• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.12
• /
• pp.6447-6453
• /
• 2012

Background: The mucin components of the gastric gel layer function as a protective and lubricating factor against luminal acid and proteolytic enzymes. Alteration of mucin expression in gastric preneoplastic and neoplastic lesions has suggested potential roles in neoplastic processes. This study aimed to assess the clinicopathological and prognostic significance of MUC-2, MUC-4 and MUC-5AC in Japanese gastric cancer. Methods: Expression of MUC-2, -4 and -5AC was evaluated on tissue microarrays of gastric carcinomas and adjacent non-cancerous mucosa specimens by immunohistochemistry and compared with clinicopathological parameters and survival time of the patients. Results: The three mucins were found to be expressed to a lesser extent in gastric carcinomas in comparison with non-cancerous mucosa (p<0.05). MUC-2 expression was negatively correlated with tumor size, depth of invasion, and TNM staging of gastric cancer (p<0.05), while that of MUC-5AC was negatively associated with the depth of invasion, venous invasion, lymph node metastasis and TNM staging (p<0.05), but positively with MUC-4 and MUC-2 expression (p<0.05). There was higher MUC-2 expression in intestinal- than diffuse-type carcinomas (p<0.05). Kaplan-Meier analysis indicated no relationship between expression of the three mucins and the cumulative survival rate of patients, even stratified according to the depth of invasion (p>0.05). Conclusion: Down-regulated expression of MUC-2, -4 and -5AC may be involved in pathogenesis, invasion, metastasis or differentiation of gastric carcinoma. Their altered expression might therefore be employed as an indicator of pathobiological behavior.

• Journal of the Computational Structural Engineering Institute of Korea
• /
• v.33 no.1
• /
• pp.25-33
• /
• 2020

In this study, parametric analyses are performed using the coupled Eulerian-Lagrangian scheme for the collision behaviors of a vessel and an underwater slope that constitutes part of an artificial protective island. The vessel parameters considered in the analysis are bow angle, stem angle, draft, and impact velocity. The gradient of the slope, the friction coefficient between the bow and the slope, and soil strength are considered as parameters of the slope. For each parameter, the dissipated collision energy and the collision force are estimated from the behavior of the vessel, and the energy dissipation mechanism is identified in terms of the ground deformation. The collision force is assumed as an exponential function, and the effects of the parameters are estimated. As a result, only two parameters, the gradient of the slope and the friction coefficient between the vessel and the soil, can affect the exponential coefficient of the function. The dissipated energy by the soil can thus be estimated adequately. The relationship between the volume of the soil pushed out by the bow and the dissipated collision energy is estimated as a linear function. This relationship is independent of the magnitude of the collision energy, and affected more by the friction coefficient and the soil strength than by the parameters of the vessel.

• Journal of Oriental Neuropsychiatry
• /
• v.24 no.4
• /
• pp.419-434
• /
• 2013

Objectives: The object of this study is to observe the cognition and motor function recovery effects of Joojakwhan (JJW), a traditional Korean poly-herbal formula for treating various neuropsychiatric diseases such as dementia, for the mildly stroke rats, with 60 minutes of reperfusion transient middle cerebral artery occlusion (tMCAO). Methods: In the present study, 125, 250 and 500 mg/kg of JJW were orally administered, once per day for 10 continuous days 2 hours after the tMCAO. The body weight changes, infarct sizes under 2% 2, 3, 5-triphenyl tetrazolium chloride (TTC) stain, sensorimotor functions and cognitive motor behavior tests were serially monitored with cerebral caspase-3 and cleaved poly (ADP-ribose) polymerase (PARP)-immunoreactivities and histopathological changes. The effects of tMCAO on sensorimotor functions were evaluated by using of limb placing and body-swing tests, and the cognitive motor behaviors were also observed with water maze tests. Results: From the results of tMCAO, with marked decreases of body weights, disorders of sensorimotor functions increases the limb placing test scores, and decrease the numbers and percentages of body swings to the ipsilateral sides. The cognitive motor behaviors increases the distances and time to reach the escape platform which included the inhibitions of the decreases with repeated trials that were observed with focal cerebral cortex infarct volumes. In addition, the marked increases of the atrophy, numbers of degeneration, caspase-3- and PARP-immunoreactive cells around peri-infarct ipsilateral cerebral cortex were also observed in tMCAO controls when compared with the sham control rats, respectively. Conclusions: The results obtained from this study suggest that oral administrations of JJW indicate obvious cognitions and motor function recoveries of the rats with tMCAO, mild strokes, which are mediated by neuro-protective effects through known antioxidant effects of components.

• Journal of the Korean Geotechnical Society
• /
• v.20 no.9
• /
• pp.133-144
• /
• 2004

Pre-reinforcement ahead of a tunnel face using long steel or FRP (Fiberglass Reinforced Plastic) pipes in NATM(New Austrian Tunnelling Method), known as the RPUM(Reinforced Protective Umbrella Method) or UAM (Umbrella Arch Method), is the promising method to sustain the stability of a shallow tunnel face and reduce the ground settlements. In addition, horizontal reinforcing of the face is recently emphasized to improve the stability of the face. However, the characteristics on longitudinal arching around the face have not yet been established quantitatively with the RPUM (crown-reinforcing) and/or the face horizontal reinforcing. In this study, therefore, the behavior of cohesionless soil around the face reinforced by the reinforcing member representing the RPUM and horizontal reinforcing is investigated through two-dimensional laboratory model tests. A series of tests were carried out on various conditions by changing lengths and angles of the reinforcing members. Based on the vertical pressure around the face, the characteristics of longitudinal arching have been found for the case of the non-reinforced and the reinforced.

• Korean Chemical Engineering Research
• /
• v.48 no.2
• /
• pp.172-177
• /
• 2010

This study reports the high-temperature oxidation kinetics, ASR(area specific resistance), and interfacial microstructure of metallic interconnects coated with conductive oxides in oxidation atmosphere at $800^{\circ}C$, The conductive material LSC($La_{0.8}Sr_{0.2}CoO_3$, prepared by Solid State Reaction) was coated on the Crofer22APU. The contact behavior of coating layer/metal substrate was increased by sandblast. The electrical conductivity of the LSC coated Crpfer22APU was measured by a DC two probe four wire method for 4000hr, in air at $800^{\circ}C$. Microstructure and composition of the coated layer interface were investigated by SEM/EDS. These results show that a coated LSC layer prevents the formation and growth of oxide scale such as $Cr_2O_3$ and enhances the long-term stability and electrical performance of metallic interconnects for SOFCs.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.18 no.8
• /
• pp.72-83
• /
• 2017

This study was conducted to investigate nursing students' safety-climate: perception and performance of standard precautions for healthcare-associated infection control. We also identified actors influencing performance of standard precautions. Data were collected from 246 junior and senior nursing students at nine colleges in D city from July to September, 2016. The mean score of performance was significantly lower than that of perception in all areas of standard precautions. The biggest difference between perception and performance was in the usage of personal protective equipment and safe injection practices. We also detected significant positive correlations among safety-climate, perception, and performance of standard precautions. In the regression analysis, performance of standard precautions was influenced by safety-climate and grade accounting for 10.7% of variance. To improve healthcare-associated infection control among nursing students, safer and more supportive practical environments need to be provided, and new training strategies such as simulation education need to be expanded.

• Polymer(Korea)
• /
• v.37 no.6
• /
• pp.744-752
• /
• 2013

The miscibility between poly(L-lactide) (PLLA) and poly(methyl methacrylate) (PMMA) was investigated using thermal analyses for the purpose of developing birefringence-free material at oriented state. The effect of methyl acrylate (MA) units as comonomer of PMMA on the miscibility was also studied. All the blends prepared in this study show composition-dependent single $T_g$'s between those of blend components and high transparency over the visible region, indicating the miscibility at molecular level and no discernible effect of MA units on it. No phase separation was observed at elevated temperature of $280^{\circ}C$, higher than the degradation of PLLA and PMMA. The interaction energy density in PLLA/PMMA blends with 17 mol% of MA was measured to be $-0.74J/cm^3$ from the equilibrium melting temperature depression based on the Hoffman-Weeks method. The blends show zero-${\Delta}$n behavior at a specific mixing ratio and the drawing ratio of 3 due to compensation of intrinsic orientation birefringence. Birefringence dispersion of PLLA/PMMA5 blends was also measured to examine the possibility for quarter-wave plates or polarizer protective films.

• Information Systems Review
• /
• v.17 no.3
• /
• pp.77-94
• /
• 2015

As Internet has become a popular media for sharing information, users create and share tremendous volume of information including large amount of personal information in cyberspace. Sharing private information online can enhance strength of social relationship but it could also bring negative consequences like information privacy invasion. Although many companies and governments address the importance of information privacy online, there are countless cases of crimes and hackings relating personal information online world wide. Since there are some researches investigating the role of governments and organizations on online privacy domain but there is little research regarding users' privacy protection behaviors. This study investigates relationship between Internet users' information privacy protection behavior and environmental factors. Especially, this study focuses on users' behaviors regarding information privacy protection technology adoption. According to our research results, users' online privacy protective behaviors positively affected by governmental regulations expressed as an information privacy protection law. In addition, if user is allowed to use anonymity when he or she uses online services, they have more tendencies to adopt privacy protection technologies. The detailed research findings and contribution are discussed as well.

• Journal of the Computational Structural Engineering Institute of Korea
• /
• v.32 no.5
• /
• pp.287-296
• /
• 2019

In this study, the effect of ground boundary conditions on the evaluation of blast resistance performance of precast arch structures was evaluated by a numerical analysis method. Two types of boundary conditions, namely, fixed boundary conditions and a perfectly matched layer (PML) were applied to numerical models. Blast loads that were much higher than the design load of the target structure were applied to compare the effects of the boundary conditions. The distribution and path of the ground explosion pressure, structural displacement, fracture of concrete, stress of concrete, and reinforcing bars were compared according to the ground boundary condition settings. As a result, the reflecting pressure shock wave at the ground boundaries could be effectively eliminated using PML elements; furthermore, the displacement of the foundation was reduced. However, no distinct difference could be observed in the overall structural behavior including the fracture and stress of the concrete and rebar. Therefore, when blast simulations are performed in the design of protective structures, it is rational to apply the fixed boundary condition on the ground boundaries as conservative design results can be achieved with relatively short computation times.

• Applied Chemistry for Engineering
• /
• v.34 no.6
• /
• pp.603-607
• /
• 2023

Aqueous film forming foam (AFFF) is a critical fire suppression agent used in combating hydrocarbon fires. This type of fire suppressant is highly effective due to its ability to form a protective film, dissipate heat, inhibit combustion, and utilize a blend of chemical substances to extinguish fires. While these properties offer significant advantages in responding to hydrocarbon fires, AFFF is distinct in its deployment as it is dispensed in the form of foam. Therefore, the rheological analysis of AFFF foam using a rheometer plays a crucial role in predicting the spray characteristics of AFFF for combating hydrocarbon fires, and this is closely associated with effective fire suppression. In this study, we conducted rheometer experiments to confirm the non-Newtonian behavior (shear-thinning) of AFFF foam and obtained data on the form's stability. These experimental data are expected to contribute to enhancing the efficiency of fire suppression systems utilizing AFFF.