• 대한방사선방어학회:학술대회논문집
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• 2011.11a
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• pp.86-87
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• 2011

• Molecules and Cells
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• v.24 no.3
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• pp.424-430
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• 2007

The biological effects of low-dose radiation have been investigated and debated for more than a century, but its cellular effects and regulatory mechanisms remain poorly understood. This study shows the human cellular responses to low-dose radiation in CCD-18 Lu cells, which are derived from normal human lung fibroblasts. We examined a colony-forming assay for cell survival by ionizing radiation. Live cell counting and cell cycle analysis were measured for cell proliferation and cell cycle progression following low-dose irradiation. We examined Raf and Akt phosphorylation to determine the proliferation mechanism resulting from low-dose radiation. We also observed that p53 and p21 were related to cell cycle response. We found that 0.05 Gy of ionizing radiation enhanced cell proliferation and did not change the progression of the cell cycle. In addition, 0.05 Gy of ionizing radiation transiently activated Raf and Akt, but did not change phospho-p53, p53 and p21 in CCD-18 Lu cells. However, 2 Gy of ionizing radiation induced cell cycle arrest, phosphorylation of p53, and expression of p53 and p21. The phosphorylation of Raf and Akt proteins induced by 0.05 Gy of ionizing radiation was abolished by pre-treatment with an EGFR inhibitor, AG1478, or a PI3k inhibitor, LY294002. Cell proliferation stimulated by 0.05 Gy of ionizing radiation was blocked by the suppression of Raf and Akt phosphorylation with these inhibitors. These results suggest that 0.05 Gy of ionizing radiation stimulates cell proliferation through the transient activation of Raf and Akt in CCD-18 Lu cells.

• 대한방사선방어학회:학술대회논문집
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• 2011.11a
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• pp.212-213
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• 2011

The biological effects of low dose ionizing radiation (LDIR) remain insufficiently understood. We examined for the scientific evidence to show the biological effects of LDIR using radiation-sensitive immune cells. We found that Ikaros protein was responsed to low dose-dependent effects of gamma radiation in IM-9 B lymphocytes. Ikaros encodes zinc finger transcription factors that is important regulators of a hematopoietic stem cells (HSCs) progression to the B lymphoid lineage development, differentiation and proliferation. In this study, we observed that cell proliferation was enhanced from 10% to 20% by LDIR (0.05 Gy) in IM-9 B lymphocytes. The Ikaros protein was phosphorylated in its serine/threonine (S/T) region and decreased its DNA binding activity in the cells exposed to LDIR. We found that Ikaros phosphorylation was up-regulated by CK2/AKT pathway and the residues of ser-304 and ser-306 in Ikaros was phosphorylated by LDIR. We also observed that Ikaros protein was localized from the nucleus to the cytoplasm after LDIR and bound with Autotaxin (ENPP2, ATX) protein, stimulating proliferation, migration and survival of immune cells. In addition, we found that the lysoPLD activity of ATX was dependent on Ikaros-ATX binding activity. These results indicate that the Ikaros is an important regulator of immune activation. Therefore, we suggest that low dose ionizing radiation can be considered as a beneficial effects, stimulating the activation of immune cells.

• 대한방사선방어학회:학술대회논문집
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• 2010.04a
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• pp.238-239
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• 2010

• 대한예방의학회:학술대회논문집
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• 2005.10a
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• pp.438-438
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• 2005

• Proceedings of the Acoustical Society of Korea Conference
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• 1987.11a
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• pp.24-30
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• 1987

SEA method have been developed for prediction sound radiation power from vibration of machinery. In this study, sound radiation power was predicted from coupled structures by transmission of vibration, which composed of two plates welded at right angle. The predicted sound radiation power is agreement within 2 or 3 dB on octave band comparing with values obtained from direct measurements. Also, in order to prove the validity of this method in changes of sound radiation power associated with modifications to structures, rubber pad stuck on a plate. This result is agreement approximately within 3 or 5 dB.

• Transactions of the Korean Society of Mechanical Engineers
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• v.13 no.1
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• pp.20-28
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• 1989

SEA(Statistical Energy Analysis) method has been applied to predict the sound radiation power from vibrating machinery. In this study, sound radiation power was predicted from coupled structures by transmission of vibration, which composed of two plates welded into an L shape. The predicted sound radiation power is in agreement within 2 or 3 dB on octave band comparing with values obtained from direct measurements. Also, in order to prove the validity of this method in changes of sound radiation power associated with modifications to structures, rubber pad was stuck on a plate. The results agree approximately within 3 or 5 dB. And SEA method is valuable for the optimal design to reduce the noise. Additionally, this paper suggests that the logarithmic decrement method is valid as the one for finding the loss factor.

• Proceedings of the Korean Nuclear Society Conference
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• 2005.10a
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• pp.227-228
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• 2005

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2009.11a
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• pp.210-210
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• 2009

This paper describes the analysis results of an generated power with a inclined solar radiation. 2 different types of modules were employed to study the effect of the a inclined solar radiation on the generated power amount. As a result, it was confirmed that the generated power increased with the solar radiation and the mono crystal type cells generated higher power than the thin film type cells.

• Journal of Radiation Protection and Research
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• v.1 no.1
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• pp.31-36
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• 1976