• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
• /
• v.17 no.1
• /
• pp.82-93
• /
• 2004

Recently many efforts were focused to understanding the mechanical insights of melanogenesis to develop the agents for hyper-pigmentation and hypo-pigmentation. In the melanin biosynthetic pathway, tyrosinase is the rate limiting enzyme, and ${\alpha}$-melanocyte stimulating hormone(MSH) or cAMP-elevating agents stimulate melanogenesis and enhance the melanin synthesis and the tyrosinase activity. The author has analyzed the effects of Radix Trichosanthis on the basal Melanogenic activities of Bl6/F10 mouse melanoma cells, and on the ${\alpha}$-MSH or forskolin-induced melanogenesis. Radix Trichosanthis alone markedly suppressed melanin content and tyrosinase activity in a dose-dependent manner. Pretreatment of the cells with Radix Trichosanthis also suppressed the increase of ${\alpha}$-MSH(10 nM) or forskolin(20 ${\mu}$M)-induced melanin content and tyrosinase activity. The decrease in the tyrosinase activity was paralled by a decrease in the abundance of tyrosinase protein and tyrosinase promoter activity. Pretreatment of the cells with Radix Trichosanthis also inhibited the increase of forskolin(20 ${\mu}$M) induced the amount of tyrosinase protein and tyrosinase promoter activity. The results of DOPA staining revealed that pretreatment of the cells with Radix Trichosanthis showed less intensity than B16 melanoma cells stimulated with ${\alpha}$-MSH or forskolin. These results suggest that Radix Trichosanthis inhibits melanogenesis and abrogates ${\alpha}$-MSH and cAMP-induced melanogenesis in B16 melanoma cells.

• Proceedings of the Korean Society of Crop Science Conference
• /
• 2017.06a
• /
• pp.355-355
• /
• 2017

South Korea is largely dependent on imports of forage crops. In order to raise the self-sufficiency rate of forage crops, it is necessary to cultivate forage crops in 135,100 ha reclaimed land of South Korea. This study was conducted to investigate the growth of halophytes and forage crops in order to search for stable plants on reclaimed land. The plants were cultured in Hoagland solution and grown at 0%, 0.5%, 1.0% and 2.0% of salt concentrations. Plants with good growth at 0.5% of salt concentration were halophytes such as Suaeda asparagoides and Salsola komarovii. Salicornia herbacea and Suaeda maritima showed good growth at 2.0% salinity, and Suaeda maritima showed stable growth at all of salt concentrations. In conclusion, Suaeda asparagoides showed the best growth at 0.5% of salt concentration and was considered the most biomass at reclaimed land in Korea with less than 0.5% of salt concentration.

• Proceedings of the Korean Society of Crop Science Conference
• /
• 2017.06a
• /
• pp.168-168
• /
• 2017

Drought conditions during cultivation reduce agricultural production yield less than a theoretical maximum yield under normal condition. Plant specific NAC transcription factors in rice are known to play an essential roles in stress resistance transcriptional regulation. In this study, we report the rice (Oryza sativa L japonica) NAM, AFTF and CUC transcription factor OsNAC17, which is predominantly induced by abiotic stress in leaf, was contribute to the drought tolerance mediated reactive oxygen species (ROS) in transgenic rice plants. Constitutive (PGD1) promoter was introduced to overexpress OsNAC17 and produced the transgenic PDG1:OsNAC17. Overexpression of OsNAC17 throughout the whole plant improved drought resistance phenotype at the vegetative stage. Morphological characteristics such as grain yield, grain filling rate, and total grain weight improved by 22~64% over wild type plants under drought conditions during the reproductive stage. The improved drought tolerance in transgenic rice was involved in reducing stomatal density up to 15% than in wild type plants and in increasing reactive oxygen species-scavenging enzyme. DEG profiling experiment identified 119 up-regulated genes by more than twofold (P<0.01). These genes included UDP-glycosyltransferase family protein, similar to 2-alkenal reductase (NADPH-dependent oxireductase), similar to retinol dehydrogenase 12, Lipoxygenase, and NB-ARC domain containing protein related in cell death. Furthermore, OsNAC17 was act as a transcriptional activator, which has an activation domain in C-terminal region. These result demonstrate that the overexpression of OsNAC17 improve drought tolerance by regulating ROS scavenging enzymes and by reducing stomatal density

• Proceedings of the Korean Society of Crop Science Conference
• /
• 2017.06a
• /
• pp.292-292
• /
• 2017

This study was conducted to evaluate the effect of anti-obesity and antioxidant enzyme activities in vitro by different solvent fractions from the roots of Codonopsis lanceolata. The cytotoxicity of different solvent fractions of C. lanceolata on 3T3-L1 preadipocytes were evaluated using the MTT assay, the rate of cell survival progressively decreased in a dose-dependent manner. Butyl alcohol fraction at $200{\mu}g/mL$ exhibited a pronounced cytotoxic effect (75.73%) on 3T3-L1 cell comparable to that of the hexane fraction (79.82%), methylene chloride fraction (84.02%), ethyl acetate fraction (87.62%) and DW fraction (86.30%) at the same concentration. The Oil Red O solution was used to determine whether different solvent fractions of C. lanceolata induce adipocyte differentiation in 3T3-L1 preadipocytes. Confluent 3T3-L1 cells were treated with $50{\mu}g/mL$ concentration of solvent fraction extracts from C. lanceolata. Inhibitory degree of lipid accumulation against solvent fraction extracts showed a significant level compared with the control. Both lipid accumulation and adipocyte differentiation showed relatively high effect on methyl chloride fraction. The root extract of C. lanceolata had the highest SOD enzyme activity of 84.5% in ethyl acetate partition layer and while water partition layer of diploid showed the lowest SOD enzyme activity of 57.9%. The activity of CAT, APX and POD showed a significantly higher activity in ethyl acetate partition layer compared with the other fraction. These results suggested that the roots of C. lanceolata may assist in the potential biological activity on anti-obesity and antioxidant capacity.

• Journal of Korean society of Dental Hygiene
• /
• v.9 no.4
• /
• pp.659-669
• /
• 2009

Objectives : The degree of depression in dental hygienist was analyzed to reveal the various factors related to them. Methods : The self-administered questionnaires were filled out from 202 dental hygienist in Daejeon City. The survey items included subjects' socio-demographic and job-related characteristics, health-related behaviors, depression. Chi-Square analysis and Pearson's correlation coefficient was put into survey results, in which a degree of depression was dependent variable and others were independent variable. Results : 1. The distribution for depression degree has shown the rate as 80.2% in normal range group and 19.8% in depression group. 2. As for depression, long working hours(p=0.042), poor sense satisfaction in work(p=0.000), not fit to the job(p=0.003), low personal relation with peer works or supervisors(p=0.039), without alcohol drinking(p=0.048), poor subjective condition of health(p=0.000) than their respective counterparts. 3. Concerning correlation between depression and various factors, poor sense satisfaction in work(r=-0.332, p=0.000), not fit to the job(r=-0.353, p=0.000), low personal relation with peer works or supervisors(r=-0.215, p=0.002), without alcohol drinking(r=-0183, p=0.009), poor subjective condition of health(r=-0.333, p=0.000). Conclusions : These results showed that depression state could be influenced by various factors, which include socio-demographic, job-related characteristics and health-related behaviors. Therefore, in order to reduce depression state of dental hygienists, development and application of programs to manage and research for them are required to be revitalized as well as socio-demographic and job-related characteristics and health-related behaviors.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• v.9 no.6
• /
• pp.2271-2288
• /
• 2015

The emerging high efficiency video coding (HEVC) standard adopts the quadtree-structured transform unit (TU) in the residual quadtree (RQT) coding. Each TU allows to be split into four equal sub-TUs recursively. The RQT coding is performed for all the possible transform depth levels to achieve the highest coding efficiency, but it requires a very high computational complexity for HEVC encoders. In order to reduce the computational complexity requested by the RQT coding, in this paper, we propose a fast TU size decision method incorporating an adaptive maximum transform depth determination (AMTD) algorithm and a full check skipping - early termination (FCS-ET) algorithm. Because the optimal transform depth level is highly content-dependent, it is not necessary to perform the RQT coding at all transform depth levels. By the AMTD algorithm, the maximum transform depth level is determined for current treeblock to skip those transform depth levels rarely used by its spatially adjacent treeblocks. Additionally, the FCS-ET algorithm is introduced to exploit the correlations of transform depth level between four sub-CUs generated by one coding unit (CU) quadtree partitioning. Experimental results demonstrate that the proposed overall algorithm significantly reduces on average 21% computational complexity while maintaining almost the same rate distortion (RD) performance as the HEVC test model reference software, HM 13.0.

• Applied Chemistry for Engineering
• /
• v.5 no.3
• /
• pp.385-394
• /
• 1994

Numerical solutions were obtained to the model equations for various of the parameters characterizing the pore structure, effective internal diffusion, and the chemical reaction constant. The conversion was decreased with the cause of pore closure at the surface of reacting particles, reduction of porosity, surface area of reaction and effective diffusion coefficient in the solid with the progress of reaction. Total conversion was strongly dependent on the local conversion at surface. According to the decreasing of impregnated concentration of the copper oxide and the increase of the flue gases concentration, total conversion was increased. The conversion was affected by gas flow rate and pore size distribution in the reacting solid.

• Applied Chemistry for Engineering
• /
• v.5 no.1
• /
• pp.127-138
• /
• 1994

In the process of pervaporation separation for aqueous ethanol solution through cellulose tai-acetate(CTA) membrane, the modelling on the solution-diffusion permeation mechanism was built up on the basis of sorption and permeation experimental results. Also its function type and parameter were examined. The composition of sorption equilibrium in three component system(Ethanol/Water/CTA) were compared with the calculated value by Flory-Huggins' equation using the pure component sorption data. In order to apply the thermodynamic equilibrium relationship between the membrane free composition in the membrane and the equilibrium composition in the liquid phase, the apparent activity this system, however, the results were not satisfied. Diffusion equations were expressed with the concentration gradient considering permeate alone, and a concentration-dependent diffusion coefficient which includes a parameter was used. And this model was fitted with the measured permeation rates. If the permeation rate and the amount of sorption of one component were much larger than those of the other, the bulk flow term could not be negligible. The flux and selectivity were increased with increasing temperature, and with decreasing downstream pressure.

• Science of Emotion and Sensibility
• /
• v.18 no.3
• /
• pp.63-70
• /
• 2015

This study identified heart response of participants while listening to sounds which have 1/f fluctuations with exponent ${\alpha}$ gradient. The participants were engaged in emotional stress work. Prior studies related to 1/f fluctuation sound have reported that sound source can alleviate psychological and physiological state of users. Subjects of this study were exposed to sound with three levels of ${\alpha}$ gradient. Heart response of subjects were measured with Photoplethysmography(PPG) sensor simultaneously. The dependent variables of this study were beat per minute(BPM), very low frequency percent of pulse rate variability (VLF percent), the standard deviation of all normal RR intervals (SDNN), and high frequency power(HF power). Subject showed arousal response when exposed to sound with exponent ${\alpha}$ gradient of 3 whereas the sound with exponent ${\alpha}$ gradient of 1 and 2 resulted in relax effect. The characteristic of 1/f fluctuation sounds can be applied to alleviate stress for employers under emotional labor.

• Tunnel and Underground Space
• /
• v.27 no.1
• /
• pp.1-11
• /
• 2017

Most of the local limestone mines are developed as large-opening underground mines, while mine ventilation is heavily dependent on the natural ventilation and auxiliary systems, rather than the mechanical ventilation system using main fans. The current auxiliary ventilation system with fan and ducting requires optimization since enhanced deployment of diesel equipment demands higher airflow rate and the associated cost is expected to be too excessive for the local mine operators. This paper aims at optimizing the fan capacity for the working site ventilation through comparing the fan pressure in the mine airway and the ventilation efficiency of an axial-flow fan and a propeller fan developed in this study.