• Corrosion Science and Technology
• /
• 제2권3호
• /
• pp.141-147
• /
• 2003

Sputter-deposited Nb-Al-Cr alloys. $3-5{\mu}m$ thick, have been prepared on quartz substrates as oxidation-and sulfidation-resistant materials at high temperatures. The oxidation or the alloys in the $Ar-O_2$ atmosphere of an oxygen partial pressure of 20 kPa follows approximately the parabolic rate law, thus being diffusion controlled. Their oxidation rates are almost the same as or even lower than those ofthc typical chromia-forming alloys. The multi-lavered oxide scales are formed on the ternary alloys. The outermost layer is composed of $Cr_2O_3$, which is"mainly responsible for the high oxidation'resistance of these alloys. In contrast to sputter-deposited Cr-Nb binary alloys reported previously, the inner layer is not porous. TEM observation as well as EDX analysis indicates that the innermost layer is a mixture of $Al_2O_3$ and niobium oxide. The dispersion of $Al_2O_3$ in niobium oxide may be attributable to the prevention of the formation of the porous oxide layer. The sulfidation rates of the present ternary alloys arc higher than those of the sputter-deposited Nb-AI binary alloys, but still several orders of magnitude lower than those of conventional high temperature alloys. Two-layered sulfide scales are formed, consisting of an outer $Al_2S_3$ layer containing chromium and an inner layer composed of $NbS_2$ and a small amount of $Cr_2S_3$. The presence of $Cr_2S_3$ in the inner protective $NbS_2$ layer may be attributed to the increase in the sulfidation rates.

• The Korean Journal of Physiology and Pharmacology
• /
• 제21권6호
• /
• pp.579-589
• /
• 2017

Anesthetics are used extensively in surgeries and related procedures to prevent pain. However, there is some concern regarding neuronal degeneration and cognitive deficits arising from regular anesthetic exposure. Recent studies have indicated that brain-derived neurotrophic factor (BDNF) and cyclic AMP response element-binding protein (CREB) are involved in learning and memory processes. Genistein, a plant-derived isoflavone, has been shown to exhibit neuroprotective effects. The present study was performed to examine the protective effect of genistein against isoflurane-induced neurotoxicity in rats. Neonatal rats were exposed to isoflurane (0.75%, 6 hours) on postnatal day 7 (P7). Separate groups of rat pups were orally administered genistein at doses of 20, 40, or 80 mg/kg body weight from P3 to P15 and then exposed to isoflurane anesthesia on P7. Neuronal apoptosis was detected by TUNEL assay and FluoroJade B staining following isoflurane exposure. Genistein significantly reduced apoptosis in the hippocampus, reduced the expression of proapoptotic factors (Bad, Bax, and cleaved caspase-3), and increased the expression of Bcl-2 and Bcl-xL. RT-PCR analysis revealed enhanced BDNF and TrkB mRNA levels. Genistein effectively upregulated cAMP levels and phosphorylation of CREB and TrkB, leading to activation of cAMP/CREB-BDNF-TrkB signaling. PI3K/Akt signaling was also significantly activated. Genistein administration improved general behavior and enhanced learning and memory in the rats. These observations suggest that genistein exerts neuroprotective effects by suppressing isoflurane-induced neuronal apoptosis and by activating cAMP/CREB-BDNF-TrkB-PI3/Akt signaling.

• 대한본초학회지
• /
• 제35권5호
• /
• pp.33-39
• /
• 2020

Objectives : Increasing evidence supports the biological and pharmacological activities of essential oils on the central nervous system such as pain, anxiety, attention, arousal, relaxation, sedation and learning and memory. The purpose of present work is to investigate the protective effect and molecular mechanism of cypress essential oil (CEO) against scopolamine (SCO)-induced cognitive impairments in C57BL/6 mice. Methods : A series of behavior tests such as Morris water maze, passive avoidance, and fear conditioning tests were conducted to monitor learning and memory functions. Immunoblotting and RT-PCR were also performed in the hippocampal tissue to determine the underlying mechanism of CEO. Results : SCO induced cognitive impairments as assessed by decreased step-through latency in passive avoidance test, relatively low freezing time in fear conditioning test, and increased time spent to find the hidden platform in Morris water maze test. Conversely, CEO inhalation significantly reversed the SCO-induced cognitive impairments in C57BL/6 mice comparable to control levels. To elucidate the molecular mechanisms of memory enhancing effect of CEO we have examined the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus. CEO effectively elevated the protein as well as mRNA expression of BDNF via activation of cAMP response element binding protein (CREB). Conclusions : Our findings suggest that CEO inhalation effectively restored the SCO-impaired cognitive functions in C56BL/6 mice. This learning and memory enhancing effect of CEO was partly mediated by up-regulation of BDNF via activation of CREB.

• 한국사회복지학
• /
• 제68권3호
• /
• pp.105-125
• /
• 2016

학교결석은 학업중단이나 비행 범죄에 대한 잠정적인 조기 예측요인으로 그 중요성이 강조되고 있다. 이에 본 연구는 생태체계적 관점을 토대로 시간의 흐름에 따라 아동의 학교결석일에 영향을 미치는 다양한 보호요인과 위험요인을 경험적으로 검증하였다. 이를 위해 한국아동 청소년패널조사에서 초4 패널의 2차년도와 3차년도의 자료를 활용하였으며, 초등학교 2,378명을 대상으로 패널회귀분석의 고정효과모형을 적용하였다. 분석결과, 아동의 컴퓨터 사용시간, 부모의 학대, 학교활동참여정도, 학업성적이 학교결석일 변화에 중요한 영향을 미치는 것으로 나타났다. 특히 컴퓨터 사용시간, 부모의 학대는 학교결석에 위험요인으로 작용하였으며, 학교활동참여와 학업성적은 학교결석에 보호요인으로 작용하였다. 이러한 연구결과들을 바탕으로 우리나라 아동 청소년 문제에 대한 예방적 접근의 필요성을 강조하고 학교결석에 대한 체계적인 모니터링 시스템 구축의 필요성을 제언하였다.

• Nuclear Engineering and Technology
• /
• 제45권7호
• /
• pp.847-858
• /
• 2013

Since 2001, a series of five irradiation test campaigns for atomized U-Mo dispersion fuel rods, KOMO-1, -2, -3, -4, and -5, has been conducted at HANARO (Korea) in order to develop high performance low enriched uranium dispersion fuel for research reactors. The KOMO irradiation tests provided valuable information on the irradiation behavior of U-Mo fuel that results from the distinct fuel design and irradiation conditions of the rod fuel for HANARO. Full size U-Mo dispersion fuel rods of 4-5 $g-U/cm^3$ were irradiated at a maximum linear power of approximately 105 kW/m up to 85% of the initial U-235 depletion burnup without breakaway swelling or fuel cladding failure. Electron probe microanalyses of the irradiated samples showed localized distribution of the silicon that was added in the matrix during fuel fabrication and confirmed its beneficial effect on interaction layer growth during irradiation. The modifications of U-Mo fuel particles by the addition of a ternary alloying element (Ti or Zr), additional protective coatings (silicide or nitride), and the use of larger fuel particles resulted in significantly reduced interaction layers between fuel particles and Al.

• 한국재료학회지
• /
• 제8권8호
• /
• pp.685-692
• /
• 1998

용융탄산염 연료전지는 $650^{\circ}C$의 부식성이 강한 용융탄산염내에서 작동되므로, 분리판 재료로 사용되고 있는 316L 스테인레스강의 부식은 용융탄산염 연료전지의 수명을 단축시키는 주요한 원인이다. 특히 분리판 wet-seal부의 부식은 보다 심각한 것으로 알려져 있다. 이를 해결하기 위하여 AI계 합금이 피복재료로 사용되어 왔지만, 본 연구에서는 보다 우수한 분리판 wet-seal부의 내식 피복재료 개발을 위하여 피복재료인 NiAI 합금에 산화 활성화 원소인 yttrium을 최고 1.5 at%까지 첨가하였다. $650^{\circ}C$의 용융탄산염내에서 yttium 함량에 따른 NiAI/Y 합금의 침지부식실험 및 분극실험을 통하여 내식성을 평가하고 부식 억제를 위해 가장 적절한 NiAI/Y 피복 재료의조성을 결정한 결과 최소의 yttrium 조성은 0.7 at% 임을 알 수 있었다.

• 한국치위생학회지
• /
• 제11권4호
• /
• pp.571-580
• /
• 2011

Objectives : This study focused on examine the relevance between behavioral changes of customers and re-use intention on medical institution after experiencing infection control through external stimuli. Methods : This research was based on self-standing survey conducted from August to November 2010, 214 people who randomly selected from five dental clinics located in Busan were analyzed as the final group. Collected data were performed using SPSS 12.0 for Window. Results : 1. 82.8% of those surveyed who experienced external stimulation have changed their behavior on hospital environments and facilities, and 80.5% of them answered the stimuli influenced their re-use intention on medical institution. 2. There were no significant differences between participants by general characteristics on 'The reason why medical team wear sanitary appliances'. In age group 30~39, 85.4% of participants chose the answer so the difference were statistically significant(p<.001). Result by household income showed significant difference in group over $1,000 to $2,000 as 82.7% response(p<.05). 3. 94.4% of participants chose 'Required' for both surgical suits and gloves in research of 'The necessity level of personal sanitary appliances' which medical teams wear for treatment and 79.4% agreed that medical teams need to change their medical gloves whenever treating each patients. 4. The survey revealed that the most important appliance in patient's awareness were surgical gloves and protective goggles has chosen as the least important one. Conclusions : Patients as medical consumer were highly noticed of importance of the infection control in dental clinic and necessity of personal sanitary appliances. The patients who has accessed dental infection control information by external stimuli in advance showed objectival changes of their visit and behavioral changes with bringing medical environments together. This aspects influenced those patient's re-use intention in conclusion.

• The Korean Journal of Physiology and Pharmacology
• /
• 제10권6호
• /
• pp.309-315
• /
• 2006

The protective effects of baicalein, one of the flavonoids in Scutellaria baicalensis Georgi, were evaluated against 6-hydroxydopamine (6-OHDA)-induced neuronal damage in mice and cultured human neuroblastoma cells. Nigrostriatal damage was induced by stereotaxically injecting 6-OHDA into the right striatum. Baicalein was administered intraperitoneally 30 min before and 90 min after lesion induction. Animals received a further daily injection of baicalein for 3 consecutive days. Two weeks after 6-OHDA injection, contralateral rotational asymmetry was observed by apomorphine challenge in lesioned mice. Tyrosine hydroxylase (TH) immunohistochemistry revealed a significant loss of terminals in lesioned striatum and the reduction of the numbers of TH-positive cell in the ipsilateral substantia nigra (SN). In addition, the levels of dopamine (DA) and DA metabolites were reduced and lipid peroxidation was increased in lesioned striatum. However, baicalein treatment reduced apomorphine-induced rotational behavior in 6-OHDA-lesioned mice, and increased TH immunoreactivity in the striatum and SN, and DA levels in lesioned striatum. Lipid peroxidation induced by 6-OHDA was also inhibited by baicalein treatment. Furthermore, when SH-SY5Y human neuroblastoma cells were treated with baicalein, 6-OHDA-induced cytotoxicity and reactive oxygen species (ROS) production were significantly reduced. These results indicate that baicalein effectively protects 6-OHDA-induced neuronal damage through antioxidant action.

• Nuclear Engineering and Technology
• /
• 제43권6호
• /
• pp.557-566
• /
• 2011

A cold spray coating (CSC) of copper was studied for its application to a high-level radioactive waste (HLW) disposal canister. Several copper coatings of 10 mm thick were fabricated using two kinds of copper powders with different oxygen contents, and SS 304 and nodular cast iron were used as their base metal substrates. The fabricated CSC coppers showed a high tensile strength but were brittle in comparison with conventional non-coating copper, hereinafter defined to as "commercial copper". The corrosion behavior of CSC coppers was evaluated by comparison with commercial coppers, such as extruded and forged coppers. The polarization test results showed that the corrosion potential of the CSC coppers was closely related to its purity; low-purity (i.e., high oxygen content) copper exhibited a lower corrosion potential, and high-purity copper exhibited a relatively high corrosion potential. The corrosion rate converted from the measured corrosion current was not, however, dependent on its purity: CSC copper showed a little higher rate than that of commercial copper. Immersion tests in aqueous HCl solution showed that CSC coppers were more susceptible to corrosion, i.e., they had a higher corrosion rate. However, the difference was not significant between commercial copper and high-purity CSC copper. The decrease of corrosion was observed in a humid air test presumably due to the formation of a protective passive film. In conclusion, the results of this study indicate that CSC application of copper could be a useful option for fabricating a copper HLW disposal canister.

• 대한기계학회논문집A
• /
• 제38권2호
• /
• pp.157-166
• /
• 2014

경수로 핵연료가 원자로내에서 연소되는 동안 핵연료 펠릿에서부터 피복관까지 온도해석은 핵연료 안전 해석에 있어 중요한 요소이며, 경수로 핵연료 온도 해석을 하기 위해서는 간극 모델 개발이 필수적이다. 간극 열전도도는 특성상 간극 두께값에 의존적이게 되며 이러한 특성으로 인해 다차원 간극 열전도도 모델이 비선형적 거동을 보인다. 본 연구에서는 선형화된 다차원 간극 열전도도 모델 개발을 위해 가상 연결 간극 요소를 제안하였다. 제안된 간극 연결 요소에 간극 열전도도를 적용하기 위해 등가 열전달 계수를 정의하였다. 제안된 모듈을 평가하기 위해 상용코드 ANSYS APDL 을 이용하여 열-구조 연계 해석 모듈을 구현하였으며, 다양한 예제를 통해 정확성과 수렴성을 평가하였다.