• Title/Summary/Keyword: radiation response

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Comparative study on Hsp25 expression in Mongolian gerbil and mouse cerebellum

  • Lee, Heang-Yeon;Kim, Seong-Hwan;Lee, Jae-Bong;Shin, Chang-Ho
    • Korean Journal of Veterinary Service
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    • v.29 no.4
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    • pp.469-482
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    • 2006
  • The term 'heat shock protein (Hsps)' was derived from the fact that these proteins were initially discovered to be induced by hyperthermic conditions. In response to a range of stressful stimuli, including hyperthermia, immobilization, UV radiation, amino acid analogues, arsenite, various chemicals, and drugs the mammalian brain demonstrates a rapid and intense induction of the heat shock protein. Moreover, Hsps were expressed on the various pathological conditions including trauma, focal or global ischemia, hypoxia, infarction, infections, starvation, and anoxia. Especially, Hsp25 has a protective activity, facilitated by the ability of the protein to decrease the intracellular levels of reactive oxygen species (ROS) as well as its chaperone activity, which favors the degradation of oxidized proteins. Recently, it has clearly demonstrated that Hsp25 is constitutively expressed in the adult mouse cerebellum by parasagittal bands of purkinje cells in three distinct regions, the central zone (lobule VI-VII) and nodular zone (lobule IX-X), and paraflocculus. The Mongolian gerbil has been introduced into stroke study model because of its unique brain vasculature. There are no significant connections between the basilarvertebral system and the carotid system. This anatomy feature renders the mongolian gerbil susceptible to forebrain ischemia-induced seizure. The present study is designed to examine the pattern of Hsp25 expression in the cerebellum of this animal in comparison with that in mouse.

Isolation and Characterization of Ultra-Violet and Gamma-radiation Resistant Bacteria from Natural Habitats (자연 생태계로 부터 자외선 및 방사선 내성 박테리아의 분리 및 특성 연구)

  • 이영남;이인정
    • Korean Journal of Microbiology
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    • v.27 no.3
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    • pp.297-303
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    • 1989
  • Attempts to isolate the naturally occurring ultra-violet resistant bacteria from environmental sources were made. The isolates, designated No.29, 100, and 107, among numbers of bacterial isolates revealed a remarkable resistance to UV ray, whose degree of resistance in dose/response kinetics was comparable to that of an endospore-former, Bacillus subtilis. In a range of 100-300 $Jm^{-2}$/min of UV irradiation, the isolates exhibited 500-1000 fold resistance compated with E. coli. The isolated appeared to possiss cell-bound pigment of organge or crimson-red. The isolate 29 is spherical in pairs or tetrads, whereas the isolates 100 and 107 are rod. All are Gram-gositive bacteria and seemed to be non-endospore-bearer. A number of biochemical studies pursued on the isolates suggested that they are quite different to each other. Electron microscopic examination and the physiological characters of the isolate 29 suggested that this UV resistant spherical bacterium might be one species of Deinococcus, probably Deinococus radiophilus. Since there is no documents on UV resistant, Gram-positive, non-sporeformer bacillus so far, the isolates 100 and 107 might be turned out as new kinds of UV resistant bacteria occurring in nature by further investigation.

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Aging and UV Irradiation Related Changes of Gene Expression in Primary Human Keratinocytes

  • Lee, Ok Joo;Lee, Sung-Young;Park, Jae-Bong;Lee, Jae-Yang;Kim, Jong-Il;Kim, Jaebong
    • Genomics & Informatics
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    • v.3 no.2
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    • pp.66-72
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    • 2005
  • The epidermis is a physiological barrier to protect organisms against environment. During the aging process, skin tissues undergo various changes including morphological and functional changes. The transcriptional regulation of genes is part of cellular reaction of aging process. In order to examine the changes of gene expression during the aging process, we used the primary cell culture system of human keratinocytes. Since UV radiation is the most important environmental skin aggressor, causing skin cancer and other problems including premature skin aging, we examined the changes of gene expression in human keratinocytes after UV irradiation using oligonucleotide microarray containing over 10,000 genes. We also compared the gene expression patterns of the senescent and UV treated cells. Expression of the variety of genes related to transcription factors, cell cycle regulation, immune response was altered in human keratinocytes. Some of down-regulated genes are represented in both senescent and UV treated cells. The results may provide a new view of gene expression following UVB exposure and aging process in human keratinocytes.

Analysis of health inequality by the type of employment on health among employees - Pathway of the effect via the exposure of hazardous factors - (임금근로자의 고용형태에 따른 건강수준의 차이 분석 - 유해위험요인 노출을 경유한 영향 경로 -)

  • Rhee, Kyung Yong
    • Journal of the Korea Safety Management & Science
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    • v.16 no.2
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    • pp.81-90
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    • 2014
  • Flexible production system has been expanded to all sectors of economy with the change of labor market and diversification of employment. The unstable employment with irregular work has replaced stable employment with regular work. This study has investigate the impact pathway of the type of employment on health status especially ill-health symptoms experiences. Among the first Korean Working Conditions Survey data, the employee's response data was used to analyze the path way with multiple regression analysis. The result has shown the direct effect of the type of employment on ill-health symptoms experience. Indirect effect of the type of employment was found the pathway via the exposure to noise, high temperature, low temperature, dust, skin contact to chemicals, painful posture, heavy material handling, standing position, repetitive movement of hands. However the exposure to the other hazardous factors such as organic solvent, wholebody vibration, radiation, lifting people, infectious materials were not influenced by the type of employment.

A Study on Dosimetric Characterization of Direct Yellow 12 Dye at High Radiation γ-Dose

  • Batool, Javaria;Shahid, Shaukat Ali;Ramiza, Ramiza;Akhtar, Nasim;Naz, Afshan;Yaseen, Maria;Ullah, Inam;Nadeem, Muhammad;Shakir, Imran
    • Bulletin of the Korean Chemical Society
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    • v.33 no.7
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    • pp.2265-2268
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    • 2012
  • Aqueous solution of oxygenated Direct yellow 12 dye has been evaluated spectrophotometrically as a possible gamma rays dosimeter. The neutral (pH-7), alkaline (pH-12.5) and acidic (pH-5.5) aqueous solution of the dye were prepared and exposed to various gamma doses. Absorption spectra of unirradiated and irradiated solutions were recorded at 400 nm peak. The increase in absorbance with the increase in irradiation dose was observed from 1 to 6 kGy. The stability response of the dye solution for different environmental conditions such as temperature (low & high), light and darkness were investigated during post irradiation storage for ten days. The dye solution showed high stability in darkness for the studied period. The optical density of the dye solution was found to be decreased at high temperature storage.

In-situ Blockage Monitoring of Sensing Line

  • Mangi, Aijaz Ahmed;Shahid, Syed Salman;Mirza, Sikander Hayat
    • Nuclear Engineering and Technology
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    • v.48 no.1
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    • pp.98-113
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    • 2016
  • A reactor vessel level monitoring system measures the water level in a reactor during normal operation and abnormal conditions. A drop in the water level can expose nuclear fuel, which may lead to fuel meltdown and radiation spread in accident conditions. A level monitoring system mainly consists of a sensing line and pressure transmitter. Over a period of time boron sediments or other impurities can clog the line which may degrade the accuracy of the monitoring system. The aim of this study is to determine blockage in a sensing line using the energy of the composite signal. An equivalent Pi circuit model is used to simulate blockages in the sensing line and the system's response is examined under different blockage levels. Composite signals obtained from the model and plant's unblocked and blocked channels are decomposed into six levels of details and approximations using a wavelet filter bank. The percentage of energy is calculated at each level for approximations. It is observed that the percentage of energy reduces as the blockage level in the sensing line increases. The results of the model and operational data are well correlated. Thus, in our opinion variation in the energy levels of approximations can be used as an index to determine the presence and degree of blockage in a sensing line.

The Impacts of Built Environmental Features on the Land Surface Temperatures for the Heat Wave Seasons in Gwangju, South Korea (도시화에 따른 건조환경이 하절기 광주시 외부공간의 열환경에 미치는 영향에 대한 연구)

  • Hong, Sung-Woon;Yang, Dongwoo;Oh, Byoung-Chull
    • Journal of the Korean Solar Energy Society
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    • v.39 no.6
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    • pp.67-82
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    • 2019
  • This study aims to examine the impacts of built environmental features on the nocturnal and diurnal temperatures during the heat wave season in Gwangju, Korea. Built environmental measures are summarized at micro-scale level, such as 50 meters and 100 meters from temperature monitoring spots. Regressing the built environment on nocturnal and diurnal temperatures, we estimate how the artificial constructs contribute to temperature either day and night times. We found that impervious surface ratio is positively and negatively associated with nocturnal and diurnal temperatures, respectively. Buildings and structures tend to construct high thermal mass and absorb heat during day time and emit it for the night time. This property contributes to the nocturnal temperature model. On the other hand, urban areas with more vertical structure tend to block sun radiation more than rural, and it is more likely to find the negative relationship between impervious surface ratio and the diurnal temperatures.

The Response of soil surface heat budget to the precipitation (지표면 열수지의 강수응답성에 관한 연구)

  • 황수진;진병화
    • Journal of Environmental Science International
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    • v.3 no.2
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    • pp.89-100
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    • 1994
  • It is very important to assess accurately the terms which are included in the heat budget equation of soil surface because they are used in the UM and miso-scale circulation modeling as well as in the micrometeorological studies. Each terms in the heat budget equation change according to the soil moisture content. So, it is necessary to specify clearly the relations between soil moisture content and these terms. Special experiment with micrometeorological measurements was executed to study these relations at Environmental Research Center of Tsukuba University, Japan. The results are as follow: 1. The soil moisture contents of 1 cm and 4 cm depth are oscillated with one day Period in drying process and the amplitude of variation of 1 cm depth is greater than that of 4 cm. 2. Increase in soil moisture contents due to precipitation result in decrease of albedo with step function. 3. Sensible heat is in reverse proportion to the soil moisture content and latent heat is in direct proportion to it. Latent heat is more sensitive than sensible heat according to the soil moisture variation. Net long wave radiation have high correlation with soil moisture. 4. Comparing with the radiative term with the flux term in wetting process due to precipitation, the energy transfer of the aero and thermodynamic flux is greater than that of the radiative heat flux.

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Photosynthetic Response of Korean Ginseng under Saline Condition

  • Cho, Jin-Woong;Kim, Choong-Soo
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.49 no.2
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    • pp.100-104
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    • 2004
  • This study was conducted to investigate the effect of the salinity on growth, inorganic ion content, and photosynthetic rate ($\textrm{P}^{N}$) in Korean ginseng (Panax ginseng C.A. Meyer) with complex fertilizer (CF) and NaCl concentrations. The salinity was applied to plant using NaCl and CF, and controlled an EC as 0.0, 1.0, 2.0 and 3.0 dS $\textrm{m}^{-1}$. The salinity treated three times at 35, 42 and 49 d after transplanting. The leaf area in different electrical conductivity (EC) decreased only the higher NaCl 1.0 dS $\textrm{m}^{-1}$. The root growth increased with CF and especially, it was two times higher at 3.0 dS $\textrm{m}^{-1}$ than that of control. But the root growth sharply decreased with NaCl compared to CF. The light saturation point of Korean ginseng was around 100 $\mu\textrm{mol}\;\textrm{m}^{-2}\textrm{s}^{-1}$ photosynthetically active radiation (PAR), and $\textrm{P}^{N}$ increased as CF increased but decreased with NaCl especially at the late growth stage. The $\textrm{Na}^{+}$ content in Korean ginseng increased sharply with NaCl.

A Simple Power Management Scheme with Enhanced Stability for a Solar PV/Wind/Fuel Cell Fed Standalone Hybrid Power Supply using Embedded and Neural Network Controller

  • Thangavel, S.;Saravanan, S.
    • Journal of Electrical Engineering and Technology
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    • v.9 no.5
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    • pp.1454-1470
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    • 2014
  • This paper propose a new power conditioner topology with intelligent power management controller that integrates multiple renewable energy sources such as solar energy, wind energy and fuel cell energy with battery backup to make best use of their operating characteristics and obtain better reliability than that could be obtained by single renewable energy based power supply. The proposed embedded controller is programmed for maintaining a constant voltage at PCC, maximum power point tracking for solar PV panel and WTG and power flow control by regulating the reference currents of the controller on instantaneous basis based on the power delivered by the sources and load demand. Instantaneous variation in reference currents of the controller enhances the controller response as it accommodates the effect of continuously varying solar insolation and wind speed in the power management. The power conditioner uses a battery bank with embedded controller based online SOC estimation and battery charging system to suitably sink or source the input power based on the load demand. The simulation results of the proposed power management system for a standalone solar/WTG/fuel cell fed hybrid power supply with real time solar radiation and wind velocity data collected from solar centre, KEC for a sporadically varying load demand is presented in this paper and the results are encouraging in reliability and stability perspective.