• 재활치료과학
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• 제7권2호
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• pp.9-16
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• 2018

목적 : 본 연구의 목적은 뇌손상 환자의 신경학적 변화 측정도구인 뇌전도의 측정도구 및 방법, 평가와 분석방법을 알아봄으로써 임상영역에서 뇌전도 측정 시 기초자료를 제시하는 것에 있다. 연구방법 : 전자 데이터 베이스인 Pubmed, Science Direct를 사용하였으며, 주요검색 용어로 'Electroencephalography', 'stroke', 'intervention OR training'을 사용하였다. 결과 : 뇌전도는 두뇌-컴퓨터 인터페이스(Brain-computer interface)를 이용하여 재활의 효과를 뇌의 활성화 상태 변화로 측정할 수 있는 도구로 기능적 뇌 재조직화 매커니즘을 확인할 수 있는 것으로 나타났다. 뇌전도 측정도구의 경우 다양한 채널, 전극의 형태 및 전극 부착 부위로 구성되어 있으며, 결과해석에 사용되는 주파수 또한 다양하게 나타났다. 결론 : 뇌전도는 중재에 대한 효과성을 신경학적으로 확인할 수 있을 뿐만 아니라 효율적인 작업치료를 위한 중재전략을 마련하는데 사용될 수 있을 것으로 사료된다.

• 재활치료과학
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• 제7권3호
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• pp.9-21
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• 2018

목적 : 본 연구는 국외 학술지를 대상으로 체계적인 문헌고찰을 통해 자폐스펙트럼장애(autism spectrum disorder, ASD)아동들을 대상으로 사용되는 조기 중재 방법의 효과를 확인하는 것이었다. 연구방법 : 2017년 12월 이전까지의 국외 학술지에 게재된 논문을 Pubmed를 통하여 검색하였다. 주요 검색어로는 'autism', 'autism spectrum disorder', 'ASD', 'high function autism', 'high function ASD', 'Asperger syndrome', 'pervasive developmental disorder', 'PDDNOS', 'intervention'과 'early intervention'를 사용하였다. 최초 검색된 논문은 724편이었으나 포함 및 배제기준을 적용하여 최종 10편의 연구가 선정되었다. 결과 : 자폐스펙트럼장애 아동의 조기 중재는 10편의 선정된 연구 중에서 8편의 연구가 응용행동분석에 기초한 중재 프로그램을 적용하였고, 다른 2편의 연구들은 감각 통합적 접근과 테크놀로지에 기반을 둔 중재접근을 사용하였다. 대부분의 연구가 조기 중재로 의사소통기술과 사회적 상호작용기술, 지능, 적응 행동의 증가, 동시집중력의 향상과 같은 긍정적인 효과를 보고하였다. 결론 : 본 연구는 자폐스펙트럼장애 아동의 조기 중재에 대한 근거를 제시하며, 향후 국내 연구에서 효과적인 조기 중재에 대한 효과를 확인하는 연구가 필요할 것으로 사료된다.

• 대한예방한의학회지
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• 제20권3호
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• pp.93-113
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• 2016

Objectives : The focus of the review was laid on differences in research pertaining to thread embedding acupuncture between domestic and foreign journals. Methods : We collected 53 Korean articles on thread embedding acupuncture study from 4 Korean article searching sites, and 80 foreign articles from Pubmed. We analyzed the number of the theses according to the publication year, study method, journal, and subject. Results : A total number of 134 thread embedding acupuncture articles were categorized as 100 clinical trials, 14 experimental papers, and 19 literature reviews. Of the collected clinical trials, 55 were case studies, 6 were CCTs and 39 were RCTs. The domestic clinical trials were comprised of 36 case studies, 1 CCT, and 2 RCTs, and foreign clinical trials were comprised of 19 case studies, 5 CCTs, and 37 RCTs. Although only 12 of the 39 domestic clinical trials exclusively treated thread embedding acupuncture to the experimental group, 38 out of 61 foreign clinical trials undertook thread embedding acupuncture as the sole treatment. While the 2 domestic RCTs research had no significant evidence that the experimental group was different from the control group, the experimental group demonstrated better responses than the control group in 31 of the 37 foreign RCT studies. Conclusions : Studies on thread embedding acupuncture are more intensively studied in the foreign field in comparison to the domestic field. Referring to the results from the foreign thread embedding acupuncture studies, domestic use of thread embedding acupuncture should be expanded. Also, more refined research needs to be conducted in the domestic field in order for the Koran medicine to lead the thread embedding acupuncture. This study is limited in that the literature search in the foreign journals were restricted.

• The Journal of Korean Physical Therapy
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• 제32권5호
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• pp.312-318
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• 2020

Purpose: This study aimed to investigate the evidence that therapeutic horseback riding can improve balance, muscle, ADL, equivalenc, GMFM, gait, emotion with developmental disabilities and neural patients. Methods: To conduct meta-analysis, the search focused on studies that employed therapeutic horseback riding for developmental disabilities and neural patients for which eight databases (KIS, RISS, DBpia, National Assembly Library, Pubmed, Embase, Google scholar and Cochrane Library) were used to extract literature published from 2002 to September 2019. The data were analyzed the RevMan 3.5.3 program. Results: As a result of meta-analysis, therapeutic horseback riding total effect size is 0.552 for children with developmental disabilities and neural patients. And effect size result of according to assessment type variable first, balance effect size is 0.594. Second, muscle activities effect size is 0.425. Third, ADL effect size is 0.430. Fourth, equivalance effect size is 0.640. Fifth, GMFM effect size is 0.482. Sixth, gait effect size is 0.400 and seventh emotion effect size is 0.876. Conclusion: These findings is horseback riding is effective The effect size by outcome was observed to be the effective for children with developmental disabilities and neural patients. and also the horseback riding provided the positive effects of balance, muscle activities, ADL, equivalance, GMFM, gait, emotion for children with developmental disabilities and neural patients. It is hoped that this study will contribute to the development of effective treatments for children with developmental disabilities and neural patients therapeutic horseback riding and the development of study.

• Korean Journal of Acupuncture
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• 제28권3호
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• pp.1-12
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• 2011

Objectives : The purpose of this study is to review laser acupuncture studies to find possibility for applying high intensity laser to acupuncture and moxibustion treatment. Methods : Searching papers was performed using search engines of five electronic databases, including Pubmed, Thomson ISI, EMBASE, Sciencedirect, and EBSCO, from inception to May 2011 without language limitation. Inclusion criteria were clinical studies with human, randomized controlled trials (RCTs), case-control studies, and case reports. Selecting papers was performed with titles and abstracts in first step, scrutinize full text in second step, and then the extrated data was analyzed by two authors independently. The methodological quality for RCTs was evaluated using Jadad's scale. Results : Total 8 papers, (3 RCTs, 5 controlld studies, and 1 case reports), were finally selected. The study dealt with surgical laser, argon and $CO_2$ laser was one for each, with GaAs laser was two, and with new semiconductor laser, GaN, were four. The output range was from 110 mW to 15 W. The study diseases were alcohol addiction, knee osteoarthritis, bronchopneumonia and asthma for children, and circulation. All studies reported positive effect. The methodological quality in all RCTs was low because of below 3 points and all studies had few subject numbers. Conclusions : We suggest that high intensity laser can be applied to acupuncture and moxibustion. Further rigorous and well-designed study will be needed for various disease. The oriental medical society needs to take active measures to study and clinical application of acupuncture and moxibustion treatment with high intensity laser.

• 한국한의학연구원논문집
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• 제13권2호통권20호
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• pp.101-112
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• 2007

Objective : This study was aimed to review the trend of clinical research articles of acupuncture and moxibustion from the year of 1995 to 2006. Methods : The retrieving and analyzing period were from January 1995 to July 2006. Articles were collected by retrieving Pubmed database. Search terms were as follows; 'Acupuncture', 'Acupuncture & Meridian', 'Moxibustion'. After reviewing articles by our pre-defined criteria, Correlation was assessed qualitatively between contents of the final selected articles and those of Korea Institute of Oriental Medicine. Results : The number of acupuncture research articles have increased with higher rate since the year of 2000. In the field of medical devices, the articles were sparsely existed. The percentage of clinical acupuncture research articles was 75%. However, in the category of Korean investigators' researches, it was 46%. Publications by Korean investigators were concentrated to several specific journals of which their impact factor were below 1 point. Conclusion : There needs more qualifying studies in acupuncture studies which are represented by impact factor in Journal Citation Reports. It is necessary to research and develop the medical devices quantatively rating the outcome of acupuncture trials. The secondary research, such as, systematic reviews, meta-analysis, would be a key approach to evaluate the effectiveness and safety of acupuncture treatments. Moxibustion research would be noticeable in regard to its historical effectiveness and its variable indications.

• 한국임상약학회지
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• 제27권4호
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• pp.207-213
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• 2017

Background: It is recommended to use aerosolized (AS) colistin in patients undergoing mechanical ventilation therapy as an adjunctive in the latest guidelines, in spite of high nephrotoxicity and limited studies. In this study, systematic reviews and meta-analyzes were conducted to evaluate the safety and efficacy of AS colistin in patients with ventilator-associated pneumonia Methods: Two authors independently searched related literature published from Pubmed and EMBASE until July 2016 and included a study comparing adjunctive AS colistin with intravenous (IV) colistin monotherapy. The primary outcome was the clinical response rate, the secondary outcome was the overall mortality, and nephrotoxicity. The publication bias was evaluated using the Egger's test. Results: Of the total 279 articles, nine were finally included in the final analysis. There was a significant difference between the adjunctive AS colistin group and the IV colistin monotherapy group for the treatment-response rate (odds ratio (OR), 1.56; 95% CI, 1.14-2.14; p = 0.005; $I^2=36%$), although there was no significant difference in overall mortality (OR, 0.77; 95% CI, 0.57-1.04; p = 0.09; $I^2=20%$). However, there was no significant difference between the two groups in nephrotoxicity (OR, 1.13; 95% CI, 0.74-1.74; p = 0.57; $I^2=4%$). Conclusion: The addition of aerosolized colistin to IV colistin monotherapy showed better results in terms of efficacy than IV colistin monotherapy and did not show any significant difference in terms of total mortality and nephrotoxicity. Additional large-scale studies of this need to be verified.

• 대한한의학방제학회지
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• 제28권4호
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• pp.407-428
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• 2020

Objectives : The purpose of this study is to review the effect of Guaruhaebaekbaekju-tang (GHBJ), Guaruhaebaekbanha-tang (GHBH) and Jisilhaebaekgyeji-tang (JHGJ) by summarizing Korean and English articles. Methods : The study was based on 23 papers published since 1995. Papers were searched on seven domestic electronic databases including Koreantk, NDSL, RISS, KISS, OASIS, Koreamed and Library of Korea University and three international electronic databases including PUBMED, Embase and Science Direct. Results : 1. 23 research papers were collected, including 13 in vitro studies, 6 in vivo studies, 2 case reports and 2 literature studies. 2. GHBJ, GHBH and JHGJ showed significant myocardial protective and anti-hyperlipidemic and anti-inflammatory effects. In addition, researches on anti-oxidant, thrombosis, and atherosclerosis have been conducted in various ways. 3. It can be confirmed that these studies are related to Chest and back pain (胸背痛), Insomnia by chest paralysis (胸痺不得臥), Stabbing pain that radiates from chest to back (心痛徹背), Chest numbness (心中痞), Obstruction of qi in the chest (留氣結在胸), Fullness sensation in chest (胸滿) among the terms. Conclusion : Through these results, close association was found between classic description and modern research about GHBJ, GHBH and JHGJ, and the possibility of providing objective evidence was confirmed. To improve the quality of the study, large scale studies will be required to evaluate the authority of GHBJ, GHBH and JHGJ.

• 대한한의학방제학회지
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• 제28권4호
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• pp.429-441
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• 2020

Objectives : Systemic sclerosis(SSc) is an autoimmune disease characterized by fibrosis of the skin and internal organs and vasculopathy. The purpose of this study was to investigate the trend in the research on SSc using herbal medicine. Methods : We searched for papers which had both systemic sclerosis and herbal medicine from Pubmed, KCI and NDSL. After searching papers, we classified according to the study design and analyzed selected studies. Results : 18 studies were searched. The types and numbers of study were as follows: 11 were in vitro or in vivo studies using herbal medicine or active components, and 7 were clinical research including case reports. 1. Herbal medicines include the therapeutic effects of "tonifying qi(補氣)" or "active blood(活血)" improved systemic sclerosis in vivo and in vitro studies. 2. Active components isolated from Herbal Medicine such as Astragalus membranaceus(黃芪), Zhizi(梔子), Salvia miltiorrhiza(丹蔘) have anti-fibrotic effects. 3. Clinical trials showed that herbal medicine can improve the symptom of systemic sclerosis including skin fibrosis, Raynaud's phenomenon, pain and gastric dysmotility. Conclusions : This study showed that herbal medicine can be effective for treating SSc. However, further studies are needed to develop novel medicine for SSc.

• 대한한방내과학회지
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• 제39권3호
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• pp.338-349
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• 2018

Objective: The purpose of this study is to investigate recent clinical studies on the effects of acupuncture on dementia. Method: We searched RCTs (randomized controlled trials) using the database PubMed (2000-2018). Clinical RCT studies of acupuncture used to treat dementia in humans were included. Nine randomized controlled trials were included. Results: Various acupoints such as Baihui (GV20), Sishencong (EX-HN1), Fengchi (GB20), and Shenting (GV24) were used to treat symptoms. The studies reported a decrease in evaluation criteria, such as the Mini Mental State Examination (MMSE) and activities of daily living (ADL), for measuring cognitive ability. The acupuncture process, the results for outcome measure, and the effectiveness of studies were analyzed. We then assessed "risk of bias." Conclusions: Through this review, we found that acupuncture is applicable for the treatment of dementia. This can be used for future study.