• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.244-244
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• 1994

Cortex Mori, the root bark of mulbery tree has been used as an antiphlogistic, diuretic, and expectorant in herbal medicine. The purpose of this study is to evaluate chicken gamma globulin (CGG)-specific IgE-induced morphologic and functional changes in rat peritoneal mast cells (RPMC), and to determine whether Cortex Mori could inhibit the CGG-specific IgE-depeildent mast cell degranulation and histamine release from RPMC. Results are 1) the degranuration and histamine release from RPMC were not induced within 1 hour after addition of Cortex Mori alone, 2) the CGG and CGG-specific IgE-Induced degranulation from RPMC was observed within 10 minutes, 3) the histamine release from RPMC sensitised with CGG-specific IgE was induced by tile addition of CGG, 4) CGG-specific IgE-dependent degranulation rate in RPMC pretreated with Cortex Mori was significantly Inhibited, compared to that of control group without Cortex Mori pretreatment, and 5) the CGG-specific IgE-dependent histamine release from RPMC was significantly inhibited by pretreatment with Cortex Mori. These data suggest that Cortex Mori contains some substances with capabilities to inhibit CGG-specific IgE-dependent degranulation and histamine release from RPMC.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.23 no.2
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• pp.198-209
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• 1999

This study reports the selection of dependent variables for momentum equations in general curvilinear coordinates. Catesian, covariant and contravariant velocity components were examined for the dependent variable. The focus of present study is confined to staggered grid system Each dependent variable selected for momentum equations are tested for several flow fields. Results show that the selection of Cartesian and covariant velocity components intrinsically can not satisfy mass conservation of control volume unless additional converting processes ore used. Also, Cartesian component can only be used for the flow field in which main-flow direction does not change significantly. Convergence rate for the selection of covariant velocity component decreases quickly as with the increase of non-orthogonality of grid system. But the selection of contravariant velocity component reduces the total mass residual of discretized equations rapidly to the limit of machine accuracy and the solutions are insensitive to the main-flow direction.

• BMB Reports
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• v.39 no.6
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• pp.774-781
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• 2006

Human nucleolar phosphoprotein p140 (hNopp140) is a nucleolar phosphoprotein that can bind to doxorubicin, an anti-cancer agent. We have examined the interaction between hNopp140 and doxorubicin as well as the folding property of hNopp140. Also, the effects of ATP and phosphorylation on the affinity of hNopp140 to doxorubicin are investigated by affinity dependent co-precipitation and surface plasmon resonance methods. Doxorubicin preferentially binds to un-phosphorylated form of hNopp140 with a $K_D$ value of $3.3\;{\times}\;10^{-7}$ M. Furthermore, doxorubicin reduces the protein kinase CK2-dependent phosphorylation of hNopp140, indicating that doxorubicin may perturb the cellular function of hNopp140 by reducing the protein kinase CK2-dependent phosphorylation of hNopp140. Low contents of the secondary structures of hNopp140 and the fast rate of proteolysis imply that hNopp140 has a high percentage of flexible regions or extended loop structures.

• Nuclear Engineering and Technology
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• v.49 no.8
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• pp.1660-1668
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• 2017

The flow of liquids submerged with nanoparticles is of significance to industrial applications, specifically in nuclear reactors and the cooling of nuclear systems to improve energy efficiency. The application of nanofluids in water-cooled nuclear systems can result in a significant improvement of their economic performance and/or safety margins. Therefore, in this paper, Marangoni thermal convective boundary layer dusty nanoliquid flow across a flat surface in the presence of solar radiation is studied. A two phase dusty liquid model is considered. Unlike classical temperature-dependent heat source effects, an exponential space-dependent heat source aspect is considered. Stretching variables are utilized to transform the prevailing partial differential system into a nonlinear ordinary differential system, which is then solved numerically via the Runge-Kutta-Fehlberg approach coupled with a shooting technique. The roles of physical parameters are focused in momentum and heat transport distributions. Graphical illustrations are also used to consider local and average Nusselt numbers. We examined the results under both linear and quadratic variation of the surface temperature. Our simulations established that the impact of Marangoni flow is useful for an enhancement of the heat transfer rate.

• Bulletin of the Korean Chemical Society
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• v.31 no.4
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• pp.959-964
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• 2010

In this work, equilibrium molecular dynamics (MD) simulations in a microcanonical ensemble are performed to evaluate the friction coefficient of a Brownian particle (BP) in a Lennard-Jones (LJ) solvent. The friction coefficients are determined from the time dependent friction coefficients and the momentum autocorrelation functions of the BP with its infinite mass at various ratios of LJ size parameters of the BP and solvent, ${\sigma}_B/{\sigma}_s$. The determination of the friction coefficients from the decay rates of the momentum autocorrelation functions and from the slopes of the time dependent friction coefficients is difficult due to the fast decay rates of the correlation functions in the momentum-conserved MD simulation and due to the scaling of the slope as 1/N (N: the number of the solvent particle), respectively. On the other hand, the friction coefficient can be determined correctly from the time dependent friction coefficient by measuring the extrapolation of its long time decay to t=0 and also from the decay rate of the momentum autocorrelation function, which is obtained by time integration of the time dependent friction coefficient. It is found that while the friction coefficient increases quadratically with the ratio of ${\sigma}_B/{\sigma}_s$ for all ${\sigma}_B$, for a given ${\sigma}_s$ the friction coefficient increases linearly with ${\sigma}_B$.

• BMB Reports
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• v.51 no.1
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• pp.1-2
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• 2018

Positive selection on a new beneficial mutation generates a characteristic pattern of DNA sequence polymorphism when it reaches an intermediate allele frequency. On genome sequences of African Drosophila melanogaster, we detected such signatures of selection at 37 candidate loci and identified "sweeping haplotypes (SHs)" that are increasing or have increased rapidly in frequency due to hitchhiking. Based on geographic distribution of SH frequencies, we could infer whether selective sweeps occurred starting from de novo beneficial mutants under simple constant selective pressure. Single SHs were identified at more than half of loci. However, at many other loci, we observed multiple independent SHs, implying soft selective sweeps due to a high beneficial mutation rate or parallel evolution across space. Interestingly, SH frequencies were intermediate across multiple populations at about a quarter of the loci despite relatively low migration rates inferred between African populations. This invokes a certain form of frequency-dependent selection such as heterozygote advantage. At one locus, we observed a complex pattern of multiple independent that was compatible with recurrent frequency-dependent positive selection on new variants. In conclusion, genomic patterns of positive selection are very diverse, with equal contributions of hard and soft sweeps and a surprisingly large proportion of frequency-dependent selection in D. melanogaster populations.

• Communications of the Korean Mathematical Society
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• v.20 no.3
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• pp.589-602
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• 2005

We present the numerical algorithm for the model for high-strain rate deformation in hyperelastic-viscoplastic materials based on a fully conservative Eulerian formulation by Plohr and Sharp. We use a hyperelastic equation of state and the modified Steinberg and Lund's rate dependent plasticity model for plasticity. A two-dimensional approximate Riemann solver is constructed in an unsplit manner to resolve the complex wave structure and combined with the second order TVD flux. Numerical results are also presented.

• Proceedings of the Acoustical Society of Korea Conference
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• 1992.06a
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• pp.43-48
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• 1992

In the area of speech vocoder systems, the MBE vocoder allows the high quality and low bit rate. In the MBE parameters detection, the dicision methods of V/UV region proposed until now are dependent highly to the other parameters, fundamental frequency and formant information. In this paper, thus, we propose a new V/UV detection method that uses a zero-crossing rate of flatten harmonices spectrum. This method can reduce the influences of the other parameters for the V/UV regions detection.

• Proceedings of the Safety Management and Science Conference
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• 2001.05a
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• pp.199-203
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• 2001

In today's business transactions, it is more and more common to see that the buyers are allowed some grace period before they settle the account with the supplier. In this regard, we analyze the problem of determining the buyer's EOQ when the supplier allows day-terms credit. For the analysis, it is assumed that the buyer's demand rate is a function of the on -hand inventory level and the relevant mathematical model is developed.

• Journal of applied mathematics & informatics
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• v.9 no.2
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• pp.731-744
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• 2002

The temperature distribution in human skin and subdermal tissue layer is presented using bioheat transfer equation. The body temperature is determined by the balance between heat produced and heat lost by our body. The time-dependent solutions have been found to be affected by the metabolic heat generation rate, blood mass flow, the rate of evaporation of perspiration and also by the atmospheric temperature. The analytic solutions for different layers have been calculated numerically and are also shown graphically.