• Korean Institute of Interior Design Journal
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• v.24 no.1
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• pp.34-42
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• 2015

This research is about shared living facilities for the solitary elderly in Gyeonggi province (so called "Carnation House"), which was opened after 2013. These facilities aim to help solving the social problems of the growing number of the solitary elderly. The research was conducted from April 2014 to October 2014 by using observation, measurement, photography, and interview methods. This research reviewed floor plan, area, accessibility, visual openness, and furniture and equipments. The results are as follows: First, considering the need for rest area and the protection of privacy, livingroom should at least be equipped with a variable wall or have a separate room. Secondly, for the kitchen plan, considering the fact that large number of people move simultaneously, kitchen entrance should be widened or LDK type is preferable. Thirdly, the bathroom entrance should be widened to at least 800mm and should have barrier free design. Fourthly, porch entrance should be planned to secure enough space and shoe cabinets for multiple users. Fifthly, to allow the users to enjoy outside view, the windows of living spaces should be placed no higher than 800mm from the floor level. Finally, for the location of the facility, people prefer the location be at the center of the village or near home. In addition, location with easy accessibility for the elderly is advisable. Therefore, establishing local guidelines for shared living facilities for the solitary elderly is advisable. When establishing local guidelines, local characters, culture and usage patterns should be considered.

• Journal of Chest Surgery
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• v.42 no.1
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• pp.100-103
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• 2009

Traumatic rupture of the thoracic aorta is the second most common cause of death from motor vehicle accidents after head injury. About 85% of these patients do not survive to reach the hospital. The most common mechanism for this is deceleration injury, as occurs in a high speed motor vehicle accident. The aortic isthmus is the site of disruption for about 95% of all blunt thoracic aortic injuries. Another mechanism is crush injury which causes compression of the aorta between the displaced sternal body or manubrium and the thoracic vertebral column. These forces tear the inner layer of the aortic wall at an unusual location. We report here on a case of aortic arch dissection where the injury clearly occurred due to a crush injury and not because of deceleration. The surgical repair was delayed for 10 days after administering intensive medical therapy. The ascending aorta and aortic arch were replaced with an artificial graft with the patient under circulatory arrest and cerebral protection.

• 한국방재학회:학술대회논문집
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• 2011.02a
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• pp.218-218
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• 2011

2중곡면 반파공의 월파 특성을 검토하기 위하여 입사파고 및 주기가 각각 다른 불규칙파를 대상으로 수리실험을 실시하였으며, 2중곡면 반파공과 직립형 구조물에 대해 동일한 조건으로 실험하여 이를 명확히 하였다. 특히 2중곡면 상부의 곡률반경에 따라 외해측으로 되돌리는 파랑의 비말효과에서 큰 차이가 있을 것에 착안하여 상부곡면부의 곡률반경이 증가한 정상 2중곡면 반파공(FSW)과 상부곡면부의 곡률반경이 감소한 역 2중곡면 반파공(IFSW)에 대해 실험을 수행하였다. 그리고 2중곡면 원호 크기의 비 B/D=0, 20%, 40%, 60% 및 80%인 경우에 대해서도 월파특성을 비교 검토하여 다음과 같은 결론를 얻었다. 1. 2중곡면 원호 크기의 비 B/D가 증가할수록 월파저지 효과가 개선됨을 확인 하였으며 최대 B/D가 0.8인 경우 0.2에 비해 50% 이상 월파유량이 감소하여 B/D의 변동에 따른 월파저지특성을 확인하였다. 2. 역2중곡면 반파공(IFSW)의 실험결과 기존 정상2중곡면 반파공(FSW)에 비하여 20%이상 월파량이 감소하고 있음을 알 수 있었으며 이는 2중곡면 상부측의 곡률 반경이 증가함에 따른 기하학적 특성에 의해 외해측으로의 되돌림 파랑(수괴)이 증가한 것으로 판단된다. 3. 동일한 마루높이에 대해 직립형 호안에 의한 월파량 비교결과 역 2중곡면 반파공(IFSW)의 경우 최대 80%이상의 월파량 저감 효과가 나타나는 것으로 검토되었다. 4. 월파저지의 측면에서 2중 곡면공에 비해 역2중 곡면공이 우수한 것으로 예측되었으나 2중곡면 반파공의 소파원리가 반파공의 원호내에서 쇄파를 야기하여 파에너지를 소멸하는 것이므로 쇄파를 유도하는 과정에서 충격쇄파압의 발생이 예측되는 바 이에 대한 계속적인 연구가 필요한 것으로 판단된다.

• The Korean Journal of Physiology and Pharmacology
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• v.20 no.6
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• pp.621-628
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• 2016

Hypertension can be caused by various factors while the predominant causes include increase in body fluid volume and resistance in the circulatory system that elevate the blood pressure. Consumption of probiotics has been proven to attenuate hypertension; however, the effect is much strain-dependent. In this study, a newly isolated Lactobacillus casei (Lb. casei ) strain C1 was investigated for its antihypertensive properties in spontaneously hypertensive rats (SHR). Lactic acid bacteria (LAB) suspension of 11 log colony-forming unit (CFU) was given to SHR (SHR+LAB, n=8), and phosphate buffer saline (PBS) was given as a control in SHR (SHR, n=8) and in Wistar rats as sham (WIS, n=8). The treatment was given via oral gavage for 8 weeks. The results showed that the weekly systolic blood pressure (SBP), mean arterial pressure (MAP), diastolic blood pressure (DBP) and aortic reactivity function were remarkably improved after 8 weeks of bacterial administration in SHR+LAB. These effects were mostly attributed by restoration of wall tension and tensile stress following the bacterial treatment. Although not statistically significant, the level of malondialdehye (MDA) in SHR+LAB serum was found declining. Increased levels of glutathione (GSH) and nitric oxide (NO) in SHR+LAB serum suggested that the bacterium exerted vascular protection through antioxidative functions and relatively high NO level that induced vasodilation. Collectively, Lb. casei strain C1 is a promising alternative for hypertension improvement.

• The Korean Journal of Physiology and Pharmacology
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• v.17 no.2
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• pp.133-137
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• 2013

Vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), P- and E-selectin play a pivotal role for initiation of atherosclerosis. Ginsenoside, a class of steroid glycosides, is abundant in Panax ginseng root, which has been used for prevention of illness in Korea. In this study, we investigated the mechanism(s) by which ginsenoside Rg2 may inhibit VCAM-1 and ICAM-1 expressions stimulated with lipopolysaccharide (LPS) in human umbilical vein endothelial cell (HUVEC). LPS increased VCAM-1 and ICAM-1 expression. Ginsenoside Rg2 prevented LPS-mediated increase of VCAM-1 and ICAM-1 expression. On the other hand, JSH, a nuclear factor kappa B (NF-${\kappa}B$) inhibitor, reduced both VCAM-1 and ICAM-1 expression stimulated with LPS. SB202190, inhibitor of p38 mitogen-activated protein kinase (p38 MAPK), and wortmannin, phosphatidylinositol 3-kinase (PI3-kinase) inhibitor, reduced LPS-mediated VCAM-1 but not ICAM-1 expression. PD98059, inhibitor of mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK/ERK) did not affect VCAM-1 and ICAM-1 expression stimulated with LPS. SP600125, inhibitor of c-Jun N-terminal kinase (JNK), reduced LPS-mediated ICAM-1 but not VCAM-1 expression. LPS reduced IkappaB${\alpha}$ ($I{\kappa}B{\alpha}$) expression, in a time-dependent manner within 1 hr. Ginsenoside Rg2 prevented the decrease of $I{\kappa}B{\alpha}$ expression stimulated with LPS. Moreover, ginsenoside Rg2 reduced LPS-mediated THP-1 monocyte adhesion to HUVEC, in a concentration-dependent manner. These data provide a novel mechanism where the ginsenoside Rg2 may provide direct vascular benefits with inhibition of leukocyte adhesion into vascular wall thereby providing protection against vascular inflammatory disease.

• Nutrition Research and Practice
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• v.11 no.5
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• pp.381-387
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• 2017

BACKGROUND/OBJECTIVES: Vascular dementia (VaD) caused by reduced blood supply to the brain manifests as white matter lesions accompanying demyelination and glial activation. We previously showed that arabinoxylan consisting of arabinose and xylose, and arabinose itself attenuated white matter injury in a rat model of VaD. Here, we investigated whether larch arabinogalactan (LAG) consisting of arabinose and galactose could also reduce white matter injury. MATERIALS/METHODS: We used a rat model of bilateral common carotid artery occlusion (BCCAO), in which the bilateral common carotid arteries were exposed and ligated permanently with silk sutures. The rats were fed a modified AIN-93G diet supplemented with LAG (100 mg/kg/day) for 5 days before and 4 weeks after being subjected to BCCAO. Four weeks after BCCAO, the pupillary light reflex (PLR) was measured to assess functional consequences of injury in the corpus callosum (cc). Additionally, Luxol fast blue staining and immunohistochemical staining were conducted to assess white matter injury, and astrocytic and microglial activation, respectively. RESULTS: We showed that white matter injury in the the cc and optic tract (opt) was attenuated in rats fed diet supplemented with LAG. Functional consequences of injury reduction in the opt manifested as improved PLR. Overall, these findings indicate that LAG intake protects against white matter injury through inhibition of glial activation. CONCLUSIONS: The results of this study support our hypothesis that cell wall polysaccharides consisting of arabinose are effective at protecting white matter injury, regardless of their origin. Moreover, LAG has the potential for development as a functional food to prevent vascular dementia.

• YAKHAK HOEJI
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• v.52 no.1
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• pp.73-78
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• 2008

Immune system can protect host attacking from a variety of microorganism and virus through innate and adaptive immunities. The innate immune system can be activated by recognition of conserved carbohydrates on the cell surface of pathogen resulting in protection, immunity regulation and inflammation. Immunostimulating and anti-tumor ${\beta}$-glucan, major cell wall component of many fungi, could be recognized as pathogen associated molecular pattern (PAMP) by C-type lectin such as pathogen recognition receptor (PRR) of host innate immunity cells. In spite of many studies of basidiomycetes ${\beta}$-glucan on immunostimulation, little is known about the precise mechanism as molecular-level. Among C-type lectins, dectin-1 was cloned and reported as a ${\beta}$-glucan receptor. In this report, we demonstrated induction of cytokine gene transcription by Ganoderma lucidum ${\beta}$-glucan in the absence or presence of lipopolysaccharide (LPS) by RT-PCR analysis. The expression of murine dectin-1 (MD-1) on RAW264.7 macrophage by RT-PCR showing both the full length, 757 bp $(MD-1{\alpha})$ and alternative spliced form, 620 bp $(MD-1{\beta})$. Both $MD-1{\alpha}$ and $MD-1{\beta}$ mRNAs were induced by ${\beta $-glucan both in the absence and presence of LPS. To explore expression of inflammatory cytokines by ${\beta}$-glucan, RAW264.7 cells were treated with ${\beta}$-glucan for 12 hours. As a result, the expressions of IL-1 IL-6, IL-l0 and $TNF-{\alpha}$ were increased by ${\beta}$-glucan treatment in a dose-dependent fashion. From these results, ${\beta}$-glucan induced transcriptions of dectin-1 and immune activating cytokine genes, indicating induction of immune allertness by expressing dectin-1 and secreting inflammatory cytokines.

• The Journal of Korean Obstetrics and Gynecology
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• v.20 no.2
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• pp.43-59
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• 2007

Purpose : Astragalus membranaceus is a herb which has effectiveness of energy increase, protection against pathogenic and organ immune response control. Endometriosis has been thought to be related with immune response in uterus. Therefore in this study, the effects of Astragalus membranaceus on endometriosis were investigated. Methods : The endometrial tissue was autografted to rat's small intestine. Rats with surgically induced endometriosis was administerd with Astragalus membranaceus extracts for 40 days orally or rectally. We observed the size of ectopic uterine implants at the mesenteric with the naked eye and examined the concentrations of estradiol, progesterone, $TNF-{\alpha}$ and IL-2, IL-4, IL-6 and IL-10 in serum. Also, we inquired out the efficiency between oral and rectal administration groups. Results : The size of ectopic uterine implants of oral and rectal treated groups were much smaller than those of control groups. The concentration of estradiol, progesterone. $TNF-{\alpha}$ and IL-2 were significantly decreased in oral administration experimental group compared with the control group. The concentration of progesterone were significantly decreased in rectal administration experimental group compared with the control group. The efficiency of oral administration group was better than that of rectal administration group in the serum concentration of estradiol, $TNF-{\alpha}$ and IL-2. Conclusion : Our data suggest that Astragalus membranaceus reduce the size of ectopic uterine implants at the mesenteric wall and inhibit the growth of ectopic uterine implants. Judging from the above results, it can be suggested that Astragalus membranaceus should be a useful agent for inhibiting the proliferation of uterine endometrial tissue. May be, oral administration of Astragalus membranaceus is more effective than rectal administration for inhibiting the proliferation of endometriosis.

• Proceedings of the Korea Concrete Institute Conference
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• 2008.11a
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• pp.49-52
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• 2008

The plain and simple shape water front structure were designed and installed for wave protection and wave resistance. But the installation of these plain and simple structure cause deficiency of environmental affinity. Also the resonance phenomena from the reflective wave and shipwave of the harbor incident wave caused high tide and wave, consequently maintaining the tranquility of inside harbor, give difficulty for mooring the ship and loading-unloading, increase the possibility of ship collision at the quray wall and landing place To solve these problems, we develop the environmentally friendly wave dissipation block. And installation efficiency, stability of the blocks through experiment of C.E Block Joint.

• KOREAN JOURNAL OF PACKAGING SCIENCE & TECHNOLOGY
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• v.25 no.3
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• pp.125-130
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• 2019

Shock and vibration inputs are transmitted from the vehicle through the packaging to the fruit. Inside, these cause sustained bouncing of fruits against each other and container wall. These steady state vibration input may cause serous fruit injury, and this damage is particularly severe whenever the fruit inside the package is free to bounce, and is vibrated at its resonance frequency. The determination of the resonance frequencies of the fruit and vegetables may help the packaging designer to determine the proper packaging system providing adequate protection for the fruit, and to understand the complex interaction between the components of fruit when they relate to expected transportation vibration inputs. Instrumentation and technologies are described for determining the vibration response characteristics of the pears for exporting with frequency range from 10 to 200 Hz, sweep rate of 1 octave/min, sweep method of logarithmic up and down and acceleration levels of 0.2, 0.4, 0.6, 0.8 and 1.0 G considering the domestic transportation environment. The resonance frequency of the pears ranged from 49.04 to 87.16 Hz and the amplitude at resonance was between 0.96 and 4.02 G in test frequency band and acceleration level. The resonance frequency and amplitude at resonance frequency band of the pears decreased with the increase of the sample mass. The multiple nonlinear regression equations for predicting the resonance frequency of the pears were developed using the independent variables such as mass, input acceleration.