixing layer for our experimental condition.

• Korean Management Science Review
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• v.18 no.1
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• pp.119-133
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• 2001

It is important to find the equilibrium level of real interest rate for it affects real and financial sector of economy. However, it is difficult to find the equilibrium level because like the most macroeconomic model the real interest model has parameter instability problem caused by structural change and it is supported by various theories and definitions. Hence, in order to cover these problems structural change detection model of real interest rate is developed to combine the real interest rate equilibrium model and the procedure to detect structural change points. 3 equations are established to find various effects of other interest-related macroeconomic variables and from each equation, structural changes are found. Those structural change points are consistent with common expectation. Oil Crisis (December, 1987), the starting point of Economic Stabilization Policy (January, 1982), the starting point of capital liberalization (January, 1988), the starting and finishing points of Interest deregulation (January, 1992 and December, 1994), Foreign Exchange Crisis (December, 1977) are detected as important points. From the equation of fisher and real effects, real interest rate level is estimated as 4.09% (October, 1988) and dependent on the underlying model, it is estimated as 0%∼13.56% (October, 1988), so it varies so much. It is expected that this result is connected to the large scale simultaneous equations to detect the parameter instability in real time, so induces the flexible economic policies.

• Journal of Pharmaceutical Investigation
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• v.31 no.2
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• pp.101-106
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• 2001

Alginate-chitosan (anion-cationic polymeric complex) was prepared to control the release rate of silver sulfadiazine (AgSD). Na-alginate (2%) solution containing AgSD was gelled in $CaCl_2$ solution. The gel beads formed were immediately encapsulated with chitosan (CS). The gel matrix and membrane were then reinforced with chondroitin-6-sulfate (Ch6S). Release rate of AgSD from the gel matrix was investigated by placing alginate beads in the sac of cellulose membrane simmered in HEPES-buffer solution. The concentration of AgSD released was analyzed by UV at 264 nm. Incorporation capacity of AgSD in Ca-alginate gel was more than 90%. Alginate-Ch6S-CS could control the release rate of AgSD. The amount of AgSD release was dependent on the AgSD loading dose. Incorporation of tripolyphosphate (polyanionic crosslinker) onto the alginate-Ch6S-CS bead increased the release rate of AgSD. Collagen-coating had no influence on the AgSD release rate. Alginate-Ch6S-CS beads with a sufficiently high AgSD encapsulation were capable of controlling the release of the drug over 10 days. In summary, alginate-Ch6S-CS beads could be used as a sustained delivery for AgSD and provide local targeting with low silver toxicity and patient discomfort.

• Journal of the Korean Vacuum Society
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• v.7 no.3
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• pp.214-220
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• 1998

We have studied the factors influencing the growth rate of TiN deposited from TDEAT using a bubbler. The growth rate of TiN was primarily dependent on the bubbler temperature, deposition temperature, gas delivery line conductance and carrier gases. In addition, the heating of the gas line through which carrier gas was delivered to the bubbler increased the growth rate slightly. Also heating of the delivery gas line between the bubbler and the chamber caused the increase of the growth rate of TiN, Showing the Arrehenius behaviour with the activation energy of 0.2 eV.