• Communications for Statistical Applications and Methods
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• 제25권4호
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• pp.385-396
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• 2018

Competing risks are commonly encountered in biomedical research. Regression models for competing risks data can be developed based on data routinely collected in hospitals or general practices. However, these data sets usually contain the covariate missing values. To overcome this problem, multiple imputation is often used to fit regression models under a MAR assumption. Here, we introduce a multivariate imputation in a chained equations algorithm to deal with competing risks survival data. Using pseudo-observations, we make use of the available outcome information by accommodating the competing risk structure. Lastly, we illustrate the practical advantages of our approach using simulations and two data examples from a coronary artery disease data and hepatocellular carcinoma data.

• 응용통계연구
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• 제25권6호
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• pp.947-958
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• 2012

When modeling event times in biomedical studies, the outcome might be incompletely observed. In this paper, we assume that the outcome is recorded as current status failure time data. Despite well-developed literature the routine practical use of many current status data modeling methods remains infrequent due to the lack of specialized statistical software, the difficulty to assess model goodness-of-fit, as well as the possible loss of information caused by covariate grouping or discretization. We propose a model based on pseudo-observations that is convenient to implement and that allows for flexibility in the choice of the outcome. Parameter estimates are obtained based on generalized estimating equations. Examples from studies in bile duct hyperplasia and breast cancer in conjunction with simulated data illustrate the practical advantages of this model.

• Applied Microscopy
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• 제29권1호
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• pp.95-103
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• 1999

Pseudo-brookite 구조의 $MgTi_2O_5$와 이와 유사한 구조를 갖는 $(In_{0.36}Zn_{1.09})Ti_2O_{5.64}$에 관한 미세구조를 200kV에서 작동되는 고분해능 투과전자현미경을 사용하여 관찰하였다. 변조구조는 $MgTi_2O_5$에서는 발견되지 않았으나, $(In_{0.36}Zn_{1.09})Ti_2O_{5.64}$에서는 복잡한 구조가 발견되었다. $(In_{0.36}Zn_{1.09})Ti_2O_{5.64}$ 구조의 전자회절패턴은 $MgTi_2O_5$와 fundamental 회절점들은 유사하나 4가지 형태의 초격자 회절점이 더 존재하였다. 변조구조의 주기는 [220] 방향으로 3.63nm, 0.79nm, 그러고 0.64 nm를 이루고 [420] 방향으로는 0.81nm를 이룬다. 미세구조 관찰중 전자빔에 의하여 상전이가 야기되어 변조된 구조에서 좀 더 단순화된 변조없는 구조로 가역적으로 전환한다. 가해지는 전자빔에 의한 손상기구는 ledge 구조의 kink에서 void가 형성되어 작은 결정들로 갈라지고 손상이 커지면, 최종적으로 결정성을 잃게 된다.

• 천문학회보
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• 제38권2호
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• pp.35.2-35.2
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• 2013

I will present a new approach to constrain galaxy physical parameters from the combined interpretation of stellar and nebular emission in wide ranges of observations. This approach relies on a comprehensive library of synthetic spectra, assembled using state-of-the-art models of star formation and chemical enrichment histories, stellar population synthesis, nebular emission and attenuation by dust. We focus on the constraints set by 5-band photometry and low- and medium-resolution spectroscopy at optical rest wavelengths on a few physical parameters characterizing the stars and interstellar medium. Since these parameters cannot be known a priori for any galaxy sample, we assess the accuracy to which they can be retrieved by simulating 'pseudo-observations' using models with known parameters. We find that the combined analysis of stellar and nebular emission in low-resolution (50A FWHM) galaxy spectra provides valuable constraints on all physical parameters. The approach can be extended to the analysis of any type of observation and during this talk i will present some applications to observed galaxies up to redshift 1.5.

• 한국항공우주학회지
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• 제42권3호
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• pp.270-278
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• 2014

본 논문에서는 우주물체 궤도예측의 개선 방안에 관하여 기술하였다. 운용위성과 우주물체와의 근접 가능성 여부를 확인하기 위해 이용되는 TLE(Two-Line Element)를 가관측으로 사용하였고, 비행역학시스템을 통해 궤도결정 및 예측을 수행하였다. 궤도를 결정함에 있어 일정기간 내 일련의 TLE를 이용하여 상태벡터를 가정하였고, 결정기간 및 가관측수(pseudo-observations)에 따른 예측결과 오차를 분석하였다. 또한, 제안된 방식을 적용할 경우 궤도예측 정밀도가 향상 되는지를 알아보기 위해 수 미터 수준의 정밀궤도 확인이 가능한 아리랑위성 2, 3호를 대상으로 먼저 적용하였으며, 동일한 조건으로 우주물체에 적용한 결과를 분석하였다. 우주물체 궤도예측의 RMS 오차 비교 결과, 7일 전파기준으로 궤도 예측 정밀도를 약 90% 향상시킬 수 있었다. 우주물체의 개선된 궤도예측은 매일 수행되는 충돌가능성 분석에 이용되어 위험성이 높은 근접 우주물체의 1차적인 선별에 활용가능 할 것이다.

• 한국해양바이오학회지
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• 제2권1호
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• pp.60-67
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• 2007

For the first time in Vietnam, morphological and molecular studies of a species belonging to Bacillariophyceae collected in Northern coast of Vietnam are presented. Observations with microscope showed that this species belong to genus: Pseudo-nitzschia and seem like P. pungens. Sequence data from the partial 18S small subunit ribosomal RNA gene (18S rDNA) and the internal transcribed spacer 1 - 5.8S - internal transcribed 2 have been used to determine clearly and generate a phylogenetic framework of the obtained sequences to previously reported sequences in GenBank. These results allowed us to highlight described species of Bacillariophyceae in Northern coast of Vietnam. Furthermore, accumulation of molecular study would be helpful for the identification of scientific name of harmful algal species and further taxonomic studies in Vietnam.

• 한국지진공학회논문집
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• 제28권4호
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• pp.205-213
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• 2024

In the seismic evaluation of underground utility tunnels, selecting an analytical method is critical to estimating reasonable seismic responses. In simplified pseudo-static analysis methods widely applied to typical seismic design and evaluation of underground tunnels in practice, it is essential to check whether the methods provide valid results for cut-and-cover tunnels buried in shallow to medium depth. The differences between the two simplified pseudo-static methods are discussed in this study, and the analysis results are compared to those obtained from FLAC models. In addition to the analysis methods, seismic site classification, overburden soil depth, and sectional configuration are considered variables to examine their effects on the seismic response of underground utility tunnels. Based on the analysis results, the characteristics derived from the concepts and details of each simplified model are discussed. Also, general observations are made for the application of simplified analysis methods.

• 응용통계연구
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• 제34권2호
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• pp.255-266
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• 2021

본 연구는 미국 국립암연구소의 SEER 프로그램에서 제공하는 위암 3기 자료에 대해 항암치료의 효과를 비교하고 위암 생존율에 유의한 영향을 미치는 요인을 알아보고자 한다. 본 연구에서 분석한 위암 3기 자료는 비례위험 가정이 성립하지 않아 대안으로 제한된 평균 생존시간을 이용한 분석 방법을 자료 분석에 적용하였다. 의사-관측들을 이용하여 제한된 평균 생존시간을 추정하였고, 제한된 평균 생존시간 추정량에 기반한 검정통계량을 이용하여 항암치료의 효과를 파악하였다. 일반화 선형모형을 이용한 회귀모형을 통해 위암 3기 환자의 평균 생존시간에 유의한 영향을 미치는 공변량들의 효과를 추정하였다. 항암치료법에 따라 위암 3기 환자의 평균 생존시간에 유의한 차이가 있음을 확인하였고, 진단연령, 인종, 세분화병기, 분화도, 종양의 크기, 수술여부, 항암치료가 위암 3기 환자의 평균 생존시간에 유의한 영향을 미치는 요인들이였으며, 그 중 수술여부가 위암 3기 환자의 평균 생존시간을 늘리는데 가장 큰 영향을 미치는 요인임을 확인하였다.

• Communications for Statistical Applications and Methods
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• 제25권2호
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• pp.217-234
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• 2018

Copulas are a tool for constructing multivariate distributions and formalizing the dependence structure between random variables. From copula literature review, there are a few asymmetric copulas available so far while data collected from the real world often exhibit asymmetric nature. This necessitates developing asymmetric copulas. In this study, we discuss a method to construct a new class of bivariate asymmetric copulas based on products of symmetric (sometimes asymmetric) copulas with powered arguments in order to determine if the proposed construction can offer an added value for modeling asymmetric bivariate data. With these newly constructed copulas, we investigate dependence properties and measure of association between random variables. In addition, the test of symmetry of data and the estimation of hyper-parameters by the maximum likelihood method are discussed. With two real example such as car rental data and economic indicators data, we perform the goodness-of-fit test of our proposed asymmetric copulas. For these data, some of the proposed models turned out to be successful whereas the existing copulas were mostly unsuccessful. The method of presented here can be useful in fields such as finance, climate and social science.

• 한국자동차공학회논문집
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• 제15권1호
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• pp.64-70
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• 2007

Raising exhaust gas temperature during cold-start period is very crucial to improve emission performance of SI engines because it enhances the performance of catalyst in the early stage of engine start. In this study, control variables such as ignition timing, idle speed actuator(ISA) opening and fuel injection duration were extensively investigated to analyze variations in exhaust gas temperature and engine stability during cranking period. Experimental results showed that spark timing affected engine stability and exhaust gas temperature but the effects were small. On the other hand, shortened injection duration and increased ISA opening led to a significant increase in exhaust gas temperature. Under such conditions, increase in cranking time was also observed, showing that it becomes harder to start the engine. Based on these observations, a pseudo fuel-air ratio, defined as a ratio of fuel injection time to degree of ISA opening, was introduced to analyze the experimental results. In general, decrease in pseudo fuel-air ratio raised exhaust gas temperature with the cost of stable and fast cranking. On the contrary, an optimal range of the pseudo fuel-air ratio was found to be between 0.3 to 0.5 where higher exhaust gas temperatures can be obtained without sacrificing the engine stability.