• Journal of Pharmaceutical Investigation
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• 제29권1호
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• pp.47-53
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• 1999

Gastrodia elata (GE) is an oriental medicinal herb which has been used traditionally for the treatment of various brain diseases including convulsion and epilepsy. The purpose of this study was to determine pharmacokinetic parameters of 4-hydroxy-3-methoxybenzaldehyde (HMBA) and p-hydroxybenzaldehyde (PHBA), constituents of GE, in rats. Male rats were cannulated in the femoral vein, femoral artery, bile duct and ureter. They received a single i.v. bolus dose of either HMBA or PHBA through the femoral vein. The concentration of HMBA or PHBA in plasma, bile and urine samples were analyzed by reversed-phase HPLC. HMBA and PHBA have very short half-lives, i.e. 4.03 and 2.26 minutes respectively. Most of HMBA and PHBA were thought to be eliminated through metabolism as the metabolized fraction approaches unity. Derivatives of HMBA or PHBA with longer biological half-lives should be designed to develop better anticonvulsants and more complete qualitative and quantitative understanding of the overall pharmacokinetic fate of these compounds awaits further investigation.

• Journal of the Korean Geotechnical Society
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• 제19권5호
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• pp.319-326
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• 2003

In site investigation for tunnel designs, nowadays, geophysical exploration such as seismic exploration and electric resistivity exploration as well as drilling logging is frequently carried out. A method which can systematically make the utmost use of all available data obtained from investigation, therefore, is strongly required for the optimal evaluation of ground conditions in terms of rock mass class, etc. Many researchers have proposed using qualitative data to cope with the lack of quantitative data. In this study, an evaluation technique of rock mass classes in undrilled region was proposed based upon multiple indicator kriging method which is a geostatistical technique. It was shown that two types of data with different degree of uncertainty, for example, drilling logging data and geophysical exploration data, could be simultaneously utilized in evaluating rock mass classes for a real tunnel design.

• Transactions of the Korean Society of Mechanical Engineers
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• 제8권5호
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• pp.416-424
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• 1984

A numerical and experimental investigation was carried out on the single-phase natural circulation system. This study is concerned with the multiloop system which is relevant to the primary system of the pressurized water reactor. For numerical analysis, five time-dependent governing equations were derived using the one-dimensional lumped parameter model. These equations were discretized by the space-time integration technique, and a simplified computer program, SIMFARS, was developed to solve those discretized equations. Experiments were performed for two purposes-one is to validate the developed code, and the other is to understand the qualitative behavior of the natural circulation loop. Comparison of the computational results with experiments, and several experimental and numerical results are presented in this article.

• Transactions of the Korean Society of Mechanical Engineers B
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• 제41권1호
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• pp.29-36
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• 2017

The paper presents a basic investigation for the development of cleaning technology employing an annular nozzle ejector for application to cleaning water supply and air bubble generation. The quantitative flow characteristics of the primary and suction flows, the qualitative visualization behavior of the mixed jet, and the percentage concentration of pesticide residual at different values of the ejector screw pitch were investigated. It was seen that the primary flow rate increased, while the mass ratio decreased with increase in screw pitch. Further, the mixed jet behaved like a buoyancy jet or horizontal bubbly jet, and the residual concentration of pesticide first decreased and then increased with increase in screw pitch.

• Steel and Composite Structures
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• 제42권2호
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• pp.151-159
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• 2022

This study discusses a hypothetical method for tracking the propagation damage of Carbon Reinforced Fiber Plastic (CRFP) components underneath vibration fatigue. The High Cycle Fatigue (HCF) behavior of composite materials was generally not as severe as this of admixture alloys. Each fissure initiation in metal alloys may quickly lead to the opposite. The HCF behavior of composite materials is usually an extended state of continuous degradation between resin and fibers. The increase is that any layer-to-layer contact conditions during delamination opening will cause a dynamic complex response, which may be non-linear and dependent on temperature. Usually resulted from major deformations, it could be properly surveyed by a non-contact investigation system. Here, this article discusses the scanning laser application of that vibrometer to track the propagation damage of CRFP components underneath fatigue vibration loading. Thus, the study purpose is to demonstrate that the investigation method can implement systematically a series of hypothetical means and dynamic characteristics. The application of the relaxation method based on numerical simulation in the Artificial Intelligence (AI) Evolved Bat (EB) strategy to reduce the dynamic response is proved by numerical simulation. Thermal imaging cameras are also measurement parts of the chain and provide information in qualitative about the temperature location of the evolution and hot spots of damage.

• Korean Journal of Culture and Social Issue
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• 제28권2호
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• pp.241-272
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• 2022

This purpose of this study was to use the meta-summary method to systematically integrate the findings of the heterogeneous qualitative research on the factors influencing the sexual identity formation process of lesbian, gay, and bisexual groups in Korea. The integrative investigation of the universal or unique factors affecting the identity formation of sexual minority is important to understand their internal experiences and support their psychological adaptation. Using a qualitative meta-summary, this study systematically identified and abbriviated the psychological and social factors that promote or impede the sexual identity acceptance and integration of LGB individuals. First, a total of 9 studies which were published in Korea up to 2021 were identified through the research database. The included studies were critically evaluated by using the Critical Appraisal Screening Programme tool. A total of 179 statements were extracted from the findings of each study and 34 abstracted statements were generated. The 34 abstracted statements were categorized into four groups, psychological factors that promote or impede sexual identity formation and social factors that promote or impede it. These four main categories and corresponding factors in each category were explained. The implications and limitations were also discussed.

• BMB Reports
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• 제53권5호
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• pp.241-247
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• 2020

As an intracellular degradation system, autophagy is an essential and defensive cellular program required for cell survival and cellular metabolic homeostasis in response to various stresses, such as nutrient deprivation and the accumulation of damaged organelles. In general, autophagy flux consists of four steps: (1) initiation (formation of phagophore), (2) maturation and completion of autophagosome, (3) fusion of autophagosomes with lysosomes (formation of autolysosome), and (4) degradation of intravesicular components within autolysosomes. The number of genes and reagents that modulate autophagy is increasing. Investigation of their effect on autophagy flux is critical to understanding the roles of autophagy in many physiological and pathological processes. In this review, we summarize and discuss ways to analyze autophagy flux quantitatively and qualitatively with the use of imaging tools. The suggested imaging method can help estimate whether each modulator is an inhibitor or a promoter of autophagy and elucidate the mode of action of specific genes and reagents on autophagy processes.

• 한국방재학회:학술대회논문집
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• 한국방재학회 2007년도 정기총회 및 학술발표대회
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• pp.45-48
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• 2007

The aim of this study is to estimate the compressive force of steel member using a system identification technique with vibration measurements. To date, several methods have been presented to estimate the compressive force using static and/or dynamic responses of the steel member. However, each and every one of these methods has its disadvantages as well as advantages in its procedures, level of accuracy, and equipment requirements. The paper reports a qualitative investigation of vibration under monoharmonic excitation. The methodology utilizes the relationship between the natural frequencies, the structural parameters, and the compressive force of the member. In this paper, experimental results are presented with a steel beam subjecting to several compressive forces and the proposed method is validated using both numerical and experimental data.

• Journal of the korean Society of Automotive Engineers
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• 제14권6호
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• pp.81-90
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• 1992

This paper deals with an experimental study on the initial condition of liquid film surface waves disintegration and investigation on the behavior of liquid film surface waves formed by the high speed air flow on the solid plane surface. The authors conducted the qualitative and quantitative study to in vestigate the liquid film flow phenomena, the liquid film disintegration mechanism, and droplet formation process with breaking the liquid film surface wave. The newly devised transparent rectangular test section which has semi-two-dimensional flow at the center of the bottom was introduced to perform the experimental study, and it can generate the uniform thickness liquid film at the bottom. The strobo streak camera was used to obtain the instantaneously transformed photographs. The electronic measuring device was also used to measure the liquid film thickness variation in order to perform the easy and effective analysis of complex flow phenomena in the air-water cocurrent flow.

• Proceedings of the KSME Conference
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• 대한기계학회 2004년도 추계학술대회
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• pp.1418-1423
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• 2004

A parametric study on the interactions of two spheres aligned in the streamwise direction is carried out using an immersed boundary method. The numerical results for the case of single sphere for the range of Re ${\leq}$ 300 are in good agreement with other authors' experimental and numerical results currently available. Then, our main investigation is focused on identifying the change of the vortical structures in the presence of a nearby sphere aligned in the streamwise direction for the range Re ${\leq}$ 220. It turns out that significant changes in physical characteristics are noticed depending on how close the two spheres are. In this paper, not only quantitative changes in the key physical parameters such as the force coefficients, but also qualitative changes in vortex structures are reported and analyzed.