• Journal of Oriental Neuropsychiatry
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• v.20 no.1
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• pp.1-19
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• 2009

Objectives : This Study was performed to assess the antioxidative and neuroprotective effect of Guibi-tang(Guipi-tang) and Guibi-tang gamibang(Guipitang jiaweifang) on PC12 cells. Methods : The antioxidative effect was investigated through the DPPH radical and ABTS cation scavenging methods and total polyphenol amount of Guibi-tang(Guipitang) and Guibi-tang gamibang(Guipitang jiaweifang). The neuroprotective effect of Guibi-tang(Guipitang) and Guibi-tang gamibang(Guipitang jiaweifang) was assessed using MTT assay in PC12 cells. The scavenging effect of Guibi-tang(Guipitang) and Guibi-tang gamibang(Guipitang jiaweifang) on NO and ROS production induced by 6-OHDA in PC12 cells was evaluated, as well as the attenuating effect of Guibi-tang gamibang(Guipitang jiaweifang) on GSH reduction. Results : 1. Guibi-tang(Guipitang) and Guibi-tang gamibang(Guipitang jiaweifang) had concentration-dependent scavenging activities of DPPH radical 2. Guibi-tang(Guipitang) and Guibi-tang gamibang(Guipitang jiaweifang) had concentration-dependent scavenging activities of ABTS cation. 3. Total polyphenol amount of Guibi-tang(Guipitang) and Guibi-tang gamibang(Guipitang jiaweifang) was calculated 79.10${\pm}$2.20 pg/IO mg and 121.03${\pm}$1.11 pg/IO mg, respectively. 4. Cell viability of Guibi-tang(Guipitang) was increased in a dose dependent manner. Guibi-tang gamibang(Guipitang jiaweifang) was increased at low concentrations, but decreased at high concentrations. 5. In Guibi-tang(Guipitang), cell viability of PC12 cell treated with 6-OHDA was decreased by pre-treatment, and increased by post- and co- treatment. Cell viability of Guibi-tang gamibang(Guipitang jiaweifang) showed variable effects by pre-treatment, but increased by post- and co- treatment. 6. NO production rate of Guibi-tang(Guipitang) didn't show a significant effect, but that of Guibi-tang gamibang(Guipitang jiaweifang) was decreased in a dose dependent manner. 7. ROS production rate of Guibi-tang(Guipitang) was decreased at some concentrations. In Guibi-tang gamibang(Guipitang jiaweifang), ROS production rate was decreased at high concentrations. 8. Guibi-tang gamibang(Guipitang jiaweifang) protected the 6-OHDA-induced GSH reduction. Conclusions : These results demonstrate that both Guibi-tang(Guipitang) and GBTGMB have antioxidative and neuroprotective effect, but Guibi-tang gamibang(Guipitang jiaweifang) has more antioxidative and neuroprotective effect than Guibi-tang.

• Korean Journal of Organic Agriculture
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• v.28 no.2
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• pp.251-261
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• 2020

The developmental ecology and temperature-dependent growth model were calculated to develop the Scotinophara lurida control technology, which is mainly affected by environmentally friendly rice cultivation. The survival rate of S. lurida after overwintering in 2019 showed that 167 of 224 survived and the survival rate was 72.8%. Overwintering adult of S. lurida occur in rice fields in mid-June, spawn in early July, and first-generation adults develop in mid-August. In order to determine the temperature-dependent growth model, the growth periods by temperature and development stage were investigated in a incubator at 18, 21, 24, 27, 30℃ and 14L: 10D. The period from egg to adult at the temperature of 18, 21, 24, 27, 30℃ was 119.8, 73.1, 53.5, 39.4, and 82.0 days, respectively. The best development temperature was at 27℃. The regression curve was obtained by analyzing the relationship between temperature and growth rate using the Excell program, and the base temperature threshold and effective cumulative temperature for each development stage were calculated. From eggs to 5 nymphs of S. lurida the base temperature threshold was 17.9℃ and the effective cumulative temperature was 380.2 DD.

• YAKHAK HOEJI
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• v.29 no.3
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• pp.124-129
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• 1985

A dissolution characteristics of phenylbutazone deposited on Avicel and dibasic calcium phosphate by solvent deposition method were studied. The solvent deposition was confirmed by scanning electron microscopy. Avicel was superior to dibasic calcium phosphate as excipient in dissolution rate. Total amount of phenylbutazone dissolved from Avicel deposition system at 30minutes were enhanced 1.2-1.6 times compared with physical mixtures of them. The dissolution rate of 10% solvent deposition system was highest and that of 75% solvent deposition system was lowest in Avicel system and dibasic calcium phosphate system. Dissolution profile of commercial products was dependent on manufacturing conditions and dissolution rate of 10% Avicel system was greater than that of commercial products.

• Journal of the Korean Geotechnical Society
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• v.15 no.6
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• pp.17-28
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• 1999

In order to analyze effects of strain rate on consolidation of natural clay, this paper presents a nonlinear elasto viscoplastic model in which viscoplastic behavior is modeled by a unique effective stress-strain-strain rate relationship (equation omitted). The predicted values using numerical analysis are compared with measured ones in several laboratory tests such as creep test, multistage load test, and relaxation test for Berthierville clay. It is possible to estimate consolidation behavior of natural clay with reasonable accuracy using the proposed nonlinear viscoplastic model.

• 한국신재생에너지학회:학술대회논문집
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• 2007.06a
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• pp.172-175
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• 2007

The Performance of a PEMFC stack is strongly dependent on the uniform reactants distribution on MEA. The uniform distribution can be achieved by flow-field pattern and manifold design optimized to satisfy operating conditions. This paper investigates uniform reactants distribution in channels by changing manifold shape and inlet mass flow rate. Typical U and Z shape and modified U and Z shape manifolds with buffer zone were designed. To check the uniform reactants distribution, standard deviation of mass flow rate was compared. The numerical results show that the inlet mass flow rate, inlet shape, and manifolds shape are critical factor for uniform distribution.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.11 no.4
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• pp.492-498
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• 1999

Mass flow rates of R407C and R290 through capillary tubes were measured with various capillary tube geometries and flow conditions. For all refrigerants tested in the present study, mass flow rate through the capillary tube was strongly dependent on the condensing pressure, subcooling and capillary length and diameter. The flow rate of R407C was 5~10［%］ higher than that of R22 at the same condensing temperature and degree of subcooling, while flow rate for R290 was 40［%］ lower than that for R22. Based on experimental results, an empirical correlation was developed using Pi theorem to predict the mass flow rate through capillary tubes. The predicted flow rates using the model were consistent with the experimental data within ${\pm}$10[%］.

• The Korean Journal of Ecology
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• v.21 no.4
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• pp.329-335
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• 1998

The growth of Phytolacca L. grown under three light regimes at three nutrient concentrations was analyzed. The effect of shading treatment on plnat growth was greater than that of nutrient treatment. Plant dry mass increased more than 5-fold during 21 days under 33% and 100% irradiances, whereas that was strongly reduced under 8% irradiance. Net assimilation rate decreased with plant growth irrespective of light and nutrient treatments, though the highest net assimilation rate was shown under 100% irradiance. Under 33% irradiance leaf area in plants supplied with nutrient solution increased to such extent as to compensate reduction in net assimilation rate, whic maintains almost identical growth rate with that under 100% irradiance. The relatonship between total plant nitrogen and leaf nitrogen content was dependent on the growth irradiance. Moreover, leaf nitrogen and specific leaf weight were also changed depending on the light and nutrient conditions. Based on these findings, it is suggested that the adaptive characteristics of Pokeberry plant to light and nutrient conditions may contribute to rapid extension of Pokeberry habital in Korea rocently.

• Journal of the Korean Society for Precision Engineering
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• v.22 no.7 s.172
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• pp.177-184
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• 2005

Recently, the engineering designer of injection mould has become more and more dependent on the CAE. In the design factors of injection mould, the shrinkage rate should be considered as one of the important performances to produce the reliable products. therefore the shrinkage rate can be mostly calculated by the MoldFlow and Pro-engineering. in the design process. However it is not easy to predict the shrinkage rate of a plastic injection mold in its design process because the analysis can take minutes to hours, the high computational costs of performing the analysis limit their use in design optimization. In this study, the surrogate models, DACE model, based on the Kriging in order to optimize the shrinkage rate of electric microwave oven window is used in lieu of the original models, facilitating design optimization.

• The Journal of Korean Medicine
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• v.21 no.2
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• pp.79-86
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• 2000

Objectives and Methods : In order to elucidate toxic mechanism of myocardial damage and protective effect of myrrha water extract against cytotoxic effect of xanthine oxidase/hypoxanthine(XO/HX), cardioprotective effect of myrrha water extract was examined by MTT assay, LDH (Lactate Dehydrogenase) activity and heart beating rate after cultured myocardial cells derived from neonatal mouse were treated with various concentration of XO/HX, a free radical. Results : XO/HX induced a decrease of cell viability, an increase in the amount of LDH, and a decrease of heart beating rate on cultured myocardial cells in a dose-dependent manner. In cardioprotective effect of myrrha water extract, it showed a decrease in the amount of LDH and an increase of heart beating rate on cultured myocardial cells damaged by XO/HX. Conclusions : From the above results, it is suggested that XO/HX showed toxic effect in cultured myocardial cells derived from neonatal mouse and that myrrha water extract is very effective in the prevention of XO/HX-induced cardiotoxicity.

• Convergence Security Journal
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• v.13 no.1
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• pp.3-10
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• 2013

In this paper, reliability software model considering fault detection rate based on observations from the process of software product testing was studied. Adding new fault probability using the S-shaped distribution model that is widely used in the field of reliability problems presented. When correcting or modifying the software, finite failure non-homogeneous Poisson process model was used. In a software failure data analysis considering the time-dependent fault detection rate, the parameters estimation using maximum likelihood estimation of failure time data and reliability make out.