• 제목/요약/키워드: puberty

검색결과 367건 처리시간 0.026초

후기 학령기 아동의 성지식 요구 (The needs for sex knowledge in the late schooler)

  • 이은주
    • Child Health Nursing Research
    • /
    • 제6권2호
    • /
    • pp.167-185
    • /
    • 2000
  • The goal of this research was to provide the basic data of sexual education for late schooler by finding out what they want to know about sex, or to see, if any, its relevancy between female and male students and between each grade. The sample for this research was a total of 453 students in 4th, 5th and 6th grade from 12 different classes at two elementary schools which were located in C city and in B province. The children were requested to write down three points on what they want to know or to learn most about sex, and their answers were put through two analytical stages in order to classify and to examine. The followings are the conclusions from the data. 1. The female cluster took 44.2% out of the whole sample, and there were 151 students per each grade. The specific girl ratios for each grade were 42.4%, 50.3% and 39.7% respectively. 2. It was noted that a total of 1,195 questions were gathered from the students writings, 45% of the questions was raised by the female students. The 4th grade students raised 432questions (43.8% by the girl) while the 5th. and the 6th grade students raised 387 (53.2% by the girl) and 376 questions (42.3% by the girl) respectively. The average number of questions per students was 2.6 while the female students raised 2.8 questions which was more than the average 2.5 questions by male students. It was the 4th grade female student cluster, which raised the most question (3.0) while the 6th grade male students raised the least question (2.4) in average. 3. The questions raised by the children could be divided into seven categories of the knowledge need on sex. They were Reproduction (310 questions, 25.9%), Sexual Culture (230, 19.2%), Concept of sex (125, 18.0%), Changes of Puberty (172, 14.4%), Sexual Health (119, 10.0%), Anatomy and Physiology of Reproductive System (78, 6.5%) and Sexual Tendency and behavior (71, 5.9%). 4. 'Reproduction' was the most frequently raised questions not only by both sex groups but also by the 5th grade students. Both sexes in the 4th grade showed the highest interest in Sexual Culture while it was Changes in Puberty for the both sexes in the 6th grade. The knowledge need on sex of the children indicated what they understand sexuality. They apprehended sex as sex, gender and sexuality in an inclusive way. They showed a major interest in the biological sex and the sexual activities. It seems that the children managed to understand clearly the meaning of gender, furthermore, they even pointed out that the streotyped sex role, patrimonial system and the sexual discrimination were unreasonable. The students possessed not only the least but also the most negative understanding in regard of sexuality. Two suggestions were made from the above conclusions for the practical sex education as well as its research. 1. For the practice: The sex education for the elementary upper grade school student should be relevant with their cognitive characteristics, also it should be more specific on the reproductive organs of both sexes, the actual scenes of the pregnancy and child delivery procedures. The gender concept should be added to the biological sex education, which will lead them to understand the unreasonableness of today's male-superior phenomenon and correct them. It is also necessary to develop educational programs for this age group so as to help them to understand sex in the sense of sexuality as well. 2. For the research: It is not easy to draw out a through conclusion since this study was carried out as one-time data collection. Yet it is undeniably helpful for the sex education if we can understand what the children want to know about sex, how much they know about it by conducting deep-interview researches through a small number of sample.

  • PDF

서울지역 일 여자 상업고등학교의 성에 대한 지식 및 태도에 관한 연구 (A Study on the Knowledge and Attitude about Sex in One Commercial Girls' High school in Seoul)

  • 김은희
    • 한국학교보건학회지
    • /
    • 제4권2호
    • /
    • pp.100-118
    • /
    • 1991
  • This study was conducted in order to grasp the condition of the student's knowledge and attitude about sex. And to offer the basic materials for sex education of school health service. The objects were comprised of 464 volunteered students who study in commercial girls' high school. The material of this study was the questionaire suited to the purposed of this research which has been made through studying references. All the questionaire written by students. The self reported questionaires were collected immediately without explanation on supervision of school nurse. The data was collected from 28th to 30th of June on 1990. Analysis of the data was done utilizing SPSS for percentage, mean, ANOVA and Pearson Correlation Coefficients. The Results are as follows; 1. General features of the objects of study School grade distribution was similar. Fathers of 41-50 years were the highest(58.3%), mothers of 41-50 years were the highest(64.3%), family of living together were the highest(87.5%), fathers of graduated high school were highest(60.7%), mothers of graduated middle school were the highest(43.0%) and neuclear families were highest(91.5%). 2. The Conditions of Knowledge about sex When 5 Point was given to "Well known" and 1 point was given to "Never known", the total average was 2.97, Especially the mean of Female physiology was shown 3.93, 73.4% of students have known. But the mean of male physiology was shown 2.23, 17.2% of students only. And Family planning item was 3.54, hymen item was 3.38, female genitalia item was 3.35, abortion item was 3.25, Intercourse and pregnancy item was 3.24, Ovulation item was 3.02, Contraception item was 2.97, Veneral disease and masturbation item was 2.82, maintenance of pregnancy item was 2.76, Anatomical differences between male and female item was 2.59, male genitalia item was 2.31, ejaculation item was 2.27. 3. The conditions of attitude about Sex When 5 point was given to "Very affirming" and 1 point was given to "Very deny" the total average was 3.20. Especially the mean of social intercourse between other sex was shown 3.92, 73.4% of students have affirmed. But the mean of psychic response on menstruation was shown 2.24, 8.8% of students only. And baby birth item was 3.72, the fact that I am a woman item was 3.53, marriage item was 3.49. Secondary body change item was 3.38, puberty item was 3.31, delivery and sexual intercourse item was 3.05, pregenancy item was 3.02, psychic condition on menarche item was 2.50. Also present counsellors about sex were teachers in charge (44.9%), friends(21.6%), mothers(20.6%), elder sisters (10.6%), mass-communications (1.5%), fathers (0.4%), school nurses and elder brother(0.2%). In addition to, future counsellors about sex were friends (37.7%), mothers(30.6%), elder sister (18.4%), school nurses (4.6%), mass communication (3.8%), teachers in charge (2.5%), elder brothers (1.4%) and fathers(1.0%). 4. Correlation between the general features and knowledge variables School grade and knowledge condition has relationship to female genitalia(P<0.05), female physiology (P<0.00), male physiology (P<0.05),ovulation (P<0.00), and femily planning (P<0.005). Fathers age and knowledge condition has relationship to male physiology(P<0.05), and abortion (P<0.05). Marrital status and knowledge condition has relationship to female physiology (P<0.01), masturbation (P<0.05). Fathers educational background and knowledge condition has relationship to masturbation (P<0.00). Mothers age and knowledge condition has relationship to family planning (P<0.05). 5. Correlation between the general futures and attituded variables Fathers age and attitude condition has relationship to psychic response on menstruation (P<0.05). Mothers age and attitude condition has relationship to fact that I am a woman (P<0.00). Mothers educational background and attitude condition has relationship to social intercourse between other sex (P<0.05). Type of family and attitude condition has relationship to puberty (P<0.01). 6. Correlation between knowledge condition and attitude condition Those who had more knowledge about sex have more affirmative response (P<0.001).

  • PDF

포유류 생식 내분비 기능 조절에서 Ghrelin의 역할 (Role of Ghrelin in the Control of Reproductive Endocrine Function)

  • 이성호
    • 한국발생생물학회지:발생과생식
    • /
    • 제13권4호
    • /
    • pp.207-215
    • /
    • 2009
  • 시상하부-뇌하수체-생식소(hypothalamus-pituitary-gonad, HPG) 호르몬 축의 활성에 영향을 미치는 수많은 인자들은 생식 기능을 조절하고, 사춘기 개시와 폐경기 진입과 같은 뚜렷한 생식 능력의 단계 전이를 초래한다. 지방세포로부터 분비되는 다기능적 호르몬인 leptin의 발견 이후, 곧 이어 생식과 신체의 에너지 균형 사이의 긴밀한 관계에 대한 증거들이 밝혀졌다. 위장관으로부터 분비되는 또 다른 다기능 호르몬인 ghrelin은 이미 알려져 있던 growth hormone secretagogue receptor(GHSR)의 내인성 리간드이며, 에너지 항상성의 조절에서 leptin에 상응하는 물질로 알려졌다. 예상대로, ghrelin 또한 HPG 축의 활성의 조절을 통해 생식 능력을 조절함이 증명되었다. 이 논문은 ghrelin의 발견과 유전자 구조, 조직 내의 분포, 그리고 역할과 HPG 축에서의 생식 호르몬 분비 조절에 대한 포유동물의 생식에서의 ghrelin-GHSR 신호에 관한 최신 정보를 요약한 것이다. 뇌하수체에서의 POMC 유전자 발현과 유사하게, preproghrelin 유전자는 alternative splicing과 번역 후 변형(posttranslational modification)을 거치는 복잡한 레퍼토리의 전사체들과 펩티드 산물을 만들어 낸다. 에너지 항상성을 제외한 신체 생리 기능의 조절에서의 preproghrelin 유전자 산물의 역할에 관한 정보는 제한적이지만, 신진 대사와 생식 사이에서의 ghrelin의 상호작용에 관해서는 충분한 증거들이 있다. 흰쥐와 인간에서, ghrelin 수용체인 GHSRs(GHSR1a와 GHSR1b)의 분포는 본래 ghrelin의 표적으로 여겨진 시상하부와 뇌하수체뿐만 아니라 정소와 난소에서도 확인되었다. 뇌와 생식소에서도 preproghrelin 유전자 발현이 확인되었는데, 이것은 HPG 축에서 ghrelin이 국부적인 역할을 담당할 가능성을 시사한다. 비록 뇌하수체에서의 기능은 아직 확실치 않지만, ghrelin은 시상하부의 GnRH, 뇌하수체의 생식소자극호르몬과 생식소의 성 스테로이드 호르몬 분비에 대한 음성적인 조절자로서의 역할을 수행하는 것으로 보인다. 최근의 연구들은 사춘기 개시, 그리고 아마도 폐경기 진입의 조절에서 ghrelin의 관여를 시사한다. 이제 ghrelin이 '뇌-위장관' 축의 필수적인 호르몬 요인이며, 신 진 대사와 생식 사이를 연결하는 조절 물질이라는 가능성은 매우 높다. '배부름'을 반영하는 leptin 신호와는 정반대인 ghrelin 신호는 신체 에너지 균형 상태로 볼 때 '배고픔'을 표현하는 것으로 생각되며, 항상성의 유지에서 최우선 사항으로 고려되지 않는 생식으로의 에너지 투자가 이루어지지 않도록 하는데 필수적일 것으로 사료된다. 생식능력 조절에 있어서 ghrelin의 보다 명확한 작용 메커니즘과 역할에 대한 깊은 통찰력을 얻고 성공적인 생의학적 적용을 위해서는 향후 더 많은 연구들이 필요하다.

  • PDF

예측성인신장이 작은 조기사춘기 여아에서 성선자극호르몬 방출호르몬 효능약제와 성장호르몬 병합치료의 성장획득 효과 (Growth promoting effect of combined gonadotropin releasing hormone analogue and growth hormone therapy in early pubertal girls with predicted low adult heights)

  • 홍은정;한헌석
    • Clinical and Experimental Pediatrics
    • /
    • 제50권7호
    • /
    • pp.678-685
    • /
    • 2007
  • 목 적 : 조기사춘기 여아에게 성선자극호르몬 방출호르몬 효능약제(gonadotropin releasing hormone analogue, GnRHa)와 성장호르몬(growth hormone, GH)의 병합치료를 시행하여 성인신장획득에 대한 효과를 알아보고자 하였다. 방 법 : 2001년 1월부터 2004년 1월까지 조기사춘기로 소아과 외래를 내원한 여아 중 예측성인신장이 -2 표준편차점수 이하로 표적키보다 훨씬 작은 23명($9.73{\pm}1.59$세)을 대상으로 초경을 시작하지 않은 군(Group 1, n=19, $9.59{\pm}1.59$세)과 초경을 시작한 군(Group 2, n=4, $10.38{\pm}1.44$세)으로 나누어 GnRHa와 GH의 병합치료를 시행하고, 치료 시작 전후 및 두 군 간의 역연령, 골연령, 성장속도, 신장, 예측성인신장, 혈청 IGF-1, IGFBP-3 치, BMI를 비교 분석하였다. 결 과 : 치료 시작 시의 두 군의 역연령, 성장속도, BMI는 유의한 차이는 없었으나 골연령 및 골연령과 역연령의 차이는 Group 2에서 Group 1보다 유의하게 증가되어 있었다. 신장은 Group 1의 평균이 $130.7{\pm}7.4cm$, Group 2의 평균이 $140.7{\pm}6.0cm$으로 유의하게 차이가 있었으나 표적키, 예측성인신장, 혈청 IGF-1과 IGFBP-3은 유의한 차이가 없었다. 치료 종료 시의 Group 1의 골연령은 평균 $12.18{\pm}1.02$세, Group 2의 골연령은 평균 $13.56{\pm}0.83$세로 치료 시작 전과 마찬가지로 Group 2에서 유의하게 높았으나, 골연령과 역연령의 차이, 신장, 그리고 IGF-1은 차이가 없었다. 전체에서 골연령과 역연령의 차이가 치료 시작 전에 평균 $2.50{\pm}2.46$세, 치료 종료 후에 평균 $1.10{\pm}0.97$세로 감소되었고, 역연령에 대한 골연령의 비도 $1.22{\pm}0.16$에서 $1.10{\pm}0.10$으로 감소되어서 결국 골연령의 증가는 현저히 감소하였다. 성장 속도 역시 평균 $7.46{\pm}2.44cm$/년에서 $5.65{\pm}2.08cm$/년으로 감소하였다. 예측성인신장은 치료 전에 평균 $146.6{\pm}3.50cm$, 치료 후에 평균 $153.8{\pm}4.7cm$으로 현저히 증가하였으며 신장의 표준편차점수도 $-0.66{\pm}1.02$ SDS에서 $-0.34{\pm}1.04$ SDS로 유의하게 증가하였다. BMI는 치료 전 평균 $18.80{\pm}2.35kg/m^2$, 치료 후에 평균 $20.4{\pm}2.53kg/m^2$로 유의하게 증가하였고, 혈청 IGF-1은 치료 후에 유의하게 증가하였으나 IGFBP-3는 유의한 변화가 없었다. 치료 전후에 두 군에서 각 성장 변수의 변화를 보면 골연령과 역연령의 차이는 유의하게 감소하였고 신장, 예측성인신장, BMI는 유의하게 증가하였다. 그러나 혈청 IGF-1의 경우, Group 1에서는 치료 후에 현저히 증가하였으나 Group 2에서는 별 차이가 없었다. 혈청 IGFBP-3는 모두에서 유의한 차이가 없었다. 결 론 : 조기사춘기 여아에게 GnRHa와 GH의 병합치료를 시행했을 때, 골연령의 증가 속도와 성장속도가 감소하고, 혈청 IGF-1이 증가함으로써 예측성인신장이 의미 있게 증가하며 표적키에 가깝게 증가한다. 또한 IGF-1의 변화를 보면 초경을 시작하지 않은 조기사춘기 여아가 초경을 시작한 경우보다 성장획득에 대한 가능성이 더 클 것으로 생각된다.

도시와 농촌 초등학생의 성의식 및 성가치관에 관한 비교 연구 (A comparative study on sex-consciousness and sexual values between urban and rural elementary schoolers)

  • 노미영;박영수
    • 한국학교ㆍ지역보건교육학회지
    • /
    • 제6권
    • /
    • pp.17-34
    • /
    • 2005
  • The purpose of this study was to examine the sex-consciousness and sexual values of school children by geographic region. It's specifically attempted to make a comparative analysis of sex-consciousness and sexual values between urban and rural elementary schoolers to help provide efficient sex education for them to build the right sexual values. The subjects in this study were 400 elementary schoolers in their sixth year of elementary schools located in Danyang-gun and Chungju city, north Chungcheong province. After a survey was conducted, answer sheets from 387 students that were analyzable were analyzed. For data handling, SPSS program was employed, and t-test was utilized to see if there's any differences between the urban and rural elementary school youngsters in sex consciousness and sexual values. And $x^2$ test was used to make a comparative analysis of their view of sex education. The findings of the study were as follows : First, regarding sex-consciousness, they had general knowledge on sex. Especially, they were highly aware of sexual violence and the generation of baby, but many of them didn't know about where and how egg cells were produced. This indicated that systematic education should be offered in various ways. Concerning geographic gap, there was a significant difference in sexual knowledge between the urban and rural students. As to sexual attitude, they took a relatively positive attitude toward display of affection or sex-related talk on TV or in movies, as they viewed it as natural. This finding implied that the elementary schoolers were recipient toward sex and took an active attitude toward sexual expressions. Concerning geographic gap, there was no difference between the rural and urban students. As for sexual practices, the largest group of the students had a liking for the opposite sex, which showed that their needs for sex were unveiled in the course of having some trouble due to the other sex rather than through firsthand experiences or activities. As to geographic gap, there was a significant difference between the urban and rural students in that regard. Besides, the urban students put their sex-consciousness in practice more often than the rural students did. After they are educated to build the right sexual values, systematic sex-education programs should also be offered for them to be exposed to sustained sex education and to team how to apply their sex-consciousness to real life. Second, as for sexual values, the school children had relatively positive and equalitarian sexual values. Regarding geographic gap, there were significant gaps between the two groups' view of the opposite sex, sexual roles and chastity. Concerning view of the opposite sex, they attached more importance to the inner aspects of the opposite sex than his or her look, and they wanted to date in a natural manner. Regarding sexual roles, they were relatively well cognizant of gender equity and the importance of male and female roles. As to view of chastity, they looked upon sex as natural, not as what's ugly or ashamed of. Third, concerning their outlook on sex education, approximately more than half the students felt the needs for sex education, and there was a significant difference between the urban and rural students. They wanted to receive education about the prevention of sexual violence and physical changes during puberty the most, and there was a significant gap between the urban and rural students in this aspect. As to the time for sex education, they thought that students should start to be exposed to sex education in their fifth or sixth year. This finding signified that fifth or sixth graders who were in the beginning of puberty started to have a lot of interest in their own physical changes. Therefore, sex education would produce better effects when it's provided to fifth or sixth graders. Nearly half them preferred single-gender class when they received sex education, and there's no gap between the urban and rural students in that regard.

  • PDF

농후사료 급여수준 및 방목이 춘계분만 한우 암송아지의 성장발육, 번식능력 및 사료이용성에 미치는 효과 (Effect of the Level of Concentrates and Pasture Grazing on Growth, Reproductive Performance and Feed Efficiency in Spring born Hanwoo Heifers)

  • 강수원;임석기;정종원;우제석;전기준
    • Journal of Animal Science and Technology
    • /
    • 제45권1호
    • /
    • pp.101-112
    • /
    • 2003
  • 봄에 태어난 한우 암송아지 60두를 방목전의 농후사료 급여수준 및 개량초지에서의 방목유무에 따라 5개 처리(T1: 전기간 우사 내 사육, 농후사료 체중의 1.5%, T2: 방목전 농후사료 체중의 0.5%, 방목, T3: 방목전 농후사료 체중의 1.0%, 방목, T4: 방목전 농후사료 체중의 1.5%, 방목, T5 : 방목전 농후사료 체중의 2.0%, 방목)를 두어 450일간 사양 시험한 결과를 요약하면 다음과 같다. 1. 전기간의 일당증체량은 T5, T4, T1, T3 및 T2가 각각 0.465, 0.428, 0.423, 0.387kg 및 0.322 kg으로 방목전 육성기의 농후사료 급여수준이 증가할수록 높았으며, 방목기의 일당증체량도 방목전 육성기의 농후사료 급여수준이 증가할수록 높았다. 2. 공시기간 동안 kg 증체에 소요된 TDN량은 9.13-9.79kg(평균 9.49kg)이었고, T1, T3, T5, T4 및 T2의 순으로 사료이용성이 높았으며, 방목전 사사기의 농후사료 급여수준이 증가할수록 TDN 이용성이 높았다. 방목기간의 처리구별 kg 증체에 소요된 TDN량은 12.39-12.98 kg(평균 12.68kg)으로 방목전의 농후사료 급여수준에 따른 차이는 없었으나 축사내 사육시 보다 TDN 소요량이 15.6% 증가하였다. 그리고 전기간동안 농후사료에 대한 조사료비율은 57.8-73.6%(평균 63.7%)이었다. 3.성성숙기인 15개월령 체중은 201.2-237.3 kg(평균 223.8kg)으로 육성기 농후사료 급여수준이 증가할수록 증가하였고, 초임시기인 21개월령 체중은 270.2-331.4kg(평균 307.6kg)으로 방목전 사사기의 배합사료 급여수준이 체중대비 0.5% 증가할수록 20.4kg이 증가하였다. 또한 체중 225kg에 도달되는 시기는 14.0-17.6개월령(평균 15.3개월령), 그리고 체중 275 kg에 도달되는 시기는 17.9-21.7개월령(평균 19.4개월령)으로 육성기의 배합사료 급여수준이 체중 대비 0.5% 증가함에 따라 초임시기가 약 1.3개월씩 단축되었다. 이상과 같은 결과들을 종합해 볼 때 봄에 태어난 한우 암송아지를 축사에서 볏짚 위주로 사육할 때의 농후사료 급여수준은 체중의 1.8% 그리고 개량초지에서 방목사육 할 때에는 체중의 1.5%가 적정 수준인 것으로 판단된다.

Estimation of Genetic Parameters for Four Reproduction Component Traits in Two Chinese Indigenous Pig Breeds

  • Zhu, M.J.;Ding, J.T.;Liu, B.;Yu, M.;Fan, B.;Li, C.C.;Zhao, S.H.
    • Asian-Australasian Journal of Animal Sciences
    • /
    • 제21권8호
    • /
    • pp.1109-1115
    • /
    • 2008
  • The reproduction component traits are important components of sow efficiency. The objective of this study was to evaluate the phenotypic and genetic parameters of four reproduction component traits (age at puberty (AP), preweaning number dead (PND), weaning to service interval (WSI), and intra-individual SD in litter size (IISDLS)) of sows in two Chinese indigenous pig breeds. Available reproductive records including 22,591 piglets born from 2,054 litters by 574 Jiangquhai sows and 464 Meishan sows were used in this investigation. A set of mixed models and restricted maximum likelihood methodology were used for the multiple trait analyses of these traits. The results showed that the estimates of heritabilities (${\pm}$standard error) for AP, PND, WSI and IISDLS were $0.40{\pm}0.05$, $0.06{\pm}0.03$, $0.20{\pm}0.02$ and 0.09{\pm}0.03 in Jiangquhai sows, and $0.35{\pm}0.06$, $0.05{\pm}0.03$, $0.18{\pm}0.03$ and $0.10{\pm}0.04$ in Meishan sows, respectively. There was moderate genetic correlation between AP and WSI, while there were low genetic correlations between the other pairwise traits. The genetic correlations were positive for most of the pairwise traits, except for the one between AP and IISDLS. The results indicated that all traits except for AP were difficult to make genetic improvement by traditional selection methods due to low heritabilities and the favorable improvement of AP might result in unfavorable changes of IISDLS due to the trend of genetic antagonism.

LC-MS/MS 시스템을 이용한 모유 중 파라벤류 분석법 확립 (Analysis Method of Parabens in Human Breast Milk by LC-MS/MS System)

  • 박나연;이은희;고영림
    • 대한화학회지
    • /
    • 제60권2호
    • /
    • pp.118-124
    • /
    • 2016
  • 파라벤은 화장품, 식품, 의약품 등에 첨가되는 살균성 보존제로 미생물의 성장을 억제한다. 그러나 체내에서 에스트로겐과 유사한 작용을 하는 내분비계 교란물질이며, 특히 독성물질에 민감한 영유아 및 태아에게 노출될 경우 생식기 기형, 고환암, 성조숙증 등 성장발달에 큰 영향을 미친다. 따라서 본 연구에서는 영아가 주로 섭취하는 모유에서의 파라벤 수준을 확인하기 위하여 모유 중 4가지 파라벤(methyl paraben, ethyl paraben, propyl parabne, butyl paraben)의 분석법을 확립하였다. 시료는 액체상추출(Liquid-liquid extraction, LLE)을 통하여 전처리 한 후, 액체크로마토그래피 텐덤 질량분석기(liquid chromatography tandem mass spectrometry, LC-MS/MS)를 사용하여 정량분석 하였다. 확립된 분석조건에서 얻어진 검량선의 직선성은 r2 > 0.999이고, 검출한계(LOD)는 0.019~0.044 ng/mL이었다. 또한 정확도는 85.3~105.9%, 정밀도는 10% 이하의 값을 나타내었다. 10개의 모유시료 중 파라벤류의 평균농도 ± 표준편차는 MP 0.660 ± 0.519 ng/mL, EP 1.631 ± 2.081 ng/mL, PP 0.326 ± 0.320 ng/mL이었고, BP는 불검출 되었다.

초등학교 여학생의 초경시기와 관련된 결정요인 분석 (Determinants of age at menarche in Korean elementary school girls)

  • 권미경;서은민;박경
    • Journal of Nutrition and Health
    • /
    • 제48권4호
    • /
    • pp.344-351
    • /
    • 2015
  • 본 연구는 초경시기의 결정요인을 규명하기 위하여 대구 3개 지역 초등학교 5, 6학년 여학생 190명을 대상으로 개별 짝짓기 환자-대조군 연구를 실시하였고, 본 연구 결과를 요약하면 다음과 같다. 첫째, 비초경군에 비하여 초경군의 평균 수면시간이 더 적었다. 둘째, 어머니의 초경 나이가 빠를 수록 같은 또래에 비해 더 이른 초경 경험을 할 확률이 높았다. 셋째, 초경시기와 관련된 요인 중 비만이 가장 강한 연관성을 보였다. 전 세계적으로 초경 나이가 낮아지는 경향을 보이고 있으며, 우리나라 여성의 초경 나이도 현저하게 낮아지는 상황에서 본 연구의 결과는 중요한 기초자료로 활용될 것이다.

Expression Pattern of Antioxidant Enzymes Genes in the Ventral Prostates of Rats Exposed to Procymidone and/or Testosterone after Castration

  • Lee, Jong-Geol;Yon, Jung-Min;Jung, Ki-Youn;Lin, Chunmei;Jung, A-Young;Lee, Beom-Jun;Yun, Young-Won;Nam, Sang-Yoon
    • 한국수정란이식학회지
    • /
    • 제26권4호
    • /
    • pp.265-270
    • /
    • 2011
  • Procymidone is a fungicide with anti-androgenic properties widely used to protect fruits from fungal infection, which induces an excessive reactive oxygen species production in male reproductive organs. In this study, to clarify whether procymidone affect the cellular antioxidant system of prostate at onset of puberty, gene expression patterns of the representative antioxidant enzymes such as cytoplasmic glutathione peroxidase (GPx1), phospholipid hydroperoxide GPx (PHGPx), selenoprotein P (SePP), cytoplasmic copper/zinc superoxide dismutase (SOD1), and manganese SOD (SOD2) were investigated in the rat ventral prostates exposed to procymidone using real-time RT-PCR analyses. Seven-week-old Sprague-Dawley rats castrated at 6 weeks old were treated with procymidone (25, 50, or 100 mg/kg per day) orally for 7 consecutive days after testosterone propionate (0.4 mg/kg per day) administration by subcutaneous injection. As compared to normal control animals, GPx1 mRNA expression in prostates significantly increased by the administration with TP and/or procymidone. However, PHGPx and SOD1 mRNA levels significanatly decreased by over 25 mg/kg of procymidone treatment and SePP and SOD2 mRNA levels was significanatly reduced by over 50 mg/kg of procymidone treatment. These findings indicate that procymidone may affect the antioxidant system of prostatic cells in up-regulation mode of GPx1, but in down-regulation modes of PHGPx, SePP, SOD1, and SOD2, suggesting that procymidone may affect differently the cellular antioxidant system of prostate according to the exposure doses.