• Asian Pacific Journal of Cancer Prevention
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• v.15 no.6
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• pp.2785-2791
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• 2014

Aims: To analyze time-dependent changes in female breast cancer (BC) mortality in China, forecast the trend in the ensuing 5 years, and provide recommendations for prevention and management. Materials and Methods: Mortality data of breast cancer in China from 1991 to 2011 was used to describe characteristics and distribution, such as the changes of the standardized mortality rate, urban-rural differences and age differences. Trend-surface analysis was used to study the geographical distribution of mortality. In addition, curve estimation, time series modeling, Gray modeling (GM) and joinpoint regression were performed to estimate and predict future trends. Results: In China, the mortality rate of breast cancer has increased yearly since 1991. In addition, our data predicted that the trend will continue to increase in the ensuing 5 years. Rates in urban areas are higher than those in rural areas. Over the past decade, all peak ages for death by breast cancer have been delayed, with the first death peak occurring at 55 to 65 years of age in urban and rural areas. Geographical analysis indicated that mortality rates increased from Southwest to Northeast and from West to East. Conclusions: The standardized mortality rate of breast cancer in China is rising and the upward trend is predicted to continue for the next 5 years. Since this can cause an enormous health impact in China, much better prevention and management of breast cancer is needed. Consequently, disease control centers in China should place more focus on the northeastern, eastern and southeastern parts of China for breast cancer prevention and management, and the key population should be among women between ages 55 to 65, especially those in urban communities.

• The Korean Journal of Physiology and Pharmacology
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• v.17 no.4
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• pp.339-345
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• 2013

We investigated the antihypertensive effect of lutein on $N^G$-nitro-L-arginine methyl ester hydrochloride (L-NAME)-induced hypertensive rats. Daily oral administration of L-NAME (40 mg/kg)-induced a rapid progressive increase in mean arterial pressure (MAP). L-NAME significantly increased MAP from the first week compared to that in the control and reached $193.3{\pm}9.6$ mmHg at the end of treatment. MAP in the lutein groups was dose-dependently lower than that in the L-NAME group. Similar results were observed for systolic and diastolic blood pressure of L-NAME-induced hypertensive rats. The control group showed little change in heart rate for 3 weeks, whereas L-NAME significantly reduced heart rate from $434{\pm}26$ to $376{\pm}33$ beats/min. Lutein (2 mg/kg) significantly prevented the reduced heart rate induced by L-NAME. L-NAME caused hypertrophy of heart and kidney, and increased plasma lipid peroxidation four-fold but significantly reduced plasma nitrite and glutathione concentrations, which were significantly prevented by lutein in a dose-dependent manner. These findings suggest that lutein affords significant antihypertensive and antioxidant effects against L-NAME-induced hypertension in rats.

• Electrical & Electronic Materials
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• v.9 no.8
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• pp.789-798
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• 1996

The double nitride layer Metal Nitride Oxide Semiconductor(MNOS) structures were fabricated by variating both gas ratio and nitride thickness, and by duplicating nitride deposited and one nitride layer MNOS structure to improve nonvolatile memory characteristics of MNOS structures by Low Pressure Chemical Vapor Deposition(LPCVD) method. The nonvolatile memory characteristics of write-in, erase, memory retention and degradation of Bias Temperature Stress(BTS) were investigated by the homemade automatic .DELTA. $V_{FB}$ measuring system. In the trap density double nitride layer structures were higher by 0.85*10$^{16}$ $m^{-2}$ than one nitride layer structure, and the AVFB with oxide field was linearly increased. However, one nitride layer structure was linearly increased and saturated above 9.07*10$^{8}$ V/m in oxide field. In the erase behavior, the hole injection from silicon instead of the trapped electron emission was observed, and also it was highly dependent upon the pulse amplitude and the pulse width. In the memory retentivity, double nitrite layer structures were superior to one nitride layer structure, and the decay rate of the trapped electron with increasing temperature was low. At increasing the number on BTS, the variance of AVFB of the double nitride layer structures was smaller than that of one nitride layer structure, and the trapped electron retention rate was high. In this paper, the double nitride layer structures were turned out to be useful in improving the nonvolatile memory characteristics.

• Proceedings of the Korean Geotechical Society Conference
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• 2005.03a
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• pp.1070-1077
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• 2005

The purpose of this study is to establish a proper criterion for the constant rate of loading consolidation(CRLC) test which is a kind of the continuous loading consolidation(CLC) and widely used as alternative methods to the incremental loading consolidation(ILC)test. With those results, the preconsolidation pressure estimated by the CRLC test turned out to be comparatively larger than that of the ILC test, and it is increased in proportion to the applied loading rates. However, the compression index in the CRLC test is less influenced on by the loading rates. The coefficient of consolidation and permeability in the CRLC test are dependent on excess pore pressure ratio mainly. In other words, if the pore pressure ratios are too low, the coefficient of consolidation and permeability become smaller than those of the ILC test. On the other hand, if the excess pore pressure ratios are too high, the coefficient of consolidation and permeability become so larger than those of the ILC test. Therefore, loading rates should be carefully determined to generate proper excess pore pressure ratio inside the soil specimen. From this study, good results are obtained from the CRLC test if the excess pore pressure ratios were in the range of 2.5 to 6.0 %, performed with loading rates between 0.0015 and 0.005 $kgf/cm^2/min$.

• Korean Journal of Health Education and Promotion
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• v.7 no.1
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• pp.54-63
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• 1990

This study aims to find out the prevalence of smoking, and to analyze the effect of smoking for health status, and then to emphasize the necessity of stop smoking. The data used in this study are obtained from periodic health care programe at Health Care Center in a suburban hospital, and selected 435 males who have occupation. The independent varibles chosen for the analysis are general charactersitic variables and smoking habit. The dependent variables are designed to cover the health status of individual cases, and include blood pressure, blood cholesterol level with HDL-cholesterol and blood triglyceride level, recent symptoms and recently being managed diseases. The result of this study are summarized as follows. 1) Percentage of smoker by the age groups is highest in 4th decade, being 71.1%. The second and third ranks are 6th and 7th decades, being 53.5% and 44.4%, respectively. 2) In the view of socio-economic levels, smoking rate is higher in the groups who live at rural area and whoes occupation is labor or merchant. Smoking rate is significantly higher in the heavy drinking group. 3) Among the atherosclerotic risk factors, which include hypertension, HDL-cholesterol by total cholesterol ratio lower than 0.2 and triglyceride level higher than 200gm/dl, hypertension was not statistically associated with smoking, but others revealed statistically high association with smoking. 4) The groups who have the symptoms of severe fatigue, gastrointestinal symptoms, pulmonary symptoms, palpitation and chest tightness havepositive association with smoking. 5) The groups who have hypertension with cardiovascular diseases and gastrointestinal diseases showed highly significant association with non-smoking. 6) In relation of the smoking habit to the atherosclerotic risk factor index, smokers have more atherosclerotic risk factors, but that is not statistically significant. 7) In relation of the smoking habit to the recent symptom index, smokers have more symptoms than non-smokers with statistical significance. In conclusion, smokers have worse health status than non-smokers especially in the atherosclerotic risk factors such as hypertension or abnormal blood lipid status and have more symptoms such as severe fatigue, gastrointestinal symptoms, pulmonary symptoms, palpitation and chest tightness. And the campaingn against smoking should direct for the male in 4th decade because they have highest smoking rate.

• BMB Reports
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• v.36 no.2
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• pp.196-200
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• 2003

Previously, we reported the biochemical properties of RGA1 that is expressed in Escherichia coli (Seo et al., 1997). The activities of RGA1 that hydrolyzes and binds guanine nucleotide were dependent on the $MgCl_2$ concentration. The steady state rate constant ($k_{cat}$) for GTP hydrolysis of RGA1 at 2 mM $MgCl_2$ was $0.0075{\pm}0.0001\;min^{-1}$. Here, we examined the effects of pH and cations on the GTPase activity. The optimum pH at 2 mM $MgCl_2$ was approximately 6.0; whereas, the pH at 2 mM $NH_4Cl$ was approximately 4.0. The result from the cation dependence on the GTPase (guanosine 5'-triphosphatase) activity of RGA1 under the same condition showed that the GTP hydrolysis rate ($k_{cat}=0.0353\;min^{-1}$) under the condition of 2mM $NH_4Cl$ at pH 4.0 was the highest. It corresponded to about 3.24-fold of the $k_{cat}$ value of $0.0109\;min^{-1}$ in the presence of 2 mM $MgCl_2$ at pH 6.0.

• Nuclear Engineering and Technology
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• v.23 no.3
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• pp.299-305
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• 1991

Corrosive environment may be generated within steam generators from condenser cooling water in-leakage. Theoretical analysis of the accumulation of chloride as a sea water impurity is being carried out for the condenser cooling water used at YGN-1,2 nuclear power stations. Calculations have shown that highly concentrated chloride solution would be produced within the steam generators in the case of sea water in-leakage. Maximum allowable design condenser leak rate(0.5 gpm) leads chloride concentration of 2.3 ppm at steam generetor and 0.6 ppm at hotwell with the maximum blowdown rate and condensate purification. Concentration factor at steam generator is dependent only on both blowdoum rate and condensate purification efficiency as follows, Concentration Factor（equation omitted）(B$\neq$O) Blowdown and condensate purification are evaluated as the only effective measures to remove impurities from the secondary systems.

• Tunnel and Underground Space
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• v.27 no.5
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• pp.324-332
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• 2017

In this paper, a numerical analysis of one-dimensional viscous fluid flow in a rock joint using UDEC code is performed to evaluate the effect of design parameters on injection performance. We consider injection pressure, fluid compressibility, time dependence of yield strength and viscosity of injected grout fluid, and mechanical deformation of joint as the design parameters, and penetration length and flow rate of injection are investigated as the injection performance. Numerical estimations of penetration length and flow rate were compared to analytical solution and were well comparable with each other. We showed that cumulative injection volume can be over-estimated by 1.2 times than the case that the time-dependent viscosity evolution is not considered. We also carried out a coupled fluid flow and mechanical deformation analysis and demonstrated that injection-induced joint opening may result in the increment of cumulative volume by 4.4 times of that from the flow only analysis in which joint aperture is kept constant.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.19 no.4
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• pp.390-402
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• 2009

This study aimed to examine the general characteristics of individual workers, psychosocial working environment, and ergonomic risk factors which affect the status of musculoskeletal disorders. Self-report was carried out for musculoskeletal symptoms and ergonomic risks in working environment in 856 production workers in 16 small to medium sized manufacturing companies. Musculoskeletal symptoms were examined with a standardized questionnaire, and ergonomic risks were evaluated with a qualitative self-administered instrument for the tasks related to musculoskeletal disorders. Major findings were as follows: 1) Complaint rate for musculoskeletal symptoms was higher in female, aged, married workers with longer working hours, less leisure/hobby activity, longer household working hours and history of disease or accident. 2) Complaint rate for musculoskeletal symptoms was significantly higher in workers with dissatisfaction, difficult tasks, and no self-control at work. 3) Complaint rate for musculoskeletal symptoms was significantly higher in workers involved in tasks with major ergonomic risk factors, and handling heavy equipment. 4) Explanatory power increased the model with the musculoskeletal symptoms as dependent variable and demographic variables, psychosocial working environment and ergonomic risk factors included, and total explanatory power of 18.6% revealed the significant effect. Based on the results, we can conclude that musculoskeletal symptoms in manufacturing workers are associated with individual demographic characteristics, psychosocial working environment and ergonomic risk factors.

• Food Science of Animal Resources
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• v.35 no.1
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• pp.108-113
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• 2015

The purpose of this study was to develop predictive models for the growth of Listeria monocytogenes in pork Bulgogi at various storage temperatures. A two-strain mixture of L. monocytogenes (ATCC 15313 and isolated from pork Bulgogi) was inoculated on pork Bulgogi at 3 Log CFU/g. L. monocytogenes strains were enumerated using general plating method on Listeria selective medium. The inoculated samples were stored at 5, 15, and $25^{\circ}C$ for primary models. Primary models were developed using the Baranyi model equations, and the maximum specific growth rate was shown to be dependent on storage temperature. A secondary model of growth rate as a function of storage temperature was also developed. As the storage temperature increased, the lag time (LT) values decreased dramatically and the specific growth rate of L. monocytogenes increased. The mathematically predicted growth parameters were evaluated based on the modified bias factor ($B_f$), accuracy factor ($A_f$), root mean square error (RMSE), coefficient of determination ($R^2$), and relative errors (RE). These values indicated that the developed models were reliably able to predict the growth of L. monocytogenes in pork Bulgogi. Hence, the predictive models may be used to assess microbiological hygiene in the meat supply chain as a function of storage temperature.