• 패션비즈니스
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• 제6권3호
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• pp.28-40
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• 2002

For modern man and woman, footwear is considered a fashion for expressing oneself, and not merely a protective tool for the feet. The purpose of this research is to increase the effect of sales promotional activities by emphasizing product image and by enhancing sales environment. Towards this end, this research focuses on the study of environment at footwear stores that meet the challenges incurred by the changing lifestyles of consumers and the ensuing dynamics of the society in general. Research is based on an in-depth, thorough study of the previous research works and entails examining theoretical background and the concept of Visual Merchandising Display (VMD). Research will focus on the analysis of current situation at footwear stores located in department store based on material research on footwear stores and theoretical examination. Research on the current situation of footwear stores at department store will be conducted from the VMD perspective. In the end, this research paper will make suggestions on the VMD measures for footwear stores with the aim of increasing sales by satisfying consumers' sensibility and purchasing desire. Suggestions will be made based on the results of the research. -Study of current VMD status per fixture centered on 18 brands at department store -Suggestions for VMD at footwear stores based on the survey results of customer purchasing behavior This research intends to develop structured VMD methodology for footwear stores based on the research centered on VMD research of footwear stores at department store. Significance of this research lies in its aim to contribute to the sales increase, no matter how trivial it might be. Going a step further, this research work could be considered one of the foundations for defining the role of VMD methodology at footwear stores. Suggested results are as follows. (1) Need to cast away from simple, one-dimensional type of display method at footwear stores and transform into product image oriented VMD (2) Need to highlight product image by fully leveraging props and by developing footwear display methods that are suitable for different types of fixtures (3) Need to stabilize VMD by developing footwear manual that enables efficient management by store operator.

• 방사선산업학회지
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• 제10권4호
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• pp.231-242
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• 2016

This study was conducted to evaluate the synergistic protective effects of mixtures of corn silk, perilla leaf and grape stem extract (CPG mixture) against UVB-induced skin damage and compound 48/80-induced pruritus in mice. The results showed that treatment with CPG mixture exhibited much stronger suppressive effect on erythema and melanin index as well as melanin formation than treatment with ascorbic acid (AA) in UVB-irradiated mice. Moreover, the treatment with CPG mixture showed ameliorative effect on immune cell infiltration and collagen fiber destruction in UV-irradiated mice. The treatment with CPG mixture inhibited glutathione (GSH) depletion, lipid peroxidation and production of pro-inflammatory cytokines in UVB-irradiated mice. Furthermore, the treatment with CPG mixture inhibited compound 48/80-induced scratching behavior and histological changes in mice. Taken together, these results indicated that CPG mixture has potentials as functional and therapeutic materials against skin damage and itch-related skin diseases.

• Steel and Composite Structures
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• 제33권1호
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• pp.67-79
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• 2019

Composite columns made of high strength materials have been used in high-rise construction owing to its excellent structural performance resulting in smaller cross-sectional sizes. However, due to the limited understanding of its structural response, current design codes do not allow the use of high strength materials beyond a certain strength limit. This paper reports additional test data, analytical and numerical studies leading to a new design method to predict the ultimate resistance of composite columns made of high strength steel and high strength concrete. Based on previous study on high strength concrete filled steel tubular members and ongoing work on high strength concrete encased steel columns, this paper provides new findings and presents the feasibility of using high strength steel and high strength concrete for general double symmetric composite columns. A nonlinear finite element model has been developed to capture the composite beam-column behavior. The Eurocode 4 approach of designing composite columns is examined by comparing the test data with results obtained from code's predictions and finite element analysis, from which the validities of the concrete confinement effect and plastic design method are discussed. Eurocode 4 method is found to overestimate the resistance of concrete encased composite columns when ultra-high strength steel is used. Finally, a strain compatibility method is proposed as a modification of existing Eurocode 4 method to give reasonable prediction of the ultimate strength of concrete encased beam-columns with steel strength up to 900 MPa and concrete strength up to 100 MPa.

• Asian Journal for Public Opinion Research
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• 제10권4호
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• pp.316-339
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• 2022

The effects of the COVID-19 pandemic across various sectors are far-reaching, and the education sector is not an exemption. Approved and recognized vaccines are clinically proven to provide protection and have been considered one of the primary mitigations against the virus. Knowledge, attitude, and related practices (henceforth KAP) toward the virus is widely considered to be an essential cognitive key in public health for health intervention, prevention, and promotion. Previous studies revealed a positive correlation between knowledge and attitude. This study investigated the KAP and their relationship among the 857 college students in one state college in the Philippines using an online survey. Using descriptive statistics, the findings showed that the majority of the respondents have been fully vaccinated against COVID-19. Respondents were shown to be knowledgeable about COVID-19, specifically about its transmission, clinical symptoms, treatment, risk groups, isolation, prevention, and control. Positive attitudes toward individual and governmental mitigation and control of the virus were shown. Their scores on practices revealed that they always exhibit protective and preventive behavioral practices. Pearson correlation revealed a weak significant relationship between knowledge and practice, and a fair significant relationship between attitude and practice. No significant relationship is found between knowledge and attitude. This study hopes to find its place in the literature worthy of consideration as empirical support toward understanding a specific group's perceptive risk and preventive behavior toward the virus, policy making, and health intervention and promotion.

• 대한본초학회지
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• 제34권3호
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• pp.1-7
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• 2019

Objectives : Amyloid ${\beta}(A{\beta})$ could induce cognitive deficits through oxidative stress, inflammation, and neuron death in Alzheimer's disease (AD). This study was investigated the effect of Angelica keiskei KOIDZUMI (AK) on memory in $A{\beta}$-induced an AD model. Methods : AK was extracted uses 70% ethanol solvent. Total polyphenol and flavonoids content were obtained by the Folin-Ciocalteu and the Ethylene glycol colorimetric methods, respectively. The antioxidant activities were assessed through free radical scavenging assays using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazolin-6-sulfonic acid) (ABTS) methods. Intracerebroventrical (i.c.v) injection of $A{\beta}$ 1-42 was used to induce AD in male ICR mice, followed by administrations of 5, 10 or 20 mg/kg AK on a daily. Animals were subjected to short and long term memory behavior in Y-maze and passive avoidance test. Results : The total polyphenol and flavonoids contents of the AK extract were $88.73{\pm}6.36mg$ gallic acid equivalent/g, $84.21{\pm}5.04mg$ rutin equivalent/g, respectively. The assays of DPPH and ABTS revealed that AK extract in treated concentrations (31.25, 62.5, 125, 250, 500, $1000{\mu}g/m{\ell}$) increased antioxidant activity in a dose-dependent manner. Oral administration of AK extract significantly reversed the $A{\beta}$ 1-42-induced decreasing of the spontaneous alternation in the Y-maze test and $A{\beta}$ 1-42-induced shorting of the step-through latency in the passive avoidance test. Conclusions : The findings suggest that AK indicated the antioxidant protective effects against $A{\beta}$-induced memory deficits, and therefore a potential lead natural therapeutic drug or agent for AD.

• Nutrition Research and Practice
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• 제16권5호
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• pp.577-588
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• 2022

BACKGROUND/OBJECTIVES: Poorly regulated inflammation is believed to be the most predominant factor that can result in a wide scope of diseases including atopic dermatitis (AD). Despite many studies on the effect of pear pomace in obesity-related disorders including dysregulated gut microbiota, the protective effect of pear pomace in AD is still unknown. This study aimed to evaluate the effect of pear pomace ethanol extract (PPE) on AD by inhibiting inflammation. MATERIALS/METHODS: In the in vivo experiment, 2, 4-dinitrochlorobenzene (DNCB) was applied to NC/Nga mice to induce AD-like skin lesions. After the induction, PPE was administered daily by oral gavage for 4 weeks. The clinical severity score, serum IgE levels, spleen weight, histological changes in dorsal skin, and inflammation-related proteins were measured. In the cell study, RAW 264.7 cells were pretreated with PPE before stimulation with lipopolysaccharide (LPS). Nitrite oxide (NO) production and nuclear factor kappa B (NF-𝛋B) protein expression were detected. RESULTS: Compared to the AD control (AD-C) group, IgE levels were dramatically decreased via PPE treatment. PPE significantly reduced scratching behavior, improved skin symptoms, and decreased ear thickness compared to the AD-C group. In addition, PPE inhibited the DNCB-induced expression of inducible nitrite oxide synthase (iNOS), the receptor for advanced glycation end products, extracellular signal-regulated kinase (ERK) 1/2, and NF-𝛋B. PPE inhibited the LPS-induced overproduction of NO and the enhanced expression of iNOS and cyclooxygenase-2. Moreover, the phosphorylation of ERK1/2 and NF-𝛋B in RAW 264.7 cells was suppressed by PPE. CONCLUSIONS: These results suggest that PPE could be explored as a therapeutic agent to prevent AD.

• 융합정보논문지
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• 제12권3호
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• pp.55-65
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• 2022

파킨슨병 노인은 낙상의 신체적, 정신적 위험요인을 가진 비율이 비 파킨슨병 노인에 비해 높아, 파킨슨병 노인의 낙상 경험 유무에 따라 낙상에 영향을 주는 신체적, 정신적 위험요인을 한국 노인 전체를 모집단으로 하는 국가 데이터를 이용하여 규명하였다. 2017년 보건복지부의 노인실태 자료조사를 이용한 2차 분석연구로, 파킨슨병 노인은 총 103명이었으며 결측값을 제외하고 총 96명의 대상자를 분석하였다. 파킨슨병 노인에게서 낙상에 가장 큰 영향을 미치는 요인은 IADL로 나타났으며, IADL은 운동 조절기능과 관련이 있다. 운동 조절기능의 저하는 일상생활에 필수적으로 요구되는 신체 움직임에 제약을 가하며 위급상황에서의 자기 보호적 행동까지도 영향을 미쳐 낙상에 영향을 미친다. IADL이 낙상에 영향을 줄 수 있다는 본 연구결과를 바탕으로 파킨슨병 노인의 낙상 예방 중재를 위한 다양한 운동요법을 제안할 수 있을 것이다.

• 대한예방한의학회지
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• 제20권3호
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• pp.55-65
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• 2016

Objectives : Mibyeong is a korea medicine have original concept of the disease. However, no previous report has effect of mibyeong herbal medicine in fatigue types of mibyeong. This study investigated the question of whether Dang Gui Bo Hyul-tang(DGBHT) of effect on fatigue types of Mibyeong. Methods : C57BL/6 mice were randomaly divided into three group (n=10). The mice were then group (1) Nocontrol, (2) Restraunt stress(veh), (3) Dang Gui Bo Hyul-tang 200mg/kg. The administered Dang Gui Bo Hyul-tang 200mg/kg or distilled water (orally) 1 hr prior to daily exposure to repeated restraint stress (2 h) for 15 days. The performed behavior test (Mechanical hyperalgesia test,, Open-field test, Forced swimming test, Sucrose preference test and immunostaining and biochemical measured in serum. Results : Stress fatigue induced mices significantly increased lethargic, hyperalgesia through behavior test (Mechanical hyperalgesia test (decrease 43%), Open-field test ($4,809{\pm} 226.13cm$ vs. $3121{\pm}226.64cm$), Forced swimming test ($11.45{\pm}3.96$ vs. $79.10{\pm}8.12sec$), Sucrose preference test (decrease 58%)). In addition, chronic fatigue model evidently increased corticosterone level ($122.54{\pm}18.88$ vs. $186.94{\pm}18.26ng/ml$), AST level ($46.22{\pm}3.23$ vs. $31.40{\pm}3.86U/L$), ALT level ($38.78{\pm}5.72$ vs. $17.60{\pm}1.30$), liver necrosis, lateral ventricle size. These alterations were significantly ameliorated by DGBHT. DGBHT significantly attend the elevated serum concentrations of corticosterone ($155.90{\pm}6.29ng/ml$), AST ($31.40{\pm}3.86U/L$), ALT ($17.60{\pm}1.30U/L$). Moreover, DGBHT improved lethargic, hyperalgesia when compared the stress fatigue (Mechanical hyperalgesia test (improve 28%), Open-field test ($4,038{\pm}615.81cm$), Forced swimming test ($7.56{\pm}1.88sec$), Sucrose preference test (increase 21%) Conclusions : Theses result suggest that DGBHT have improved lethargic, hyperalgesia and fatigue-associated hormone and liver protective on stress fatigue model. It will be necessary to research to present evidences on benefits and effects of Korean medical treatment for Mibyeong through clinical researches based on benefits and effects of those animal models.

• 동의신경정신과학회지
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• 제26권3호
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• pp.319-336
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• 2015

Objectives: The object of this study was to evaluate the cognition and motor function recovery effects of Sungshim-san (SSS), a traditional Korean cardio-protective polyherbal formula in the severe rat stroke, permanent middle cerebral artery occlusion (pMCAO) model. Methods: The experimental animals were divided into 6 groups. SSS aqueous extracts (yield=16.82%; 400, 200 and 100 mg/kg) were administered orally by using Sonde, once daily, for 28 continuous days from 24 hrs post-pMCAO. Donepezil 10 mg/kg, a representative drug for dementia, was used as a reference drug. The body weight changes, infarct/defect sizes, sensorimotor function and cognitive motor behavior were serially monitored. Limb placing and body-swing test for sensorimotor functions were conducted at 1 day before operation (base line), and 1, 3, 7, 14, 21 and 28 days post-pMCAO; and water maze test for the cognitive motor behavior was conducted at 14 and 28 days post-pMCAO, respectively. Results: Focal cerebral cortex infarct and defects due to pMCAO resulted in marked decreases of body weight, disorders of sensorimotor functions and cognitive motor behaviors. However, the pMCAO-related ischemic damages were markedly and dose-dependently inhibited by treatment with SSS 400 and 200 mg/kg, respectively. Donepezil markedly decreased the body weight and gains, as compared with pMCAO control rats; however, SSS 400 and 200 mg/kg favorably ameliorated the pMCAO-induced decreases in body weight and gains. SSS 100 mg/kg treated rats did not show any favorable effects on the pMCAO-related ischemic damages, as compared with pMCAO control rats. Conclusions: The results of the study indicated that oral administration of SSS 400 and 200 mg/kg accelerated cognition and motor function recovery in the rat pMCAO model. The treatment effect was potentially mediated by neuroprotection via the known augmentation of cerebral antioxidant defense system of SSS itself or its individual herbal components. Especially, the overall effects of SSS 200 mg/kg were similar to those of donepezil 10 mg/kg, but less toxic.

• 한국터널지하공간학회 논문집
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• 제9권2호
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• pp.109-120
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• 2007

대형 대단면 터널의 시공시 지반 변형을 억제시키고 지반의 강성을 증가시키며 차수 및 지수를 확보하기 위해 다양한 사전 보강공법들이 굴착전 막장 천단부 전방에 적용되고 있으나 물성치 결정 및 시공단계 해석에 있어서 여러 오류를 안고 있다. 본 연구에서는 탄성파를 이용하여 사전보강영역의 시간 의존적 강도 및 강성 특성을 분석하는 기법을 제시하였다. 실내실험을 통해 획득한 탄성파속도와 전단강도는 경화시간에 따라 증가하며, 전단강도와 전단강도정수는 탄성파 속도와 일정한 관계를 갖는 것으로 분석된다. 재령에 따른 탄성계수와 점착력을 터널의 시공단계에 따른 시뮬레이션에 적용하여 경시효과가 터널 변위 거동에 미치는 영향을 분석하였다. 해석결과 $1{\sim}2$일 강도 및 강성을 적용한 결과가 경시효과를 고려한 경우와 갱구부에서 유사한 거동을 하며, 특히 초기 시공부분 및 갱구부에서 터널의 안정성에 큰 영향을 미치는 것으로 분석된다. 본 연구에서 제안된 기법을 통해 향후 사전보강영역의 경시효과를 고려한 터널 거동해석을 위해 실내실험과 수치해석을 병용하여 신뢰성 있는 터널 해석 및 설계를 수행하는 것이 바람직 할 것이다.