• YAKHAK HOEJI
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• v.32 no.2
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• pp.129-136
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• 1988

Effects of the selective alpha-adrenoceptor agonists, clonidine, oxymetazoline and phenylephrine, on heart rate and contractile force were investigated in the isolated frog atria and it was attempted to examine the influence of adrenoceptor antagonist upon those. Clonidine produced dose-dependent negative chronotropic and positive inotropic effects. The negative chronotropic effect was significantly attenuated in the presence of prazosin and yohimbine but not propranolol. The positive inotropic effect was significantly attenuated by prazosin, yohimbine and propranolol. Oxymetazoline produced dose-dependent negative chronotropic and inotropic effects. The negative chronotropic effect was significantly attenuated in the presence of prazosin, which was partially augmented by yohimbine but was not affected by propranolol. The negative inotropic effect was not affected by propranolol but it was partially augmented by yohimbine and was partially attenuated by prazosin. Phenylephrine produced dose-dependent positive chronotropic and inotropic effects. The positive chronotropic and inotropic effect were significantly attenuated in the presence of propranolol but were not affected by prazosin and yohimbine. These results suggest that the negative chronotropic effect by clonidine and oxymetazoline is mediated by alpha-adrenoceptors, the positive chronotropic and inotropic effects by phenylephrine are mediated by beta-adrenoceptors, and alpha-adrenoceptors mediated the inhibitory chronotropic responses exists in the isolated frog atria.

• Convergence Security Journal
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• v.19 no.2
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• pp.73-81
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• 2019

In this paper, we propose a user-dependent mid-point navigation system using a time weighted mid-point navigation algorithm and a user preference based mid-point neighborhood recommendation system. The proposed system consists of a mid-point navigation module for calculating an mid-point by applying a time weight of each user based on a departure point between users, and a search module for providing a search for a route to the calculated mid-point. In addition, based on the mid-point search result, it is possible to increase the utilization rate of users by including a place recommending function based on user's preference. Experimental results show that the proposed system can increase the efficiency of using by the user-dependent mid-point navigation and place recommendation function.

• International Journal of Advanced Culture Technology
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• v.9 no.2
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• pp.91-99
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• 2021

In Korea, some pharmaceutical companies and agricultural machine manufacturers associate the length of the credit period with the retailer's order size. This kind of commercial practice is based on the principle of economy of scale from the supplier's point of view and tends to make retailer's order size large enough to qualify a certain credit period break. Also, the credit period allowed by the supplier makes it possible to reduce the retail price expecting that the retailer can earn more profits by the stimulating the customer's demand. Since the retailer's order size is affected by the end customer's demand, it is reasonable to determine the retail price and the order size simultaneously. In this regard, this paper analyzes the retailer's problem who has to decide his sales price and order quantity from a supplier who offers different credit periods depending on his order size. And we show that the retailer's order size large enough to qualify a certain credit period break. Also, it is assumed that the end customer's demand rate is represented by a linear decreasing function of the retail price.

• Bulletin of the Korean Chemical Society
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• v.8 no.4
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• pp.280-285
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• 1987

FMN-dependent glycolate oxidase from spinach is inactivated by diethyl pyrocarbonate at pH 7.0. Inactivation of both apo- and holoenzyme by diethyl pyrocarbonate follows pseudo-first-order kinetics and first order with respect to the reagent. A series of difference spectra of inactivated and native enzymes show a single peak at 240 nm, indicating the modification of histidyl residues. No decrease in absorbance at around 280 nm due to formation of O-carbethoxytyrosine is observed. The rate of inactivation is dependent on pH, and the data for pH dependent rates implicate the involvement of a group with a pKa of 6.9. The activity lost by treatment with diethyl pyrocarbonate could be almost fully restored by incubation with 0.75M hydroxylamine. The reactivation by hydroxylamine and the pH dependence of inactivation are also consistent with that the inactivation is due to modification of histidyl residues. Although coenzyme FMN is without protective effect, the substrate glycolate, the product glyoxylate, and two competitive inhibitors, oxalate and oxalacetate, provide marked protection against the inactivation of the holoenzyme. These results suggest that the inactivation of the oxidase by diethyl pyrocarbonate occurs by modification of essential histidyl residue(s) at the active site.

• Asia-Pacific Journal of Business
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• v.11 no.2
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• pp.27-43
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• 2020

Purpose - This study explores the impact of the real estate industry on related industries for the perspective of Chinese steel companies. Design/methodology/approach - The impact of housing prices on the 41 listed steel companies' performance was analyzed by using the panel data model. We used two kinds of housing price indexes that are set in the panel data models to estimate the range of the real estate market, driving the performance growth of steel listed companies. Moreover, the net profit of steel companies is used as the dependent variable. To test the stability of the model, ROA used as a dependent variable for the robustness test. Also, to avoid the time trend of housing prices, this paper selects the growth rate of housing prices as the primary research variable. After Fisher-type testings, there is no unit root problem in both independent and dependent variables. Findings - The results indicated that the rise in the housing price has a positive influence on the steel company performance. When the housing price increases by 1%, the net profit of steel enterprises will increase by 5 to 20 million yuan. Research implications or Originality - In this paper, empirical data at the micro-level and panel model are used to quantify China's real estate industry's driving effect on the iron and steel industry, providing evidence from the microdata level. It helps us to understand further the status and role of China's real estate industry in the economic structure.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.27 no.4
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• pp.207-212
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• 2015

The use of groundwater and ground_heat is one of the ways to use natural and renewable energy, and it has been considered as a technology to reduce greenhouse gas emissions and increase energy-saving. There are a few researches on the optimum design for the open-loop geothermal system. In this study, to develop the optimal design method numerical simulation of the open-loop geothermal system with two-wells was performed by a groundwater and heat transfer model. In this paper, a study was performed to analyze the system performance according to well distance and pumping flow rate. In the result, average heat exchange rate and heat source temperature were calculated and it was found that they were dependent on the pumping rate.

• Asian-Australasian Journal of Animal Sciences
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• v.9 no.6
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• pp.651-654
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• 1996

The effect of guanethidine on feeding behavior was investigated in the chicken. Graded levels of chronically administered guanethidine, an adrenergic neurone blocker, at 0, 25, 50 and 100 mg/kg body weight, decreased body weight gain and food intake in a dose dependent manner. The effect of acute guanethidine administration on crop emptying rate of the chicken was also investigated. The highest level (10 mg i.v./kg body weight) of guanethidine significantly delayed crop emptying compared with the control. These results suggest that the sympathetic nervous system in the chicken is an important factor for the regulation of feeding behavior associated with food passage from the crop.

• Environmental Analysis Health and Toxicology
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• v.17 no.4
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• pp.357-362
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• 2002

Tests for the toxicity of tributyltin (TBT) were conducted on mysid collected from Dadepo beach, Pusan, Korea. The toxic effects of tributyltin on the survival, growth and oxygen consumption of the mysid, Neomysis awatschensis have been evaluated. Mysids were exposed to several concentrations of TBT (0, 0.56, 1.15, 3.07 and 6.12 $\mu\textrm{g}$/L) for 6 weeks. Survival rate was decreased with increases in concentration and exposure time and the reduction of more than 40％ occurred at TBT concentration greater than 1.15 $\mu\textrm{g}$/L after 6 weeks. Growth rate was significantly decreased at concentrations greater than 1.15 $\mu\textrm{g}$/L. Oxygen consumption rate was also decreased in a concentration-dependent way and significantly decreased to 39,47 and 69％ of the control at 1.15, 3.07 and 6.12 $\mu\textrm{g}$/L, respectively. These results indicate that the contamination of aquatic environment by TBT has the potential to significantly reduce coastal and estuaries recruitment of mysids.

• Transactions of the Korean Society of Automotive Engineers
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• v.8 no.4
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• pp.149-157
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• 2000

Computer simulations of the mechanical behavior of a three point bend specimen with a quarter notch under impact load are performed. The case with a load application point at the side is considered. An elastic-plastic von Mises material model is chosen. Three phases such as impact bouncing and bending phases are found to be identified during the period from the moment of impact to the estimated time for crack initiation. It is clearly shown that no plastic deformation near the crack tip is appeared at the impact phase. However it is confirmed that the plastic zone near the crack tip emerges in the second phase and the plastic hinge has been formed in the third phase. Gap opening displacement crack tip opening displacement and strain rate are compared with rate dependent material(visco-plastic material). The stability during various dynamic load can be seen by using the simulation of this study.

• Biotechnology and Bioprocess Engineering:BBE
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• v.10 no.4
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• pp.341-345
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• 2005

Since it is troublesome to estimate adequate flow rates in four sections of SMB chromatography, a systematic determination of the flow rates has been suggested by using ketoprofen as a model chiral enantiomer. S-ketoprofen. less retained species, was separated from raffinate stream and the variation in its purity was dependent on the changes of the flow rate of section 4 ($Q_4$), the raffinate flow rate ($Q_{raf}$), and the feed flow rate ($Q_{feed}$) under a fixed switch­ing time t$^{\ast}$. When one parameter was changed at the given experimental condition, purities of product were changed and these phenomena has be well explained by the triangle theory.