• 제목/요약/키워드: rTMS

검색결과 99건 처리시간 0.023초

근위축성 측삭 경화증의 하 운동 신경원 과흥분성: 운동유발전위를 이용한 분석 (Lower Motor Neuron Hyperexcitability in Amyotrophic Lateral sclerosis: Analysis Using Motor Evoked Potentials)

  • 배종석;홍석찬;김민기;김병준
    • Annals of Clinical Neurophysiology
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    • 제5권1호
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    • pp.21-26
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    • 2003
  • Background & Objectives: Hyperexcitablity of motor system is a well-established characteristic pathophysiologic finding of amyotrophic lateral sclerosis (ALS). Whereas little is known about the source of excitability according to the progression of the disease. We evaluated the excitability and its source in advanced ALS patients using transcranial magnetic stimulation (TMS). Meterial & Methods: Motor evoked potentials (MEP) by TMS were recorded for abductor pollicis brevis muscles in 20 patients, 11 men and 9 women, with ALS. Mean age was $54.2{\pm}12.1years$, and mean disease duration was $13.9{\pm}13.4years$. Serial magnetic stimulations were applied to get the parameters; excitability threshold (ET), amplitude and latency of MEP. We also had a facilitated MEP (fMEP). Results: The parameters were analyzed according to the clinical settings. ET was higher in ALS(mean $63.5{\pm}18.1$) than normal control (mean $46.0{\pm}8.4$, p<0.01). Amplitudes of MEP were reduced in ALS ($2.6{\pm}3.6mV$; control $6.5{\pm}3.1mV$, p<0.01). Duration of the disease and ET showed significant inverse correlation (Spearson correlation coefficient = -0.57, p<0.01). Duration of the disease and fMEP/MEP ratio showed less but also significant inverse correlation (Spearson correlation coefficient, r = -0.52, p < 0.05). Conclusions: Lower ET in advanced ALS patients, in spite of decreased fMEP/MEP ratio, may indicate the hyperexcitability of lower motor neurons in these patients. This study suggests that lower motor neurons is hyperexcitable due to upper motor neuron dysfunction at advanced stage.

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GC-MS를 이용한 혈장 중 호모겐티식산의 분석;알캅톤뇨증의 진단 (Determination of homogentisic acid in human plasma by GC-MS for diagnosis of alkaptonuria)

  • 마헤셜타파;유준동;이원재;이스람포크롤;윤혜란
    • 분석과학
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    • 제28권5호
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    • pp.323-330
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    • 2015
  • 알캅톤뇨증은 극히 드문 희귀 유전성 대사이상질환으로, 호모겐티세이트 디옥시게나제의 부족이나 결손으로 인한 질환이며 호모겐티식산 (HGA)의 축적을 특징으로 한다. 임상적으로는 호모겐티식산 혈증, 관절염 및 퇴자병 (ochronosis) 등을 보인다. 본 연구는 고가이고 시간이 많이 걸리는 고체상 추출단계 없이 신속하게 우수한 감도로 혈장 중 HGA의 정량분석을 위해 개발되었다. 통합 혈장 중 100 µL를 취하여 에틸아세테이트로 액체-액체 추출(LLE)한 후, 트리메틸 실릴 유도체 (TMS) 화한 후 GC-MS로 정량하였다. 카르복실기 및 히드록실 관능기의 TMS 유도체화의 형성은 80 ℃에서 5 분 동안 BSTFA (10% TMCS 포함)로 반응시켜 수행 하였다. GC-MS 의 선택 이온 모니터링을 위한 HGA의 선택 이온은 m/z=384, m/z= 341, m/z=25로 설정 하였다. 통합 혈장에 여러 농도로 표준품을 첨가하여 검토한 검량선은 1-100 ng/µL 범위에서 직선성은 R2=0.9991로 양호하게 나타났다. 통합 혈장에 HGA를 2, 20과 80 ng/µL 농도를 첨가하여 회수율, 정확도와 정밀도를 측정하였을 때, 일간내 회수율은 99-125% 였고, 일간외 회수율은 95-115% 였고, 정확도는 1-15% 이내로 양호하였다. LOD와 LOQ는 각각 0.4 ng/µL, 4 ng/µL로 관찰되었다. 한국인 정상 혈장으로부터 HGA를 분석하였을 때, 적용된 모든 시료에서 HGA는 검출되지 않았다. 결론적으로 본 연구에서 개발된 분석 방법을 이용하면 알캅톤뇨증 환자를 신속하게 진단할 수 있으며 그 치료과정에서의 HGA 모니터링에 유용하게 응용할 수 있음을 시사한다.

비대칭과도 전류와 과전류계전기의 동작시간 특성에 관한 연구 (Study on the Asymmetrical Fault Currents and the Operating Time Characteristics of OCR)

  • 김남호;김일남;박종근
    • 대한전기학회논문지
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    • 제41권9호
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    • pp.953-959
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    • 1992
  • As the TC(time-current) curve corresponding to symmetrical time invariant RMS value has been traditionally chosen and used for setting the relay, it has caused the misoperation errors on relay coordination because of CT secondary current being actually an asymmetrical time varying RMS value. In this paper, an algorithm for calculating the relay operating time is developed to study the asymmetrical effect using the step-by-step method. We represent the relay operating time errors between with and without DC offset versus PSM(plug setting multiplier), TMS(time multiplier setting) and X/R ratio. And also we present the correction factor. Finally we confirm the validity of this technique through the case study.

하이브리드형 선형 펄스모터의 디지털 서보 제어기 설계 (Design of Digital Servo Controller for Hybrid Linear Pulse Motor)

  • 배동관;안재영;김광헌
    • 전력전자학회:학술대회논문집
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    • 전력전자학회 2003년도 춘계전력전자학술대회 논문집(1)
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    • pp.389-392
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    • 2003
  • A use of micro processor having H-com functions is gradually increased, and this paper describes the digital servo controller applied to linear pulse motor The TMS320LF2407, made by TI(Texas Instruments Co.), is used as a arithmetic unit in control circuit, designed f3r motor drive and available for the implement of high performance and miniaturization. Also, it can allow the sufficient debugging and downloading into control board for independent operation. A current control in order to carry out a position control is of a digital current control mode, and its implement confirmed the servo control performance of position control.

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홀 센서의 양극 바이어스 수직모드를 이용한 맥파측정시스템 구현 (Implementation of the Pulse Wave Measurement System Using Bipolar Biased Head on Mode of the Hall Sensor)

  • 진상곤;김명남
    • 센서학회지
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    • 제20권5호
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    • pp.322-328
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    • 2011
  • There are many ways to detect the heart rate non-invasively such as ECG, PPG, strain gauge, and pressure sensor. In this paper, the pulse wave measurement system using bipolar biased head on mode of the Hall sensor is proposed for measuring the radial artery pulse. TMS320F2812 was used to implement the proposed system and a portable wireless network(zig-bee) was used to show the experimental result. It was confirmed from experiment that the performance of the implemented system was more stable and faster than PPG sensor or piezoelectric film pressure sensor.

벡터제어 시스템에 의한 유도 전동기의 속응제어와 토오크 특성에 관한 연구 (A Study on torque characteristics and rapid response control of induction motor by vector control system)

  • 황락훈;장은성;남우영;조상로;신양호;조문택;이춘상;나승권
    • 전력전자학회:학술대회논문집
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    • 전력전자학회 2003년도 춘계전력전자학술대회 논문집(2)
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    • pp.807-811
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    • 2003
  • In this paper, the speed control system of induction motor was proposed using vector control algorithm and space voltage vector PWM method to improve the dynamic performance of Induction motor. The control system is composed of the PI controller for speed control and the current controller using space voltage vector PWM technique. The high-speed calculation and processing for vector control is carried out by TMS320C31 digital signal processor and IGBT module. The proposed scheme is verified through digital simulations and experiments for 3.7[kw] induction motor and shows good dynamic performance.

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dSPACE 시스템에 의한 유도전동기 구동 시스템의 벡터 제어 (Vector control of Induction motor drive system of dSPACE system)

  • 지준근;이동민
    • 한국산학기술학회:학술대회논문집
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    • 한국산학기술학회 2006년도 춘계학술발표논문집
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    • pp.284-287
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    • 2006
  • 본 논문에서는 dSPACE사의 PowerPC603e과 TMS320F240를 사용하는 dSPACE시스템에 의한 유도전동기 구동 시스템의 벡터제어에 대하여 소개한다. MATLAB/Simulink 소프트웨어와 DS1104 R&D 제어보드, Leroy SOMER사의 0.3KW 유도전동기와 IPM 인버터를 본 연구에 사용하였다. dSPACE 시스템은 Simulink 블록들을 사용함으로써 짧은 시간동안에 다양한 형태의 제어기를 설계 및 구현할 수 있는 장점이 있기 때문에 유도전동기의 벡터제어를 쉽게 설계하고 구현할 수 있다.

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An Improved Control Approach for DSTATCOM with Distorted and Unbalanced AC Mains

  • Singh, Bhim;Solanki, Jitendra
    • Journal of Power Electronics
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    • 제8권2호
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    • pp.131-140
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    • 2008
  • This paper presents a new control approach of DSTATCOM (distribution static compensator) for compensation of reactive power, unbalanced loading and harmonic currents under unbalanced non-sinusoidal ac mains. The control of DSTATCOM is achieved using Adaline based current estimator based on LMS algorithm to maintain source currents real and undistorted. The dc bus voltage of voltage source converter (VSC) working as DSTATCOM is maintained at constant voltage using a proportional-integral (PI) controller. The DSTATCOM system alongwith proposed control scheme is modeled in MATLAB to simulate the behavior of the system. The practical implementation of the DSTATCOM is carried out using dSPACE DS1104 R&D controller having TMS320F240 as a slave DSP. Simulated and implementation results are presented to demonstrate the effectiveness of the DSTATCOM with Adaline based control to meet the severe load perturbations with different types of loads (linear and non-linear) under distorted and unbalanced AC mains.

사전감지기술 및 송풍량 자동제어를 기반으로 한 저에너지 하수관리기술에 관한 연구 (Study on the Low Energy Sewage Management Based on Pre-sensing Technology and Automatic Blower Control)

  • 이승명;김한래;기경서
    • 환경영향평가
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    • 제28권6호
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    • pp.592-603
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    • 2019
  • 본 연구는 하수처리시 가장 많은 에너지가 소비되는 송풍기의 효과적인 제어를 통한 저에너지 하수관리기술 구현에 관한 것으로, 미생물에 필요한 산소의 양을 산정함에 있어 생물반응조내 운전지표나 방류수의 원격수질감시체계(Tele-Monitoring System, TMS) 데이터를 활용하는 기존방식과 달리 하수처리 시설로 유입되는 하수의 CODcr, NH4+-N 농도변화를 유입단에서 미리 감지하여 송풍에너지를 절감하고자 하였다. 사용된 사전감지기술은 기존 상용화된 제품과 비교 시 높은 상관관계를 보였다. 사전감지기술과 연계하여 송풍기를 자동제어한 결과 인력에 의한 수동제어방식에 비해 평균 9.9%의 송풍에너지를 줄일 수 있음이 확인되었다. 이처럼, 유입단에서 유입하수를 사전감지할 경우 실시간으로 유입수질의 변동파악 및 송풍량 제어가 가능해져 인력에 의한 수동운전방식에 의존하고 있는 다수 하수처리시설에 적용시 저에너지 하수처리를 기대할 수 있으며, 이를 통해 온실가스 배출 절감에 기여할 수 있을 것으로 판단된다.

Modeling and a Simple Multiple Model Adaptive Control of PMSM Drive System

  • Kang, Taesu;Kim, Min-Seok;Lee, Sa Young;Kim, Young Chol
    • Journal of Power Electronics
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    • 제17권2호
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    • pp.442-452
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    • 2017
  • This paper deals with the input-output modeling of a vector controlled PMSM drive system and design of a simple multiple model adaptive control (MMAC) scheme with desired transient responses. We present a discrete-time modeling technique using closed-loop identification that can experimentally identify the equivalent models in the d-q coordinates. A bank of linear models for the equivalent plant of the current loop is first obtained by identifying them at several operating points of the current to account for nonlinearity. Based on these models, we suggest a simple q-axis MMAC combined with a fixed d-axis controller. After the current controller is designed, another equivalent model including the current controller in the speed control loop shall be similarly obtained, and then a fixed speed controller is synthesized. The proposed approach is demonstrated by experiments. The experimental set up consists of a surface mounted PMSM (5 KW, 220V, 8 poles) equipped with a flywheel load of 220kg and a digital controller using DSP (TMS320F28335).