• Asian Pacific Journal of Cancer Prevention
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• v.14 no.5
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• pp.3351-3355
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• 2013

Photodynamic therapy (PDT) is a promising cancer treatment modality that uses dye-sensitized photooxidation of biologic matter in target tissue. This study explored effects of the photosensitizer BCPD-17 during PDT for osteosarcoma. LM-8 osteosarcoma cells were treated with BCPD-17 and cell viability after laser irradiation was assessed in vitro with the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide assay. The effects of BCPD-17 during PDT recurrence were then examined on tumor-bearing mice in vivo. BCPD-17 had dosedependent cytotoxic effects on LM-8 osteosarcoma cells after laser irradiation which also had energy-dependent effects on the cells. The rate of local recurrence was reduced when marginal resection of mice tumors was followed by BCPD-17-mediated PDT. Our results indicated BCPD-17-mediated PDT in combination with marginal resection of tumors is a potentially new effective treatment for osteosarcoma.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.35 no.2
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• pp.94-100
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• 2009

Purpose: As the interest and demand for esthetics grow up with medical development, the number of patients who want to correct dentofacial deformities by orthognathic surgery has increased. And the success of orthognathic surgery is dependent upon satisfaction of patients in great measure. Therefore the purpose of this study is to examine functional disability, sensory disturbance and esthetic satisfaction of the patients after orthognathic surgery. Material and methods: Among 89 patients who orthognathic surgery was performed at Seoul National University Bundang Hospital during the period from July 2003 to July 2008, 46 patients were considered in the study. Patients were surveyed with questionnaires and visual analogue scale(VAS) which author has designed. The analysis and comparison were performed according to gender, follow up span, and type of surgery based on answer of questionnaires. Results and conclusions: Total satisfaction rate was 76%. And there was statistical significant difference between subjective evaluation of facial esthetics before the surgery and that of after surgery(p<0.05). Differences in occurrence of functional disability, sensory disturbance between groups were not observed. In conclusion, the operator should understand the postoperative self-satisfaction of the patients and complications. If we can communicate with the patients before operation. patients' satisfaction rate will increase after operation.

• Korean Membrane Journal
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• v.8 no.1
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• pp.21-30
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• 2006

A faujasite NaY zeolite membrane was prepared on a tubular ${\alpha}-Al_2O_3$ support by the secondary growth process, and effects of permeation test conditions on the $CO_2/N_2$ separation were investigated. A NaY zeolite membrane with good $CO_2/N_2$ separation was successfully synthesized by using the hydrothermal solution ($Al_2O_3:SiO_2:Na_2O:H_2O$ = 1:6:14:840 in a molar base): at a permeation temperature of $30^{\circ}C$, its $CO_2$ permeance and $CO_2/N_2$ separation factor were $2.5{\times}10^{-7}mol/m^2secPa$ and 34, respectively. The $CO_2$ and $N_2$ permeations were highly dependent on permeation test conditions (feed composition, feeding rate, feed pressure, He sweeping rate and permeation temperature). The results indicated that (i) $CO_2$ and $N_2$ permeations through NaY zeolite membrane are governed by surface and micropore diffusions, respectively, (ii) the preparation of NaY zeolite membrane with a large permeating area is one of the most difficult hurdles for its real applications, and (iii) the retardation of $N_2$ permeation is an effective key to improve $CO_2/N_2$ separation factor in NaY zeolite membrane.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.41 no.1
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• pp.34-44
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• 1996

Several major agronomic traits of 4 isogenic lines for tillering(Kindred, Morex)were investigated under the different seeding rates and seedling mortality grown in the pots. The normal-tillering phenotypes had higher grain yield(46％) and leaf area index(56％) than their uniculm isogenic counterparts. The assortment rate(69％) and 1,000 grain weight(27％) in uniculm type were greater than the normal type. Uniculm plants were earlier in heading(4∼8days) and maturing(2∼3 days) dates compared with their counterparts. The grain yield was fitted to linear regression, ranged 0.659g to 0.5g per spike number. On increasing the seedling mortality rates, the grains per spike and 1,000 grain weight were slightly decreased, but the grain yield per plot was decreased markedly because of decrease of spikes per plot. The assortment rate, leaf photosynthetic capacity and reproductive tiller number were increased with increase of seedling mortality. The grain yield was largely dependent on the number of spikes per plot on occurrence of seedling mortality. For the uniculm genotypes to be introduced and bred into a present leading variety, the isogenic lines were precisely tested in the open field for a couple of years.

• Transactions of the Korean Society of Automotive Engineers
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• v.22 no.4
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• pp.121-130
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• 2014

This paper is the second investigation on the effects of intake flow control methods on the part load performance in a spark ignition engine. In the previous work, two control methods, port throttling and masking, were compared with respect to lean misfire limit, fuel consumption and emissions. In this work, the effects of these two methods on EGR characteristics were studied and simultaneously the differences between EGR and lean combustion as a dilution method were investigated. The results show that EGR limit is expanded up to 23% and 3 ~ 5% improvement in the fuel consumption are achieved around 8 ~ 13% rates by the flow controls comparing with 10% limit and 1.5% reduction around 3% rate of non-control case. The masking method is more effective on the limit expansion than throttling as like as lean misfire limit; however there is no substantial difference in fuel consumptions improvement regardless the control methods except high load condition. Also it is observed that there exist critical EGR rates around which the combustion performance and NOx formation change remarkably and these rates generally coincide with optimum rates for the fuel consumption. In addition, dilution with fresh air is much more advantageous than that of the exhaust gas from the view point of dilution limit and fuel consumption, while utilization of the exhaust gas is more effective on NOx reduction in spite of considerably small dilution compared with the use of fresh air. Finally, the improvement of fuel consumption by massive EGR is highly dependent on the EGR limit at which the engine runs stably, therefore the stratified combustion technique might be a best solution for this purpose.

• Analytical Science and Technology
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• v.30 no.6
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• pp.338-347
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• 2017

The purpose of this study is to investigation of the decomposition characteristics in a pilot-scale burial site of livestock in three kinds of typical soils in Korea: sandy loam soil, clay loam soil, and sandy soil. In this study, we confirmed that most of the animals in the condition were decomposed within three years as mentioned in the "Livestock burial regional environmental research guidelines." We also determined that the decomposition rate of dead cows was higher than that of dead pigs, and that the biodegradation rate depends on the soil types in the following order: sandy soil > clay loam soil > sandy loam soil. The various external environment factors, such as temperature, moisture, pH, earthiness, nutrient, and the burial depth, should be managed properly for appropriate decomposition of dead animals.

• The Korean Journal of Physiology and Pharmacology
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• v.22 no.5
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• pp.585-595
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• 2018

Amitriptyline, a tricyclic antidepressant, is commonly used to treat depression and neuropathic pain, but its mechanism is still unclear. We tested the effect of amitriptyline on 5-hydroxytryptamine 3 ($5-HT_3$) receptor currents and studied its blocking mechanism because the clinical applications of amitriptyline overlapped with $5-HT_3$ receptor therapeutic potentials. Using a whole-cell voltage clamp method, we recorded the currents of the $5-HT_3$ receptor when 5-HT was applied alone or co-applied with amitriptyline in cultured NCB-20 neuroblastoma cells known to express $5-HT_3$ receptors. To elucidate the mechanism of amitriptyline, we simulated the $5-HT_3$ receptor currents using Berkeley $Madonna^{(R)}$ software and calculated the rate constants of the agonist binding and receptor transition steps. The $5-HT_3$ receptor currents were inhibited by amitriptyline in a concentration-dependent, voltage-independent manner, and a competitive mode. Amitriptyline accelerated the desensitization of the $5-HT_3$ receptor. When amitriptyline was applied before 5-HT treatment, the currents rose slowly until the end of 5-HT treatment. When amitriptyline was co-applied with 5-HT, currents rose and decayed rapidly. Peak current amplitudes were decreased in both applications. All macroscopic currents recorded in whole cell voltage clamping experiments were reproduced by simulation and the changes of rate constants by amitriptyline were correlated with macroscopic current recording data. These results suggest that amitriptyline blocks the $5-HT_3$ receptor by close and open state blocking mechanisms, in a competitive manner. We could expand an understanding of pharmacological mechanisms of amitriptyline related to the modulation of a $5-HT_3$ receptor, a potential target of neurologic and psychiatric diseases through this study.

• Journal of Energy Engineering
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• v.16 no.3
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• pp.120-127
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• 2007

The purpose of this study is experimentally to analyze that the fuel mass fractions of multi-component mixed fuels have an effect on the characteristics of spray ignition and combustion under the ambient conditions of diesel combustion fields. The characteristics of ignition and combustion were investigated by chemiluminescence images and direct photography. The experiments were conducted in the RCEM(rapid compression expansion machine) with optical access. Multi-component fuels mixed with i-octane, n-dodecane and n-hexadecane are injected in RCEM by the electronic control of common rail injector. Experimental conditions set up 42, 72 and 112 MPa in injection pressure, 700, 800 and 900 K in ambient gas temperature. The results show that the ignition delay was dependent on high cetane number. In case of low ambient temperature, the more low boiling point fuels were mixed, the lower luminance regime had a remarkable effect and also shortened diffusion combustion by increasing heat release rate.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.5
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• pp.1223-1235
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• 2008

This experiment was performed to investigate the effects of Hyeonsamdansameum(HDE) on hypertension. For the study of HDE, we had divided Sprague-Dawley rats to three groups-normal, control, HDE. The control group was injected subcutaneous with monocrotaline(50 mg/kg). The treatment group was injected subcutaneous with monocrotaline(50 mg/kg) and orally administered with HDE extract for 4 weeks(once a day, 208 mg/kg). Then we measured blood pressure, heart rate, on the plasma aldosterone, catecholamine, electrolyte, uric acid, BUN, creatinine, and observed the lung, cardiac muscle. liver. etc. The results of these were as follows: 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity and superoxide dismutase(SOD) - like activity were increased. reactive oxygen species (ROS) was decreased. Angiotensin converting enzyme(ACE) inhibitory activity was increased in a concentration-dependent by HDE. HDE significantly increased body weight in monocrotaline hypertensive rat, so supported nearly normal group. HDE significantly decreased blood pressure and heart rate in monocrotaline hypertensive rat. HOE significantly decreased aldosterone in adrenocortical hormones. HDE significantly decreased dopamine. norepinephrine, epinephrine. Na+. Cl- were intended to decrease. K+ was decreased significantly by HDE. Uric acid. BUN were significantly decreased and creatinine was intended to decrease by HDE. HDE inhibited lung, liver and heart injury connected with hypertension. These results suggest that HDE is usefully applied in treatment and prevention of hypertension.

• Health Policy and Management
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• v.19 no.1
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• pp.49-61
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• 2009

Background: The appropriate management of diabetes mellitus(DM) can help reduce its relapse and economic burden, but the level of management of DM in Korea is reported to be insufficient. This study aims to identify the management level of DM by figuring out the HbA1c examination performance rate of the diabetics and analyzing the variation according to the characteristic of a diabetic. Methods: This study used the Korean National Health Insurance Database which includes E10-14(ICD-10 code) as a primary or secondary disease as of 2006. Study population is 1,892,062 diabetics excluding 393,784 patients with the first attack of DM in 2006, 33,440 diabetics who died in 2006, and 21,299 patients with DM having no record of ambulatory care among the 2,340,585 DM patients in total. Results: The HbA1c examination performance rate of all DM patients in our country is estimated to be 41.5% as of 2006 and shows variation according to the characteristic of individual DM patients. The highest performance odds was shown by the patients who were below 19 of age, insured for health insurance, attended more than 3 ambulatory care providers, made ambulatory care visits more than 10 times annually, attended a specialized general hospital as their main attending medical institution, had a record of hospitalization or had co-morbidity. Conclusion: This study propose that is necessary to make politic preparations for the appropriate management of diabetes at a national level, and particularly, the patients with advanced age, the ones dependent on Medical Aid, and the ones using hospitals or clinics, whose appropriate management seems vulnerable, demand a careful management.